World Science and Technology最新文献_第2页

Behavioral Observation and Analysis of PMS Liver-qi Depression Rat Model Established by Chronic Restraint Stress and Resident-Intruder Paradigm 经前症候群肝气郁结大鼠慢性抑制应激模型的行为学观察与分析

World Science and Technology Pub Date : 2012-08-01 DOI: 10.1016/S1876-3553(13)60009-5

Wei Sheng , Wang Haiping , Qiao Mingqi

{"title":"Behavioral Observation and Analysis of PMS Liver-qi Depression Rat Model Established by Chronic Restraint Stress and Resident-Intruder Paradigm","authors":"Wei Sheng , Wang Haiping , Qiao Mingqi","doi":"10.1016/S1876-3553(13)60009-5","DOIUrl":"10.1016/S1876-3553(13)60009-5","url":null,"abstract":"<div><p>This study was aimed at investigating the feasibility of establishing premenstrual syndrome (PMS) liver-<em>qi</em> depression rat model with resident-intruder paradigm compared to chronic restraint stress. The PMS liver-<em>qi</em> depression rat model was prepared with chronic restraint stress and resident-intruder paradigm. The effect was systematically evaluated through behavioral methods such as open-field test and tail suspension test. Then, results from both groups were compared. The results showed that both chronic restraint stress and resident-intruder paradigm can effectively simulate the state of premenstrual depression and postmenstrual disappearance. The results of the open-field test suggested that there was no significant difference between these two methods (<em>P</em> > 0.05). It was concluded that as a social psychological stress method the resident-intruder paradigm can preferably simulate the process of clinical PMS liver-<em>qi</em> depression caused by emotional abnormality and overcome the disadvantage of obvious body stress of the chronic restraint stress method. But the success ratio was too low, and further inspection was needed to examine its stability.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 4","pages":"Pages 1848-1852"},"PeriodicalIF":0.0,"publicationDate":"2012-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(13)60009-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87530061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Thought and Practice of Study of Tumor Treatments by Traditional Chinese Medicine Based on Collection and Analysis Platform of Known TCM Veteran Physicians 基于老中医名医荟萃分析平台的中医药肿瘤治疗研究思路与实践

World Science and Technology Pub Date : 2012-08-01 DOI: 10.1016/S1876-3553(13)60007-1

Zhang Runshun , Zhou Xuezhong , Wang Yinghui , Liu Baoyan , Zheng Honggang , Wu Jie , Li Daorui

引用次数: 0

Decade Research Progress and Development Trend of Complex Prescription Compatibility of Traditional Chinese Medicine 中药复方配伍十年研究进展及发展趋势

World Science and Technology Pub Date : 2012-06-01 DOI: 10.1016/S1876-3553(13)60003-4

Ge Yingli , Lu Yanliu , Yang Ming , Song Haiyan , Liu Ping , Ji Guang

引用次数: 3

Effect of Glytan on Liver Fibrosis in Portal Hypertensive Rats 格坦对门脉高压大鼠肝纤维化的影响

World Science and Technology Pub Date : 2012-06-01 DOI: 10.1016/S1876-3553(13)60004-6

Du Qinghong , Han Lin , Jiang Junjie , Li Pengtao , Wang Xinyue , Jia Xu

{"title":"Effect of Glytan on Liver Fibrosis in Portal Hypertensive Rats","authors":"Du Qinghong , Han Lin , Jiang Junjie , Li Pengtao , Wang Xinyue , Jia Xu","doi":"10.1016/S1876-3553(13)60004-6","DOIUrl":"10.1016/S1876-3553(13)60004-6","url":null,"abstract":"<div><p>The aim of this research was to observe the effect of Glytan on rat liver fibrosis and to investigate the mechanism of portal hypertension (PHT). SD male rats with weight between 240 g and 260 g were randomly divided into a sham group, model group, propranolol group, and Glytan group, according to their weight. PHT and liver fibrosis were induced by common bile duct ligation. After 2 and 4 weeks, the hydroxyproline (Hyp) content of liver tissues was tested by spectrophotometer. The collagen formation was evaluated by Masson staining and ultrastructural changes were evaluated by transmission electron microscopy (TEM). The results showed that Glytan inhibited the Hyp production at 2 weeks and 4 weeks. Masson staining revealed the same results with Hyp. Glytan inhibited the pseudolobule formation. TEM showed swelling sinusoid endothelial cells (SEC), reduced fenestra between the SEC, widened Disse's space, and reduced hepatocyte microvilli in the model group rats. At 4 weeks, loss of the hepatocyte microvilli and the basement membrane were clearly seen. Glytan promoted degeneration of the matrix and restoration of the SEC at 2 weeks and 4 weeks. It was concluded that Glytan inhibited collagen formation and ameliorated sinusoidal capillarization. This is one of the mechanisms of Glytan used to decrease the portal venous pressure. The results provided precise and reliable proof to develop new treatments for PHT.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 3","pages":"Pages 1631-1635"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(13)60004-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74393629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exploration of Action Patterns and Mechanisms of Traditional Chinese Medicine Incompatibility of Qi–Qing Antagonism and Mutual Inhibition/Restraint based on Drug Interaction 基于药物相互作用的气清拮抗和相互抑制/抑制中药配伍作用模式及机制探讨

