World Science and Technology最新文献

{"title":"Discussion on Establishment of Brain Interstitial Fluid Pharmacology based on Microdialysis","authors":"Liu Jianxun,&nbsp;Song Wenting,&nbsp;Xu Li","doi":"10.1016/S1876-3553(12)60036-2","DOIUrl":"10.1016/S1876-3553(12)60036-2","url":null,"abstract":"<div><p>Brain interstitial fluid (BIF) is a biological matrix of cerebral neurons. The medicine composition that is permeated into the brain and the endogenous substances released into synaptic space are available in BIF, which make it an ideal vehicle for research on drug targeting and an efficacious mechanism of neuroprotective medicine. Based on the microdialysis sampling technique, BIF can be used in not only <em>in vivo</em> studies but also <em>in vitro</em> experiments. On the basis of serum pharmacology, the concept of BIF pharmacology was proposed by our team. This article also discusses the feasibility and advantages of BIF pharmacology application in Chinese medicine prescription. This new mode of study serves as a creative attempt of facilitating the international orientation of Chinese medicine.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 2","pages":"Pages 1363-1366"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60036-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74984342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex Systems Entropy Network and Its Application in Data Mining for Chinese Medicine Tumor Clinics","authors":"Yang Ming ,&nbsp;Jiao Lijing ,&nbsp;Chen Peiqi ,&nbsp;Wang Jue ,&nbsp;Xu Ling","doi":"10.1016/S1876-3553(12)60038-6","DOIUrl":"10.1016/S1876-3553(12)60038-6","url":null,"abstract":"<div><p>This study was aimed at investigating the method of data mining for complex Chinese medicine tumor clinical data. This article introduces a complex systems entropy network for data mining in tumor clinics. A mutual information algorithm based on the random permutation test was proposed for assessing the correlation of multi-variables, and a complex network was established. Based on the tumor clinical data (718 cases) collected, data mining was performed with the help of the statistical information of the complex network. The results showed that interaction effects among multi-variables were discovered by a complex systems entropy network. A total of 116 pairs of synergy variables and 14 core synergy cliques, 82 pairs of antagonistic variables and 7 core antagonistic cliques were found after 718 cases of data mining. The results, for the most part, correspond with the actual clinics. It was concluded that the complex systems entropy network is suitable for the analysis of interaction effects among multi-variables and also for data mining in complex Chinese medicine clinics.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 2","pages":"Pages 1376-1384"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60038-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75640537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on Preparation and in Vitro Sustained Release of Bu-Yang-Huan-Wu Sustained-Release Tablet","authors":"Yang Yantao ,&nbsp;Wu Chunying ,&nbsp;Zhou Jin ,&nbsp;Shi Jilian ,&nbsp;Liu Wenlong ,&nbsp;He Fuyuan","doi":"10.1016/S1876-3553(12)60034-9","DOIUrl":"10.1016/S1876-3553(12)60034-9","url":null,"abstract":"<div><p>Aim of this study was to prepare <em>Bu-Yang-Huan-Wu</em> (BYHW) elementary osmotic pump sustained-release tablets and to investigate the situation of its main effective components of “synchronous control and sustained release.” The releasing similarity of chromatographic fingerprints of BYHW <em>in vitro</em> dissolution was evaluated. The results showed that BYHW elementary osmotic pump sustained-release tablet was prepared and the chromatographic fingerprints were extracted. And data of its release similarity was also obtained. It was concluded that BYHW elementary osmotic pump sustained-release tablet can achieve the synchronous control and sustained release of many ingredient. It is also fit for the characteristic of Chinese herbal medicine compound.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 1","pages":"Pages 1211-1214"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60034-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123586447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of Isofraxidin in Extracellular Fluids of Striatum in Rats Using Microdialysis-UPLC Method","authors":"Liu Shumin,&nbsp;Tang Bo,&nbsp;Lu Fang,&nbsp;Fan Zhenqun,&nbsp;Zhou Shihui","doi":"10.1016/S1876-3553(12)60033-7","DOIUrl":"10.1016/S1876-3553(12)60033-7","url":null,"abstract":"<div><p>This study aimed to observe the pharmacokinetic characteristics of isofraxidin in extracellular fluids of striatum in rats after oral administration of isofraxidin. Microdialysis and UPLC-MS analytical technology were used in this study to detect the concentration of isofraxidin in microdialysis dialysate of extracellular fluids of striatum in rats, within 60 min after a single oral administration, with isofraxidin of 10 and 20 mg/kg, respectively. The results were revised by relative recovery <em>in vivo</em>. The pharmacokinetic parameters were calculated through noncompartment model method with software of WINONLIN 6.1 program. The main pharmacokinetic parameters of isofraxidin in extracellular fluids of striatum in rats after a single oral administration of isofraxidin at 10 mg/kg and 20 mg/kg were AUC_0-∞ (13973.88 ± 1582.984) and (28059.76 ± 4207.66) ng·min/mL; t_1/2 (16.68 ± 0.49) and (17.41 ± 2.88) min; C_max(498.87 ± 64.36) and (899.81 ± 133.22) ng/mL. The t_max of both two groups was 15 min. Both the C_max and t_max were measured. It was concluded that isofraxidin quickly permeates the bloodbrain barrier and reaches the striatum. The maximal concentration of isofraxidin is 15 min after oral administration. And then the concentration decreases at a faster rate. It showed a significant dose-dependent phenomenon of the concentration of isofraxidin in extracellular fluids of striatum in rats.