WFUMB Ultrasound Open最新文献

{"title":"Rethinking ultrasound probe maintenance in the era of AI","authors":"Rebeca Tenajas, David Miraut","doi":"10.1016/j.wfumbo.2023.100014","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100014","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting female breast cancer by artificial intelligence: Combining clinical information and BI-RADS ultrasound descriptors","authors":"Wen-Jia Shen ,&nbsp;Hai-Xia Zhou ,&nbsp;Ye He ,&nbsp;Wei Xing","doi":"10.1016/j.wfumbo.2023.100013","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100013","url":null,"abstract":"<div><p>This study aimed to use Artificial Intelligence (AI) Deep Learning (DL) techniques to predict female breast cancer detected by ultrasound based on clinical data and Breast Imaging Reporting and Data System (BI-RADS) Ultrasound (US) descriptors. We retrospectively gathered data on clinical information and BI-RADS US descriptors of breast lesions from 1051 female patients, forming a comprehensive dataset. Two datasets (A and B) were derived by selecting different variables. A BI-RADS DL-based Network (BD-Net) was developed and trained on Dataset A and B, and its performance was evaluated on an external test set. Radiologists also classified Dataset B and the external test set using BI-RADS US. Performance in predicting the probability of malignancy was evaluated by calculating the Area Under Curve (AUC), accuracy, sensitivity, and specificity. BD-Net achieved an accuracy of 92.5% (95%CI, 90.5–94.2) in predicting breast cancer with a sensitivity of 93.0% (95%CI, 90.3–95.4), a specificity of 92.1% (95%CI, 89.7–94.6), and an AUC of 0.97 (95%CI, 0.96–0.98) on the training data set of dataset A. On the external dataset, the BD-Net showed a sensitivity of 93.8% (95%CI, 87.5–98.8), a specificity of 91.0% (95%CI, 85.0–96.0), and an AUC of 0.92 (95%CI, 0.88–0.97) for predicting breast cancer. The radiologists predicted breast cancer on Dataset B and the external test set with AUC values between 0.75 (95%CI, 0.75–0.79) and 0.82 (95%CI, 0.77–0.87). These results indicate that the BD-Net is effective for predicting ultrasound-detected female breast cancer.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100013"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in ultrasound elevational beam width (slice thickness) between popular handheld devices","authors":"Harm J. Scholten ,&nbsp;Gert Weijers ,&nbsp;Marco de Wild ,&nbsp;Hendrikus H.M. Korsten ,&nbsp;Chris L. de Korte ,&nbsp;R. Arthur Bouwman","doi":"10.1016/j.wfumbo.2023.100009","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100009","url":null,"abstract":"<div><h3>Background</h3><p>Handheld ultrasound devices are increasingly used by medical professionals for bedside ultrasound-guided interventions. Especially for vascular access procedures, the width of the imaging plane, known as the slice thickness or elevational beam width is a prominent source for misinterpretation. A wide slice thickness can lead to the interpretation that 2 objects (i.e. needle and vessel) are on the same plane while in fact they are not and thereby negatively influencing the performance of in-plane ultrasound-guided interventions. Therefore, the beam profiles of three popular handheld US devices are tested and compared to a conventional US device.</p></div><div><h3>Methods</h3><p>The GE VScan, Philips Lumify and Butterfly IQ ​+ ​are tested using a slice phantom to determine the slice thickness. For comparison, a Philips Affiniti machine was investigated. Both linear and curved array settings were analyzed. In a slice phantom, a diffuse scattering plane at an angle of exactly 45° is scanned. For each imaging depth, the vertical height of the imaged rectangle corresponds to the slice thickness at that depth.</p></div><div><h3>Main results</h3><p>For the linear array transducers, the focus depth ranges from 1.5 to 3.5 cm. At the focus depth, all transducers have a reasonable slice thickness of approximately 1 mm. More superficially, the slice thickness varies between 1 and 4 mm. The curved array probes have larger focus depths, ranging from 2.7 to 7.3 cm. The slice thickness at focus depth varies between 1.4 and 3.8 mm, but at 2 cm depth is even more than 5 mm.</p></div><div><h3>Conclusions</h3><p>The slice thickness of handheld ultrasound transducers varies between the different devices, and can be suboptimal for superficial in-plane ultrasound-guided interventions. The larger slice thickness of the curved array settings may complicate in-plane guidance. Handheld ultrasound users should be aware of the beam characteristics of their devices to optimize guidance for interventions.