Advances in clinical chemistry最新文献_第2页

Volatile organic compound sensing: Conventional to advanced approaches. 挥发性有机化合物传感：传统到先进的方法。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-07-28 DOI: 10.1016/bs.acc.2025.06.007

Akhilesh Kumar Pathak

引用次数: 0

Preface. 前言。

Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00036-8

Gregory S Makowski

引用次数: 0

Lupus nephritis II: Treatment and monitoring. 狼疮性肾炎 II：治疗和监测。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1016/bs.acc.2025.01.001

Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma

引用次数: 0

Extracellular vesicles and microRNAs in cancer progression. 细胞外囊泡和microrna在癌症进展中的作用。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-01-28 DOI: 10.1016/bs.acc.2024.11.004

Nicola S Orefice, Gianluca Petrillo, Claudia Pignataro, Martina Mascolo, Giada De Luca, Sara Verde, Francesca Pentimalli, Gerolama Condorelli, Cristina Quintavalle

{"title":"Extracellular vesicles and microRNAs in cancer progression.","authors":"Nicola S Orefice, Gianluca Petrillo, Claudia Pignataro, Martina Mascolo, Giada De Luca, Sara Verde, Francesca Pentimalli, Gerolama Condorelli, Cristina Quintavalle","doi":"10.1016/bs.acc.2024.11.004","DOIUrl":"10.1016/bs.acc.2024.11.004","url":null,"abstract":"Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication in cancer. These membranous structures, secreted by normal and cancerous cells, carry a cargo of bioactive molecules including microRNAs (miRNAs) that modulate various cellular processes. miRNAs are small non-coding RNAs that play pivotal roles in post-transcriptional gene regulation and have been implicated in cancer initiation, progression, and metastasis. In cancer, tumor-derived EVs transport specific miRNAs to recipient cells, modulating tumorigenesis, growth, angiogenesis, and metastasis. Dysregulation of miRNA expression profiles within EVs contributes to the acquisition of cancer hallmarks that include increased proliferation, survival, and migration. EV miRNAs influence the tumor microenvironment, promoting immune evasion, remodeling the extracellular matrix, and establishing pre-metastatic niches. Understanding the complex interplay between EVs, miRNAs, and cancer holds significant promise for developing novel diagnostic and therapeutic strategies. This chapter provides insights into the role of EV-mediated miRNA signaling in cancer pathogenesis, highlighting its potential as a biomarker for cancer detection, prognosis, and treatment response assessment.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"23-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spotting targets with 2D-DIGE proteomics. 用2D-DIGE蛋白质组学定位靶标。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1016/bs.acc.2024.11.003

Kent Marshall, Yaw Twum, Yulu Li, Weimin Gao

引用次数: 0

Extracellular vesicles in clinical chemistry: A focus on biomarkers. 临床化学中的细胞外囊泡：生物标志物的焦点。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-07-12 DOI: 10.1016/bs.acc.2025.06.001

Cristina Mas-Bargues, Javier Huete-Acevedo, Marta Arnal-Forné, Sandra Atencia-Rabadán, Consuelo Borrás

{"title":"Extracellular vesicles in clinical chemistry: A focus on biomarkers.","authors":"Cristina Mas-Bargues, Javier Huete-Acevedo, Marta Arnal-Forné, Sandra Atencia-Rabadán, Consuelo Borrás","doi":"10.1016/bs.acc.2025.06.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.06.001","url":null,"abstract":"Extracellular vesicles (EVs) are nanoscale particles released by cells into body fluids and serve as crucial mediators of intercellular communication. This chapter explores their biogenesis, cargo composition, and biological functions on target cells. It discusses the diverse molecular cargo of EVs that includes lipids, proteins, and nucleic acid and focuses on their sorting, analysis, and functional significance. It highlights their importance as biomarkers as diagnostic and prognostic tools, particularly their potential application in clinical chemistry. The chapter also provides an overview of the current techniques for isolating and characterizing EVs from various body fluids and recent technological advancements. It compares EV and liquid biopsy biomarkers, outlines their advantages and limitations, and examines their translational impact on personalized medicine. Furthermore, this chapter emphasizes the clinical relevance of EV biomarkers, especially in monitoring aging, evaluating anti-aging therapy, and diagnosing age-related diseases such as neurodegenerative, cardiovascular, and musculoskeletal disorders. The chapter concludes with a critical discussion about the potential of EV research to revolutionize clinical diagnostics, which unfortunately remains constrained by regulatory hurdles and a lack of standardization.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"128 ","pages":"1-81"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tau and Amyloid beta causes microglial activation in Alzheimer's disease. Tau蛋白和β淀粉样蛋白在阿尔茨海默病中引起小胶质细胞激活。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-07-11 DOI: 10.1016/bs.acc.2025.06.002