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 1","pages":"Pages 1206-1210"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60033-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73072830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Shear Rate on the Aggregation Behavior of Self-Aggregated Glycyrrhizin Micelles by MesoDyn","authors":"Wang Yuguang ,&nbsp;Shi Xinyuan ,&nbsp;Qiao Yanjiang","doi":"10.1016/S1876-3553(12)60032-5","DOIUrl":"10.1016/S1876-3553(12)60032-5","url":null,"abstract":"<div><p>MesoDyn has been carried out to elaborate the micellar properties of natural surfactant glycyrrhizin which is frequently used in traditional Chinese medicine (TCM). The effect of shear rate on the aggregation behavior of glycyrrhizin has been investigated. The results showed that the critical micelle concentration (CMC) of glycyrrhizin increased with the addition of shear rate. And the glycyrrhizin aggregation transformed from spherical micelle to cylindrical micelle as the increase of shear rate. Furthermore, the aggregation behavior of the as-formed micelle was not stable to the change of shear rate. Removal of shear rate was unable to recover the micelle completely in the changing process of shear rate. The simulation results provide mesoscopic information for the solubilization of poorly water-soluble drug, and at the same time provide guidance for high efficient experiments.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 1","pages":"Pages 1201-1205"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60032-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79841341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Rules of Chinese and Western Medicine Used in the Treatment of Osteoporosis by Text Mining","authors":"Zhou Qi ,&nbsp;Chen Weini ,&nbsp;Jiang Miao ,&nbsp;Zheng Guang ,&nbsp;Guo Hongtao ,&nbsp;Lv Aiping","doi":"10.1016/S1876-3553(12)60035-0","DOIUrl":"10.1016/S1876-3553(12)60035-0","url":null,"abstract":"<div><p>This study was aimed at exploring the rules of Chinese patent medicine and Western medicine, as well as their combination rules used in the treatment of osteoporosis by text mining. Data on osteoporosis were queried and downloaded from SinoMed in March 2011. After transferring semi-structured data into the Microsoft SQL Server, the algorithm of data slicing based on frequency analysis was applied. A few simple, meaningful networks were achieved. The data of these networks were imported into Cytoscape and visualized. The results showed that in the treatment of osteoporosis, Chinese patent medicines, such as <em>Zuogui</em> pills, <em>Liuwei Dihuang</em> pills, <em>Gusongbao</em> granules, <em>Yougui</em> pills, and <em>Shengu</em> capsules, are widely used in the clinical practice. Chinese herbal medicines, such as <em>Herba Epimedii, Radix Rehmannia, Radix Astragali, Rhizoma Drynariae, Salvia Miltiorrhiza, Fructus Psoraleae, Radix Puerariae, Radix Angelica, and Cortex Eucommiae</em>, are frequently dealt with in articles on osteoporosis. <em>Herba Epimedii</em> and <em>Radix Rehmannia</em> are major herbal medicines that are most frequently used in the herbal combination. The most important treatment method of treating osteoporosis is by strengthening the kidney and spleen by activating and nourishing blood. Among all Western medicines, estrogen agents, Vitamin D, calcium, and thyrocalcitonin are the most frequently used in the treatment of osteoporosis. In this article, the rules pertaining to Chinese patent medicine and Western medicine used in the treatment of osteoporosis were described. The combination of Chinese patent medicine and Western medicine was also calculated for the clinical application and basic research reference.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 1","pages":"Pages 1288-1293"},"PeriodicalIF":0.0,"publicationDate":"2012-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60035-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78916692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kappa Analysis on the Application of Selecting Traditional Chinese Medicine Five-Element Music under Syndrome Differentiation","authors":"Liao Juan,&nbsp;Yang Yufei,&nbsp;Zhao Yuanchen,&nbsp;Xiang Chunyan,&nbsp;Wu Yu","doi":"10.1016/S1876-3553(12)60027-1","DOIUrl":"10.1016/S1876-3553(12)60027-1","url":null,"abstract":"<div><p>The quality of traditional Chinese medicine (TCM) five-element music was evaluated and selected under syndrome differentiation by using the Kappa test. Two different Kappa values between the physician and the cancer patient were compared in order to analyze the interconsistency of TCM five-element music selection. A total of 73 hospitalized cancer patients were allocated to receive TCM five-element music. The results of a single tune selection showed that a Kappa value greater than 0.4 for four modals, with moderate degree of consistency and statistical consistent for each other. However, there was neither consistent measurement nor statistical consistency for the <em>Zhi</em> tune. Multi-modal music selection showed that a Kappa value greater than 0.4 was related to heart-kidney deficiency, heart-spleen deficiency, liver-kidney deficiency, lung-kidney deficiency, and lung-spleen deficiency in modal choice. There was a moderate degree of statistical consistency. It was concluded that a consistency of TCM five-element music selection was observed between physician and patient by using the Kappa analysis. The study laid a good foundation for TCM five-element music for cancer patients.