WFUMB Ultrasound OpenPub Date : 2023-12-01Epub Date: 2023-06-22DOI: 10.1016/j.wfumbo.2023.100008
Joris van Houte , Rob Eerdekens , Erik Dieters , Mariska te Pas , Inge Wijnbergen , Pim Tonino , Arthur Bouwman
{"title":"Immediate hemodynamic effects of transcatheter aortic valve replacement on left ventricular stroke volume and carotid artery blood flow","authors":"Joris van Houte , Rob Eerdekens , Erik Dieters , Mariska te Pas , Inge Wijnbergen , Pim Tonino , Arthur Bouwman","doi":"10.1016/j.wfumbo.2023.100008","DOIUrl":"10.1016/j.wfumbo.2023.100008","url":null,"abstract":"<div><h3>Introduction</h3><p>Transcatheter aortic valve replacement (TAVR) is performed in selected patients with severe aortic valve stenosis, leading to immediate relief of left ventricular outflow obstruction. The purpose of this study was to evaluate the immediate hemodynamic effects of TAVR on left ventricular stroke volume (SV<sub>LVOT</sub>) and common carotid artery stroke volume (SV<sub>CCA</sub>).</p></div><div><h3>Material and methods</h3><p>Twenty-five TAVR patients were included in this prospective observational study. Patients were treated under either local, or general anesthesia. Echocardiographic, and carotid ultrasound measurements were performed in the operating room pre (T1), and post (T2) TAVR. Changes in SV<sub>LVOT,</sub> SV<sub>CCA,</sub> carotid peak systolic velocity (PSV), pulsatility index (PI) and other carotid Doppler parameters were evaluated.</p></div><div><h3>Results</h3><p>Following TAVR, the aortic valve area (AVA) increased from 0.8 [0.6–0.9] to 1.9 [1.6–2.3] cm<sup>2</sup> (p < 0.001), and the peak transvalvular gradient (PG<sub>AV</sub>) decreased from 70 [65–81] to 15 [11-18] mm Hg (p < 0.001) from T1 to T2. SV<sub>LVOT</sub> increased from 58 ± 17 to 69 ± 24 ml, p < 0.01, whereas SV<sub>CCA</sub> remained unchanged (from 10 [7-11] to 10 [8-11] ml, p = 0.50). Δ SV<sub>LVOT</sub> was 19 [7–31] % and Δ SV<sub>CCA</sub> was 1 [-7-20] %, p < 0.05. PSV increased from 68 ± 17 to 81 ± 17 cm/s, p < 0.001, and PI increased from 1.7 [1.5–2.2] to 2.2 [1.7–2.6], p < 0.001.</p></div><div><h3>Conclusion</h3><p>Successful TAVR resulted in immediate improvement of left ventricular stroke volume, whereas carotid stroke volume remained unchanged.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000083/pdfft?md5=1f9ea753cecedbdc889544d8d4da2747&pid=1-s2.0-S2949668323000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88898639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
WFUMB Ultrasound OpenPub Date : 2023-12-01Epub Date: 2023-11-14DOI: 10.1016/j.wfumbo.2023.100027
Priyanka Modi, Sanjeev Bhoi, Savan Pandey
{"title":"Pupillary clonus - an abnormal pupillary unrest on POCUS of pupil in patients with altered sensorium","authors":"Priyanka Modi, Sanjeev Bhoi, Savan Pandey","doi":"10.1016/j.wfumbo.2023.100027","DOIUrl":"10.1016/j.wfumbo.2023.100027","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000277/pdfft?md5=3e2a7e669c2eb3c023bb16eefd6b44a7&pid=1-s2.0-S2949668323000277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
WFUMB Ultrasound OpenPub Date : 2023-12-01Epub Date: 2023-07-10DOI: 10.1016/j.wfumbo.2023.100014
Rebeca Tenajas, David Miraut
{"title":"Rethinking ultrasound probe maintenance in the era of AI","authors":"Rebeca Tenajas, David Miraut","doi":"10.1016/j.wfumbo.2023.100014","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100014","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The updated roles of new ultrasound imaging techniques in assessing carotid vulnerable plaques","authors":"Yangyang Cheng , Aidi Wu , Michael Ying , Xiangyan Chen","doi":"10.1016/j.wfumbo.2023.100023","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100023","url":null,"abstract":"<div><p>Carotid atherosclerosis, a subtype of large artery atherosclerosis, is a significant contributor to ischemic stroke events. Considering the pivotal role of ultrasound in assessing carotid artery pathology, this review emphasizes its application in visualizing carotid atherosclerosis, with a particular interest in distinguishing stable from vulnerable carotid plaques. Recent advancements have improved our understanding of the relationship between plaque stability and ischemic stroke. This has motivated a comparative analysis of cutting-edge ultrasound techniques to evaluate extracranial carotid plaque, particularly focusing on areas of intraplaque vulnerability. The B-Mode remains the standard first-line imaging modality for both detecting carotid plaques and their morphology. However, its diagnostic potential is typically realized during the intermediate to advanced stages of atherosclerosis. In contrast, the latest innovations in ultrasound imaging techniques, such as contrast-enhanced ultrasound (CEUS), shear wave elastography (SWE), grayscale median (GSM), and the refined Doppler method (superb microvascular imaging, SMI), offer a detailed quantitative approach to categorize carotid plaques into “stable” or “vulnerable” categories. Their application, however, is not widespread in outpatient settings due to factors such as exorbitant costs, extended imaging duration, and a prevalent lack of technical knowledge among healthcare providers. Beyond conventional echogenicity markers, both CEUS and SMI imaging possess the capability to evaluate intraplaque neovascularization, illuminating deep and microvessels within hypoechoic plaques. This aids in identifying high-risk plaque attributes, such as morphological irregularities and ulcerations, which are paramount for risk stratification and monitoring therapeutic responses. SWE offers insights into tissue rigidity and carotid plaque constituents, such as the fibrous cap and lipid core by gauging shear wave velocity and quantifying shear deformation with a specificity of 66.7 % which is higher than that of CEUS (58.3 %). Therefore, a multiparametric ultrasound approach offers a viable strategy for a holistic evaluation of carotid plaques. The timely identification of susceptible plaques can tailor therapeutic interventions, potentially averting cerebrovascular incidents, including acute ischemic strokes (AIS) and transient ischemic attacks (TIA).</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hayden M. Fox , Alexander Douglas , Griffin Hughes , Zachariah Fisher , Matt Vassar
