Advances in clinical chemistry最新文献_第3页

Advances in biomimetic sensor technology. 仿生传感器技术的进展。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-05-02 DOI: 10.1016/bs.acc.2025.04.003

Merve Asena Özbek, Özge Altıntaş, Fatma Yılmaz, Adil Denizli

{"title":"Advances in biomimetic sensor technology.","authors":"Merve Asena Özbek, Özge Altıntaş, Fatma Yılmaz, Adil Denizli","doi":"10.1016/bs.acc.2025.04.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.04.003","url":null,"abstract":"Biomimetic sensor technology, inspired by nature's ingenious designs, has garnered significant attention for its potential in revolutionizing various fields, ranging from healthcare to environmental monitoring. Recent advances in biomimetic sensor technology have made it possible to develop unique and extremely sensitive sensors that imitate the capabilities of biological systems. The enhanced detection of different analytes with high specificity and sensitivity is facilitated by these sensors, which draw inspiration from natural organisms and their sensory capacities. New developments in materials science and nanotechnology have further enabled the development of novel biomimetic sensing platforms, such as nanostructured surfaces, membranes, and nanoparticles. This chapter highlights recent advances in biomimetic sensor technology, elucidating the principles, design strategies and applications driving its rapid development. We provide an overview of the most recent advancements in biomimetic sensor technology, which are driving the field forward by exploring the diverse applications of biomimetic sensors across various fields. Challenges and future aspects in biomimetic sensor research are also addressed, such as improving sensor biocompatibility, enhancing sensor stability-reproducibility and scaling up production for commercialization.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"127 ","pages":"85-117"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-associated carbohydrate antigens: Biomarker discovery and clinical application. 肿瘤相关碳水化合物抗原：生物标志物的发现和临床应用。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-07-20 DOI: 10.1016/bs.acc.2025.06.006

Teresa Freire, Valeria da Costa

{"title":"Tumor-associated carbohydrate antigens: Biomarker discovery and clinical application.","authors":"Teresa Freire, Valeria da Costa","doi":"10.1016/bs.acc.2025.06.006","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.06.006","url":null,"abstract":"Tumor-Associated Carbohydrate Antigens (TACAs) are carbohydrate structures uniquely expressed on the surface of tumor cells while being absent or minimally present in normal tissues. These molecular signatures play crucial roles in tumor progression, contributing to essential processes such as cell adhesion, motility, invasion, immune evasion, angiogenesis, metastasis, and proliferation. TACAs arise due to aberrant glycosylation, a hallmark of cancer cells, leading to their overexpression in various malignancies. Notably, elevated levels of certain TACAs have been associated with poor clinical outcomes in cancer patients. Because of their selective expression, TACAs serve as important biomarkers for cancer detection, prognosis, and disease monitoring. Their presence in the bloodstream of patients with epithelial carcinomas, neuroblastomas, and melanomas has led to the development of assays capable of quantifying these antigens in sera, providing valuable tools for clinical applications. The ability to measure TACAs in biological fluids enables early diagnosis and improved patient management, making them attractive targets for liquid biopsy strategies. Beyond their diagnostic utility, TACAs hold great promise for therapeutic applications, particularly in cancer immunotherapy. Their restricted expression on cancer cells makes them ideal targets for vaccine development, monoclonal antibody therapy, and chimeric antigen receptor (CAR) T-cell approaches. By exploiting the immune system's ability to recognize and target these antigens, novel treatment strategies are being explored to enhance anti-tumor immunity. Continued research into TACAs may lead to innovative diagnostic and therapeutic advancements, improving cancer patient outcomes and broadening the scope of precision medicine.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"128 ","pages":"249-278"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visceral fat distribution: Interracial studies. 内脏脂肪分布：跨种族研究。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-11-05 DOI: 10.1016/bs.acc.2024.10.001

Santasree Banerjee, Jiayin Lv, Chang He, Baiyu Qi, Weijie Ding, Kongrong Long, Junrong Chen, Jianping Wen, Peng Chen

