WFUMB Ultrasound Open最新文献

{"title":"Ultrasound imaging for assessing aortic phenotypes: A preclinical tool for measuring cardiac disease model progression and therapeutic effect","authors":"James Cao ,&nbsp;Alex Jayyosi ,&nbsp;Jennifer Nietupski ,&nbsp;Giulio Tomassy ,&nbsp;Ingeborg M. Langohr ,&nbsp;Michelle Potter ,&nbsp;Srinivas Rao ,&nbsp;Dinesh S. Bangari ,&nbsp;Xiaoyou Ying","doi":"10.1016/j.wfumbo.2024.100060","DOIUrl":"10.1016/j.wfumbo.2024.100060","url":null,"abstract":"<div><p>Cardiac dysfunction is a common feature of numerous diseases, ranging from metabolic disorders like Mucopolysaccharidosis Type 1 (MPS I), a.k.a. Hurler syndrome to neuromuscular disorders such as Myotonic Dystrophy type 1 (DM1). The ability to quantify cardiac abnormalities in animal models of these diseases is a valuable translational tool for preclinical testing of novel therapeutic approaches. In contrast to methods that measure the left ventricle (LV) phenotype, we employed ultrasound imaging to assess the ascending aortic diameter and ascending aortic blood velocity.</p></div><div><h3>Methods</h3><p>We imaged two disease models - MPS I Hurler mouse model and DM1 mouse model (DMSXL) - using the Vevo2100 platform. Ascending aortic diameter in the proximal thoracic aortic region and ascending aortic blood velocity just before the branching point of the brachiocephalic artery were measured as rapid imaging readouts. In addition, histopathology was performed on relevant tissue samples.</p></div><div><h3>Results</h3><p>The two mouse models demonstrate opposing aorta phenotypes. Hurler mice had a dilated aorta and slightly increased blood velocity with disease progression, while the aorta diameter in DMSXL mice narrowed and had a blood velocity decrease as the disease progressed. In the Hurler model, we demonstrated that a single dose of adeno-associated virus (AAV) delivered gene therapy provides aortic phenotype improvement. In the DMSXL model, we established aortic phenotype criteria at baseline.</p></div><div><h3>Conclusion</h3><p>Ultrasound imaging of aortic diameter and blood velocity can offer objective and longitudinal assessments of disease progression and treatment efficacy in real time. This method might therefore have noninvasive clinical applicability as phenotype indicator of cardiac dysfunction.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000284/pdfft?md5=1a56e979162a16019bd4a64cd6c8458f&pid=1-s2.0-S2949668324000284-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound role in diagnosis and as an assisting tool in prognostication of surgery in neonates with necrotizing enterocolitis","authors":"Elham Zarei ,&nbsp;Mehdi Vafadar ,&nbsp;Amir S. Mounesi Sohi ,&nbsp;Jilla Armandeh ,&nbsp;Ehsan Ranjbar","doi":"10.1016/j.wfumbo.2024.100048","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2024.100048","url":null,"abstract":"<div><h3>Objective</h3><p>Abdominal ultrasonography (AUS) assessment of the neonatal abdomen is emerging as a potential useful addition to traditional abdominal radiographs (AXR) to confirm the diagnosis of necrotizing enterocolitis (NEC). The goal of this study was to assess the abdominal sonographic findings of premature infants with NEC, in order to determine whether AUS is more effective than AXR in the diagnosis of NEC.</p></div><div><h3>Methods</h3><p>This cross-sectional study was performed on consecutive neonates with clinical suspicion of NEC admitted in our hospital’s NICU (Ali-Asghar Children’s Hospital, Tehran, Iran). We prospectively evaluated the hospitalized subjects using AXR and AUS from May 2018 to May 2020.</p></div><div><h3>Results</h3><p>A total of 53 neonates were included in the study. These patients were divided into two groups: suspected NEC patients (stage I) including 31 subjects and definite NEC patients (stage II and III) including 22 neonates. We found a substantial agreement between the two modalities regarding the detection of pneumoperitoneum and pneumatosis intestinalis (κ: 0·658 for both). The concordance concerning portal venous gas detection was considered slight (κ: 0·315). Thirty-eight patients did not show any signs of portal venous gas in either of AUS or AXR. On the contrary, four patients demonstrated evidences of portal venous gas in both AUS and AXR. AUS detected ten more portal venous gas than AXR. AXR found no cases with positive portal venous gas that were undetected by AUS. The most predictive indicator for surgical intervention in neonates was the presence of free echogenic ascites and loculated fluid.