Zhan Libin , Lin Haiyan , Gong Xiaoyang , Liu Li , Liang Lina
{"title":"滋补补饮方对脾阴型阿尔茨海默病大鼠脑组织内质网应激的影响","authors":"Zhan Libin , Lin Haiyan , Gong Xiaoyang , Liu Li , Liang Lina","doi":"10.1016/S1876-3553(12)60028-3","DOIUrl":null,"url":null,"abstract":"<div><p>The effects of Chinese herbs for <em>Zibu Piyin</em> Recipe (ZBPYR) on spleen-<em>Yin</em> deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-<em>Yin</em> deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-<em>Yin</em> Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (<em>P</em> < 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (<em>P</em> < 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 6","pages":"Pages 993-998"},"PeriodicalIF":0.0000,"publicationDate":"2011-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60028-3","citationCount":"1","resultStr":"{\"title\":\"Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in the Brain Tissue of Spleen-Yin Deficiency Alzheimer's Disease Rats\",\"authors\":\"Zhan Libin , Lin Haiyan , Gong Xiaoyang , Liu Li , Liang Lina\",\"doi\":\"10.1016/S1876-3553(12)60028-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The effects of Chinese herbs for <em>Zibu Piyin</em> Recipe (ZBPYR) on spleen-<em>Yin</em> deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-<em>Yin</em> deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-<em>Yin</em> Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (<em>P</em> < 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (<em>P</em> < 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.</p></div>\",\"PeriodicalId\":101287,\"journal\":{\"name\":\"World Science and Technology\",\"volume\":\"13 6\",\"pages\":\"Pages 993-998\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2011-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60028-3\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1876355312600283\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876355312600283","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of Zibu Piyin Recipe on Endoplasmic Reticulum Stress in the Brain Tissue of Spleen-Yin Deficiency Alzheimer's Disease Rats
The effects of Chinese herbs for Zibu Piyin Recipe (ZBPYR) on spleen-Yin deficiency Alzheimer's Disease (AD) rats were investigated. A new rat model was established based on both AD and the spleen-Yin deficiency syndrome. Then, expressions of glucose- regulated protein78 (GRP78), CCAAT/EBP homologous protein (CHOP) in the hippocampus (CA1, CA3, and DAG regions) and cerebral cortex that were correlated to endoplasmic reticulum stress were determined. The results showed that in contrast to the Spleen-Yin Deficiency AD groups, the expression of the GRP78 protein was obviously upregulated (P < 0.05) in the ZBPYR group; whereas the expression of the CHOP protein was obviously downregulated (P < 0.05). It is concluded that Chinese herbs for ZBPYR improve the ability of learning and memory by reinforcing the survival pathway of ERS, and inhibiting the apoptosis pathway of ERS.
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