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100009"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study on the application of sono-elastography in differentiating endometrial carcinoma from benign endometrial lesions in a tertiary government hospital in the Philippines","authors":"Catherine M. Santos,&nbsp;Nelinda Catherine P. Pangilinan,&nbsp;Maria Cristina C. Franada","doi":"10.1016/j.wfumbo.2023.100012","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100012","url":null,"abstract":"<div><h3>[Objective]</h3><p>To evaluate the diagnostic value of sonoelastography to distinguish endometrial cancer from benign endometrial lesions.</p></div><div><h3>[Methods]</h3><p>A cross-sectional study was conducted and included 31 subjects with abnormal uterine bleeding who required endometrial sampling. Sonoelastography assessment was done qualitatively and quantitatively using Tsukuba elasticity score and strain ratio, respectively. Results were compared between those with endometrial cancer and those with benign endometrial lesions (hyperplasia and polyp) using Kruskal-Wallis test and Mann-Whitney <em>U</em> test. Diagnostic accuracies of Tsukuba elasticity score and strain ratio in differentiating endometrial cancer from benign endometrial lesions were determined with cut-off values derived from ROC analysis.</p></div><div><h3>[Discussion]</h3><p>Both the Tsukuba elasticity score and strain ratio value were significantly higher among patients with endometrial cancer (n = 15; mean age: 55.07 ± 8.53 years) compared to those with benign endometrial lesions (n = 16; mean age: 41.63 ± 8.02 years) (P &lt; 0.0001). A Tsukuba elasticity score of ≥3 showed the highest diagnostic accuracy at 93.5%(95%CI: 79.3%–98.2%), with sensitivity of 86.7%(95%CI: 62.1%–96.3%), specificity of 100%(95%CI: 80.6%–100%), PPV of 100%(95%CI: 77.2%–100%), NPV of 88.9%(95%CI: 67.2%–96.9%), positive LR of undefined indicating high value and negative LR of 0.10(95%CI: 0.05–0.40). A Strain ratio value of ≥2 showed the highest diagnostic accuracy at 93.5%(95%CI: 79.3%–98.2%), with sensitivity of 93.3%(95%CI: 70.2%–98.8%), specificity of 93.8%(95%CI: 71.7%–98.9%), PPV of 93.3% (95%CI: 70.2%–98.8%), NPV of 93.8%(95%CI: 71.7%–98.9%), positive LR 14.9(95%CI: 2.1–107.1), and negative LR of 0.07(95%CI: 0.01–0.51).</p></div><div><h3>[Conclusion]</h3><p>The results indicate that sonoelastography can distinguish endometrial cancer from benign endometrial lesions.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100012"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserving sound arguments and academic dialogue by promoting free-of-charge opinion pieces and letters in WFUMB Ultrasound Open Journal","authors":"Rebeca Tenajas ,&nbsp;David Miraut","doi":"10.1016/j.wfumbo.2023.100011","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100011","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100011"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound imaging measurements to determine reduced diaphragm thickness and relevance to breathing pattern disorders diagnosis in females","authors":"S. Peirce ,&nbsp;S. Mooney ,&nbsp;M. Rohan ,&nbsp;R. Ellis","doi":"10.1016/j.wfumbo.2023.100010","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100010","url":null,"abstract":"<div><h3>Background</h3><p>Breathing pattern disorders (BPD) are commonly managed by physiotherapists. As no gold-standard assessment diagnostic tools are currently available, diagnosis is challenging. Ultrasound imaging has become popular in physiotherapy. This research examined diaphragm thickness using ultrasound imaging in females with BPD and healthy female controls to ascertain if diaphragm thickness at different measurement points related with reduced diaphragm thickness.</p></div><div><h3>Methods</h3><p>Observational cross-sectional design was used. Two female groups were recruited from an outpatient setting: BPD group (<em>n</em> = 19) and control group (<em>n</em> = 18) with normal body mass index (BMI). BPD inclusion criteria assessment included: Nijmegen Questionnaire (NQ) score, respiratory rate, Hi-Lo test, and breath hold time. USI measured diaphragm thickness at the measurement points of: tidal exhalation (Tvex), tidal inhalation (Tvin), maximum inhalation (Tmax) and exhalation to residual volume (Tmin); diaphragm thickening fraction (TF) was calculated.