Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie最新文献

{"title":"Über das unterschiedliche Verhalten von Straßenwutund Virus fixe-Stämmen bei Parabioseversuchen mit Ratten","authors":"Peter Becker ,&nbsp;Martin Zunker °","doi":"10.1016/S0172-5599(80)80032-0","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80032-0","url":null,"abstract":"<div><p>To resolve the problem by which route rabies virus is migrating within the infected organism, coelioanastomosis was performed by operating two albino rats each so that a connection between blood vessels, however not between nerves was established. One of the partners was infected in each case. As soon as one of the parabionts exhibited specific disease, the animals were disconnected again.</p><p>A comparison of street virus and strains of virus fixé that had been maintained by intracerebral, plantar, and intramuscular passage revealed basic differences. Street virus was found to be transmitted to the non-infected partner almost regularly while virus fixé maintained by intracerebral passage almost never was transmitted. After i.m. passages, plantar virus held an intermediate position.</p><p>Zusammenfassung</p><p>Zur Untersuchung der Frage, auf welchem Wege das Tollwutvirus im infizierten Organismus wandert, wurden zwischen jeweils zwei Albinoratten operativ Coelioanastomosen geschaffen, die zwar Blutgefäß-, nicht aber Nervenverbindungen aufwiesen. Ein Partner wurde jeweils infiziert. Sobald ein Parabiont spezifisch erkrankte, wurde die Verbindung wieder gelöst.</p><p>Beim Vergleich von Straßenwutvirus mit intrazerebral sowie plantar und intramuskulär geführten Virus fixe-Stämmen zeigten sich grundlegende Unterschiede: Straßenvirus ging fast regelmäßig, intrazerebral geführtes Virus fixe nie auf den nicht infizierten Partner über. Plantarvirus nahm nach intramuskulären Passagen eine Mittelstellung ein.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 290-295"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80032-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91774740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrastructure and Viability of K. pneumoniae Treated with Fosfomycin","authors":"Ernst N. Schmid","doi":"10.1016/S0172-5599(80)80038-1","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80038-1","url":null,"abstract":"<div><p>The effect of Fosfomycin on <em>K. pneumoniae</em> ATCC 10031 was studied. The morphology on the electron microscopical level and the viability were markedly altered after application of 6 μg/ml and 60 μg/ml of Fosfomycin, respectively. These were chosen because they can be attained in man by oral or parenteral administration.</p><p>Until 30 min after the administration of 6 μg/ml, and 10 min after administration of 60 μg/ml the turbidity increased in the same range as in the control. Thereafter the turbidity decreased but did not fall below its initial values; after application of 6 μg/ml of Fosfomycin the OD remained at higher levels than after applying 60 μg/ml of Fosfomycin, at all corresponding times.</p><p>The number of viable cells, after application of 6 μg/ml of Fosfomycin, was maximally reduced for 70% of the value at the time of administration.</p><p>60 μg/ml quickly impaired the ability of reproduction/Consequently, the CFU were reduced continuously, e.g. by 80% after 30 min and by more than 99% after 180 min.</p><p>The finestructural alterations were characterized by loss of contrast and regular shape. The occurrence of protruded protoplasts and defects in the cell wall indicate the action of Fosfomycin on the bacterial envelope, preferably on the peptidoglycan layer.</p></div><div><p>Feinstruktur und Vermehrungsfähigkeit von <em>K. pneumoniae</em> ATCC 10031 wurden nach Einwirkung von 6 und 60 μg Fosfomycin/ml untersucht. Diese Konzentrationen sind nach oraler bzw. parenteraler Applikation in vivo erreichbar (<em>Mata</em> et al., 1974). Innerhalb der ersten 30 Min. nach Zugabe von 6 μg/ml bzw. 10 Min. nach 60 μg/ml nahm die optische Dichte in gleichem Maße wie in der Kontrolle zu. Die folgende Abnahme der optischen Dichte verlief bei beiden Konzentrationen auf unterschiedlichem Niveau und unterschritt in keinem Fall die im Moment der Fosfomycinzugabe gemessenen Werte.</p><p>Im Gegensatz hierzu trat bei der Zahl der vermehrungsfähigen Zellen eine starke Reduktion ein, so daß nach 6 μg/ml der Ausgangswert um maximal 70% unterschritten wurde. (Wenn die nach anfanglicher Vermehrung erreichte Zellzahl als Referenz herangezogen wird - 30 Min. nach Zugabe statt 0 Min. -, trat sogar eine Reduktion um ca. 90% ein.) Unter dem Einfluß von 60 μg Fosfomycin/ml reduzierte sich die Zellzahl innerhalb 30 Min. um ca. 80% und innerhalb 180 Min. um mehr als 99%.