WFUMB Ultrasound Open最新文献

{"title":"Towards quantitative CEUS assessments of ex-vivo feto-placental (micro)vasculature: A feasibility study","authors":"Pascalle Wijntjes ,&nbsp;Ferenc I. Kandi ,&nbsp;Sophie Dassen ,&nbsp;Luna Beijnsberger ,&nbsp;Peiran Chen ,&nbsp;Jingchao Sui ,&nbsp;Myrthe van der Ven ,&nbsp;Judith van Laar ,&nbsp;Beatrijs van der Hout-van der Jagt ,&nbsp;Simona Turco ,&nbsp;Loes Monen ,&nbsp;Massimo Mischi","doi":"10.1016/j.wfumbo.2025.100099","DOIUrl":"10.1016/j.wfumbo.2025.100099","url":null,"abstract":"<div><div>Placental dysfunction contributed to many pregnancy complications, highlighting the need to clarify normal placental mechanisms and improve early detection. Contrast-enhanced ultrasound (CEUS) has demonstrated utility in visualizing the (micro)vasculature across other fields of medicine. However, its use in obstetrics for detailed visualization and characterization of the placental (micro)vasculature remains to be validated.</div><div>This pilot study explores the feasibility of CEUS for ex-vivo visualization of the fetal placenta, aiming to improve the understanding of feto-placental vascularization. It evaluates CEUS as a viable imaging method and its potential for quantifying vascular patterns in pregnancy complications, using advanced techniques like semi-quantitative CEUS and ultrasound localization microscopy (ULM) for detailed vascular assessments.</div><div>In this ex-vivo feasibility study, CEUS imaging of the fetal side of the placenta was performed by injecting an ultrasound contrast agent (UCA) in the umbilical vein. This allowed assessing the (micro)vascular perfusion using semi-quantitative CEUS, by analysis of the gray-level time evolution. In addition, ultrasound localization microscopy (ULM) was used to characterize the (micro)vascular architecture at high resolution.</div><div>Our finding demonstrate the feasibility of advances CEUS imaging approaches for both quantitative analysis and localization microscopy, providing high-resolution visualization and comprehensive characterization of the fetal side of the placental vasculature.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic cavitation in medicine: Current status and applications","authors":"Teng Zhang ,&nbsp;Yongzhen Jin ,&nbsp;Ruixiang Yu ,&nbsp;Yuanyuan Li ,&nbsp;Hao Wu","doi":"10.1016/j.wfumbo.2025.100100","DOIUrl":"10.1016/j.wfumbo.2025.100100","url":null,"abstract":"<div><div>With rapid advances in ultrasonic technologies, cavitation has emerged as a versatile tool in medicine. Its intense mechanical and chemical effects have been leveraged for biomedical material processing, drug extraction, sterilization, cellular modulation, and targeted drug delivery. This review systematically summarizes recent progress in these applications and highlights cavitation-based clinical strategies, including sonodynamic therapy, tissue fragmentation, and light-mediated ultrasound therapy. While challenges remain-such as incomplete mechanistic understanding and lack of standardized parameters-ultrasonic cavitation holds promise as a controllable, efficient, and environmentally sustainable biophysical modality with significant potential for clinical translation.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Uterine contrast-enhanced ultrasound (CEUS): new insights into adenomyosis using an innovative technique”","authors":"Shatha Jamal Almushayt","doi":"10.1016/j.wfumbo.2025.100102","DOIUrl":"10.1016/j.wfumbo.2025.100102","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"4 1","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine contrast-enhanced ultrasound (CEUS): new insights into adenomyosis using an innovative technique","authors":"Eva J.E. de Bock ,&nbsp;Barbara Stoelinga ,&nbsp;Jan Hein T.M. van Waesberghe ,&nbsp;Ferenc I. Kandi ,&nbsp;Catarina Dinis Fernandes ,&nbsp;Massimo Mischi ,&nbsp;Judith A.F. Huirne ,&nbsp;Nicole B. Burger ,&nbsp;Lynda J.M. Juffermans","doi":"10.1016/j.wfumbo.2025.100095","DOIUrl":"10.1016/j.wfumbo.2025.100095","url":null,"abstract":"<div><h3>Objectives</h3><div>Heavy menstrual bleeding, dysmenorrhea and subfertility are associated with adenomyosis, a benign uterine condition characterised by ectopic endometrium within the myometrium. Currently, diagnosing adenomyosis is challenging. Imaging the uterine microcirculation using contrast-enhanced ultrasound (CEUS) may improve diagnostics. We aimed to 1) determine the feasibility of transvaginal two-dimensional (2D) uterine CEUS, 2) compare features of adenomyosis on 2D CEUS with conventional ultrasound and Magnetic Resonance Imaging (MRI), and 3) qualitatively and quantitatively analyse 2D CEUS scans of patients with adenomyosis.</div></div><div><h3>Methods</h3><div>We included ten pre-menopausal adult patients with prominent direct Morphological Uterus Sonographic Assessment (MUSA) features of adenomyosis on B-mode. MRI scans were collected when clinically available. Conventional ultrasound and a 3-min transvaginal 2D CEUS scan were performed and analysed. Uterine wash-in and wash-out of the contrast agent were analysed qualitatively, and quantitatively using time-intensity curve parameters.