WFUMB Ultrasound Open最新文献

{"title":"Towards quantitative CEUS assessments of ex-vivo feto-placental (micro)vasculature: A feasibility study","authors":"Pascalle Wijntjes ,&nbsp;Ferenc I. Kandi ,&nbsp;Sophie Dassen ,&nbsp;Luna Beijnsberger ,&nbsp;Peiran Chen ,&nbsp;Jingchao Sui ,&nbsp;Myrthe van der Ven ,&nbsp;Judith van Laar ,&nbsp;Beatrijs van der Hout-van der Jagt ,&nbsp;Simona Turco ,&nbsp;Loes Monen ,&nbsp;Massimo Mischi","doi":"10.1016/j.wfumbo.2025.100099","DOIUrl":"10.1016/j.wfumbo.2025.100099","url":null,"abstract":"<div><div>Placental dysfunction contributed to many pregnancy complications, highlighting the need to clarify normal placental mechanisms and improve early detection. Contrast-enhanced ultrasound (CEUS) has demonstrated utility in visualizing the (micro)vasculature across other fields of medicine. However, its use in obstetrics for detailed visualization and characterization of the placental (micro)vasculature remains to be validated.</div><div>This pilot study explores the feasibility of CEUS for ex-vivo visualization of the fetal placenta, aiming to improve the understanding of feto-placental vascularization. It evaluates CEUS as a viable imaging method and its potential for quantifying vascular patterns in pregnancy complications, using advanced techniques like semi-quantitative CEUS and ultrasound localization microscopy (ULM) for detailed vascular assessments.</div><div>In this ex-vivo feasibility study, CEUS imaging of the fetal side of the placenta was performed by injecting an ultrasound contrast agent (UCA) in the umbilical vein. This allowed assessing the (micro)vascular perfusion using semi-quantitative CEUS, by analysis of the gray-level time evolution. In addition, ultrasound localization microscopy (ULM) was used to characterize the (micro)vascular architecture at high resolution.</div><div>Our finding demonstrate the feasibility of advances CEUS imaging approaches for both quantitative analysis and localization microscopy, providing high-resolution visualization and comprehensive characterization of the fetal side of the placental vasculature.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound backscatter parameters to assess upper trapezius muscle hypertonicity in adults","authors":"Jing Gao ,&nbsp;Isaac Hartman ,&nbsp;Eliaz Lynch ,&nbsp;David S. Park ,&nbsp;Katherine Park ,&nbsp;Yassin Labyed","doi":"10.1016/j.wfumbo.2026.100112","DOIUrl":"10.1016/j.wfumbo.2026.100112","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the feasibility of ultrasound backscatter parameters in assessing upper trapezius muscle (UTM) hypertonicity.</div></div><div><h3>Methods</h3><div>We prospectively measured pixel intensity on B-mode ultrasound images of UTM and adjacent subcutaneous tissue (SUBC) using Image J histogram, and calculated backscatter reduction rate and anisotropy following beam steering at 5°, 10°, 15°, and 20° from 0°. We analyzed differences in backscatter parameters of UTM and SUBC between three age groups using one-way analysis of variance (ANOVA), between normal and hypertonic UTMs using paired <em>t</em>-test, diagnostic performances of backscatter parameters for determining ≥ mild hypertonic UTM using area under receiver operating characteristic curve (AUC), and inter- and intra-observer reliability in measuring pixel intensity using intraclass correlation coefficient (ICC) and Blant-Altman analysis.</div></div><div><h3>Results</h3><div>We recruited 125 adult subjects (39 with normal UTM, 86 with hypertonic UTM) in three age groups (young age: 18-44y; middle age: 45-64y; old age: ≥65y). Differences in backscatter parameters between normal and hypertonic UTM were significant in young and middle-aged groups (p &lt; 0.01) but not in old-aged group (<em>p</em> &gt; 0.05). AUC of muscle backscatter reduction rate at beam steering 20° for determining ≥ mild hypertonicity was 0.89, 0.80, and 0.64 in young, middle-aged, and old-aged participants, respectively. ICCs of observer reliability for measuring pixel intensity were &gt;0.80.</div></div><div><h3>Conclusions</h3><div>The muscle backscatter reduction rate at beam steering 20° can distinguish hypertonic muscles from normal muscles in young and middle-aged with good intra- and inter-operator reliability. Muscle backscatter reduction rate in adults decreases with aging and the occurrence of hypertonicity.