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Advances in clinical chemistry最新文献

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Ion mobility spectrometry and ion mobility-mass spectrometry in clinical chemistry. 离子迁移谱法和离子迁移-质谱法在临床化学中的应用。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-11-01 DOI: 10.1016/bs.acc.2024.10.003
Kyle E Lira, Jody C May, John A McLean
{"title":"Ion mobility spectrometry and ion mobility-mass spectrometry in clinical chemistry.","authors":"Kyle E Lira, Jody C May, John A McLean","doi":"10.1016/bs.acc.2024.10.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2024.10.003","url":null,"abstract":"<p><p>Advancements in clinical chemistry have major implications in terms of public health, prompting many clinicians to seek out chemical information to aid in diagnoses and treatments. While mass spectrometry (MS) and hyphenated-MS techniques such as LC-MS or tandem MS/MS have long been the analytical methods of choice for many clinical applications, these methods routinely demonstrate difficulty in differentiating between isomeric forms in complex matrices. Consequently, ion mobility spectrometry (IM), which differentiates molecules on the basis of size, shape, and charge, has demonstrated unique advantages in the broad application of stand-alone IM and hyphenated IM instruments towards clinical challenges. Here, we highlight representative IM applications and approaches and describe contemporary commercial offerings of IM technology and how these can be, or are currently being, applied to the field of clinical chemistry.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"124 ","pages":"123-160"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface.
Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00025-3
Gregory S Makowski
{"title":"Preface.","authors":"Gregory S Makowski","doi":"10.1016/S0065-2423(25)00025-3","DOIUrl":"https://doi.org/10.1016/S0065-2423(25)00025-3","url":null,"abstract":"","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"xi-xii"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus nephritis: Biomarkers. 狼疮性肾炎：生物标志物。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.1016/bs.acc.2024.10.002
Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma
{"title":"Lupus nephritis: Biomarkers.","authors":"Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma","doi":"10.1016/bs.acc.2024.10.002","DOIUrl":"https://doi.org/10.1016/bs.acc.2024.10.002","url":null,"abstract":"<p><p>Lupus nephritis (LN) or renal involvement of systemic lupus erythematosus (SLE), is a common manifestation occurring in at least 50 % of SLE patients. LN remains a significant source of morbidity, often leading to progressive renal dysfunction and is a major cause of death in SLE. Despite these challenges, advances in the understanding of the pathogenesis and genetic underpinnings of LN have led to a commendable expansion in available treatments over the past decade. This chapter provides a foundation for the understanding LN pathogenesis, diagnosis, and epidemiology, and guides the reader through recent advances in biomarkers, genetic susceptibility of this intricate condition.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"124 ","pages":"87-122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coagulopathy prediction in traumatic brain injury.
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.acc.2025.01.003
Evangelos Kalogirou, Spyridon Voulgaris, George A Alexiou
{"title":"Coagulopathy prediction in traumatic brain injury.","authors":"Evangelos Kalogirou, Spyridon Voulgaris, George A Alexiou","doi":"10.1016/bs.acc.2025.01.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.01.003","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) represents a significant public health concern. Besides the initial primary injury, a defining point of TBI is causing secondary, delayed damage through inflammatory biochemical processes. Among the complications arising from this inflammatory response, coagulopathy emerges as a critical concern. With an overall prevalence of 32.7 %, TBI-induced coagulopathy significantly contributes to increased mortality rates and unfavorable patient outcomes, through its clinical manifestations, such as progressive hemorrhagic injury (PHI). This chapter investigates biomarkers capable of accurately detecting coagulopathy and PHI in TBI, evaluating their potential utility based on statistical evidence from various studies and exploring their possible association in the biochemical processes guiding or following TBI-induced coagulopathy. Notably, glucose emerges as a standout candidate, exhibiting a sensitivity of 91.5 % and specificity of 87.5 % for predicting coagulopathy. Furthermore, interleukin-33, with a sensitivity of 93.3 % and specificity of 66.7 %, and galectin-3, with a sensitivity of 67.7 % and specificity of 85.5 %, are promising for PHI. Despite these encouraging findings, significant efforts remain necessary to translate biomarker diagnostic utility into clinical practice effectively. Further research and validation studies are imperative to elucidate the intricate biochemical processes underlying TBI-induced coagulopathy and to refine the clinical application of biomarkers for improved patient management and outcomes in real-world settings.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"199-231"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles and microRNAs in cancer progression.
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-01-28 DOI: 10.1016/bs.acc.2024.11.004
Nicola S Orefice, Gianluca Petrillo, Claudia Pignataro, Martina Mascolo, Giada De Luca, Sara Verde, Francesca Pentimalli, Gerolama Condorelli, Cristina Quintavalle
{"title":"Extracellular vesicles and microRNAs in cancer progression.","authors":"Nicola S Orefice, Gianluca Petrillo, Claudia Pignataro, Martina Mascolo, Giada De Luca, Sara Verde, Francesca Pentimalli, Gerolama Condorelli, Cristina Quintavalle","doi":"10.1016/bs.acc.2024.11.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2024.11.004","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication in cancer. These membranous structures, secreted by normal and cancerous cells, carry a cargo of bioactive molecules including microRNAs (miRNAs) that modulate various cellular processes. miRNAs are small non-coding RNAs that play pivotal roles in post-transcriptional gene regulation and have been implicated in cancer initiation, progression, and metastasis. In cancer, tumor-derived EVs transport specific miRNAs to recipient cells, modulating tumorigenesis, growth, angiogenesis, and metastasis. Dysregulation of miRNA expression profiles within EVs contributes to the acquisition of cancer hallmarks that include increased proliferation, survival, and migration. EV miRNAs influence the tumor microenvironment, promoting immune evasion, remodeling the extracellular matrix, and establishing pre-metastatic niches. Understanding the complex interplay between EVs, miRNAs, and cancer holds significant promise for developing novel diagnostic and therapeutic strategies. This chapter provides insights into the role of EV-mediated miRNA signaling in cancer pathogenesis, highlighting its potential as a biomarker for cancer detection, prognosis, and treatment response assessment.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"23-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface.
Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00036-8
Gregory S Makowski
{"title":"Preface.","authors":"Gregory S Makowski","doi":"10.1016/S0065-2423(25)00036-8","DOIUrl":"https://doi.org/10.1016/S0065-2423(25)00036-8","url":null,"abstract":"","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"xiii-xiv"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus nephritis II: Treatment and monitoring. 狼疮性肾炎 II：治疗和监测。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1016/bs.acc.2025.01.001
Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma
{"title":"Lupus nephritis II: Treatment and monitoring.","authors":"Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma","doi":"10.1016/bs.acc.2025.01.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.01.001","url":null,"abstract":"<p><p>Renal involvement in systemic lupus erythematosus (SLE), lupus nephritis (LN), is common and can result in significant morbidity, including progressive renal dysfunction, and even ultimately leading to death. LN is heterogeneous complicated by the immunologic component, and it is critical to accurately classify LN to direct optimal therapy. Accordingly, identification of objective markers is paramount in reflecting disease stage and monitoring treatment response. In part two of this series, we comprehensively examine LN disease classification, therapies and potential markers to guide therapeutic options.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"121-154"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spotting targets with 2D-DIGE proteomics.
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-12-17 DOI: 10.1016/bs.acc.2024.11.003
Kent Marshall, Yaw Twum, Yulu Li, Weimin Gao
{"title":"Spotting targets with 2D-DIGE proteomics.","authors":"Kent Marshall, Yaw Twum, Yulu Li, Weimin Gao","doi":"10.1016/bs.acc.2024.11.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2024.11.003","url":null,"abstract":"<p><p>Two-dimensional difference gel electrophoresis (2D-DIGE) has been a staple of protein studies for almost three decades since first described in 1997. Although the advent of omic technologies has greatly expanded protein research and discovery, 2D-DIGE has consistently been the mainstay in biomedical applications. Differential protein expression is a hallmark of many disease states and identification of these biomarkers can improve diagnosis, prognosis and treatment. In this review, we examine the use of 2D-DIGE in exploring the cellular environment in physiologic and pathophysiologic states. We highlight this technology in protein identification and quantification, functional modification and biochemical pathways of interest. 2D-DIGE remains a useful tool due low cost and high resolving power for comparative and quantitative purposes in assessing disease states and facilitating identification of unique and novel biomarkers.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain white matter damage biomarkers.
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-12-10 DOI: 10.1016/bs.acc.2024.11.005
Fardin Nabizadeh
{"title":"Brain white matter damage biomarkers.","authors":"Fardin Nabizadeh","doi":"10.1016/bs.acc.2024.11.005","DOIUrl":"https://doi.org/10.1016/bs.acc.2024.11.005","url":null,"abstract":"<p><p>White matter (WM), constituting nearly half of the human brain's mass, is pivotal for the rapid transmission of neural signals across different brain regions, significantly influencing cognitive processes like learning, memory, and problem-solving. The integrity of WM is essential for brain function, and its damage, which can occur due to conditions such as multiple sclerosis (MS), stroke, and traumatic brain injury, results in severe neurological deficits and cognitive decline. The primary objective of this book chapter is to discuss the clinical significance of fluid biomarkers in assessing WM damage within the central nervous system (CNS). It explores the biological underpinnings and pathological changes in WM due to various neurological conditions and details how alterations can be detected and quantified through fluid biomarkers. By examining biomarkers like Myelin Basic Protein (MBP), Neurofilament light chain (NFL), and others, the chapter highlights their role in enhancing diagnostic precision, monitoring disease progression, and guiding therapeutic interventions, thus providing crucial insights into maintaining WM integrity and preventing cognitive and physical disabilities.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"55-91"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in neurofilament light chain analysis. 神经丝蛋白轻链分析的进展。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1016/bs.acc.2025.01.006
Arejas J Uzgiris, Lance A Ladic, Sophia X Pfister
{"title":"Advances in neurofilament light chain analysis.","authors":"Arejas J Uzgiris, Lance A Ladic, Sophia X Pfister","doi":"10.1016/bs.acc.2025.01.006","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.01.006","url":null,"abstract":"<p><p>This chapter provides a comprehensive summary of clinical laboratory testing for neurofilament light chain (NfL) in neurologic disease. A primer on the NfL structure and function is presented with its potential use as a biomarker. The most widely utilized methods for NfL in biologic samples are highlighted and examined. Limitations of current knowledge are considered, as are outstanding questions related to dissemination and standardization of testing. Herein we focus on methods available today and those in development for clinical use. In the final section, a broad vision is presented of how NfL may be utilized in the future to improve diagnosis and treatment of neurologic diseases as well as for maintaining health.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"31-71"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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