</p></div><div><h3>Conclusion</h3><p>Our findings demonstrated that AUS is superior to AXR in demonstrating portal venous gas and pneumatosis intestinalis. Hence, it seems that AUS is a useful adjunct to AXR in the management of NEC.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000168/pdfft?md5=fbf6aec924c4dc158f65ae6bbae8b53f&pid=1-s2.0-S2949668324000168-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an algorithm that separates gaseous micro-embolic signals and artifacts during transcranial Doppler persistent foramen ovale examinations","authors":"Rudolf W.M. Keunen ,&nbsp;Hester Temmink ,&nbsp;Mirjam Schipper ,&nbsp;Geert Jan Romers ,&nbsp;Paulien M. van Kampen ,&nbsp;Sayonara Daal","doi":"10.1016/j.wfumbo.2024.100067","DOIUrl":"10.1016/j.wfumbo.2024.100067","url":null,"abstract":"<div><h3>Objective</h3><div>Persistent foramen ovale (PFO) is a risk factor for young stroke. Agitated saline serum is used to deliver small gaseous emboli to the brain in transcranial Doppler ultrasound (TCD) for the detection and grading of PFO. In this study we validated a PFO algorithm that can differentiate between gaseous emboli and artifacts.</div></div><div><h3>Methods</h3><div>The validation cohort comprised 18 patients with positive PFO examinations. The PFO algorithm uses a binary tree that separates high-intensity transients signals (HITs) into gaseous emboli or artifacts based on intensity, zero-crossing, and velocity parameters.</div></div><div><h3>Results</h3><div>The cohort exhibited 385 macroscopic gaseous emboli meeting the &gt;3 dB criterion. An additional 137 gaseous emboli were noticed below the 3-dB intensity cutoff value. The low-intensity gaseous emboli included both macroscopic and microscopic air bubbles observed in curtains. Nearly all emboli (98 %) above the 3-dB level showed overt frequency modulation. The overall accuracy of the PFO algorithm in discriminating macroscopic gaseous emboli and artifacts was 96.4 %, with a similar percentage of sensitivity and specificity (96.4 %). The inter-observer agreement of human experts was excellent (ic-CC 0.989 and 0.953).</div></div><div><h3>Conclusions</h3><div>Macroscopic gaseous emboli and artifacts during PFO exams can be accurately discriminated by the PFO algorithm. The PFO algorithm cannot be used as a standalone system as microscopic air bubbles might escape proper identification. This knowledge will be important in the design of future PFO algorithms which should make it possible to classify the PFO grade without the interference of humans.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a deep-learning modular prototype to guide novices to acquire diagnostic ultrasound images from urinary system","authors":"Silvia Ossaba ,&nbsp;Áurea Diez ,&nbsp;Milagros Marti ,&nbsp;María Luz Parra-Gordo ,&nbsp;Rodrigo Alonso-Gonzalez ,&nbsp;Rebeca Tenajas ,&nbsp;Gonzalo Garzón","doi":"10.1016/j.wfumbo.2024.100049","DOIUrl":"10.1016/j.wfumbo.2024.100049","url":null,"abstract":"<div><h3>Importance</h3><p>Artificial intelligence (AI) application in guiding the acquisition of ultrasonography images represents a pioneering field of research. A new developed hybrid deep-learning (DL) algorithm, trained on more than high quality 60.000 curated and labelled reference images (distilled from a set of more than 600.000 abdominal ultrasound images) from La Paz Hospital, can provide real-time prescriptive guidance for novice operators to obtain standard planes images of the target organs.</p></div><div><h3>Objective</h3><p>This study aims to evaluate the capability of novice users to acquire diagnostic-quality abdominal ultrasound images of the urinary system using the deep-learning (DL)-based guiding research prototype provided by GMV.