MDDB:结核诊断中宿主microrna的公共数据库。

Advances in clinical chemistry Pub Date : 2025-01-01 Epub Date: 2025-06-10 DOI:10.1016/bs.acc.2025.04.006
Piyush Agrawal, Aditya Upadhyay, Ravindra Kumar Chauhan, Awanish Kumar
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引用次数: 0

摘要

由于结核病死亡率高,它仍然是一个重大的全球卫生挑战。延迟诊断、耐药性的出现和生物膜的形成是几个重要因素。虽然结核病的诊断方法多种多样,如痰涂片镜检、培养技术和实时聚合酶链反应(PCR)。它们有明显的局限性,包括误报和误报、及时性和高成本。因此,迫切需要一种早期和准确的诊断方法来控制感染。基于MicroRNA (miRNA)的诊断已经成为一种很有前途的替代方法,提供了早期检测和减少假阳性的潜力。然而,这一领域仍处于发展阶段,需要专门的工具来加速miRNA的研究,简化过程,并促进创新诊断方法的创建。为了满足这一需求,MicroRNA疾病数据库(MDDB)被开发为一个集中的平台,提供广泛的mirna相关信息。免费访问https://mddb.nitrr.ac.in/. MDDB提供有关miRNA位置、相关疾病特征、探针序列和分子机制的全面详细信息。该资源旨在支持开发新的基于mirna的诊断生物标志物。本文对MDDB工具进行了深入的概述,重点介绍了它的构造、特性和可访问性。目前,MDDB专注于与结核病相关的宿主miRNA,使研究人员能够快速获取关键的miRNA数据。通过利用这一资源,研究人员将有可能在未来加速开发结核病和其他慢性疾病的有效诊断生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MDDB: A public databank of host microRNAs in Tuberculosis diagnosis.

Tuberculosis (TB) remains a major global health challenge due to its high mortality rate. Several factors contribute significantly including delayed diagnosis, emergence of drug resistance, and biofilm formation. Although various diagnostic methods are available for TB, such as sputum smear microscopy, culture techniques, and real-time polymerase chain reaction (PCR). They have notable limitations, including false positives and negatives, timeliness, and high cost. Therefore, there is an urgent need for an early and accurate diagnostic approach to control the infection. MicroRNA (miRNA)-based diagnostics have emerged as a promising alternative, offering the potential for earlier detection and reduced false-positivity. However, this field is still in development and requires specialized tools to accelerate miRNA research, streamline the process, and facilitate the creation of innovative diagnostic methods. To address this need, the MicroRNA Disease Databank (MDDB) was developed as a centralized platform providing extensive miRNA-related information. Freely accessible at https://mddb.nitrr.ac.in/., MDDB offers comprehensive details on miRNA locations, associated disease characteristics, probe sequences, and molecular mechanisms. This resource aims to support the development of novel miRNA-based diagnostic biomarkers. This article provides an in-depth overview of the MDDB tool, highlighting its construction, features, and accessibility. Currently, MDDB focuses on host miRNAs relevant to TB, allowing researchers to quickly access critical miRNA data. By leveraging this resource, researchers will potentially accelerate the development of effective diagnostic biomarkers for TB and other chronic diseases in the future.

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