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100112"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic cavitation in medicine: Current status and applications","authors":"Teng Zhang ,&nbsp;Yongzhen Jin ,&nbsp;Ruixiang Yu ,&nbsp;Yuanyuan Li ,&nbsp;Hao Wu","doi":"10.1016/j.wfumbo.2025.100100","DOIUrl":"10.1016/j.wfumbo.2025.100100","url":null,"abstract":"<div><div>With rapid advances in ultrasonic technologies, cavitation has emerged as a versatile tool in medicine. Its intense mechanical and chemical effects have been leveraged for biomedical material processing, drug extraction, sterilization, cellular modulation, and targeted drug delivery. This review systematically summarizes recent progress in these applications and highlights cavitation-based clinical strategies, including sonodynamic therapy, tissue fragmentation, and light-mediated ultrasound therapy. While challenges remain-such as incomplete mechanistic understanding and lack of standardized parameters-ultrasonic cavitation holds promise as a controllable, efficient, and environmentally sustainable biophysical modality with significant potential for clinical translation.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a lifestyle intervention on fat infiltration in skeletal muscle among colorectal cancer survivors with cancer-related fatigue: a randomized controlled trial","authors":"Lara Schepers ,&nbsp;Koen Manusama ,&nbsp;Judith de Vries-ten Have ,&nbsp;Auke J.C.F. Verkaar ,&nbsp;Sharon A.G. Bloemhof ,&nbsp;Ellen Kampman ,&nbsp;Renate M. Winkels","doi":"10.1016/j.wfumbo.2026.100110","DOIUrl":"10.1016/j.wfumbo.2026.100110","url":null,"abstract":"<div><h3>Objective</h3><div>Reducing fat infiltration in skeletal muscle may potentially improve health outcomes, such as overall survival and cancer-related fatigue, among colorectal cancer (CRC) survivors. We investigated the effect of a person-centred lifestyle intervention on fat infiltration in skeletal muscle assessed with ultrasound echointensity among CRC survivors with cancer-related fatigue.</div></div><div><h3>Methods</h3><div>This secondary analysis of a parallel randomized controlled trial included stage I-III CRC survivors with cancer-related fatigue. The intervention comprised twelve lifestyle coaching sessions over six months to improve physical activity and dietary intake. The control group did not receive lifestyle coaching. Fat infiltration in the rectus femoris muscle, assessed using 8-bit B-mode ultrasound-derived echointensity (arbitrary units [a.u.]), and cancer-related fatigue, measured using the Functional Assessment of Chronic Illness Therapy Fatigue scale, were evaluated at baseline and six months. Mediation analysis explored whether fat infiltration in skeletal muscle mediates the intervention's effect on cancer-related fatigue.</div></div><div><h3>Results</h3><div>We included 161 CRC survivors with cancer-related fatigue (64.1 ± 10.9 years, 55.3% women), who were randomized to the intervention (n = 80) or control group (n = 81). The change in echointensity over time did not differ between the intervention and control group (Δ 2.21 a.u. 95%CI: −1.04; 5.46). Additionally, fat infiltration in skeletal muscle did not mediate the effect of the lifestyle intervention on cancer-related fatigue.</div></div><div><h3>Conclusions</h3><div>The lifestyle intervention had no effect on fat infiltration in the rectus femoris muscle among CRC survivors with cancer-related fatigue. Although no effect on skeletal muscle echointensity was observed in the present study, our findings demonstrate the feasibility of echointensity assessment in studies focusing on muscle quality and support its potential value for future research in this field.