</p></div><div><h3>Design</h3><p>Setting, and Participants: This prospective diagnostic study was conducted within the facilities of an academic hospital. A cohort of 24 technically-oriented volunteers, lacking prior knowledge in anatomy or medicine and without experience in conducting ultrasound examinations, was recruited. After a brief training session focused on various organs, each pair of volunteers performed scans of each other's urinary system, exclusively guided by AI support. These scans were subsequently repeated by experienced sonographers using identical ultrasound equipment but without AI assistance. Four radiologists, each with decades of experience, independently and blindly assessed the quality of each acquisition.</p></div><div><h3>Results</h3><p>Over 90.6 % of the images scanned by volunteers were identified as valuable clinical picture, using only an AI-based guidance system. This is nearly comparable to the results achieved by experienced radiologists, who attained a 98.6 % success rate.</p></div><div><h3>Conclusions</h3><p>This deep-learning (DL) prototype enables novices lacking experience in ultrasonography to acquire diagnostic ultrasound images suitable for subsequent expert evaluation. The modular prototype works on a large range of ultrasound device models and vendors. This advancement has the potential to extend the application of ultrasound beyond traditional clinical environments, particularly in situations requiring immediate anatomical and functional interrogation, as well as in resource-limited settings.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294966832400017X/pdfft?md5=e41dc962072eea69f5f658dcad073e27&pid=1-s2.0-S294966832400017X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141409918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of sonographic signs in acute injury of anterior talofibular ligament","authors":"Meijun Zhou ,&nbsp;Jialin Ye ,&nbsp;Sushu Li ,&nbsp;Wenhong Yi ,&nbsp;Yu Wang ,&nbsp;Jiangting Ji ,&nbsp;Tianyue Wang ,&nbsp;Yi Yin ,&nbsp;Yanni He ,&nbsp;Hongmei Liu","doi":"10.1016/j.wfumbo.2024.100056","DOIUrl":"10.1016/j.wfumbo.2024.100056","url":null,"abstract":"<div><h3>Objectives</h3><p>The present study aimed to determine the diagnostic value of sonographic signs in patients who have experienced an acute injury of the anterior talofibular ligament (ATFL), and provide diagnostic evidence for improving the classification of ATFL injuries.</p></div><div><h3>Methods</h3><p>We retrospectively analyzed a total of 158 ATFL injuries, confirmed by surgery or magnetic resonance imaging (MRI), in 157 patients (one patient had bilateral ankle injury). A group of senior radiologists, along with two junior radiologists, identified the direct and indirect sonographic signs of ATFL injuries on ultrasound (US) images, and determined the ATFL injury classification. We then compared the diagnostic accuracy of the ATFL injury classifications, as well as the consistency of sonographic sign identification, between the senior radiologist group and the two junior radiologists. The sonographic signs identified by the senior radiologist group were used as the standard by which we analyzed the diagnostic efficacy of each sonographic sign for ATFL injury classification.</p></div><div><h3>Results</h3><p>The diagnostic accuracy for complete ATFL tears was 88.5 % in the senior radiologist group, which was higher than that for the two junior radiologists (72.3 % and 67.7 %). Compared to the senior radiologist group, the consistency between the two junior radiologists in identifying all sonographic signs of ATFL injuries was low (kappa value &lt; 0.75). Most complete tear, partial tear, and sprain/normal ATFL showed ligament thickening and were predominantly hypoechoic, but there were significant differences in ligament tension, clarity, and continuity (<em>P</em> &lt; 0.05). The sensitivity of direct sonographic signs alone in the diagnosis of complete ATFL tears reached 100 %, and the positive predictive value, negative predictive value, and accuracy rate were all &gt; 80 %. Direct sonographic signs were further combined with indirect sonographic signs to improve the diagnostic specificity and positive predictive value for the diagnosis of ATFL injuries.