</p><p>Beide Fosfomycin-Konzentrationen bewirkten - nach unterschiedlichen Zeiten - cytologische Veränderungen. Die irreguläre Gestalt und aus der geschädigten Zellwand hervor-tretende Protoplasten (<em>Rodicio</em> et al., 1978) legen einen Vergleich mit den durch Penicillin-behandlung hervorgerufenen Veränderungen am Mureinsacculus nahe.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 339-346"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80038-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91725931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yersinia enterocolitica: Einfluß der Bebrütungstemperatur auf Antibiotika-Resistenz, Beta-Lactamaseproduktion und Wachstumsverhalten","authors":"M. Kist ,&nbsp;E. Sanabria De Isele","doi":"10.1016/S0172-5599(80)80040-X","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80040-X","url":null,"abstract":"<div><p>The influence of incubation temperature (37, 30 and 22 °C) on antibiotic susceptibility, β-lactamase activity and growth characteristics was studied on 43 unselected strains of <em>Y. enterocolitica</em> (Serovar O:3 and 0:9) freshly isolated from clinical specimens. Antibiotic susceptibility was measured by the disc diffusion technique and by a broth dilution test (MIC). β-lactamase activity was detected with chromogenic cephacetrile using standard curves prepared for 37, 30 and 22 °C. Continiuous increase of β-lactamase activity was found when incubation temperatures were lowered. All strains were found to be resistant to ampicillin and cephalothin at the three temperatures tested. Some strains showed an intermediate susceptibility to carbenicillin in the disc diffusion test. A temperature reduction of 37 to 30 °C significantly decreased the inhibitory zone diameters for the β-lactam antibiotics ampicillin, carbenicillin and cephalothin, but also for other substances like tetracycline, chloramphenicole and cotrimoxazole. This suggests, that the observed decrease is caused by a better growth of <em>Y. enterocolitica</em> at 30 °C rather than increased β-lactamase production. From 30 to 22 °C a further decrease in inhibitory zone diameters was only seen with ampicillin and carbenicillin. This seems to be mainly due to the increased β-lactamase activity observed at 22 °C. In contrast the resistance to cephalothin was apparently not influenced by this additional β-lactamase activity. Resistance to cephalothin therefore depends probably more on other, not β-lactamase-related, factors such as permeability variations of the outer membrane or modifications of binding proteins involved in the peptidoglycan biosynthesis.</p><p>The correlation between β-lactamase activity at various incubation temperatures and resistance to β-lactam antibiotics was less pronounced when the broth dilution test (MIC) was applied. Only carbenicillin showed significantly increasing MIC values from 30 to 22 °C.</p><p>All the <em>Y. e.</em> strains investigated could be divided into two groups with respect to their ß-lactamase production characteristics. The first group showed continuously increasing ß-lactamase values at lower incubation temperatures. In the second group generally lower amounts of β-Mactamase values were found and temperature dependence was not observed. On the other hand variations in cell wall permeability, resulting in a diminished accessability of the cell wall bound enzymes must also be considered.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 353-363"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80040-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91765083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation of Revertants from Antigenic Variants of Leptospiras","authors":"Emiko Shimono ,&nbsp;Ryo Yanagawa (Head: Prof. Dr.) ,&nbsp;George Torres Barranca","doi":"10.1016/S0172-5599(80)80044-7","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80044-7","url":null,"abstract":"<div><p>The revertants were isolated from the antigenic variants of <em>Leptospira interrogans</em> serovar <em>copenhageni</em> Shibaura by plating the variants on the solid medium containing the homologous immune serum, and by noting the growth of small colonies. The revertants which produced the small colonies were antigenically identical with the parents. The variants which retained their antigenicity for 2 to 3 years produced only a small number of revertants. On the other hand, the variants which phenotypically changed to the parent during the same period of maintenance produced many revertants. The revertant-clones and the variant-clones showed a similar generation time. No revertant was isolated from the variants of <em>hebdomadis</em> Hebdomadis.