World Science and Technology最新文献

{"title":"Research Status and Methods of Rationality of Daily Oral Administration Times of Traditional Chinese Medicine Preparations","authors":"Yuan Hailong,&nbsp;Xiao Xiaohe","doi":"10.1016/S1876-3553(12)60030-1","DOIUrl":"10.1016/S1876-3553(12)60030-1","url":null,"abstract":"<div><p>The rationality of daily oral administration times of traditional Chinese medicine (TCM) is a key scientific problem on its safety and efficacy in clinical application. In this article, the current research situation and essentiality of daily oral administration times of TCM were stated. One evaluation pattern was put forward on the basis of pharmacodynamic/pharmacokinetic (PD-PK) and mainly on the basis of pharmacodynamic biomarkers (PD-Markers).</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 6","pages":"Pages 952-955"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60030-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78225800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion on the Laws of Traditional Chinese Medical Treatment of H1N1 Influenza Based on a Cohort Study","authors":"Zhou Hong,&nbsp;Tao Lanting,&nbsp;Xu Huicong,&nbsp;Jiang Yaoguang,&nbsp;Deng Yiqi,&nbsp;Luo Yi,&nbsp;Lu Chuanjian","doi":"10.1016/S1876-3553(12)60023-4","DOIUrl":"10.1016/S1876-3553(12)60023-4","url":null,"abstract":"<div><p>This article was aimed at discussing the laws of compound medicine application of traditional Chinese medicine (TCM) in the treatment of influenza A (H1N1). Data on 4037 influenza A (H1N1) cases were collected in a multicenter cohort study using compound TCM treatment during the influenza A (H1N1) outbreak in <em>Guangzhou</em> from December 2009 to April 2010. The laws of TCM compound medicine application were summarized based on syndrome differentiation. The results showed that 156 kinds of Chinese herbs were used: heat-clearing and detoxifying medicinal, cough-suppressing, phlegm-relieving and panting-calming medicinal, wind-cold dispersing medicinal, wind-heat dispersing medicinal, heat-clearing and fire-purging medicinal. These medicinal occupy 51.90% in the prescription. Twenty-eight kinds of TCM medicinals were commonly used. The channel tropism involved 12 channels. The main channels were the Lung meridian, Stomach meridian, Heart meridian, and Liver meridian. The proportion of these medicinals occupies 78.71%, and all medicinals cover 7 kinds of tastes. The top three tastes are bitter, sweet, and pungent. Their proportion was 99.57%. The top 10 commonly used TCM medicinals (except for <em>RADIX GLYCYRRHIZAE</em>) were <em>RADIX PLATYCODONIS, FRUCTUS FRUCTUS FORSYTHIAEE, FLOS LONICERAE, FOLIUM MORI, RHIZOMA PHRAGMITIS, HERBA MENTHAE, FLOS CHRYSANTHEMI, HERBA LOPHATHERI, FRUCTUS ARCTII</em>, and <em>SEMEN ARMENIACAE AMARUM</em>. The most frequently used prescription in the group of expelling exogenous wind heat was <em>Yin-Qiao</em> Powder. The prescription of expelling exogenous wind cold was <em>Jing-Fang-Bai-Du</em> Powder. The frequency of using <em>Ma-Xing-Shi-Gan</em> Decoction to remove toxic heat blocking in the lungs was approximately 100%. It is concluded that the efficacy, taste, channel tropism, and compatibility of the TCM medicinals used in the treatment of H1N1 flu were closely related to the etiological factor and the pathogenesis of Influenza A (H1N1).</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 5","pages":"Pages 777-782"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60023-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79840943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoughts on Sustainable Development of Chinese Medicine Industry in “High Concept” Era","authors":"Xu Shijun ,&nbsp;Zhao Yijun ,&nbsp;Xin Wenfeng ,&nbsp;Zhang Wensheng","doi":"10.1016/S1876-3553(12)60022-2","DOIUrl":"10.1016/S1876-3553(12)60022-2","url":null,"abstract":"<div><p>With a rapid shift from the “Information Age” to the “Conceptual Age,” creative thinking in the “High Concept” era has been advocated for the human society. The large Chinese medicine industry, as the most original thought, is an integral part of Chinese medicine. The question of the entire industry is how to adapt it to time and achieve sustainable development. According to the requirements for