</div></div><div><h3>Results</h3><div>Performing transvaginal CEUS scans was feasible, providing good visualisation of uterine macro- and microcirculation. CEUS visualised smaller and deeper-lying blood vessels than Doppler ultrasound. In the myometrium, non-to hypo-enhanced areas interspersed with hyper-enhanced regions, and vessels with enlarged lumen were observed. Hyper-echoic islands on B-mode showed either hypo- or hyper-enhancement on CEUS. Qualitative analysis and time-intensity maps showed clear heterogeneous myometrial perfusion in all patients with adenomyosis.</div></div><div><h3>Conclusions</h3><div>Transvaginal CEUS is a feasible technique for qualitative and quantitative analysis of the uterine macro- and microcirculation. It holds promise as a diagnostic imaging modality for adenomyosis.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145360999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing IRB approval statement and the IRB registration number in previously published articles","authors":"","doi":"10.1016/j.wfumbo.2025.100086","DOIUrl":"10.1016/j.wfumbo.2025.100086","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100086"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wall tracking method to estimate ejection fraction from the parasternal long axis view in point of care ultrasound","authors":"Roberto Vega ,&nbsp;Arun Nagdev ,&nbsp;Masood Dehghan ,&nbsp;Seyed Ehsan Seyed Bolouri ,&nbsp;Brian Buchanan ,&nbsp;Jeevesh Kapur ,&nbsp;Jacob L. Jaremko ,&nbsp;Dornoosh Zonoobi","doi":"10.1016/j.wfumbo.2025.100097","DOIUrl":"10.1016/j.wfumbo.2025.100097","url":null,"abstract":"<div><h3>Objective:</h3><div>The left ventricular ejection fraction is a key metric for evaluating the systolic function in critically ill patients. Traditionally, it is computed using apical 2- and 4-chamber views in an echocardiogram; however, obtaining these views in an acutely ill patient in the emergency department is often difficult. A parasternal long-axis view, acquired with point of care ultrasound, is a faster and easier alternative. Unfortunately, the methods for estimating the ejection fraction from this view underperform when the left ventricular wall movement is not uniform or when its shape is not properly modeled as an ellipsoid. We propose a novel method that tracks the movement of the visible portions of the walls during the full cardiac cycle, and then estimates the ejection fraction based on that movement.</div></div><div><h3>Methods:</h3><div>We compared the performance of this method with the ejection fraction from the cardiology report on a dataset of 613 patients.</div></div><div><h3>Results:</h3><div>Our experiments showed an accuracy of 85% for identifying critically low values for ejection fraction (EF <span><math><mo>&lt;</mo></math></span> 30%) and 87% for abnormal ones (EF <span><math><mo>&lt;</mo></math></span> 50%). These values are comparable with the results obtained from the apical views and superior to current methods for the parasternal long-axis view.</div></div><div><h3>Conclusion:</h3><div>Since our method is fully automated, we expect that it can be adopted at scale in real-world clinical scenarios, giving practitioners a new tool to properly estimate the ejection fraction in clinically challenging scenarios.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145324296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of the hepatorenal index with additional standardized acoustic depth assessment for steatotic liver disease diagnosis","authors":"Maksym Zhaivoronok ,&nbsp;Oleg Dynnyk ,&nbsp;Natalia Deresh ,&nbsp;Ludovico Abenavoli ,&nbsp;Nazarii Kobyliak","doi":"10.1016/j.wfumbo.2025.100083","DOIUrl":"10.1016/j.wfumbo.2025.100083","url":null,"abstract":"<div><div>Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common pathology among all chronic liver diseases. In the early stages, steatotic liver disease (SLD) has an asymptomatic clinical course, which makes it difficult to detect. Ultrasound (US) is a safe, noninvasive, first-line method for SLD diagnosis, including determination of the hepatorenal index (HRI). The HRI is a convenient, semiquantitative, noninvasive method for SLD diagnostics. This case‒control observational study aimed to compare the diagnostic accuracy of conventional HRI and HRI with that of additional standardized acoustic depth assessments for SLD using MRI-PDFF as a reference.</div></div><div><h3>Materials and methods</h3><div>A total of 161 patients aged 18–67 years were examined. Patients &gt;18 years of age were referred for MRI-PDFF assessment of suspected liver pathology. The only exclusion criterion was an absent or invalid HRI or MRI-PDFF.</div></div><div><h3>Results</h3><div>The quality of the HRI diagnostic model with a baseline (BL) was slightly higher, with an AUROC of 0.917 (p &lt; 0.001), and the sensitivity and specificity were 83.0 % and 95.9 %, respectively. The AUROC for HRI without BL was 0.862 (p &lt; 0.001) with sensitivity and specificity of 84.2 % and 85.1 %, respectively. Bland‒Altman analysis of the comparison of HRIs with and without BL revealed an error of 0.007 (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>Our study revealed that it is better to determine the semiquantitative HRI using a reference BL at a standardized uniform depth to preserve acoustic attenuation effects. The advantages of US SLD evaluation for HRI with BL are simplicity of performance and the accuracy of acoustic echogenicity measurements.