</p></div><div><h3>Conclusions</h3><p>High-frequency US is the first choice for the diagnosis of ATFL injuries; however, radiologists with different levels of experience may classify ATFL injuries differently. Refined sonographic signs, especially ligament tension, clarity, and continuity, are helpful in the classification and diagnosis of ATFL injuries and provide guidance for the treatment and management of ankle injuries in clinical practice.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000247/pdfft?md5=05dde5b3d2a59adfe42be5124b536b80&pid=1-s2.0-S2949668324000247-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lasting liver injury following COVID-19 infection characterized by ultrasound shear wave elastography","authors":"Firouzeh Heidari ,&nbsp;Theodore T. Pierce ,&nbsp;Madeleine Sertic ,&nbsp;Siddhi Hegde ,&nbsp;David Hunt ,&nbsp;Arinc Ozturk ,&nbsp;Anthony E. Samir","doi":"10.1016/j.wfumbo.2024.100074","DOIUrl":"10.1016/j.wfumbo.2024.100074","url":null,"abstract":"<div><h3>Objective</h3><div>To assess for lasting hepatic injury using ultrasound shear wave elastography (SWE) in patients following COVID-19 infection.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, patients with SWE exams between January 2019 and 2022 were categorized into three groups: 1) post-COVID-19 subjects with positive COVID-19 PCR assay, 2) random sample of contemporaneous unexposed patients with only negative prior COVID-19 PCR tests, and 3) random sample of pre-pandemic patients to address possible undiagnosed COVID-19 infection in the contemporaneous group. The average difference in median Young's modulus between post-COVID-19 patients and controls was calculated using a linear regression model after controlling for confounders.</div></div><div><h3>Results</h3><div>130 patients (mean age ± SD, 56 years ± 13; 66 women) were evaluated, including 30 patients after COVID-19 infection (mean age ± SD, 53 years ± 11; 15 women), 50 contemporaneous unexposed patients (mean age ± SD, 55 years ± 13; 27 men), and 50 pre-pandemic patients (mean age ± SD, 58 years ± 13; 28 women). SWE scans were performed on General Electric LOGIQ E9 or E10 an average of 44 (range, 12–81) weeks after COVID-19 infection. COVID-19 infection was associated with an average increase in median Young's modulus of 1.5 kPa (95 % CI [0.44, 2.355], p = 0.006) after controlling for age, sex, obesity, history of chronic liver disease, and time period. Post-COVID-19 patients had higher liver stiffness compared to contemporaneous controls (median = 7.58 vs 5.99 kPa, p = 0.001) but not pre-pandemic controls (median = 7.00 kPa, p = 0.51).</div></div><div><h3>Conclusions</h3><div>COVID-19 infection is associated with increased liver stiffness, which may reflect lasting hepatic injury such as ongoing inflammation or the development of fibrosis. US SWE may serve as a noninvasive tool for long-term liver health monitoring after COVID-19 infection.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriate body position and site for diaphragm ultrasound: Comparison with inspiratory mouth pressure","authors":"Kazunori Okada ,&nbsp;Akiko Kamiya ,&nbsp;Yusuke Yanagi ,&nbsp;Masahiro Nakabachi ,&nbsp;Yasuhiro Hayashi ,&nbsp;Michito Murayama ,&nbsp;Sanae Kaga","doi":"10.1016/j.wfumbo.2024.100052","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2024.100052","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to examine the appropriate body position and anatomical site for DUS through comparisons with maximal inspiratory pressure (MIP).</p></div><div><h3>Methods</h3><p>Thirty healthy adults were included in the study. MIP was measured using a spirometer. DUS was performed in both the right and left intercostal spaces in both sitting and supine positions. The diaphragm thickness at functional residual volume (TD_FRC) and total lung capacity (TD_TLC) were measured, and the fractional change in diaphragm thickness (TF) was calculated under each condition. To assess interobserver reproducibility, DUS was performed by an experienced examiner and a novice examiner.