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Uterine contrast-enhanced ultrasound (CEUS): new insights into adenomyosis using an innovative technique”","authors":"Shatha Jamal Almushayt","doi":"10.1016/j.wfumbo.2025.100102","DOIUrl":"10.1016/j.wfumbo.2025.100102","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating proximal vs distal IPACK techniques: A step-by-step sonographic guide and anatomical considerations","authors":"Llewellyn Davies ,&nbsp;Sashrika Pillay-Addinall ,&nbsp;Sabashnee Govender-Davies","doi":"10.1016/j.wfumbo.2026.100111","DOIUrl":"10.1016/j.wfumbo.2026.100111","url":null,"abstract":"<div><div>The infiltration between the popliteal artery and the capsule of the knee (IPACK) block is a motor-sparing regional anaesthetic technique that provides analgesia to the posterior knee capsule by targeting sensory articular branches of the tibial, sciatic, common peroneal, and obturator nerves. It is commonly used as part of multimodal analgesia for total knee arthroplasty, cruciate ligament surgery, and other knee procedures, with its clinical effectiveness and safety depending on accurate identification of posterior knee sono-anatomy. This narrative educational review aims to provide a detailed, anatomy-focused sonographic guide to standardise identification of key posterior knee structures relevant to the safe and effective performance of both proximal and distal IPACK block techniques. The review synthesises current knowledge of posterior knee sono-anatomy, procedural considerations, and available clinical evidence. Ultrasound-guided IPACK techniques are described, including patient positioning, probe orientation, identification of sono-anatomical landmarks, needle trajectories, and expected patterns of local anaesthetic spread for proximal and distal approaches. Particular emphasis is placed on anatomical relationships critical for safe needle placement, avoidance of vascular and neural injury, and optimisation of posterior capsular analgesia, with comparison between proximal and distal techniques. Consistent sonographic identification of the femur–popliteal artery interval and adjacent neural structures is essential for reliable IPACK performance. Evidence from existing clinical studies suggests that both proximal and distal approaches provide effective posterior knee analgesia, although the proximal technique may offer more consistent visualisation and a lower risk of unintended motor blockade. Clarifying and standardising relevant posterior knee sono-anatomy may enhance anatomical understanding, improve technical accuracy, and support safer, more effective application of the IPACK block within multimodal perioperative analgesia for knee surgery.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and prospects of artificial intelligence-enhanced multimodal ultrasound in diagnosing breast non-mass lesions","authors":"Mujie Duan ,&nbsp;Xiao Zhang ,&nbsp;Zhouran Wang ,&nbsp;Jiayu Quan ,&nbsp;Chunmei Jia","doi":"10.1016/j.wfumbo.2026.100113","DOIUrl":"10.1016/j.wfumbo.2026.100113","url":null,"abstract":"<div><div>Non-mass lesions (NMLs) of the breast lack the typical mass effect, which makes conventional ultrasound diagnosis difficult and often leads to missed or incorrect diagnoses. Multimodal ultrasound (MUS) integrates gray-scale ultrasound, elastography, contrast-enhanced ultrasound, and automated breast volume scanning to assess lesions from multiple angles—morphology, stiffness, blood flow perfusion, and spatial structure—greatly improving diagnostic accuracy. In recent years, rapid advances in AI have further driven the intelligent evolution of MUS. Studies show that multimodal ultrasound fusion strategies can achieve an AUC above 0.930 for distinguishing benign from malignant non-mass lesions. Adding deep learning pushes the AUC to 0.960, and machine learning–based multimodal models reach an AUC of 0.947 for molecular subtyping prediction. Moreover, ultrasound imaging features correlate to some extent with molecular subtypes such as Luminal, HER2-overexpressing, and triple-negative breast cancer. Emerging techniques like explainable artificial intelligence and multi-view visual Transformers also show promise. This paper systematically reviews the progress of integrating multimodal ultrasound with artificial intelligence for diagnosing non-mass breast lesions, focusing on deep learning models, radiomics, and molecular subtyping prediction, aiming to guide future research and clinical translation.