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Advances in clinical chemistry最新文献

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Ion mobility spectrometry and ion mobility-mass spectrometry in clinical chemistry. 离子迁移谱法和离子迁移-质谱法在临床化学中的应用。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-11-01 DOI: 10.1016/bs.acc.2024.10.003
Kyle E Lira, Jody C May, John A McLean
{"title":"Ion mobility spectrometry and ion mobility-mass spectrometry in clinical chemistry.","authors":"Kyle E Lira, Jody C May, John A McLean","doi":"10.1016/bs.acc.2024.10.003","DOIUrl":"10.1016/bs.acc.2024.10.003","url":null,"abstract":"<p><p>Advancements in clinical chemistry have major implications in terms of public health, prompting many clinicians to seek out chemical information to aid in diagnoses and treatments. While mass spectrometry (MS) and hyphenated-MS techniques such as LC-MS or tandem MS/MS have long been the analytical methods of choice for many clinical applications, these methods routinely demonstrate difficulty in differentiating between isomeric forms in complex matrices. Consequently, ion mobility spectrometry (IM), which differentiates molecules on the basis of size, shape, and charge, has demonstrated unique advantages in the broad application of stand-alone IM and hyphenated IM instruments towards clinical challenges. Here, we highlight representative IM applications and approaches and describe contemporary commercial offerings of IM technology and how these can be, or are currently being, applied to the field of clinical chemistry.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"124 ","pages":"123-160"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface. 前言。
Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00025-3
Gregory S Makowski
{"title":"Preface.","authors":"Gregory S Makowski","doi":"10.1016/S0065-2423(25)00025-3","DOIUrl":"https://doi.org/10.1016/S0065-2423(25)00025-3","url":null,"abstract":"","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"xi-xii"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolomics of nephrotic syndrome. 肾病综合征的代谢组学。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-06-24 DOI: 10.1016/bs.acc.2025.04.004
Shereen M Aleidi, Abeer Malkawi, Hiba Al Fahmawi, Anas M Abdel Rahman
{"title":"Metabolomics of nephrotic syndrome.","authors":"Shereen M Aleidi, Abeer Malkawi, Hiba Al Fahmawi, Anas M Abdel Rahman","doi":"10.1016/bs.acc.2025.04.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.04.004","url":null,"abstract":"<p><p>This chapter reviews the emerging role of metabolomics in nephrotic syndrome (NS), a kidney disorder characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia. Metabolomics provides valuable insights into the complex metabolic changes associated with NS, including disruptions in lipid, amino acid, and energy metabolism and oxidative stress markers. Through untargeted and targeted approaches, metabolomics enables the discovery of novel potential biomarkers that could enhance diagnosis, monitor disease progression, and personalize treatment strategies. Despite challenges such as methodological variability and the need for extensive computational resources, advancements in metabolomics technology and data integration are poised to improve our understanding of NS. Integrating metabolomics with genomics and proteomics may enable a comprehensive molecular profile of NS, offering new opportunities for precision medicine and improved patient outcomes.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"127 ","pages":"63-84"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gel electrophoresis-based proteoform separation and analysis. 基于凝胶电泳的蛋白质形态分离与分析。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-05-15 DOI: 10.1016/bs.acc.2025.04.002
Paul Dowling, Kay Ohlendieck
{"title":"Gel electrophoresis-based proteoform separation and analysis.","authors":"Paul Dowling, Kay Ohlendieck","doi":"10.1016/bs.acc.2025.04.002","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.04.002","url":null,"abstract":"<p><p>Proteomics using gel electrophoresis (GE) for efficient protein separation prior to mass spectrometry is a frequently employed and proteoform-centric analysis tool of biomedical chemistry. Isolated molecular species can be visualized by various protein staining techniques and their characterization being combined with protein interaction analyses and the determination of dynamic post-translational modifications. This chapter describes the bioanalytical usefulness of one-dimensional GE (1D-GE) approaches, including the gel electrophoresis liquid chromatography (GeLC) mass spectrometry method, as well as commonly used two-dimensional gel electrophoresis (2D-GE) techniques, including fluorescence difference GE (DIGE) for sophisticated comparative studies. The ways in which advanced protein identification and gel-based proteomics can help to discover novel biomarker candidates is discussed.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"127 ","pages":"119-171"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus nephritis: Biomarkers. 狼疮性肾炎：生物标志物。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.1016/bs.acc.2024.10.002
Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma
{"title":"Lupus nephritis: Biomarkers.","authors":"Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma","doi":"10.1016/bs.acc.2024.10.002","DOIUrl":"10.1016/bs.acc.2024.10.002","url":null,"abstract":"<p><p>Lupus nephritis (LN) or renal involvement of systemic lupus erythematosus (SLE), is a common manifestation occurring in at least 50 % of SLE patients. LN remains a significant source of morbidity, often leading to progressive renal dysfunction and is a major cause of death in SLE. Despite these challenges, advances in the understanding of the pathogenesis and genetic underpinnings of LN have led to a commendable expansion in available treatments over the past decade. This chapter provides a foundation for the understanding LN pathogenesis, diagnosis, and epidemiology, and guides the reader through recent advances in biomarkers, genetic susceptibility of this intricate condition.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"124 ","pages":"87-122"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coagulopathy prediction in traumatic brain injury. 外伤性脑损伤凝血功能预测。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-02-10 DOI: 10.1016/bs.acc.2025.01.003
Evangelos Kalogirou, Spyridon Voulgaris, George A Alexiou
{"title":"Coagulopathy prediction in traumatic brain injury.","authors":"Evangelos Kalogirou, Spyridon Voulgaris, George A Alexiou","doi":"10.1016/bs.acc.2025.01.003","DOIUrl":"10.1016/bs.acc.2025.01.003","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) represents a significant public health concern. Besides the initial primary injury, a defining point of TBI is causing secondary, delayed damage through inflammatory biochemical processes. Among the complications arising from this inflammatory response, coagulopathy emerges as a critical concern. With an overall prevalence of 32.7 %, TBI-induced coagulopathy significantly contributes to increased mortality rates and unfavorable patient outcomes, through its clinical manifestations, such as progressive hemorrhagic injury (PHI). This chapter investigates biomarkers capable of accurately detecting coagulopathy and PHI in TBI, evaluating their potential utility based on statistical evidence from various studies and exploring their possible association in the biochemical processes guiding or following TBI-induced coagulopathy. Notably, glucose emerges as a standout candidate, exhibiting a sensitivity of 91.5 % and specificity of 87.5 % for predicting coagulopathy. Furthermore, interleukin-33, with a sensitivity of 93.3 % and specificity of 66.7 %, and galectin-3, with a sensitivity of 67.7 % and specificity of 85.5 %, are promising for PHI. Despite these encouraging findings, significant efforts remain necessary to translate biomarker diagnostic utility into clinical practice effectively. Further research and validation studies are imperative to elucidate the intricate biochemical processes underlying TBI-induced coagulopathy and to refine the clinical application of biomarkers for improved patient management and outcomes in real-world settings.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"199-231"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MDDB: A public databank of host microRNAs in Tuberculosis diagnosis. MDDB：结核诊断中宿主microrna的公共数据库。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-06-10 DOI: 10.1016/bs.acc.2025.04.006
Piyush Agrawal, Aditya Upadhyay, Ravindra Kumar Chauhan, Awanish Kumar
{"title":"MDDB: A public databank of host microRNAs in Tuberculosis diagnosis.","authors":"Piyush Agrawal, Aditya Upadhyay, Ravindra Kumar Chauhan, Awanish Kumar","doi":"10.1016/bs.acc.2025.04.006","DOIUrl":"https://doi.org/10.1016/bs.acc.2025.04.006","url":null,"abstract":"<p><p>Tuberculosis (TB) remains a major global health challenge due to its high mortality rate. Several factors contribute significantly including delayed diagnosis, emergence of drug resistance, and biofilm formation. Although various diagnostic methods are available for TB, such as sputum smear microscopy, culture techniques, and real-time polymerase chain reaction (PCR). They have notable limitations, including false positives and negatives, timeliness, and high cost. Therefore, there is an urgent need for an early and accurate diagnostic approach to control the infection. MicroRNA (miRNA)-based diagnostics have emerged as a promising alternative, offering the potential for earlier detection and reduced false-positivity. However, this field is still in development and requires specialized tools to