World Science and Technology最新文献

{"title":"Study on the Nature of Spleen Qi Deficiency Based on Metabonomics","authors":"Zhan Libin ,&nbsp;Chu Yan ,&nbsp;Zhao Xinjie ,&nbsp;Xu Guowang ,&nbsp;Zhang Li ,&nbsp;Sui Hua ,&nbsp;Liu Ying ,&nbsp;Wu Benhui","doi":"10.1016/S1876-3553(12)60019-2","DOIUrl":"10.1016/S1876-3553(12)60019-2","url":null,"abstract":"<div><p>This study aimed at analyzing small molecule metabolites c in plasma in order to find the spectra of plasma in metabolic syndromes (MS) of spleen <em>qi</em> deficiency, which is different from other kinds of deficiency. The basic documents related to subjects were collected in combination with the diagnostic criteria of metabolic syndrome and spleen <em>qi</em> deficiency. UPLC-Q-TOF-MS was used in the separation of plasma metabolites. The results showed that the spectrum of plasma in MS of the spleen <em>qi</em> deficiency is different from healthy subjects in metabonomics (<em>P</em> &lt; 0.05). It is concluded that three compounds are possibly the latent markers of MS; another three compounds may be the potential markers of the spleen <em>qi</em> deficiency.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 4","pages":"Pages 622-625"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60019-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84724494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Platelet-Monocyte Aggregation in the Onset of Acute Cardiovascular and Cerebrovascular Diseases","authors":"Peng Li ,&nbsp;Zhang Guangyin ,&nbsp;Ding Yi ,&nbsp;Cao Yang ,&nbsp;Zhang Junping","doi":"10.1016/S1876-3553(12)60012-X","DOIUrl":"10.1016/S1876-3553(12)60012-X","url":null,"abstract":"<div><p>Atherosclerosis is the main pathological basis of cardiovascular and cerebrovascular diseases. Adhesion and aggregation of platelet and monocyte play an important role in patients with acute cardiovascular and cerebrovascular diseases. This article reviews the molecular mechanism of aggregation formation, mechanism of inducing plaque rupture, pathogenesis of impacting acute cardiovascular and cerebrovascular disease occurrence, targets of Chinese medicine and western medicine, corresponding monoclonal antibodies and gene knockout, etc. Problems that existed in the current study are also analyzed to arouse the attention of fellow researchers.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 3","pages":"Pages 493-497"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60012-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77865800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tongluo-Jiunao Injection on Cerebral Ischemia–Reperfusion Injury Rats","authors":"Tang Yibo,&nbsp;Tang Huiling,&nbsp;Zhang Wei,&nbsp;Wang Runjun,&nbsp;Yan Yangyang,&nbsp;Xu Liwei,&nbsp;Li Pengtao","doi":"10.1016/S1876-3553(12)60016-7","DOIUrl":"10.1016/S1876-3553(12)60016-7","url":null,"abstract":"<div><p>The aim of this study was to investigate the protective effects of <em>Tongluo-Jiunao</em> (TLJN) injection on brain tissues of focal cerebral ischemia-reperfusion injury rats. Cerebral ischemia-reperfusion injury rat model was established by middle cerebral artery occlusion. All animal models were divided into the following four groups: sham, model, TLJN, and edaravone groups. The brain infarct volume, concentration of IGF-1 in brain tissues and serum were detected at 24 h, 3 d, and 7 d after cerebral ischemia-reperfusion injury. The results showed that compared to the model group, the brain infarct volume of TLJN group was significantly reduced, and the expression of IGF-1 of cerebral cortex was upregulated in TLJN group. It was concluded that TLJN has significant protective effects on brain tissues in focal cerebral ischemia-reperfusion injury rat, and the IGF-1 may play an important role in the protective effects of brain tissues.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 3","pages":"Pages 488-492"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60016-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77755668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empirical Study of Proteome of Hippocampus from A Rat Model with Alzheimer's Disease with Spleen Deficiency Syndrome Effected by Zibu Piyin Recipe","authors":"Zhan Libin ,&nbsp;Lu Xiaoguang ,&nbsp;Liu Li ,&nbsp;Gong Xiaoyang ,&nbsp;Liang Lina ,&nbsp;Shi Xiang","doi":"10.1016/S1876-3553(12)60013-1","DOIUrl":"10.1016/S1876-3553(12)60013-1","url":null,"abstract":"<div><p>The article is aimed at investigating Alzheimer's disease (AD) with spleen <em>yin</em> deficiency syndrome and identifying the effective therapeutic targets of <em>Zibu Piyin</em> Recipe (ZBPYR) at whole cell protein levels. The rat model of spleen <em>yin</em> deficiency syndrome was set up through combination with improper diet, overstrain, and consumption of body fluid. Then, the polymerized β-amyloid 1–40 was injected into both hippocampi of the rats. The treated group was administered with ZBPYR. Taking the control group as a standard, the