sustainable development of Chinese medicine industry in the era of “High Concept,” eight measures have been proposed. The strategies are as follows: to rationalize the standard management system and increase industry consolidation layout; to intensify policy support, strengthen and expand its Chinese brand; to speed up basic medical research and promote traditional Chinese medicine (TCM); to enhance cultivation of leading enterprises and strengthen TCM industry; to speed up innovations in order to guide and promote effective transformation of technical results; to develop conservation strategies and deal with the impact of “foreign Chinese medicines”; to promote multidisciplinary consortium and play advantage of talent from overseas; to encourage enterprises in the international market and enhance international competitiveness of Chinese medicine.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 5","pages":"Pages 755-758"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60022-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78124030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Analysis on Pulse Graph Characters of Coronary Heart Disease and Its Blood-Fat and Thrombin","authors":"Kang Ping,&nbsp;Li Fufeng,&nbsp;Yao Di,&nbsp;Qian Peng","doi":"10.1016/S1876-3553(12)60025-8","DOIUrl":"10.1016/S1876-3553(12)60025-8","url":null,"abstract":"<div><p>The study was aimed at exploring the relationship between pulse graph characters and its blood-fat and thrombin among coronary heart disease (CHD) patients. Pathological and physiological indexes had been searched for correlation with pulse graph parameters. Pulse detection system was applied in the collection of pulse graph among CHD patients, and pulse characters were analyzed with time domain method. Blood-fat and thrombin indexes were checked. Canonical correlation was used in the analysis of relationship between pulse graph characters and its blood-fat and thrombin in CHD patients. The results showed that, among the ingredients of blood-fat, change in low-density lipoprotein was closely related to t and t5/t4 of pulse graph in CHD. They were positively correlated. There was no obvious correlation between pulse graph characters and thrombin indexes. However, it was concluded that some correlation exists between the parameters of pulse graph and blood-fat indexes.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 5","pages":"Pages 810-815"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60025-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90909234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Effects of Curculigoside on Proliferation, Differentiation, and Calcification of Mouse Osteoblastic MC3T3-E1 Cells","authors":"Wang Yin,&nbsp;Sun Qizhen,&nbsp;Ma Liyan","doi":"10.1016/S1876-3553(12)60026-X","DOIUrl":"10.1016/S1876-3553(12)60026-X","url":null,"abstract":"<div><p>This study was aimed at evaluating the effects of Curculigoside (CCG) on the proliferation, differentiation, and calcification of mouse osteoblastic MC3T3-E1 cells. MTT assay was applied in the evaluation of MC3T3-E1 cell proliferation with CCG at different doses for different incubation periods. Alizarin red staining method was applied to observe the effect of CCG on the bone nodule formation of cells. The differentiating effects of CCG with different concentrations in cells were evaluated through the examination of alkaline phosphatase (ALP) activities by PNPP. The results showed that CCG is effective in promoting the proliferation of MC3T3-E1 cells cultured for 24 h, 48 h, and 72 h at doses ranging from 10⁻⁴ mol·L⁻¹ to 10⁻⁸ mol·L⁻¹. CCG at the concentration of 10⁻⁹ mol·L⁻¹ remarkably increased the bone nodule formation of cells. The activity of ALP was stimulated by CCG at doses of 10⁻⁷ mol·L⁻¹ and 10⁻⁹ mol·L⁻¹ after 96 h of incubation. It was concluded that CCG has effects on stimulating the proliferation, differentiation, and calcification of MC3T3-E1 cells.