</p></div><div><h3>Results</h3><p>Among the DUS parameters, the TD_FRC measured at the right intercostal space in the sitting position showed the strongest correlation with MIP (r = 0.68, p &lt; 0.001). The correlations of TD_TLC with MIP tended to be inferior to those of TD_FRC with MIP, and the TF parameters did not correlate significantly with MIP. DUS measurements in the supine position demonstrated greater reproducibility than those in the sitting position, and those at the right intercostal space tended to be better than those at the left intercostal space.</p></div><div><h3>Conclusion</h3><p>When evaluating respiratory muscle function during inspiration using DUS, TD_FRC at the right zone of the apposition in the sitting position was found to be appropriate. DUS measurements at the right zone of apposition in the supine position were considered adequate for clinical use because the influence of examiner experience was small.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S294966832400020X/pdfft?md5=d7a881a506b6171e9ffccbb8569d4a89&pid=1-s2.0-S294966832400020X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body habitus vs. hepatic steatosis: Understanding the drivers of non-diagnostic shear wave elastography","authors":"Sai Dhanush Reddy Jeggari ,&nbsp;Lauren A. Ling ,&nbsp;Kathleen R. Pope ,&nbsp;Anthony E. Samir ,&nbsp;Theodore T. Pierce","doi":"10.1016/j.wfumbo.2024.100073","DOIUrl":"10.1016/j.wfumbo.2024.100073","url":null,"abstract":"<div><h3>Purpose</h3><div>Shear Wave Elastography (SWE) is frequently non-diagnostic in obese patients, a key cohort at risk for liver disease. Subcutaneous fat and hepatic steatosis are suspected drivers, but their relative contribution is unknown. We compare ultrasound-guided attenuation parameter (UGAP), a marker of steatosis, body mass index (BMI), and skin-to-liver capsule distance (SCD) to predict non-diagnostic SWE.</div></div><div><h3>Materials and methods</h3><div>This IRB approved, single center retrospective study included adults with SWE and diagnostic UGAP exams between June and December 2023. Fasting patients were imaged in supine position with right arm abducted, via an intercostal window during neutral breath hold. The median of 10 measurements in the right lobe was analyzed for SWE and UGAP. SWE measurements were ≥2 cm from the capsule while UGAP depth was fixed at 4 cm from the probe. Exams were considered non-diagnostic for SWE (measured in m/s) if the Interquartile Range/Median Ratio (IQR/M) was &gt;15 % or if diagnostic measurements could not be obtained. UGAP IQR/M &gt; 30 % or complete measurement failure was considered non-diagnostic. Univariate Receiver Operating Characteristic (ROC) curves compared UGAP (dB/cm/MHz), BMI (kg/m²), and SCD (mm) prediction of non-diagnostic SWE by the DeLong test.</div></div><div><h3>Results</h3><div>87 participants (48 male) with mean age of 54.7 ± 15.7 years were analyzed. UGAP [OR: 1.63 per 0.1 dB/cm/MHz, p = 0.02, AUC = 0.66], BMI [OR: 1.23, p &lt; 0.001, AUC = 0.77], and SCD [OR: 1.27, p &lt; 0.001, AUC = 0.81) were predictors of non-diagnostic SWE. UGAP prediction of non-diagnostic SWE was similar in subgroups with the measurement region at least 1 cm (OR: 1.64, n = 68), and 2 cm (OR: 1.54, n = 16) from the liver capsule. UGAP was a worse predictor than SCD (p = 0.04), while not significantly different than BMI (p = 0.15). BMI and SCD did not differ in predicting non-diagnostic SWE (p = 0.44).</div></div><div><h3>Conclusion</h3><div>Our small preliminary study demonstrated that body habitus and hepatic attenuation, a marker of steatosis, both contribute to non-diagnostic SWE exams, however body wall thickness is the key driver. This informs patient selection for SWE exams and guides future research to mitigate these technical shortcomings.</div></div><div><h3>Clinical relevance/application</h3><div>Patients with hepatic steatosis and large body habitus are at increased risk of non-diagnostic ultrasound shear wave elastography (SWE) exams. These patients, particularly those with increased body wall thickness, may benefit from liver fibrosis evaluation with alternative approaches following an initial non-diagnostic SWE exam. Researchers working to improve SWE technique should pay particular attention to mitigating attenuation and phase aberration from the body wall as this is the key driver of non-diagnostic exams.