changes of proteins in the hippocampus were compared between the model group of AD with spleen <em>yin</em> deficiency syndrome and ZBPYR-treated group by two-dimensional gel electrophoresis. The altered protein spots were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Compared with the control group, 9 protein spots of the hippocampus in the model group of AD with spleen <em>yin</em> deficiency syndrome and 2 spots in ZBPYR-treated group were found to be changed totally. The differential protein spots were identified by MALDI-TOF-MS. The results showed that in the model group of AD with spleen <em>yin</em> deficiency syndrome, the level of annexin III was higher, but the levels of tubulin beta chain 15, dihydropyrimidinase-like 2, and guanine nucleotide-binding protein beta-1 subunit were lower than that of the control group. These differential proteins did not show significant changes between the ZBPYR-treated group and the control group. It is concluded that changes of several proteins in the hippocampus may involve in the pathogenesis of AD with spleen <em>yin</em> deficiency syndrome together. Annexin III, tubulin beta chain 15, dihydropyrimidinase-like 2, and guanine nucleotide-binding protein beta-1 subunit are possibly related to pathological changes of the hippocampus in AD with spleen <em>yin</em> deficiency syndrome. ZBPYR may produce its effects by regulating these proteins in the hippocampus.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 3","pages":"Pages 480-487"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60013-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79168540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and Thinking on the Current Status of Traditional Chinese Medicine Standardization","authors":"Yuwen Ya,&nbsp;Han Xuejie,&nbsp;Xie Yanming,&nbsp;Wang Yanping,&nbsp;Lu Aiping","doi":"10.1016/S1876-3553(12)60015-5","DOIUrl":"10.1016/S1876-3553(12)60015-5","url":null,"abstract":"<div><p>Standard is one of basic elements that constitutes core competitive power of a country. It is also an important technical system for normalizing economy and social development. This study emphasizes on the importance of enforcing traditional Chinese medicine (TCM) standardization, and summarizes the achievement, analyzes the problems, and provides the corresponding measures for settling the problems.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 3","pages":"Pages 445-449"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60015-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88828582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Zhichan Decoction on Neural Stem Cell Differentiation in Parkinson's Disease Model Rats","authors":"Li Wentao ,&nbsp;Shi Huifen ,&nbsp;Wang Yang ,&nbsp;Li Rukui ,&nbsp;Liu Yi ,&nbsp;Lu Yu","doi":"10.1016/S1876-3553(12)60011-8","DOIUrl":"10.1016/S1876-3553(12)60011-8","url":null,"abstract":"<div><p>This study was aimed at discussing the effect of <em>Zhichan</em> decoction (ZCD) on neural stem cell (NSC) differentiation in Parkinson's disease (PD) model rats. PD model rats were divided into four groups. In the normal group and model group, 0.9% normal saline was administered intragastrically. Normal culture medium was transplanted in the brain. ZCD was administered intragastrically in the treatment group after NSC transplantation. TH protein was checked with the immunohistochemical method, and mRNA expression of Ptx3, Nurrl, and Shh was checked with RT-PCR from brain slices on 7 d, 14 d, and 28 d, respectively. The results showed that TH protein was significantly increased in the treatment group on 7 d and 14 d as compared with the control group. The mRNA expression of Ptx3 and Shh was significantly increased at some time points. It is concluded that ZCD has the effect of promoting NSC differentiation in PD model rats.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 3","pages":"Pages 475-479"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60011-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81608118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Problems of Intellectual Property during Innovation of Traditional Chinese Medicine","authors":"Song Xiaoting","doi":"10.1016/S1876-3553(12)60014-3","DOIUrl":"10.1016/S1876-3553(12)60014-3","url":null,"abstract":"<div><p>Innovation of Traditional Chinese medicine (TCM) was proposed under market economy conditions. Hence, not only rules of market economy but also intellectual property law must be complied with. Innovation of TCM can be divided into two parts. One is the self innovation of TCM and the other is innovation based on knowledge and techniques of TCM. Both innovations have been presented with different questions of intellectual property derived from past events. Under market economy conditions where private rights are legitimate and interests must be maximized, a proper intellectual property legal system should be established for the innovation of TCM to protect and maintain this superior domain of China.