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 5","pages":"Pages 852-855"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60026-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72684443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum Chemistry Calculation on Demethylated Metabolites of Aconitine","authors":"Tan Peng,&nbsp;Guan Jun,&nbsp;Liu Yonggang,&nbsp;Li Fei,&nbsp;Qiao Yanjiang","doi":"10.1016/S1876-3553(12)60024-6","DOIUrl":"10.1016/S1876-3553(12)60024-6","url":null,"abstract":"<div><p>This study was aimed at evaluating the metabolites of aconitine by quantum chemistry calculation. The geometries of possible metabolites were optimized by using the density functional theory at B3LYP/6-31G(d) level. The energies of possible metabolites and hydrolysis reactions were obtained. Solvation effects were calculated by using IEFPCM. A comparison among the four possible reaction energies showed that the metabolites of aconitine were identified as 16-O-demethylaconitine and 16-O-demethylbenzoylaconine. The energy difference of possible metabolites was increased in the aqueous solution. It was concluded that the metabolites identified by quantum chemistry calculation are the same as those deduced by fragmentation regularity of mass spectrometry. Metabolites of aconitine can be studied by a combination of HPLC-MSⁿ and quantum chemistry calculation.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 5","pages":"Pages 792-795"},"PeriodicalIF":0.0,"publicationDate":"2011-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60024-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87011035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Development of Pharmaceutical Excipients Database","authors":"Ding Zhenhao ,&nbsp;Dai Xingxing ,&nbsp;Shi Xinyuan ,&nbsp;Qiao Yanjiang","doi":"10.1016/S1876-3553(12)60017-9","DOIUrl":"10.1016/S1876-3553(12)60017-9","url":null,"abstract":"<div><p>Pharmaceutical excipients database (PED) was established on the basis of MDL ISIS/Base Database Management System (DMS). Currently, 270 pharmaceutical excipients were included. The pharmaceutical excipients database consists of three tables. The first table is basic information that contains 17 attributes in total, such as Chinese and English names of excipients and so on. The second table is the basic property table that contains physical and chemical properties and so on. There are 11 attributes in total. The third table is the computed property that was calculated by the Synthia module of Materials Studio 4.1. The PED not only provides great convenience for the query of pharmaceutical excipients, but also serves as a data mining platform for the pharmaceutical excipients.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 4","pages":"Pages 611-615"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60017-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90813363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiments on Antitumor Activity and Immunological Mechanisms of Scutellaria Barbata Polysaccharides","authors":"Song Gaochen ,&nbsp;Yu Yingjun ,&nbsp;Wang Xijun","doi":"10.1016/S1876-3553(12)60020-9","DOIUrl":"10.1016/S1876-3553(12)60020-9","url":null,"abstract":"<div><p>This research aimed at studying the antitumor activity and immunological mechanisms of <em>Scutellaria barbata</em> polysaccharides (SBPS). Hepatocarcinoma H22-bearing mice were randomly divided into negative control group, SPS group, and polyporus polysaccharide group. After the drug administration for 10 consecutive days, the inhibitory rate of tumors, thymus index, and spleen index, and the phagocytic function of macrophages were observed. ELISA method was used in the determination of the serum level of IL-2. The comparison was made among the groups. The results showed that SPS can effectively inhibit the growth of HepA. The inhibitory rate of tumors was 34.35%. The weight of immune organs was also increased among HepA-bearing mice. The serum level of IL-2 and the phagocytic function of macrophages were also increased. Thus, it can be concluded that SPS has obvious antitumor activity. The mechanism is due to the enhancement of the immune function.