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 392-399"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80044-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91765079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thin Layer Chromatography for Rapid Detection of Carbohydrate Utilization by Bacteroides Strains","authors":"Rainer Hammann ,&nbsp;Ingrid Werner","doi":"10.1016/S0172-5599(80)80049-6","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80049-6","url":null,"abstract":"<div><p>19 weakly saccharolytic <em>Bacteroides</em> strains of different species were tested by thin-layer</p><p>chromatography (TLC) for their fermentative abilities for fructose, sucrose, lactose, galactose, and raffinose. Conventional fermentation tests were run in parallel. In general, a good agreement between both methods was recorded. Two strains, however, showed a degradation in the TLC test without an acidification. With some strains, sucrose as a substrate yielded a fructose spot, lactose a galactose spot, and raffinose a melibiose spot, indicating an incomplete degradation of these carbohydrates.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 424-429"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80049-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91765082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensiv-Adsorption von Viren an Gewebekulturzellen: Verbesserung der Virusisolierung?","authors":"Gerhard Schmidt,&nbsp;Reinhard Wigand","doi":"10.1016/S0172-5599(80)80031-9","DOIUrl":"10.1016/S0172-5599(80)80031-9","url":null,"abstract":"<div><p>Two procedures to improve virus cultivation from clinical material were evaluated: an intensified adsorption with 0.2 ml inoculum and 20 h rocking in a Bellco rocker and a low-speed centrifugation of the material onto the cultured cells. Prototype strains from 5 virus families (adenoviruses, herpes simplex virus, vaccinia virus, enteroviruses, para-influenza 2) as well as original specimens from patients (adenovirus, herpesvirus, enterovirus) were studied by endpoint titration in comparison with the standard procedure. In adenoviruses, a quantitative immunofluorescence was performed too.</p><p>In endpoint titrations, the centrifugation method did almost never lead to an increased virus titer, as compared with the standard method. However, in the immunofluorescence evaluation of adenoviruses the values attained were 3- to 4-fold higher. On the other hand, the intensified adsorption method led to an increased sensitivity in most adenovirus titrations with 4- to 25-fold titer increment, with prototype and original material. The procedure was ineffective in all other viruses studied.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 283-289"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80031-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86281774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yersinia enterocolitica: Einfluß der Bebrütungstemperatur auf Antibiotika-Resistenz, Beta-Lactamaseproduktion und Wachstumsverhalten","authors":"M. Kist, E. S. D. Isele","doi":"10.1016/S0172-5599(80)80040-X","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80040-X","url":null,"abstract":"","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"33 1","pages":"353-363"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76346540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Der Nachweis von Hepatitis Be-Antigen mit einem Enzymimmunoassay","authors":"W. Lange ,&nbsp;K.N. Masihi","doi":"10.1016/S0172-5599(80)80033-2","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80033-2","url":null,"abstract":"<div><p>An enzyme immunoassay (ELISA) from SEROMED was tested for ist suitability in detecting HBeAg and was compared with a radioimmunoassay (RIA) from ABBOTT and with rheophoresis.</p><p>From a total of 931 sera tested, HBeAg could be detected in 313 sera with ELISA, 347 sera with RIA and 22 sera with rheophoresis. When 8 HBeAg containing sera were titrated for end points, RIA gave titers which were 2.3-fold higher than ELISA and 575-fold higher than rheophoresis. The differences between RIA and ELISA were shown to be due to somewhat lower sensitivity of ELISA.</p><p>However, when sera from patients with Hepatitis B from various times after the onset of hepatitis (maximally 12 months) were tested, there was only a slight difference in sensitivity between ELISA and RIA.</p><p>ELISA along with RIA is considered to be a substantially sensitive test for detection of HBeAG as compared to rheophoresis and can be recommended for routine use.