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the diagnostic efficiency of the four thyroid imaging reporting and data systems","authors":"Jun Xu ,&nbsp;Wei-Bing Zhang ,&nbsp;Wen-Fang Deng ,&nbsp;Bei-Li He ,&nbsp;Ting-Yue Qi","doi":"10.1016/j.wfumbo.2024.100037","DOIUrl":"10.1016/j.wfumbo.2024.100037","url":null,"abstract":"<div><p>The purpose of this study was to comparative analyze the diagnostic efficiency of Thyroid Imaging Reporting and Data System proposed by Kwak, American College of Radiology, the European Thyroid Association and the Chinese Medical Association, respectively (Kwak TI-RADS, ACR TI-RADS, EU-TIRADS and C-TIRADS, respectively) for malignant risk stratification of thyroid nodules. A total of 1142 thyroid nodules confirmed by cytological or surgical pathologies were retrospectively classified according to Kwak TI-RADS, ACR TI-RADS, EU-TIRADS and C-TIRADS. The area under the receiver operating characteristic curve (AUC), the diagnostic sensitivity, specificity, Youden index, and accuracy of each TI-RADS for nodules was calculated and compared. The diagnostic sensitivity of ACR TI-RADS was 85.5%, which was lowest (all <em>P</em> &lt; 0.05). The diagnostic specificity of ACR TI-RADS was higher than that of Kwak TI-RADS and EU-TIRADS (all <em>P</em> &lt; 0.05), but there was no significant difference compared with that of C-TIRADS (x² = 2.335, <em>P</em> = 0.126). The diagnostic accuracies of the four methods were more than 85%, and there were no significant differences (all <em>P</em> &gt; 0.05). The AUC of C-TIRADS was highest among the four methods (all <em>P</em> &lt; 0.05). The four methods have high diagnostic efficiency in malignant risk stratification of thyroid nodules, and the AUC of C-TIRADS was higher than that of the other three methods.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000053/pdfft?md5=9bbd70ad9b7fdea4f272faf25642d6ab&pid=1-s2.0-S2949668324000053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-rater reliability of B-mode ultrasound in the measurement of soft tissue thickness and composition over the lateral proximal femur","authors":"Alyssa M. Tondat,&nbsp;Monica R. Maly,&nbsp;Marina Mourtzakis,&nbsp;Andrew C. Laing","doi":"10.1016/j.wfumbo.2024.100066","DOIUrl":"10.1016/j.wfumbo.2024.100066","url":null,"abstract":"<div><h3>Objectives</h3><div>Comprehensive characterization of soft tissue composition and distribution over the lateral proximal femur is necessary to improve our understanding of fall-related hip fractures; however, a protocol that produces reliable data is needed. Accordingly, the aim of this study was to assess the intra-rater reliability of B-mode ultrasound measured muscle, adipose, and total soft tissue thicknesses over the lateral proximal femur in a simulated sideways fall configuration.</div></div><div><h3>Methods</h3><div>Twenty-five young adults (12 males, 13 females, age (SD) = 20.8 (1.9) years) underwent B-mode ultrasound imaging of 12 locations over their lateral proximal femur while in a side-lying position. Side-lying was chosen to allow imaging of the tissues impacted during a lateral fall event. Muscle, adipose, and total soft tissue thicknesses were measured at each location (further grouped into posterolateral, lateral, and anterolateral locations for statistical analysis) and two-way mixed model absolute agreement intraclass correlation coefficients (ICCs) and standard error of measurement were used to assess reliability of tissue type, location, and sex.</div></div><div><h3>Results</h3><div>ICCs were excellent (ICC &gt;0.9) for each tissue type, measurement location, and sex. There were interactions between tissue type, measurement location, and sex on reliability. While measures of adipose thickness were excellent across all conditions, reliability of muscle and total soft tissue thickness measurements were dependent on measurement location and sex.</div></div><div><h3>Conclusions</h3><div>This ultrasound imaging protocol demonstrated good-to-excellent reliability of soft tissue-specific thickness measurements over the lateral proximal femur. This protocol has implications for subject-specific hip fracture risk screening tools and biomechanical models of impact dynamics that incorporate biofidelic soft tissue morphology.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}