World Science and Technology Pub Date : 2012-06-01 DOI: 10.1016/S1876-3553(13)60001-0

Duan Jin'ao, Su Shulan, Fan Xinsheng, Qian Dawei, Tang Yuping, Shang Erxin, Guo Jianming, Liu Pei

{"title":"Exploration of Action Patterns and Mechanisms of Traditional Chinese Medicine Incompatibility of Qi–Qing Antagonism and Mutual Inhibition/Restraint based on Drug Interaction","authors":"Duan Jin'ao, Su Shulan, Fan Xinsheng, Qian Dawei, Tang Yuping, Shang Erxin, Guo Jianming, Liu Pei","doi":"10.1016/S1876-3553(13)60001-0","DOIUrl":"10.1016/S1876-3553(13)60001-0","url":null,"abstract":"<div><p>This paper proposes three kinds of action patterns of traditional Chinese medicine (TCM) incompatibility based on the theories of Seven Ways of Compatibility and Drug Interaction. These are toxification and potential toxicity action pattern embodied in the characteristic of antagonism, efficiency reduction, and decrease in effect—patterns reflected by the characteristics of mutual inhibition/restraint and toxic-effect multiple action patterns embodying the complex characteristics of antagonism and mutual inhibition/restraint. In addition, we put forward eight possible mechanisms of TCM incompatibility. They are potential toxicity by promoting the release of toxic substances, potential toxicity by producing new toxic components, potential toxicity because of increased toxic components resulting from mutual transformation of chemical constituents, efficiency reduction through inhibiting the dissolving of active components, efficiency reduction through inactivating the active components, toxification that results from toxic metabolites generated <em>in vivo</em> based on drug interaction, adverse effects caused by affecting the physiological disposition of incompatibility combinations, and adverse effects caused by regulating and controlling the drug metabolic enzymes. Furthermore, the authors discussed the correlations between the different action patterns and mechanisms and relationships of the seven ways of compatibility. These opinions would provide references for understanding and researching the essences of TCM incompatibility.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 3","pages":"Pages 1547-1552"},"PeriodicalIF":0.0,"publicationDate":"2012-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(13)60001-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87091084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Preliminary Analysis of the Discipline from Yan Zhenghua's Prescription for the Treatment of Stomach Pain Based on Natural Medicine Combination Modes 基于自然药物结合模式的颜正华《胃痛方》学科初探

World Science and Technology Pub Date : 2012-06-01 DOI: 10.1016/S1876-3553(13)60005-8

Li Meng, Gu Hao, Zhai Huaqiang, Xiao Bin, Wang Yun

引用次数: 2

Further Study of Indicated Pharmacokinetics of Traditional Chinese Medicine 中药指示性药代动力学的进一步研究

World Science and Technology Pub Date : 2012-06-01 DOI: 10.1016/S1876-3553(13)60002-2

Liu Jianxun, Lin Li, Zhang Ying, Li Xinzhi, Lin Chengren, Fu Jianhua

引用次数: 2

Development of Mesoscopic Simulation Studies on Nonionic Block Copolymer Surfactants 非离子嵌段共聚物表面活性剂介观模拟研究进展

World Science and Technology Pub Date : 2012-04-01 DOI: 10.1016/S1876-3553(12)60040-4

Wang Yuguang , Ding Haiou , Dai Xingxing , Shi Xinyuan , Qiao Yanjiang

引用次数: 1

Establishment of Disease-syndrome Combination Rat Model of Rheumatoid Arthritis with Spleen Deficiency 类风湿关节炎脾虚病证结合大鼠模型的建立

World Science and Technology Pub Date : 2012-04-01 DOI: 10.1016/S1876-3553(12)60039-8