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 296-302"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80033-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91765092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterobakterien bei Fiedertieren (Chiroptera)","authors":"Moshe Pinus ,&nbsp;Hans E. Müller","doi":"10.1016/S0172-5599(80)80035-6","DOIUrl":"10.1016/S0172-5599(80)80035-6","url":null,"abstract":"<div><p>The aerobic gram-negative faecal flora ot 38 bats consisting of 10 species and genera respectively, of <em>Micro chiroptera</em>, and of 4 species and genera respectively, of <em>Megachiroptera</em> was studied (Table 1 and 3). There were no specific differences between Insectivora and Frugivora: <em>E. coli</em> 15–24%, <em>Citrobacter</em> 8–10%, <em>Enterobacter-Klebsiella</em>-group 40–43% and <em>Proteus-group</em> 28–30% (Table 2). The overwhelming majority of the isolated bacteria were lactose-positive (Table 3), corresponding to the membership of the bats to the mammals.</p><p>The vampire bats <em>(Desmodus rotundus)</em>, however, nourishing exclusively with mammalian blood, possess a fundamental other faecal flora. Here we always found <em>Aeromonas hydrophila</em> sometimes as a pure culture and sometimes in combination with <em>E. coli, Enterobacter, Providencia</em>, and <em>Arizona</em>. The normal habitat of <em>Aeromonas hydrophila</em> in vampire bats suggests that these bacteria are necessary for digest the drunken blood in a similar manner as in leechs.</p><p>The observations were discussed regarding their ecological, epidemiological, and phylogenetic significances.</p><p>Zusammenfassung</p><p>Wir untersuchten bei 30 Fledermäusen <em>(Microchiroptera)</em> aus 10 verschiedenen Arten bzw. Gattungen und bei 8 Flughunden <em>(Megachiroptera)</em> aus 4 verschiedenen Arten bzw. Gattungen die gram-negative, aerobe Fäkalflora. Sie war bei den Insektenfressern <em>(Insektivora)</em> und Fruchtfressern <em>(Frugivora)</em> nicht erkennbar unterschiedlich: <em>E. coli</em> 15–24%, <em>Citrobacter</em> 8–10%, <em>Enterobacter-Klebsiella</em>-Gruppe 40–43%, <em>Proteus</em>-Gruppe 28–30%. Außerdem wurden bevorzugt Laktose-positve Keime gefunden.</p><p>Eine völlig andersartige Darmflora besaßen Vampirfledermäuse <em>(Desmodus rotundus)</em>, die sich ausschließlich von Säugerblut ernähren. Hier fanden wir regelmäßig und teilweise sogar als Reinkultur <em>Aeromonas hydrophila</em>, daneben <em>E. coli, Enterobacter, Providencia</em> und <em>Arizona</em>. Die Befunde werden aus ökologischer, epidemiologischer und phylogenetischer Sicht diskutiert.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 315-322"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80035-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86985591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Response to Mycobacterium leprae: Further Studies on the Assessment of Humoral Immune Response in Mice","authors":"R.G. Navalkar","doi":"10.1016/S0172-5599(80)80041-1","DOIUrl":"https://doi.org/10.1016/S0172-5599(80)80041-1","url":null,"abstract":"<div><p>Immunocyte proliferation in the spleens of mice given both a primary and a second infection sixty days later, was detected soon after the second challenge was administered. Plaque-forming cell assay for both the direct and developed plaques indicated that all cells producing antibody of both immunoglobulin classes were present in the animals when they were administered the second challenge. Hemagglutinating antibody determinations indicated that IgG antibodies are recognizable at a time when the bacilli reach a stage of maximum multiplication in the mouse host. The IgM antibodies, however, become detectable within a short time after infection in animals given either a single infection or a dual infection, one fifteen days later and the other sixty days after the first infection. It is proposed that the low level of circulating antibodies and antibody-producing cells despite continuous, as well as enhanced, antigenic challenge could be due to the fact that in the mouse footpad <em>M. leprae</em> may be intrinsically less antigenic than organisms that cause systemic infection. Quantitative immunoglobulin assays tended to confirm the observations on the HA studies.</p><p>Present studies have once again confirmed our previous observations viz that the number of plaques in the spleens of mice infected with <em>M. leprae</em> increases on secondary stimulation, whether it is administered within a very short time after the primary infection or given later in the course of infection. They have also indicated that an IgG response will occur in the infected animals at a time when the bacillary multiplication enters the logarithmic phase of growth of <em>M. leprae</em>, They have, however, not permitted the placement of the mouse model in the overall spectrum of human leprosy.</p></div>","PeriodicalId":101293,"journal":{"name":"Zentralblatt für Bakteriologie. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie","volume":"247 3","pages":"Pages 364-373"},"PeriodicalIF":0.0,"publicationDate":"1980-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0172-5599(80)80041-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91765091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}