WFUMB Ultrasound Open最新文献

{"title":"Lasting liver injury following COVID-19 infection characterized by ultrasound shear wave elastography","authors":"Firouzeh Heidari ,&nbsp;Theodore T. Pierce ,&nbsp;Madeleine Sertic ,&nbsp;Siddhi Hegde ,&nbsp;David Hunt ,&nbsp;Arinc Ozturk ,&nbsp;Anthony E. Samir","doi":"10.1016/j.wfumbo.2024.100074","DOIUrl":"10.1016/j.wfumbo.2024.100074","url":null,"abstract":"<div><h3>Objective</h3><div>To assess for lasting hepatic injury using ultrasound shear wave elastography (SWE) in patients following COVID-19 infection.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, patients with SWE exams between January 2019 and 2022 were categorized into three groups: 1) post-COVID-19 subjects with positive COVID-19 PCR assay, 2) random sample of contemporaneous unexposed patients with only negative prior COVID-19 PCR tests, and 3) random sample of pre-pandemic patients to address possible undiagnosed COVID-19 infection in the contemporaneous group. The average difference in median Young's modulus between post-COVID-19 patients and controls was calculated using a linear regression model after controlling for confounders.</div></div><div><h3>Results</h3><div>130 patients (mean age ± SD, 56 years ± 13; 66 women) were evaluated, including 30 patients after COVID-19 infection (mean age ± SD, 53 years ± 11; 15 women), 50 contemporaneous unexposed patients (mean age ± SD, 55 years ± 13; 27 men), and 50 pre-pandemic patients (mean age ± SD, 58 years ± 13; 28 women). SWE scans were performed on General Electric LOGIQ E9 or E10 an average of 44 (range, 12–81) weeks after COVID-19 infection. COVID-19 infection was associated with an average increase in median Young's modulus of 1.5 kPa (95 % CI [0.44, 2.355], p = 0.006) after controlling for age, sex, obesity, history of chronic liver disease, and time period. Post-COVID-19 patients had higher liver stiffness compared to contemporaneous controls (median = 7.58 vs 5.99 kPa, p = 0.001) but not pre-pandemic controls (median = 7.00 kPa, p = 0.51).</div></div><div><h3>Conclusions</h3><div>COVID-19 infection is associated with increased liver stiffness, which may reflect lasting hepatic injury such as ongoing inflammation or the development of fibrosis. US SWE may serve as a noninvasive tool for long-term liver health monitoring after COVID-19 infection.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body habitus vs. hepatic steatosis: Understanding the drivers of non-diagnostic shear wave elastography","authors":"Sai Dhanush Reddy Jeggari ,&nbsp;Lauren A. Ling ,&nbsp;Kathleen R. Pope ,&nbsp;Anthony E. Samir ,&nbsp;Theodore T. Pierce","doi":"10.1016/j.wfumbo.2024.100073","DOIUrl":"10.1016/j.wfumbo.2024.100073","url":null,"abstract":"<div><h3>Purpose</h3><div>Shear Wave Elastography (SWE) is frequently non-diagnostic in obese patients, a key cohort at risk for liver disease. Subcutaneous fat and hepatic steatosis are suspected drivers, but their relative contribution is unknown. We compare ultrasound-guided attenuation parameter (UGAP), a marker of steatosis, body mass index (BMI), and skin-to-liver capsule distance (SCD) to predict non-diagnostic SWE.</div></div><div><h3>Materials and methods</h3><div>This IRB approved, single center retrospective study included adults with SWE and diagnostic UGAP exams between June and December 2023. Fasting patients were imaged in supine position with right arm abducted, via an intercostal window during neutral breath hold. The median of 10 measurements in the right lobe was analyzed for SWE and UGAP. SWE measurements were ≥2 cm from the capsule while UGAP depth was fixed at 4 cm from the probe. Exams were considered non-diagnostic for SWE (measured in m/s) if the Interquartile Range/Median Ratio (IQR/M) was &gt;15 % or if diagnostic measurements could not be obtained. UGAP IQR/M &gt; 30 % or complete measurement failure was considered non-diagnostic. Univariate Receiver Operating Characteristic (ROC) curves compared UGAP (dB/cm/MHz), BMI (kg/m²), and SCD (mm) prediction of non-diagnostic SWE by the DeLong test.</div></div><div><h3>Results</h3><div>87 participants (48 male) with mean age of 54.7 ± 15.7 years were analyzed. UGAP [OR: 1.63 per 0.1 dB/cm/MHz, p = 0.02, AUC = 0.66], BMI [OR: 1.23, p &lt; 0.001, AUC = 0.77], and SCD [OR: 1.27, p &lt; 0.001, AUC = 0.81) were predictors of non-diagnostic SWE. UGAP prediction of non-diagnostic SWE was similar in subgroups with the measurement region at least 1 cm (OR: 1.64, n = 68), and 2 cm (OR: 1.54, n = 16) from the liver capsule. UGAP was a worse predictor than SCD (p = 0.04), while not significantly different than BMI (p = 0.15). BMI and SCD did not differ in predicting non-diagnostic SWE (p = 0.44).