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine contrast-enhanced ultrasound (CEUS): new insights into adenomyosis using an innovative technique","authors":"Eva J.E. de Bock ,&nbsp;Barbara Stoelinga ,&nbsp;Jan Hein T.M. van Waesberghe ,&nbsp;Ferenc I. Kandi ,&nbsp;Catarina Dinis Fernandes ,&nbsp;Massimo Mischi ,&nbsp;Judith A.F. Huirne ,&nbsp;Nicole B. Burger ,&nbsp;Lynda J.M. Juffermans","doi":"10.1016/j.wfumbo.2025.100095","DOIUrl":"10.1016/j.wfumbo.2025.100095","url":null,"abstract":"<div><h3>Objectives</h3><div>Heavy menstrual bleeding, dysmenorrhea and subfertility are associated with adenomyosis, a benign uterine condition characterised by ectopic endometrium within the myometrium. Currently, diagnosing adenomyosis is challenging. Imaging the uterine microcirculation using contrast-enhanced ultrasound (CEUS) may improve diagnostics. We aimed to 1) determine the feasibility of transvaginal two-dimensional (2D) uterine CEUS, 2) compare features of adenomyosis on 2D CEUS with conventional ultrasound and Magnetic Resonance Imaging (MRI), and 3) qualitatively and quantitatively analyse 2D CEUS scans of patients with adenomyosis.</div></div><div><h3>Methods</h3><div>We included ten pre-menopausal adult patients with prominent direct Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis on B-mode. MRI scans were collected when clinically available. Conventional ultrasound and a 3-min transvaginal 2D CEUS scan were performed and analysed. Uterine wash-in and wash-out of the contrast agent were analysed qualitatively, and quantitatively using time-intensity curve parameters.</div></div><div><h3>Results</h3><div>Performing transvaginal CEUS scans was feasible, providing good visualisation of uterine macro- and microcirculation. CEUS visualised smaller and deeper-lying blood vessels than Doppler ultrasound. In the myometrium, non-to hypo-enhanced areas interspersed with hyper-enhanced regions, and vessels with enlarged lumen were observed. Hyper-echoic islands on B-mode showed either hypo- or hyper-enhancement on CEUS. Qualitative analysis and time-intensity maps showed clear heterogeneous myometrial perfusion in all patients with adenomyosis.</div></div><div><h3>Conclusions</h3><div>Transvaginal CEUS is a feasible technique for qualitative and quantitative analysis of the uterine macro- and microcirculation. It holds promise as a diagnostic imaging modality for adenomyosis.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145360999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing IRB approval statement and the IRB registration number in previously published articles","authors":"","doi":"10.1016/j.wfumbo.2025.100086","DOIUrl":"10.1016/j.wfumbo.2025.100086","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wall tracking method to estimate ejection fraction from the parasternal long axis view in point of care ultrasound","authors":"Roberto Vega ,&nbsp;Arun Nagdev ,&nbsp;Masood Dehghan ,&nbsp;Seyed Ehsan Seyed Bolouri ,&nbsp;Brian Buchanan ,&nbsp;Jeevesh Kapur ,&nbsp;Jacob L. Jaremko ,&nbsp;Dornoosh Zonoobi","doi":"10.1016/j.wfumbo.2025.100097","DOIUrl":"10.1016/j.wfumbo.2025.100097","url":null,"abstract":"<div><h3>Objective:</h3><div>The left ventricular ejection fraction is a key metric for evaluating the systolic function in critically ill patients. Traditionally, it is computed using apical 2- and 4-chamber views in an echocardiogram; however, obtaining these views in an acutely ill patient in the emergency department is often difficult. A parasternal long-axis view, acquired with point of care ultrasound, is a faster and easier alternative. Unfortunately, the methods for estimating the ejection fraction from this view underperform when the left ventricular wall movement is not uniform or when its shape is not properly modeled as an ellipsoid. We propose a novel method that tracks the movement of the visible portions of the walls during the full cardiac cycle, and then estimates the ejection fraction based on that movement.</div></div><div><h3>Methods:</h3><div>We compared the performance of this method with the ejection fraction from the cardiology report on a dataset of 613 patients.</div></div><div><h3>Results:</h3><div>Our experiments showed an accuracy of 85% for identifying critically low values for ejection fraction (EF <span><math><mo>&lt;</mo></math></span> 30%) and 87% for abnormal ones (EF <span><math><mo>&lt;</mo></math></span> 50%). These values are comparable with the results obtained from the apical views and superior to current methods for the parasternal long-axis view.</div></div><div><h3>Conclusion:</h3><div>Since our method is fully automated, we expect that it can be adopted at scale in real-world clinical scenarios, giving practitioners a new tool to properly estimate the ejection fraction in clinically challenging scenarios.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}