</p></div><div><h3>Results</h3><p>Results indicated significant differences of diaphragm thickness between the BPD and control groups at Tvex, Tvin, Tmax and TF on the left and Tvex and Tvin on the right side (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusion</h3><p>Diaphragm thickness is reduced in females with BPD when compared with healthy controls. Diaphragm measurement undertaken by USI may provide a useful assessment tool in BPD. Further research is required to validate this assessment and to broaden its use in BPD.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100010"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rectal endometriosis imaging: A case based pictorial essay","authors":"Garvit D. Khatri ,&nbsp;Deepashri Basavalingu ,&nbsp;Nitin Chaubal ,&nbsp;Manjiri Dighe","doi":"10.1016/j.wfumbo.2023.100002","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100002","url":null,"abstract":"<div><p>Endometriosis is a common chronic gynecological disorder presenting with cyclical pain and infertility in premenopausal females. In some patient's endometrial lesions can be advanced and infiltrate deep into the peritoneum (deep infiltrating endometriosis (DIE)) and pelvic organs, and cases can be challenging for management. Posterior compartment endometriosis, in particular involvement of the recto-sigmoid can be challenging for surgeons, and presurgical detection and proper characterization of involvement on imaging is prudent. Ultrasound and MR are the main modalities to evaluate pelvic endometriosis. Imaging evaluation requires identifying the number, location, and size of the lesions, as well as the degree of depth and circumferential involvement of the rectum. To better explain imaging evaluation and characterization of rectal endometriosis, in this paper we have elaborated pictorial review of 14 surgically proven rectal endometriosis cases. We have also mentioned about the rectal endometriosis reporting guidelines set by Society of Abdominal Radiology (SAR). To our knowledge presently there are no dedicated pictorial reviews specific to rectal endometriosis encompassing both US, MR and SAR guidelines in the English literature.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 1","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective observational 2D/3D/4D hysterosalpingo contrast sonography using mixture of lignocaine gel and normal saline as contrast in patients undergoing infertility investigations","authors":"Chegondi V. Narayanarao","doi":"10.1016/j.wfumbo.2023.100004","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100004","url":null,"abstract":"<div><h3>Background and aim</h3><p>Hysterosalpingo contrast sonography (HyCoSy) is a well-tolerated diagnostic tool to examine the uterus, ovaries, fallopian tubes, and pelvis. It has some advantages over other techniques, such as X-ray hysterosalpingography (HSG), laparoscopy, and dye intubation. This prospective study aimed to investigate the use of 2D/3D/4D HyCoSy, using lignocaine gel and normal saline as a contrast agent, to assess tubal patency and uterine abnormalities in infertile women.</p></div><div><h3>Method</h3><p>More than 5000 infertile cases were evaluated by HyCoSy 2D/3D/4D test using lignocaine gel as a contrast agent during the period of 2016–2022 at Shilpa Scanning Center, Andhra Pradesh. Among the subjects studied, a total of 850 cases were randomly selected to assess tubal patency. Of 850 patients, 54 had X-ray HSG reports that were reassessed using 2D/3D/4D HyCoSy. During the test, we also assess the intensity of the pain.</p></div><div><h3>Results</h3><p>Out of 850 infertile patients, 603 (70.94%) had primary infertility, and 247 (29.06%) had secondary infertility. The fallopian tubes were found to be patent in 702 (82.59%) of these patients, while 80 (9.41%) had unilateral occlusion and 68 (8%) had bilateral occlusion. Among the 54 patients with previous reports of X-ray HSG, three were misdiagnosed as bilateral obstruction and six as unilateral obstruction, and these misdiagnoses were confirmed by 2D/3D/4D HyCoSy using lignosal contrast and laparoscopic dye testing. During the HyCoSy procedure, 772 women (90.82%) reported mild pain that was less severe than menstrual pain.</p></div><div><h3>Conclusions</h3><p>The 2D/3D/4D-HyCoSy with lignosal gel as a contrast agent could be a promising tool for detecting fallopian tube patency and uterine abnormalities.