</div></div><div><h3>Conclusion</h3><div>Our small preliminary study demonstrated that body habitus and hepatic attenuation, a marker of steatosis, both contribute to non-diagnostic SWE exams, however body wall thickness is the key driver. This informs patient selection for SWE exams and guides future research to mitigate these technical shortcomings.</div></div><div><h3>Clinical relevance/application</h3><div>Patients with hepatic steatosis and large body habitus are at increased risk of non-diagnostic ultrasound shear wave elastography (SWE) exams. These patients, particularly those with increased body wall thickness, may benefit from liver fibrosis evaluation with alternative approaches following an initial non-diagnostic SWE exam. Researchers working to improve SWE technique should pay particular attention to mitigating attenuation and phase aberration from the body wall as this is the key driver of non-diagnostic exams.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142664029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative ultrasound for steatosis assessment using Hepatoscope®: Confounding technical factors","authors":"Adrien Besson ,&nbsp;Baptiste Hériard-Dubreuil ,&nbsp;Joel Gay ,&nbsp;Adèle Delamarre ,&nbsp;Juliette Foucher ,&nbsp;Claude Cohen-Bacrie","doi":"10.1016/j.wfumbo.2024.100069","DOIUrl":"10.1016/j.wfumbo.2024.100069","url":null,"abstract":"<div><div>Quantitative ultrasound (QUS) is a well-suited modality to address large-scale screening and monitoring of liver steatosis as it is low-cost, non-invasive, and point-of-care. However, technical and biological confounders lead to difficulties in establishing universal cutoff values for diagnosis. Hepatoscope® remedies this issue as it integrates a unique QUS measurement technique enabling the simultaneous measurements of the backscattering coefficient, the attenuation coefficient and the speed of sound. Such measurements are performed in a large two-dimensional region of interest (ROI) and in a free breathing regime such that a relatively large portion of the liver is sampled. We studied the influence of the size of the ROI, its depth and the number of measurements on the QUS parameters with Hepatoscope® both in vitro on four calibrated phantoms and clinically on 60 participants referred to a hepatology consultation for chronic liver disease. We demonstrated that using large ROIs consistently improves the system reliability and the clinical applicability. We did not observe any systematic effect related to the depth of the ROI. We also showed that averaging consecutive measurements leads to better system reliability and better clinical applicability.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of an algorithm that separates gaseous micro-embolic signals and artifacts during transcranial Doppler persistent foramen ovale examinations","authors":"Rudolf W.M. Keunen ,&nbsp;Hester Temmink ,&nbsp;Mirjam Schipper ,&nbsp;Geert Jan Romers ,&nbsp;Paulien M. van Kampen ,&nbsp;Sayonara Daal","doi":"10.1016/j.wfumbo.2024.100067","DOIUrl":"10.1016/j.wfumbo.2024.100067","url":null,"abstract":"<div><h3>Objective</h3><div>Persistent foramen ovale (PFO) is a risk factor for young stroke. Agitated saline serum is used to deliver small gaseous emboli to the brain in transcranial Doppler ultrasound (TCD) for the detection and grading of PFO. In this study we validated a PFO algorithm that can differentiate between gaseous emboli and artifacts.</div></div><div><h3>Methods</h3><div>The validation cohort comprised 18 patients with positive PFO examinations. The PFO algorithm uses a binary tree that separates high-intensity transients signals (HITs) into gaseous emboli or artifacts based on intensity, zero-crossing, and velocity parameters.</div></div><div><h3>Results</h3><div>The cohort exhibited 385 macroscopic gaseous emboli meeting the &gt;3 dB criterion. An additional 137 gaseous emboli were noticed below the 3-dB intensity cutoff value. The low-intensity gaseous emboli included both macroscopic and microscopic air bubbles observed in curtains. Nearly all emboli (98 %) above the 3-dB level showed overt frequency modulation. The overall accuracy of the PFO algorithm in discriminating macroscopic gaseous emboli and artifacts was 96.4 %, with a similar percentage of sensitivity and specificity (96.4 %). The inter-observer agreement of human experts was excellent (ic-CC 0.989 and 0.953).</div></div><div><h3>Conclusions</h3><div>Macroscopic gaseous emboli and artifacts during PFO exams can be accurately discriminated by the PFO algorithm. The PFO algorithm cannot be used as a standalone system as microscopic air bubbles might escape proper identification. This knowledge will be important in the design of future PFO algorithms which should make it possible to classify the PFO grade without the interference of humans.