accelerate miRNA research, streamline the process, and facilitate the creation of innovative diagnostic methods. To address this need, the MicroRNA Disease Databank (MDDB) was developed as a centralized platform providing extensive miRNA-related information. Freely accessible at https://mddb.nitrr.ac.in/., MDDB offers comprehensive details on miRNA locations, associated disease characteristics, probe sequences, and molecular mechanisms. This resource aims to support the development of novel miRNA-based diagnostic biomarkers. This article provides an in-depth overview of the MDDB tool, highlighting its construction, features, and accessibility. Currently, MDDB focuses on host miRNAs relevant to TB, allowing researchers to quickly access critical miRNA data. By leveraging this resource, researchers will potentially accelerate the development of effective diagnostic biomarkers for TB and other chronic diseases in the future.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"127 ","pages":"221-253"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preface. 前言。
Advances in clinical chemistry Pub Date : 2025-01-01 DOI: 10.1016/S0065-2423(25)00036-8
Gregory S Makowski
{"title":"Preface.","authors":"Gregory S Makowski","doi":"10.1016/S0065-2423(25)00036-8","DOIUrl":"https://doi.org/10.1016/S0065-2423(25)00036-8","url":null,"abstract":"","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"xiii-xiv"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles and microRNAs in cancer progression. 细胞外囊泡和microrna在癌症进展中的作用。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-01-28 DOI: 10.1016/bs.acc.2024.11.004
Nicola S Orefice, Gianluca Petrillo, Claudia Pignataro, Martina Mascolo, Giada De Luca, Sara Verde, Francesca Pentimalli, Gerolama Condorelli, Cristina Quintavalle
{"title":"Extracellular vesicles and microRNAs in cancer progression.","authors":"Nicola S Orefice, Gianluca Petrillo, Claudia Pignataro, Martina Mascolo, Giada De Luca, Sara Verde, Francesca Pentimalli, Gerolama Condorelli, Cristina Quintavalle","doi":"10.1016/bs.acc.2024.11.004","DOIUrl":"10.1016/bs.acc.2024.11.004","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) have emerged as critical mediators of intercellular communication in cancer. These membranous structures, secreted by normal and cancerous cells, carry a cargo of bioactive molecules including microRNAs (miRNAs) that modulate various cellular processes. miRNAs are small non-coding RNAs that play pivotal roles in post-transcriptional gene regulation and have been implicated in cancer initiation, progression, and metastasis. In cancer, tumor-derived EVs transport specific miRNAs to recipient cells, modulating tumorigenesis, growth, angiogenesis, and metastasis. Dysregulation of miRNA expression profiles within EVs contributes to the acquisition of cancer hallmarks that include increased proliferation, survival, and migration. EV miRNAs influence the tumor microenvironment, promoting immune evasion, remodeling the extracellular matrix, and establishing pre-metastatic niches. Understanding the complex interplay between EVs, miRNAs, and cancer holds significant promise for developing novel diagnostic and therapeutic strategies. This chapter provides insights into the role of EV-mediated miRNA signaling in cancer pathogenesis, highlighting its potential as a biomarker for cancer detection, prognosis, and treatment response assessment.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"125 ","pages":"23-54"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lupus nephritis II: Treatment and monitoring. 狼疮性肾炎 II：治疗和监测。
Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1016/bs.acc.2025.01.001
Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma
{"title":"Lupus nephritis II: Treatment and monitoring.","authors":"Chrisanna Dobrowolski, Shu Min Lao, Fadi Kharouf, Paula Parnizari Croci, Joan Wither, Dafna D Gladman, Laura Whitall Garcia, Arenn Jauhal, Zahi Touma","doi":"10.1016/bs.acc.2025.01.001","DOIUrl":"10.1016/bs.acc.2025.01.001","url":null,"abstract":"<p><p>Renal involvement in systemic lupus erythematosus (SLE), lupus nephritis (LN), is common and can result in significant morbidity, including progressive renal dysfunction, and even ultimately leading to death. LN is heterogeneous complicated by the immunologic component, and it is critical to accurately classify LN to direct optimal therapy. Accordingly, identification of objective markers is paramount in reflecting disease stage and monitoring treatment response. In part two of this series, we comprehensively examine LN disease classification, therapies and potential markers to guide therapeutic options.</p>","PeriodicalId":101297,"journal":{"name":"Advances in clinical chemistry","volume":"126 ","pages":"121-154"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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