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 1","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical ultrasonic quality assurance in Danish Radiology Departments","authors":"Karen Brage ,&nbsp;Kristina T.T. Pank ,&nbsp;Sisse Hansen ,&nbsp;Lis K. Sondergaard ,&nbsp;Mark F. McEntee ,&nbsp;Malene Roland V. Pedersen","doi":"10.1016/j.wfumbo.2023.100005","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100005","url":null,"abstract":"<div><h3>Introduction</h3><p>In general, there is a lack of technical quality assurance (TQA) in ultrasound, which threatens patients. This study aimed to map the level of ultrasound quality assurance in Danish Radiology Departments, assess the intra- and interrater reliability of the in-air method for evaluating transducer quality, and determine the prevalence of faulty transducers.</p></div><div><h3>Methods</h3><p>From October to November 2021, an anonymous survey focused on the extent of TQA was e-mailed to clinicians (via managers) responsible for ultrasound TQA. The six-item survey included both closed and open-ended questions. In addition, a sample of 63 ultrasound b-mode reverberation images was collected from four Danish Radiological Departments, later rated by two blinded radiographers on a dichotomous scale.</p></div><div><h3>Results</h3><p>A total of 46 participants responded to the survey. In the survey, 15 respondents reported not having a TQA procedure, while six thought a procedure existed but were uncertain. Various methods were reported for the respondents who answered that TQA was performed (n = 13).</p><p>Half of the respondents (n = 23, 50%) reported experiencing transducer malfunctions, and seven said they did not find the lack of regular testing problematic.</p><p>The interrater reliability was κ = 0.75 (95% CI.: 0.61–0.89), and the inter-rater reliability was κ = 0.84 (95% CI.: 0.70–0.98). Based on the agreement between the two raters, 20 out of 50 (40%) transducers were flawed.</p></div><div><h3>Conclusion</h3><p>This study demonstrates the general deficiency of TQA in Danish Radiological Departments, with 21 clinicians responsible for ultrasound TQA responding either not having a TQA procedure or being uncertain if one exists. Furthermore, the study reveals that the in-air method for assessing transducer quality demonstrates moderate to almost perfect reliability and that nearly half of the transducer tested exhibits visual faults.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 1","pages":"Article 100005"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating carotid and aortic peak velocity variation as an alternative index for stroke volume and pulse pressure variation: a method comparison study","authors":"Joris van Houte ,&nbsp;Esmée C. de Boer ,&nbsp;Luuk van Knippenberg ,&nbsp;Irene Suriani ,&nbsp;Michaël I. Meesters ,&nbsp;Loek P.B. Meijs ,&nbsp;Leon J. Montenij ,&nbsp;Arthur R. Bouwman","doi":"10.1016/j.wfumbo.2023.100001","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100001","url":null,"abstract":"<div><p>The peak velocity variation within the carotid artery (ΔVpeak_CCA) and left ventricular outflow tract (ΔVpeak_LVOT) is derived from the pulsed wave Doppler waveform and may predict fluid responsiveness. The aim of this study was to evaluate ΔVpeak_CCA and ΔVpeak_LVOT against calibrated stroke volume variation (SVV) and pulse pressure variation (PVV). Therefore, eighteen cardiac surgery patients were included in this prospective observational study. Doppler measurements were performed after induction of anesthesia, after a passive leg raise, and at the end of surgery. Simultaneously, SVV and PPV were measured by pulse-contour-analysis (PiCCO). The correlation, methodological agreement, concordance, and clinical agreement between Doppler and PiCCO measurements were assessed. The correlation between SVV and ΔVpeak_CCA was strong (ρ = 0.88). Bland-Altman analysis demonstrated a bias of 0.01%, and LOA +/− 4.6%, acceptable concordance (93%), and close to acceptable clinical agreement (88%). For PPV and ΔVpeak_CCA correlation was also strong (ρ = 0.73), bias was −0.2%, LOA +/− 7.6%, with intermediate acceptable concordance (90%), and low clinical agreement (72%). Analysis of ΔVpeak_LVOT measurements demonstrated poor statistical agreement with SVV and PPV. In conclusion, in cardiac surgery patients ΔVpeak_CCA, as opposed to ΔVpeak_LVOT, has acceptable statistical and clinical agreement with SVV measurements. ΔVpeak_CCA may qualify as a potential tool for non-invasive assessment of fluid responsiveness.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 1","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49734240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}