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-rater reliability of B-mode ultrasound in the measurement of soft tissue thickness and composition over the lateral proximal femur","authors":"Alyssa M. Tondat,&nbsp;Monica R. Maly,&nbsp;Marina Mourtzakis,&nbsp;Andrew C. Laing","doi":"10.1016/j.wfumbo.2024.100066","DOIUrl":"10.1016/j.wfumbo.2024.100066","url":null,"abstract":"<div><h3>Objectives</h3><div>Comprehensive characterization of soft tissue composition and distribution over the lateral proximal femur is necessary to improve our understanding of fall-related hip fractures; however, a protocol that produces reliable data is needed. Accordingly, the aim of this study was to assess the intra-rater reliability of B-mode ultrasound measured muscle, adipose, and total soft tissue thicknesses over the lateral proximal femur in a simulated sideways fall configuration.</div></div><div><h3>Methods</h3><div>Twenty-five young adults (12 males, 13 females, age (SD) = 20.8 (1.9) years) underwent B-mode ultrasound imaging of 12 locations over their lateral proximal femur while in a side-lying position. Side-lying was chosen to allow imaging of the tissues impacted during a lateral fall event. Muscle, adipose, and total soft tissue thicknesses were measured at each location (further grouped into posterolateral, lateral, and anterolateral locations for statistical analysis) and two-way mixed model absolute agreement intraclass correlation coefficients (ICCs) and standard error of measurement were used to assess reliability of tissue type, location, and sex.</div></div><div><h3>Results</h3><div>ICCs were excellent (ICC &gt;0.9) for each tissue type, measurement location, and sex. There were interactions between tissue type, measurement location, and sex on reliability. While measures of adipose thickness were excellent across all conditions, reliability of muscle and total soft tissue thickness measurements were dependent on measurement location and sex.</div></div><div><h3>Conclusions</h3><div>This ultrasound imaging protocol demonstrated good-to-excellent reliability of soft tissue-specific thickness measurements over the lateral proximal femur. This protocol has implications for subject-specific hip fracture risk screening tools and biomechanical models of impact dynamics that incorporate biofidelic soft tissue morphology.</div></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability testing of sonographic techniques in detecting lateral displacement of patellar tendon","authors":"Jan-Tyrone Cabrera ,&nbsp;Consuelo Gonzalez-Suarez ,&nbsp;Cristel Bernice Wee ,&nbsp;Gabriel Rodnei Geslani ,&nbsp;Emmanuel Guevara ,&nbsp;Reil Vinard Espino ,&nbsp;Ivan Neil Gomez","doi":"10.1016/j.wfumbo.2024.100065","DOIUrl":"10.1016/j.wfumbo.2024.100065","url":null,"abstract":"<div><h3>Objectives</h3><p>Patellofemoral pain syndrome (PFPS), a common knee condition, is characterized as presence of peripatellar pain during activities especially during loading of the lower extremity. Gonzalez-Suarez et al. (2021) developed a sonographic technique that assessed patellar tendon displacement within the trochlear groove. This study aims to determine the reliability of this sonographic technique.</p></div><div><h3>Methods</h3><p>Intra-rater and inter-rater reliability study of three sonologist on the lateral displacement of the patellar tendon using ultrasound. Patellar tendon displacement was assessed using the three novel sonographic measurement techniques: 1) region of trochlear groove where the patellar tendon midpoint is located, 2) distance between deepest portion of the trochlear groove and patellar tendon midpoint and 3) percentage of lateral displacement of the patellar tendon. The measurements were done with the patients in supine and standing.</p></div><div><h3>Results</h3><p>Ten participants with a mean age of 27.6 ± 1.56 years were included in the study. Pilot studies were done to improve the sonographic technique. Intraclass correlation coefficients yielded good to excellent inter-rater and excellent intra-rater reliability (&gt;0.75) in the supine and standing positions except the inter-rater reliability of the region of the trochlear groove where patellar tendon midpoint is in supine position.</p></div><div><h3>Conclusion</h3><p>The sonographic techniques for measurement of lateral patellar tendon displacement showed good to excellent intra-rater and inter-rater reliability between sonologists of different levels of expertise using a well-defined scanning protocol.