{"title":"The top 100 most-cited publications on contrast-enhanced ultrasound: A bibliometric analysis","authors":"Hayden M. Fox , Alexander Douglas , Griffin Hughes , Zachariah Fisher , Matt Vassar","doi":"10.1016/j.wfumbo.2023.100020","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100020","url":null,"abstract":"<div><h3>Introduction</h3><p>Contrast-enhanced ultrasound (CEUS) is a modality of growing interest because of its improved detection rates when evaluating lesions and better success rates when administering interventions, compared to standard ultrasound. Along with its diagnostic value, the possibilities for therapeutic innovation with CEUS are immense. While there is much discussion of CEUS and its potential applications, there is a scarcity of studies characterizing the current state of CEUS research. Bibliometric analysis, a method of gaining an overview of a body of literature, quantitatively analyzes large amounts of information within publications to reveal trends. This study used bibliometric analysis to characterize the state and nature of the 100 most-cited publications on CEUS.</p></div><div><h3>Methods</h3><p>We identified the 100 most-cited publications on contrast-enhanced ultrasound using the Scopus database. We recorded various bibliometric data points from these publications, with additional data collected for the 25 most-cited publications. Data were analyzed via R, R studio, and VOSviewer.</p></div><div><h3>Results</h3><p>Our analysis of the top 100 publications revealed that 38 of the listed first authors were from the United States. Eleven articles were in <em>Radiology</em>, six were in <em>Ultraschall in der Medizin,</em> and six were in <em>Ultrasound in Medicine and Biology,</em> with mean citation counts of 269.2, 433.3, and 291.7 per publication, respectively. The University of Virginia Health System produced the most publications in the top 100. Seventeen of the top 25 most-cited articles were clinical practice guidelines. Four of the top five papers were clinical practice guidelines pertaining to hepatocellular carcinoma.</p></div><div><h3>Conclusion</h3><p>In conclusion, several interesting trends were demonstrated in our bibliometric analysis. The most heavily cited articles from the top 100 were published between 2010 and 2019, which is in contrast to the finding that the previous decade contained more articles published in the top 100. This trend indicates a significant scientific impact from those articles published from 2010 to 2019. The substantial number of articles addressing applications of CEUS in diagnosing and treating liver diseases correlates closely with their global disease burden; therefore, this finding potentially explains the rise in impactful research production within the field. This study is the first to characterize the landscape of CEUS research, and future studies should further this work as the field continues to develop. Thus, our analysis reveals many important findings in the current state of CEUS research and its impact on medical imaging.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound: The cornerstone of Radiology in Low and Middle-income countries","authors":"Asim Mahat, Gopal Kumar Yadav, Upama Mishra, Binod Mehta","doi":"10.1016/j.wfumbo.2023.100021","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100021","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100021"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49726939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saubhagya Srivastava , Daniel Van Roekel , Jonathan L. Wright , Matthew Bruce , Manjiri Dighe
{"title":"Contrast-enhanced ultrasound (CEUS) in the evaluation of bladder pathologies: Review","authors":"Saubhagya Srivastava , Daniel Van Roekel , Jonathan L. Wright , Matthew Bruce , Manjiri Dighe","doi":"10.1016/j.wfumbo.2023.100019","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100019","url":null,"abstract":"<div><p>Contrast-enhanced Ultrasound (CEUS) is an advanced ultrasound (US) technique that utilizes specific US contrast agents (UCAs) to provide a more detailed evaluation of anatomic structures and parenchymal vasculature. Although the use of CEUS has been well-established in echocardiography and imaging of focal liver lesions, the updated guidelines by WFUMB-EFSUMB from 2018 also talk about the use of CEUS in the urinary bladder under non-hepatic applications of CEUS. The most common application of CEUS in the urinary bladder is the differentiation between bladder cancer and benign lesions such as a hematoma in patients presenting with hematuria. CEUS is also a promising imaging modality that can be used to detect and stage bladder urothelial cancers. CEUS greatly improves the diagnostic accuracy of conventional US techniques in the detection of bladder cancer. It has been shown previously that low- and high-grade bladder cancers tend to behave differently on the time-intensity curves (TIC) of CEUS. Low-grade bladder cancers tend to show a TIC with an early peak enhancement with a slow plateau and a longer time taken for contrast disappearance, whereas high-grade bladder cancers tend to show a rapid and high peak enhancement with rapid contrast disappearance (fast wash-out phase). In patients presenting with hematuria, CEUS accurately differentiates the etiology as either malignant or benign (i.e., hematoma) as hematomas are non-vascular lesions and do not show any enhancement as opposed to bladder cancers which tend to be highly vascular. CEUS holds several advantages such as being widely available, quick, and cost-efficient. CEUS is also suitable for patients who have contraindications to undergo CT, MRI, and/or conventional cystoscopy. Additionally, CEUS can be safely performed in patients with renal failure as UCAs are not nephrotoxic and not deposited in tissues as they are blood pool agents and are metabolized and excreted via pulmonary breathing.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}