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 4","pages":"Pages 641-643"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60020-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87945525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Proteinum in Clear Supernatant Liquid of Tongue Coating of Chronic Renal Failure Based on Protein Chip","authors":"Cheng Yawei ,&nbsp;He Lei ,&nbsp;Liao Ping ,&nbsp;Hu Heng ,&nbsp;Jin Yaming ,&nbsp;Li Fufeng ,&nbsp;Wang Wenjing ,&nbsp;Wang Yiqin ,&nbsp;Hao Yiming","doi":"10.1016/S1876-3553(12)60018-0","DOIUrl":"10.1016/S1876-3553(12)60018-0","url":null,"abstract":"<div><p>This study aimed at screening proteinum markers of tongue coating related to chronic renal failure (CRF) and at establishing the predictive model by comparing differences of protein spectrum expression in clear supernatant liquid of tongue coating between CRF patients and normal controls in order to explore the significance of proteinum in clear supernatant liquid in the diagnosis of CRF. Clear supernatant liquid of tongue-coating samples collected from 67 CRF patients and 38 normal controls was used in the study. The proteinum markers of tongue coating were selected according to CRF with the SELDI-TOF-MS technique. The predictive model was established and verified by bioinformatics analysis. The tongue-coating samples of the 67 CRF patients and 38 normal samples in the control group were determined by the SELDI-TOF-MS technique. All 242 proteinum peaks were detected at 1000–20000 e/m. Overall, 13 distinct mass spectrum peaks were analyzed by bioinformatics and displayed statistical significance (<em>P</em> &lt; 0.01). Seven distinct mass spectrum peaks, such as M/Z1092.68 and M/Z1508.26, show high expression in the CRF group. Six distinct mass spectrum peaks, such as M/Z13302.5 and M/Z14330.7, show low expression in the CRF group. Fuzzy-grouping algorithm was used in the fuzzy-grouping analysis and principal component analysis (PCA) between the CRF group and normal control group. The result showed discrimination, but was partly overlapping. The predictive model of CRF was analyzed and established by bioinformatics with biological markers that comprise seven distinct mass spectrum peaks, such as M/Z1049.61, M/Z1076.94, M/Z15295.7, and so on. The predictive model can be used in the sample classification between the CRF group and normal control group (The sensitivity of the predictive model is 61.4%; the specificity is 57.3%; and the predictive exactitude rate is 64.4%). It can be concluded that using the SELDI-TOF-MS technique, the proteinum markers of tongue coating of CRF have been preliminarily screened. The established predictive model provides objective evidence for the study on CRF diagnosis.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 4","pages":"Pages 616-621"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60018-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81427204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Anthraquinones by UPLC Method in Patient with Craniocerebral Injuries after Oral Administration of Rhubarb","authors":"Fan Rong ,&nbsp;Huang Xi ,&nbsp;Wang Yang ,&nbsp;Ren Ping ,&nbsp;Qin Feng ,&nbsp;Zhang Chunhu ,&nbsp;Fan Lan ,&nbsp;Gao Lichen ,&nbsp;Liu Zhaoqian ,&nbsp;Zhou Honghao","doi":"10.1016/S1876-3553(12)60021-0","DOIUrl":"10.1016/S1876-3553(12)60021-0","url":null,"abstract":"<div><p>Ultra-high performance liquid chromatography (UPLC) method was developed for determining anthraquinones in plasma of patient with craniocerebral injuries after administration of Rhubarb. Chromatographic separation was performed on an Acquity UPLC BEH C₁₈ column (2.1 mm × 100 mm, 1.7 μm) with methanol-0.5% aqueous acetic acid (12:82) as mobile phase at a flow rate of 0.5 mL·min⁻¹. The wavelength was set at 254 nm. The operating temperature was maintained at 25°C and the sample volume injected was 5 μL. Linear range was satisfactory for determination of rhein in human plasma with the concentration ranging from 0.42 to 13.429 μg·mL⁻¹. Four other anthraquinones were not detected using UPLC method. Recovery rate of this method was within the range of 97.2%−103.11%. The relative standard deviation of intra- and inter-day was less than 6%. The concentration of rhein in plasma after 1 hour administration from five TBI patients was 7.93±1.94 μg·mL⁻¹. The UPLC is a method with good precision, high recovery rate, simple operation, innocuity, and good reproducibility.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 4","pages":"Pages 676-680"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60021-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82253805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}