{"title":"Pupillary clonus - an abnormal pupillary unrest on POCUS of pupil in patients with altered sensorium","authors":"Priyanka Modi, Sanjeev Bhoi, Savan Pandey","doi":"10.1016/j.wfumbo.2023.100027","DOIUrl":"10.1016/j.wfumbo.2023.100027","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000277/pdfft?md5=3e2a7e669c2eb3c023bb16eefd6b44a7&pid=1-s2.0-S2949668323000277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The updated roles of new ultrasound imaging techniques in assessing carotid vulnerable plaques","authors":"Yangyang Cheng , Aidi Wu , Michael Ying , Xiangyan Chen","doi":"10.1016/j.wfumbo.2023.100023","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100023","url":null,"abstract":"<div><p>Carotid atherosclerosis, a subtype of large artery atherosclerosis, is a significant contributor to ischemic stroke events. Considering the pivotal role of ultrasound in assessing carotid artery pathology, this review emphasizes its application in visualizing carotid atherosclerosis, with a particular interest in distinguishing stable from vulnerable carotid plaques. Recent advancements have improved our understanding of the relationship between plaque stability and ischemic stroke. This has motivated a comparative analysis of cutting-edge ultrasound techniques to evaluate extracranial carotid plaque, particularly focusing on areas of intraplaque vulnerability. The B-Mode remains the standard first-line imaging modality for both detecting carotid plaques and their morphology. However, its diagnostic potential is typically realized during the intermediate to advanced stages of atherosclerosis. In contrast, the latest innovations in ultrasound imaging techniques, such as contrast-enhanced ultrasound (CEUS), shear wave elastography (SWE), grayscale median (GSM), and the refined Doppler method (superb microvascular imaging, SMI), offer a detailed quantitative approach to categorize carotid plaques into “stable” or “vulnerable” categories. Their application, however, is not widespread in outpatient settings due to factors such as exorbitant costs, extended imaging duration, and a prevalent lack of technical knowledge among healthcare providers. Beyond conventional echogenicity markers, both CEUS and SMI imaging possess the capability to evaluate intraplaque neovascularization, illuminating deep and microvessels within hypoechoic plaques. This aids in identifying high-risk plaque attributes, such as morphological irregularities and ulcerations, which are paramount for risk stratification and monitoring therapeutic responses. SWE offers insights into tissue rigidity and carotid plaque constituents, such as the fibrous cap and lipid core by gauging shear wave velocity and quantifying shear deformation with a specificity of 66.7 % which is higher than that of CEUS (58.3 %). Therefore, a multiparametric ultrasound approach offers a viable strategy for a holistic evaluation of carotid plaques. The timely identification of susceptible plaques can tailor therapeutic interventions, potentially averting cerebrovascular incidents, including acute ischemic strokes (AIS) and transient ischemic attacks (TIA).</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikolaos Angelopoulos , Dimitrios G. Goulis , Ioannis Chrisogonidis , Evanthia Giannoula , Ioannis Iakovou
{"title":"Ultrasound characteristics of Hashimoto’s thyroiditis in the subclinical stages of the disease","authors":"Nikolaos Angelopoulos , Dimitrios G. Goulis , Ioannis Chrisogonidis , Evanthia Giannoula , Ioannis Iakovou","doi":"10.1016/j.wfumbo.2023.100022","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100022","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the prognostic value of indicators from b-mode ultrasound, color Doppler ultrasound, and strain elastography of the thyroid gland in the diagnosis of Hashimoto's thyroiditis (HT).</p></div><div><h3>Methods</h3><p>In 70 euthyroidal patients with HT, demographic characteristics, serum thyroid profile and ultrasound parameters, including thyroid gland size, vascularity and stiffness (elastography strain index) of the parenchyma, and flow indices of the superior and inferior thyroid artery were recorded. The control group consisted of 70 age and weight matched euthyroid individuals with negative anti-thyroid antibodies (anti-TPO and anti-Tg).</p></div><div><h3>Results</h3><p>A significant difference was observed between the two groups in total thyroid size (ml, median ± standard deviation, SD) 7.86 ± 2.9 in HT vs. 6.35 ± 2.7 ml in controls, p = 0.003) and parenchymal vascularity which was increased in patients with HT (p < 0.001). Tissue strain index was higher in the HT group but without reaching statistical significance In logistic regression, thyroid size (odds ratio 1.20, 95% confidence interval: 1.02–1.41, p = 0.022) demonstrated significant prognostic value for the presence of HT. No differences were found between the two groups, regarding the peak systolic velocity (PSV), end-diastolic volume (EDV), pulsatility index (PI) and resistive index (RI) values of the thyroid arteries. In the ROC analysis (AUC 0.653, p = 0.002), a thyroid size >7.3 ml exhibited sensitivity of 61.43% and specificity of 72.6% for the diagnosis of HT.</p></div><div><h3>Conclusion</h3><p>Patients with HT exhibit larger thyroid size and increased intrathyroidal vascularity on ultrasound prior to the manifestation of hypothyroidism compared to the healthy population. Flow indices of the superior thyroid artery do not have prognostic value in the diagnosis of HT.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hayden M. Fox , Alexander Douglas , Griffin Hughes , Zachariah Fisher , Matt Vassar