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 3","pages":"Pages 466-469"},"PeriodicalIF":0.0,"publicationDate":"2011-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60014-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91020491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussion of the Clinical Research for Integrating Traditional Chinese Medicine and Western Medicine in the Treatment of HIV/AIDS Herpes Zoster","authors":"Pan Juhua, Shijing Huang, Wu Wei, Liuhua Xue, Wang Jie","doi":"10.1016/S1876-3553(12)60010-6","DOIUrl":"https://doi.org/10.1016/S1876-3553(12)60010-6","url":null,"abstract":"","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"47 1","pages":"244-247"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74038904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theory of “Analogous Patterns in the Same Disease” and Disease Identification in TCM: Development of TCM through a Scientific Outlook","authors":"Wang Wenjian","doi":"10.1016/S1876-3553(12)60008-8","DOIUrl":"10.1016/S1876-3553(12)60008-8","url":null,"abstract":"<div><p>The theory of “analogous patterns in the same disease” is important in the development of disease differentiation and treatment in traditional Chinese medicine (TCM). Syndrome differentiation and treatment were considered the characteristics of TCM. However, disease differentiation and treatment, which were included in the theory of “formula corresponds to the syndrome complex” by Dr Zhang Zhongjing, were neglected. In the modern technological environment, disease differentiation and treatment is the expansion and extension of syndrome differentiation and treatment. It is also an important way of promoting TCM development. Composite Denshen Pilulae (CDP) successfully passed Phase-II clinical trials of the Food and Drug Administration in the United States. One of the important reasons for this occurrence is that CDP adopted chronic myocardial ischemia of coronary heart disease as its indication, which met the international and modern practice of medicine. Clinical practice calls for enrichment of disease differentiation and treatment on the basis of further development of TCM syndrome differentiation and treatment. A favorable atmosphere needs to be created for innovative thought on this subject.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 2","pages":"Pages 226-231"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60008-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73357193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Smooth Muscle Axis: A Hypothesis and Its Interrelation with Comorbid Depression or Traditional Chinese Medicine Theory of Gan-Shicangxue and -Shishuxie","authors":"Huang Xi,&nbsp;Wang Yang,&nbsp;Ren Ping,&nbsp;Yunhui Li,&nbsp;Rong Fan","doi":"10.1016/S1876-3553(12)60009-X","DOIUrl":"10.1016/S1876-3553(12)60009-X","url":null,"abstract":"<div><p>Brain-smooth muscle (BSM) axis refers to a bidirectionally influencial and modulatory pathway between the encephalic region and smooth muscle. Via a local cytochrome P450 enzyme and an endogenous active material, stress reaction between the brain and vascular or visceral smooth muscle was modulated, specially implicated depressive comorbidities. Evidence provided by publications and recent experiments of this research group showed that firstly, 40%–50% depression is comorbidity of functional gastrointestinal disorders; a frequent comordibity of functional hypothalamus amenorrhea and depression; depression increases 3- to 6-fold of nocturia than in healthy people; myocardial and cerebral ischemia induce depression. Comorbidity just mentioned especially refers to simultaneous disorders of the brain and vascular or visceral smooth muscle. Secondly, a traditional Chinese medicine formula is as effective as an anti-depressive, prokinetic and vasoactive, which highlights the therapeutic mechanism of modern anti-depressive serotonin and noradrenaline reuptake inhibitors. Absorbed bioactive compounds in hippocampus, intestine and vessel wall were detected after oral administration of the formula and forced swimming rat. Thirdly, both sides of the BSM axis are the same, suggesting the common pathophysiological mechanism. Among the four axes, only “brain”, one side of the axis, is the same and the other sides are different. Fourthly, the pivotal role is that one of the important pathogenetic mechanisms involved in liver visceral manifestation of TCM theory and stress disease is the disorder of the BSM axis. The validation and improvement of the BSM axis hypothesis contribute much to the study of depression, stress diseases and liver visceral manifestation in TCM.</p></div>","PeriodicalId":101287,"journal":{"name":"World Science and Technology","volume":"13 2","pages":"Pages 221-225"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1876-3553(12)60009-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89149592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}