{"title":"Visceral fat distribution: Interracial studies.","authors":"Santasree Banerjee, Jiayin Lv, Chang He, Baiyu Qi, Weijie Ding, Kongrong Long, Junrong Chen, Jianping Wen, Peng Chen","doi":"10.1016/bs.acc.2024.10.001","DOIUrl":"10.1016/bs.acc.2024.10.001","url":null,"abstract":"Visceral adipose tissue, a type of abdominal adipose tissue, is highly involved in lipolysis. Because increased visceral adiposity is strongly associated with the metabolic complications related with obesity, such as type 2 diabetes and cardiovascular disease, there is a need for precise, targeted, personalized and site-specific measures clinically. Existing studies showed that ectopic fat accumulation may be characterized differently among different populations due to complex genetic architecture and non-genetic or epigenetic components, ie, Asians have more and Africans have less visceral fat vs Europeans. In this review, we summarize the effects of multiple non-genetic and genetic factors on visceral fat distribution across races. Non-genetic factors include diet, socioeconomic status, sex hormones and psychological factors, etc. We examine genetic factors of racial differences in visceral fat content as well as possible regulatory pathways associated with interracial visceral fat distribution. A comprehensive understanding of both genetic and non-genetic factors that influence the distribution of visceral fat among races, leads us to predict risk of abdominal obesity and metabolic diseases in ethnic groups that enables targeted interventions through accurate diagnosis and treatment as well as reduced risk of obesity-associated complications.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"124 ","pages":"57-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143018622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging biomarkers in Gaucher disease. 戈谢病新出现的生物标志物。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1016/bs.acc.2024.11.001

Danielle M Luettel, Marcia R Terluk, Jaehyeok Roh, Neal J Weinreb, Reena V Kartha

{"title":"Emerging biomarkers in Gaucher disease.","authors":"Danielle M Luettel, Marcia R Terluk, Jaehyeok Roh, Neal J Weinreb, Reena V Kartha","doi":"10.1016/bs.acc.2024.11.001","DOIUrl":"10.1016/bs.acc.2024.11.001","url":null,"abstract":"Gaucher disease (GD) is a rare lysosomal disorder characterized by the accumulation of glycosphingolipids in macrophages resulting from glucocerebrosidase (GCase) deficiency. The accumulation of toxic substrates, which causes the hallmark symptoms of GD, is dependent on the extent of enzyme dysfunction. Accordingly, three distinct subtypes have been recognized, with type 1 GD (GD1) as the common and milder form, while types 2 (GD2) and 3 (GD3) are categorized as neuronopathic and severe. Manifestations variably include hepatosplenomegaly, anemia, thrombocytopenia, easy bruising, inflammation, bone pain and other skeletal pathologies, abnormal eye movements and neuropathy. Although the molecular basis of GD is relatively well understood, currently used biomarkers are nonspecific and inadequate for making finer distinctions between subtypes and in evaluating changes in disease status and guiding therapy. Thus, there is continued effort to investigate and identify potential biomarkers to improve GD diagnosis, monitoring and potential identification of novel therapeutic targets. Here, we provide a comprehensive review of emerging biomarkers in GD that can enhance current understanding and improve quality of life through better testing, disease management and treatment.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"124 ","pages":"1-56"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-cell junctional proteins in cancer. 癌细胞中的细胞连接蛋白。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-12-14 DOI: 10.1016/bs.acc.2024.11.006

Aparajita Das, Sarbani Giri, Pubali Dey

引用次数: 0

Preface. 前言。

Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00008-3

Gregory S Makowski

引用次数: 0

Preeclampsia and eclampsia: the role of hemolytic protozoan iron. 子痫前期与子痫：溶血原生动物铁的作用。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI: 10.1016/bs.acc.2024.11.008