Du Zhongping , Zhao Hongyan , Xiao Cheng , Liu Meijie , Wang Yan , Lv Cheng , Lv Aiping , Wang Shaojun , Teng Jingru , Ju Dahong

{"title":"Establishment of Disease-syndrome Combination Rat Model of Rheumatoid Arthritis with Spleen Deficiency","authors":"Du Zhongping , Zhao Hongyan , Xiao Cheng , Liu Meijie , Wang Yan , Lv Cheng , Lv Aiping , Wang Shaojun , Teng Jingru , Ju Dahong","doi":"10.1016/S1876-3553(12)60039-8","DOIUrl":"10.1016/S1876-3553(12)60039-8","url":null,"abstract":"<div><p>This study was aimed at establishing a disease-syndrome combination rat model of rheumatoid arthritis (RA) with spleen deficiency. A group of 60 six-week-old SpragueDawley rats were randomly divided into normal control group and reserpine (RSP) group. Spleen deficiency model rat groups were made by an intraperitoneal injection of RSP. After 14 days, rats of RSP groups were subcutaneously injected with collagen type II protein to induce arthritis. The incidence of the model was observed, and the mechanism was analyzed by enzyme-linked immunosorbent assay (ELISA). The results showed that compared with the collagen-induced arthritis (CIA) group, the degree of joint swelling and joint damage was significantly increased in the RSP CIA model. The RSP CIA model rats were observed as exhibiting spleen deficiency syndrome that was similar to clinical symptoms, such as appearing apathetic, squinting, a sparse dry dull coat, a bowed back, a swollen ankle, fatigue, lazy movement, getting together, eating less, weight loss, and loose stools. Compared with the CIA control rats, spleen deficiency impaired the function of intestinal mucosa by disordering the intestinal villi, covering a large amount of goblet cells in the epithelium, and inducing exfoliation, degeneration, and necrosis fluff pieces. The content of anti-type II collagen antibody, IL-6, IL-10, and IFN-γ was increased. It was concluded that the rat model of rheumatoid arthritis with spleen deficiency syndrome by an intraperitoneal injection of reserpine has both obvious spleen deficiency syndrome and characteristics of RA. It can provide successful experiences for the rat model of rheumatoid arthritis with spleen deficiency syndrome. Spleen deficiency plays a vital role in RA.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 2","pages":"Pages 1384-1392"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60039-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90165084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Research Thoughts and Methods on Concise Prescriptions of Chinese Medicine for Prevention and Treatment of Alzheimer's Disease based on Various Kinds of Animal Models 基于多种动物模型的阿尔茨海默病防治中药简明方剂研究思路与方法

World Science and Technology Pub Date : 2012-04-01 DOI: 10.1016/S1876-3553(12)60037-4

Liu Meixia, Liu Jiangang, Li Hao, Liu Longtao, Zhou Wenquan

{"title":"Research Thoughts and Methods on Concise Prescriptions of Chinese Medicine for Prevention and Treatment of Alzheimer's Disease based on Various Kinds of Animal Models","authors":"Liu Meixia, Liu Jiangang, Li Hao, Liu Longtao, Zhou Wenquan","doi":"10.1016/S1876-3553(12)60037-4","DOIUrl":"10.1016/S1876-3553(12)60037-4","url":null,"abstract":"<div><p>In the theory of traditional Chinese medicine (TCM), the key pathogenesis of Alzheimer's disease (AD) was kidney-essence deficiency, and this resulted in phlegm stasis. So, in clinical practice, concise prescriptions that consist of herbs, which reinforce kidney <em>qi</em>, activate blood circulation, and detoxicate, exert a good effect on the AD treatment. Based on various kinds of animal models, this article discussed the pharmacological effects of concise prescriptions of Chinese medicine on AD prevention and treatment. The preparation technology and composition of concise prescriptions of Chinese medicine were determined based on the combination of Chinese medicine preparation technology and the efficacy evaluation of the drugs. According to the complex pathogenesis of AD, we developed a basic research method using concise prescriptions prepared by different technologies and various animal models of AD. Changes in some advanced indicators were observed as reflecting the pathological and physiological characteristics of AD and the pharmacodynamic effects of prescriptions. The formation of a safe and effective concise prescription is able to comprehensively reflect the pathogenesis and characteristics of AD based on various kinds of animal models.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"14 2","pages":"Pages 1367-1376"},"PeriodicalIF":0.0,"publicationDate":"2012-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60037-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73911742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2