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000338/pdfft?md5=7c69b3638c7b90051b4f85761b0c37f5&pid=1-s2.0-S2949668324000338-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transvaginal sonographic appearance of Surgicel®: A case series report","authors":"Sara Tameish ,&nbsp;Henar Guerra Mas ,&nbsp;Alba Cabello Magriñá ,&nbsp;Sandra Simón Cases ,&nbsp;Pere Cavallé Busquets","doi":"10.1016/j.wfumbo.2024.100064","DOIUrl":"10.1016/j.wfumbo.2024.100064","url":null,"abstract":"<div><h3>Background</h3><p>Surgicel® (oxidized regenerated cellulose) is widely used for hemostasis in gynecological surgery. Although intended to be absorbed within weeks, it can persist and be visualized on transvaginal ultrasound, potentially mimicking ovarian pathologies. The purpose of this study was to describe the appearance of Surgicel® on post-ovarian cystectomy and provide guidance on differentiating it from other conditions.</p></div><div><h3>Methods</h3><p>We retrospectively reviewed postoperative transvaginal sonographic examinations of 6 patients after laparoscopic ovarian cystectomy in which Surgicel® was used for hemostasis. Ultrasonographic evaluations were performed as part of routine postoperative assessment without any specific timing protocol. Sonographic examinations were performed up to 335 days after surgery. Images were reviewed for echogenicity, vascularization (color doppler) and acoustic properties. Surgical reports confirmed the use of Surgicel®in each patient.</p></div><div><h3>Results</h3><p>Surgicel® displayed varying ultrasonographic characteristics, lacking a uniform appearance. In all cases, it appeared as a hyperechoic, avascular lesion, sometimes with posterior acoustic shadowing and occasionally accompanied by a cystic component. In one patient, serial scans revealed a gradual reduction in size and changes in sonographic features over time.</p></div><div><h3>Conclusion</h3><p>Surgicel® can present with diverse ultrasound features. However, a hyperechoic avascular lesion is a key potential sign for distinguishing it from other conditions. Awareness of these sonographic appearances is essential to avoid misdiagnosis, highlighting the importance of collaboration between sonographers and surgeons to prevent unnecessary interventions.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000326/pdfft?md5=eca97803159fa23badc0c8aeeb6c7679&pid=1-s2.0-S2949668324000326-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved sonographic detection of adenomyosis with volumetric transvaginal sonography","authors":"Seoiyoung Ahn ,&nbsp;Ted L. Anderson ,&nbsp;Brannan Griffin ,&nbsp;Arthur C. Fleischer","doi":"10.1016/j.wfumbo.2024.100063","DOIUrl":"10.1016/j.wfumbo.2024.100063","url":null,"abstract":"<div><h3>Introduction</h3><p>Pre-ablation detection of adenomyosis may be clinically helpful to decrease the risk of ablation failure and subsequent hysterectomy. Two-dimensional (2D) combined with three-dimensional (3D) Transvaginal sonography (TVS) may be able to improve detection of adenomyosis prior to ablation, potentially allowing better identification of candidates for endometrial ablation and reducing the risk of ablation failure.</p></div><div><h3>Methods</h3><p>A single-center, retrospective study of patients with endometrial ablation failure and subsequent hysterectomy between 2005 and 2023 who had pre-ablation TVS and histopathology-proven adenomyosis was performed. Sensitivities of 2D and 2D/3D TVS for pre-operative detection of adenomyosis were calculated.</p></div><div><h3>Results</h3><p>Among a total of 87 women with pathology-proven adenomyosis after hysterectomy, 40 underwent 2D TVS only prior to ablation, while 47 underwent both 2D and 3D TVS. Of the 40 women who only underwent 2D TVS, 22 were found to have adenomyosis while 18 were negative for adenomyosis. Of the 47 women who underwent both 2D and 3D TVS, 34 were found to have adenomyosis while 13 were negative for adenomyosis. The sensitivities of 2D TVS and 2D/3D TVS for adenomyosis were 0.55 and 0.72, respectively.</p></div><div><h3>Conclusions</h3><p>Both 2D and 3D TVS reflect the challenge of depicting a wide spectrum of sonographic findings of adenomyosis from microscopic myometrial implants to more extensive involvement of the transmural myometrium. The use of both 2D and 3D TVS has a greater preoperative sensitivity for sonographically diagnosing adenomyosis compared to 2D TVS alone. Potential improvements for enhanced TVS detection might include elastography and vascularity assessment.