Kevin Roe

{"title":"Preeclampsia and eclampsia: the role of hemolytic protozoan iron.","authors":"Kevin Roe","doi":"10.1016/bs.acc.2024.11.008","DOIUrl":"10.1016/bs.acc.2024.11.008","url":null,"abstract":"Organisms as well as pathogens require several transition metals including iron, copper, zinc, manganese, nickel and cobalt, for genetic replication and other cellular functions. Of these, iron is vital and plays a key role in DNA replication, transcription, synthesis of cofactors and other essential enzymes. During infection, iron deprivation, particularly sequestration thereof, represents a unique response against pathogen attack. The host sequesters ferrous (Fe2+) and ferric (Fe3+) iron via lactoferrin binding at mucosal surfaces, transferrin in blood and tissue and ferritin in blood and cytoplasm. Despite this protective mechanism, pathogens can be resilient in obtaining iron. For example, hemolytic protozoan parasites can obtain iron from heme by rupturing red blood cells. Furthermore, earlier pathogens, driven from active to inactive infections by iron deprivation, could now acquire sufficient iron to enable reactivation resulting in chronic inflammation, oxidative stress to organs and/or circulatory hypertension potentially leading to death. This review discusses the impact of hemolytic protozoan parasite infection in reactivation of latent iron-deprived pathogen infections thus explaining two puzzling pregnancy disorders, pre-eclampsia (PE) and eclampsia. The unknown causations of both disorders have created centuries of confusion and killed millions of women worldwide. Furthermore, reduction-oxidation reactions with iron promote additional oxidative stress damage to vital organs, particularly the kidneys, a common symptom in PE and eclampsia.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"169-194"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomarkers of endometriosis. 子宫内膜异位症的生物标志物。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-15 DOI: 10.1016/bs.acc.2025.01.004

Hafiz Muhammad Arsalan, Hina Mumtaz, Antonio Simone Lagana

{"title":"Biomarkers of endometriosis.","authors":"Hafiz Muhammad Arsalan, Hina Mumtaz, Antonio Simone Lagana","doi":"10.1016/bs.acc.2025.01.004","DOIUrl":"10.1016/bs.acc.2025.01.004","url":null,"abstract":"Endometriosis represents a diverse disease characterized by three distinct phenotypes: superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis. The most widely accepted pathophysiological hypothesis for endometriosis is rooted in retrograde menstruation, a phenomenon observed in most patients. Endometriosis is closely linked to infertility, but having endometriosis does not necessarily imply infertility. The disease can impact fertility through various mechanisms affecting the pelvic cavity, ovaries, and the uterus itself. MicroRNAs (miRNAs) indeed represent a fascinating and essential component of the regulatory machinery within cells. Discovered in the early 1990s, miRNAs have since been identified as critical players in gene expression control. Unfortunately, ovarian endometrioma is a common gynecologic disorder for which specific serum markers are currently lacking. Some have examined urocortin for its ability to differentiate endometriomas from other benign ovarian cysts. Another potential marker, Cancer Antigen 125 (CA-125) is a well-established indicator for epithelial cell ovarian cancer and its levels can be elevated in conditions such as endometriosis. CA-125 is derived from coelomic epithelia, including the endometrium, fallopian tube, ovary, and peritoneum. In this review we examine the pathophysiologic basis for endometriosis and highlight potential markers to more fully characterize the underlying biochemical processes linked to this multifaceted disease state.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"73-120"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in malaria detection. 疟疾检测的进展。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-07-19 DOI: 10.1016/bs.acc.2025.06.004

Blessing Wisdom Ike, Vijayaraj Kathiresan, Lungelo Miya, Rajshekhar Karpoormath

{"title":"Advances in malaria detection.","authors":"Blessing Wisdom Ike, Vijayaraj Kathiresan, Lungelo Miya, Rajshekhar Karpoormath","doi":"10.1016/bs.acc.2025.06.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.06.004","url":null,"abstract":"Malaria remains a significant global health issue, especially in tropical and subtropical regions. Although Egypt attained malaria-free status in 2024, countries like Eritrea, Ethiopia, Ghana, Kenya, Nigeria, Somalia, Sri Lanka, Sudan, and Yemen are still considered \"High Burden High Impact\" zones. Malaria causes over 435,000 fatalities annually and places billions more at risk. Unfortunately, treatment resistance, atypical symptomology, analytical sensitivity, and the specificity of conventional detection methods have made diagnosis challenging. To mitigate the large reservoir of malaria parasites in disease hotspots, a more strategic non-invasive diagnostic tool with improved monitoring, multiplex capability and analytical performance is required. Fortunately, the advent of novel biosensor technology that uses advanced nanotechnology design and biochemical approaches provides rapid, sensitive, and cost-effective alternatives. Furthermore, these user-friendly devices require minimal technical expertise and are ideal at the point of care, especially in remote and resource-limited settings. Herein, we examine current and emerging diagnostic tools and evaluate their potential to revolutionize malaria control and eradication efforts worldwide.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"128 ","pages":"155-180"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00076-9

Gregory S Makowski

引用次数: 0