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 6","pages":"Pages 944-947"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60027-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90851705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in the Brain Tissue of Spleen-Yin Deficiency Alzheimer's Disease Rats","authors":"Zhan Libin ,&nbsp;Lin Haiyan ,&nbsp;Gong Xiaoyang ,&nbsp;Liu Li ,&nbsp;Liang Lina","doi":"10.1016/S1876-3553(12)60028-3","DOIUrl":"10.1016/S1876-3553(12)60028-3","url":null,"abstract":"<div><p>The effects of Chinese herbs for <em>Zibu Piyin</em> Recipe (ZBPYR) on spleen-<em>Yin</em> deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-<em>Yin</em> deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-<em>Yin</em> Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (<em>P</em> &lt; 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (<em>P</em> &lt; 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 6","pages":"Pages 993-998"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60028-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82273719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing Factor Analysis on Hospitalization Costs of 3046 Cases with Colorectal Cancer on Basic Medical Insurance in Beijing","authors":"Jia Xiaoqiang ,&nbsp;Yang Yufei ,&nbsp;Xu Renzhong ,&nbsp;Zheng Jie ,&nbsp;Yi Danhui ,&nbsp;Li Qiuyan ,&nbsp;Wu Yu ,&nbsp;Yang Huaizhong ,&nbsp;Zhang Mengmeng ,&nbsp;Zhang Jiayao","doi":"10.1016/S1876-3553(12)60029-5","DOIUrl":"10.1016/S1876-3553(12)60029-5","url":null,"abstract":"<div><p>The hospitalization cost of patients with colorectal cancer was studied to reveal influencing factors to explore traditional Chinese medicine (TCM) hospital performance characteristics, distribution law of factors affecting costs, and proposal of reducing medical costs. Retrospective analysis was conducted on the data of 3046 cases with colorectal cancer on basic medical insurance in Beijing in 2008. Factors of medical quality and costs were investigated by single and multivariate analysis. The relation of different factors and hospitalization cost was discussed. The results showed that major factors influencing hospitalization costs were hospitalization days, hospital category, main diag- nosis, hospital rank, operation or not, combination with cardiocerebral diseases, etc. It was concluded that hospitalization costs can be reduced by promoting applied rate of TCM, shortening hospitalization duration, promoting level of diagnosis and treatment, and service quality.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 6","pages":"Pages 948-951"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60029-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123587329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Research on TCM Syndrome Differentiation of 218 Patients with Postoperative Colorectal Cancer","authors":"Xu Yun ,&nbsp;Zhao Aiguang ,&nbsp;Gu Xiaohong ,&nbsp;Liu Jianping ,&nbsp;Wu Yu ,&nbsp;Yang Yufei","doi":"10.1016/S1876-3553(12)60031-3","DOIUrl":"10.1016/S1876-3553(12)60031-3","url":null,"abstract":"<div><p>This study aimed at providing objective and scientific evidence in the treatment determination of postoperative colorectal cancer based on the pathogenesis obtained through traditional Chinese medicine (TCM) syndrome differentiation. The symptoms and signs of postoperative early metaphase colorectal cancer were objectively summarized and differentiated by TCM syndrome differentiation. Mathematical statistics and multivariate analysis were applied in the clinical research. A total of 218 patients with postoperative early metaphase colorectal cancer were investigated in both Beijing and Shanghai. The contents included common data, TNM staging, the grade of oncopathology, previous treatment, symptoms, physical signs, and the TCM syndrome differentiation pattern. The database was established and managed with EPIdata 3.1. The data were entered twice in the auditing. The main statistical method employed was multivariate analysis, including cluster analysis and factor analysis. Regular TCM syndrome patterns of postoperative early metaphase colorectal cancer were objectively summarized by mathematical statistics and in combination with clinical practice. Through a clinical investigation and mathematical statistics, the diagnostic criteria of the TCM syndrome differentiation of postoperative early metaphase colorectal cancer were initially made. The seven determined TCM syndrome patterns are the syndrome of dryness of the intestine, the syndrome of insufficiency of the spleen and stomach, the syndrome of deficiency and exhaustion of spleen-<em>qi</em>, the syndrome of deficiency and exhaustion of liver-<em>yin</em> and endoretention of damp heat, the syndrome of inco-ordination between the liver and stomach, the syndrome of deficiency and exhaustion of kidney-<em>qi</em>, and the syndrome of <em>yang</em> asthenia and phlegmatic hygrosis. Meanwhile, the major as well as minor symptoms were also defined in each of these seven patterns. It is concluded that according to the results of mathematical statistics in combination with TCM theories, there are rules in the TCM syndrome patterns of postoperative early metaphase colorectal cancer. Further studies should be conducted in this area.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 6","pages":"Pages 938-943"},"PeriodicalIF":0.0,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60031-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80468881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}