子宫内膜异位症的生物标志物。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-15 DOI:10.1016/bs.acc.2025.01.004
Hafiz Muhammad Arsalan, Hina Mumtaz, Antonio Simone Lagana
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引用次数: 0

摘要

子宫内膜异位症是一种以三种不同表型为特征的多种疾病:浅表性腹膜病变、卵巢子宫内膜异位症和深浸润性子宫内膜异位症。子宫内膜异位症最被广泛接受的病理生理假说是源于月经逆行,这一现象在大多数患者中都有观察到。子宫内膜异位症与不孕症密切相关,但子宫内膜异位症并不一定意味着不孕症。这种疾病可以通过影响盆腔、卵巢和子宫本身的各种机制影响生育能力。MicroRNAs (miRNAs)确实代表了细胞内调控机制的一个迷人而重要的组成部分。发现于20世纪90年代初,mirna已被确定为基因表达控制的关键参与者。不幸的是,卵巢子宫内膜瘤是一种常见的妇科疾病,目前缺乏特定的血清标志物。一些人研究了尿皮质素区分子宫内膜异位瘤和其他良性卵巢囊肿的能力。另一个潜在的标志物,癌抗原125 (CA-125)是卵巢癌上皮细胞的一个公认的指标,其水平可以在子宫内膜异位症等情况下升高。CA-125来源于体腔上皮,包括子宫内膜、输卵管、卵巢和腹膜。在这篇综述中,我们研究了子宫内膜异位症的病理生理基础,并强调了潜在的标志物,以更充分地表征与这种多方面疾病状态相关的潜在生化过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers of endometriosis.

Endometriosis represents a diverse disease characterized by three distinct phenotypes: superficial peritoneal lesions, ovarian endometriomas, and deep infiltrating endometriosis. The most widely accepted pathophysiological hypothesis for endometriosis is rooted in retrograde menstruation, a phenomenon observed in most patients. Endometriosis is closely linked to infertility, but having endometriosis does not necessarily imply infertility. The disease can impact fertility through various mechanisms affecting the pelvic cavity, ovaries, and the uterus itself. MicroRNAs (miRNAs) indeed represent a fascinating and essential component of the regulatory machinery within cells. Discovered in the early 1990s, miRNAs have since been identified as critical players in gene expression control. Unfortunately, ovarian endometrioma is a common gynecologic disorder for which specific serum markers are currently lacking. Some have examined urocortin for its ability to differentiate endometriomas from other benign ovarian cysts. Another potential marker, Cancer Antigen 125 (CA-125) is a well-established indicator for epithelial cell ovarian cancer and its levels can be elevated in conditions such as endometriosis. CA-125 is derived from coelomic epithelia, including the endometrium, fallopian tube, ovary, and peritoneum. In this review we examine the pathophysiologic basis for endometriosis and highlight potential markers to more fully characterize the underlying biochemical processes linked to this multifaceted disease state.

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