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100063"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000314/pdfft?md5=87b453f948612a37a61887881dde029d&pid=1-s2.0-S2949668324000314-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142150045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberration correction in 3D transthoracic echocardiography","authors":"Svein-Erik Måsøy ,&nbsp;Bastien Dénarié ,&nbsp;Anders Sørnes ,&nbsp;Espen Holte ,&nbsp;Bjørnar Grenne ,&nbsp;Torvald Espeland ,&nbsp;Erik Andreas Rye Berg ,&nbsp;Ole Marius Hoel Rindal ,&nbsp;Wayne Rigby ,&nbsp;Tore Bjåstad","doi":"10.1016/j.wfumbo.2024.100062","DOIUrl":"10.1016/j.wfumbo.2024.100062","url":null,"abstract":"<div><p>Three-dimensional cardiac imaging has been available in the clinic for more than two decades. Continuous improvement in image quality has occurred in this period due to the development of probe technology and beamforming techniques. The purpose of this article is to quantitatively and qualitatively analyze the effect of a commercially available aberration correction algorithm on clinically acquired 3D transthoracic echocardiography (3D TTE) images. Clinical triplane and 3D volume cineloops of at least one cardiac cycle of pre-beamformed channel data were captured from 50 patients using a GE HealthCare Vivid E95 system with the 4Vc-D matrix array probe. This resulted in a total of 3200 vol and 3136 triplane frames. The data were post-processed with and without aberration correction. Quantitatively, assessed by an image quality parameter based on coherence, all recordings were improved by aberration correction compared to those without aberration correction. Triplane data obtained a larger improvement in image quality than volume data. Qualitatively, as demonstrated by case examples, aberration-corrected images appear sharper, have a brighter tissue signal compared to the cavity, and provide better delineation of cardiac structures. 3D rendering of valves can also be significantly improved. In general, aberration correction provides a systematic improvement in clinical cardiac triplane and 3D volume images.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000302/pdfft?md5=64eb86fc6b7e009ad2c772d5fba14c28&pid=1-s2.0-S2949668324000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142049671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods and validation of velacur determined fat fraction in patients with MASLD","authors":"Mohammad Honarvar ,&nbsp;Julio Lobo ,&nbsp;Caitlin Schneider ,&nbsp;Samuel Klein ,&nbsp;Gordon I. Smith ,&nbsp;Rohit Loomba ,&nbsp;Alnoor Ramji ,&nbsp;Tarek Hassanein ,&nbsp;Eric M. Yoshida ,&nbsp;Emily Pang ,&nbsp;Michael P. Curry ,&nbsp;Nezam H. Afdhal","doi":"10.1016/j.wfumbo.2024.100061","DOIUrl":"10.1016/j.wfumbo.2024.100061","url":null,"abstract":"<div><h3>Introduction</h3><p>As prevalence of patients with steatotic liver diseases increases throughout the world, it is necessary to have accurate and accessible methods to estimate liver fat content. Using quantitative ultrasound parameters, such as attenuation and backscatter, it is possible to estimate liver fat with MRI proton density fat fraction as the reference standard. Velacur determined fat fraction (VDFF) is a new output measurement on Velacur (Sonic Incytes Medical Corp, Vancouver, BC).</p></div><div><h3>Methods</h3><p>This study described the results of parameter fitting and validation of VDFF, which is a combination of quantitative ultrasound parameters. Patients were recruited from sites within the US and Canada. All patients had contemporaneous Velacur and MRI proton density fat fraction scans. The quantitative ultrasound parameter fitting was completed using linear regression on a random sub-sample approach, and a separate cohort was used for validation. The AUC for detection of 5 % liver fat based on MRI-PDFF and the correlation between MRI-PDFF and VDFF was measured in both cohorts.</p></div><div><h3>Results</h3><p>VDFF had an AUROC of 0.97 for the detection of MRI-PDFF &gt;5 % in the parameter fitting cohort, and 0.99 in the validation cohort. The correlation [95 % CI] between MRI-PDFF and VDFF was r = 0.84 [0.78–0.89] for the parameter fitting cohort and r = 0.90 [0.82–0.95] for the validation cohort.</p></div><div><h3>Conclusion</h3><p>The Velacur Determined Fat Fraction (VDFF) is an accurate and accessible way to estimate steatosis as measured by MRI-PDFF. Velacur VDFF can fill the unmet need of an accurate means to diagnosis hepatic steatosis and serve as a potential alternative to biopsy or MRI-PDFF.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 2","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668324000296/pdfft?md5=b2ba02eeedafea6bdb5468e19fe2dbc6&pid=1-s2.0-S2949668324000296-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141845003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}