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100083"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radial nerve sausage-like lesion caused by viral peripheral neuropathy: A case report","authors":"Ahuang Cai ,&nbsp;Yiran Gong ,&nbsp;Guanghui Hong ,&nbsp;Xinxiu Liu","doi":"10.1016/j.wfumbo.2025.100087","DOIUrl":"10.1016/j.wfumbo.2025.100087","url":null,"abstract":"<div><h3>Objectives</h3><div>Radial nerve sausage-like lesions are rare and often poorly understood, with viral infections potentially triggering immune-mediated peripheral neuropathies. This study aims to explore the diagnostic value of ultrasound in such cases and highlight its role in managing viral-induced peripheral neuropathy.</div></div><div><h3>Methods</h3><div>A 36-year-old male patient with a history of RSV infection presented with impaired dorsal extension of the left hand. Ultrasound imaging was performed to assess the radial nerve, followed by surgical exploration and pathological confirmation.</div></div><div><h3>Results</h3><div>Ultrasound revealed localized hypoechoic thickening of the radial nerve with a characteristic “sausage-like\" appearance, which correlated with intraoperative findings. Postoperative pathology, based on the evaluation of the collected soft tissue samples, confirmed the presence of nonspecific inflammatory changes suggestive of peripheral neuritis. However, no definitive nerve biopsy or detailed pathological report was available.</div></div><div><h3>Discussion</h3><div>This case highlights the importance of ultrasound in diagnosing viral peripheral neuropathy. Ultrasound is a non-invasive, cost-effective modality that allows dynamic monitoring of nerve changes, making it valuable for both preoperative diagnosis and postoperative follow-up. Further research is needed to explore its broader applications of ultrasound in diagnosing various forms of peripheral neuropathies and monitoring recovery after treatment.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100087"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-operative and early post-operative cortical resistive indices in renal transplantation: Representative values according to graft function and time of scan","authors":"L. Thebridge ,&nbsp;C. Fisher ,&nbsp;V. Puttaswamy ,&nbsp;C. Pollock ,&nbsp;J. Clarke","doi":"10.1016/j.wfumbo.2025.100093","DOIUrl":"10.1016/j.wfumbo.2025.100093","url":null,"abstract":"<div><h3>Background</h3><div>Intra-operative ultrasound during renal transplantation identifies technical abnormalities allowing immediate surgical correction as required. Cortical resistive indices (RIs) assess graft perfusion and are now measured intra-operatively. The aim of this study was to evaluate RIs intra-operatively, and to 30 days post-operatively.</div></div><div><h3>Methods</h3><div>RIs in consecutive single renal grafts in adults were analysed from 246 grafts scanned intra-operatively, on day 1 post-operatively and subsequently according to physician preference, and 125 grafts scanned intra-operatively to day 30 post-operatively according to a formal protocol.</div></div><div><h3>Results</h3><div>There was delayed graft function (DGF) in 125 grafts. The mean (±sem) intra-operative RI of 0.599 (±0.009) was significantly lower (p &lt; 0.001) than post-operatively, with the highest RIs on days 3 and 7. RIs on day 30 were similar to day 1. RIs in grafts with function were significantly lower than grafts still requiring dialysis. Mean (±sem) cortical RIs on post-operative days 1, 3, 7 and 30 in functioning grafts were 0.662(±0.005), 0.712(±0.008), 0.703(±0.007) and 0.689 (±0.006) respectively, and in grafts still requiring dialysis 0.721(±0.010), 0.780(±0.010), 0.793(±0.011) and 0.751 (±0.034). The intra-operative RI predicted DGF (AUROC 0.774) as effectively as donor status (live/deceased) (AUROC 0.767). For deceased donor grafts, intra-operative RI was a more effective predictor (AUROC 0.710) than type of donor (DCD/DBD) (AUROC 0.610).</div></div><div><h3>Conclusions</h3><div>Intra-operative RIs are significantly lower than post-operatively and are indicative of post-operative graft function. Post-operative RIs in non-functioning grafts are consistently higher than in functioning grafts. Observed RIs differ according to the post-operative day of scan, which therefore should also be reported.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100093"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating point-of-care ultrasound into internal medicine residency program in Ethiopia: An urgent call","authors":"Balew Arega","doi":"10.1016/j.wfumbo.2025.100094","DOIUrl":"10.1016/j.wfumbo.2025.100094","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"3 2","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}