Subashchandrabose Chinnathambi, Anusree Adithyan, Madhura Chandrashekar, Nagaraj Rangappa

{"title":"Tau and Amyloid beta causes microglial activation in Alzheimer's disease.","authors":"Subashchandrabose Chinnathambi, Anusree Adithyan, Madhura Chandrashekar, Nagaraj Rangappa","doi":"10.1016/bs.acc.2025.06.002","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.06.002","url":null,"abstract":"Alzheimer's disease is a neurodegenerative condition characterized by the accumulation of hyperphosphorylated Tau in neurofibrillary tangles and amyloid-beta plaques. Tau, a microtubule-associated protein essential for neuronal stability, detaches from microtubules upon hyperphosphorylation, forming aggregates that disrupt neuronal function. Amyloid beta (Aβ) plaques act as upstream triggers, promoting Tau hyperphosphorylation and activating glial cells, particularly microglia and astrocytes. While these glial cells initially serve protective roles, their chronic activation leads to neuroinflammation, oxidative stress, and neuronal damage. Calcium dysregulation further exacerbates AD pathology by contributing to Tau hyperphosphorylation, mitochondrial dysfunction, and Aβ generation. This review highlights the intricate interplay between Tau, Aβ, and glial cells in the progression of AD, emphasizing both their protective and detrimental roles. It also explores the therapeutic implications of targeting these pathways, including modulating Tau phosphorylation, enhancing Aβ clearance, regulating glial activation, restoring calcium homeostasis, and preserving mitochondrial function. By addressing these multifaceted processes, this review underscores the potential for novel therapeutic strategies to slow or manage the progression of AD, ultimately improving patient outcomes.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"128 ","pages":"83-107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cancer microbiome. 癌症微生物群。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-04-19 DOI: 10.1016/bs.acc.2025.04.001

Huapeng Li, Anne A Leaman, Qingfei Zheng

{"title":"The cancer microbiome.","authors":"Huapeng Li, Anne A Leaman, Qingfei Zheng","doi":"10.1016/bs.acc.2025.04.001","DOIUrl":"10.1016/bs.acc.2025.04.001","url":null,"abstract":"The cancer microbiome is an emerging concept that is referred to as the microorganism communities associated with cancer. There has been controversy in terms of the bona fide functions of the microbiome in carcinogenesis and cancer development, since the microorganisms were first observed within tumor tissues. Recently, there has been growing evidence showing that the microbiome indeed plays a role in cancer initiation, development, diagnosis, and treatment through diverse mechanisms and interactions between host cells and microbes. Rather than contaminants or artifacts, the cancer microbiome has been proven to be alive in the tumor microenvironment and possess significantly differential physiological and morphological properties compared to the corresponding environmental microorganisms. However, due to the low abundance of microbes within cancer tissues (especially the intratumoral microbiota) and lack of efficient analytical tools (e.g., sensitive antibodies, sensors, and probes), there are still a number of challenges and question marks in this fast-growing field. In this chapter, we made a systematic summary of the cancer microbiome, specifically focusing on its discovery and the recent research advances with respect to the studies on its functions and corresponding technology development.","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"127 ","pages":"1-61"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain white matter damage biomarkers. 脑白质损伤生物标志物。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.acc.2024.11.005

Fardin Nabizadeh

引用次数: 0

Advances in neurofilament light chain analysis. 神经丝蛋白轻链分析的进展。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1016/bs.acc.2025.01.006

Arejas J Uzgiris, Lance A Ladic, Sophia X Pfister

引用次数: 0