{"title":"The top 100 most-cited publications on contrast-enhanced ultrasound: A bibliometric analysis","authors":"Hayden M. Fox , Alexander Douglas , Griffin Hughes , Zachariah Fisher , Matt Vassar","doi":"10.1016/j.wfumbo.2023.100020","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100020","url":null,"abstract":"<div><h3>Introduction</h3><p>Contrast-enhanced ultrasound (CEUS) is a modality of growing interest because of its improved detection rates when evaluating lesions and better success rates when administering interventions, compared to standard ultrasound. Along with its diagnostic value, the possibilities for therapeutic innovation with CEUS are immense. While there is much discussion of CEUS and its potential applications, there is a scarcity of studies characterizing the current state of CEUS research. Bibliometric analysis, a method of gaining an overview of a body of literature, quantitatively analyzes large amounts of information within publications to reveal trends. This study used bibliometric analysis to characterize the state and nature of the 100 most-cited publications on CEUS.</p></div><div><h3>Methods</h3><p>We identified the 100 most-cited publications on contrast-enhanced ultrasound using the Scopus database. We recorded various bibliometric data points from these publications, with additional data collected for the 25 most-cited publications. Data were analyzed via R, R studio, and VOSviewer.</p></div><div><h3>Results</h3><p>Our analysis of the top 100 publications revealed that 38 of the listed first authors were from the United States. Eleven articles were in <em>Radiology</em>, six were in <em>Ultraschall in der Medizin,</em> and six were in <em>Ultrasound in Medicine and Biology,</em> with mean citation counts of 269.2, 433.3, and 291.7 per publication, respectively. The University of Virginia Health System produced the most publications in the top 100. Seventeen of the top 25 most-cited articles were clinical practice guidelines. Four of the top five papers were clinical practice guidelines pertaining to hepatocellular carcinoma.</p></div><div><h3>Conclusion</h3><p>In conclusion, several interesting trends were demonstrated in our bibliometric analysis. The most heavily cited articles from the top 100 were published between 2010 and 2019, which is in contrast to the finding that the previous decade contained more articles published in the top 100. This trend indicates a significant scientific impact from those articles published from 2010 to 2019. The substantial number of articles addressing applications of CEUS in diagnosing and treating liver diseases correlates closely with their global disease burden; therefore, this finding potentially explains the rise in impactful research production within the field. This study is the first to characterize the landscape of CEUS research, and future studies should further this work as the field continues to develop. Thus, our analysis reveals many important findings in the current state of CEUS research and its impact on medical imaging.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100020"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasound: The cornerstone of Radiology in Low and Middle-income countries","authors":"Asim Mahat, Gopal Kumar Yadav, Upama Mishra, Binod Mehta","doi":"10.1016/j.wfumbo.2023.100021","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100021","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100021"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49726939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saubhagya Srivastava , Daniel Van Roekel , Jonathan L. Wright , Matthew Bruce , Manjiri Dighe
{"title":"Contrast-enhanced ultrasound (CEUS) in the evaluation of bladder pathologies: Review","authors":"Saubhagya Srivastava , Daniel Van Roekel , Jonathan L. Wright , Matthew Bruce , Manjiri Dighe","doi":"10.1016/j.wfumbo.2023.100019","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100019","url":null,"abstract":"<div><p>Contrast-enhanced Ultrasound (CEUS) is an advanced ultrasound (US) technique that utilizes specific US contrast agents (UCAs) to provide a more detailed evaluation of anatomic structures and parenchymal vasculature. Although the use of CEUS has been well-established in echocardiography and imaging of focal liver lesions, the updated guidelines by WFUMB-EFSUMB from 2018 also talk about the use of CEUS in the urinary bladder under non-hepatic applications of CEUS. The most common application of CEUS in the urinary bladder is the differentiation between bladder cancer and benign lesions such as a hematoma in patients presenting with hematuria. CEUS is also a promising imaging modality that can be used to detect and stage bladder urothelial cancers. CEUS greatly improves the diagnostic accuracy of conventional US techniques in the detection of bladder cancer. It has been shown previously that low- and high-grade bladder cancers tend to behave differently on the time-intensity curves (TIC) of CEUS. Low-grade bladder cancers tend to show a TIC with an early peak enhancement with a slow plateau and a longer time taken for contrast disappearance, whereas high-grade bladder cancers tend to show a rapid and high peak enhancement with rapid contrast disappearance (fast wash-out phase). In patients presenting with hematuria, CEUS accurately differentiates the etiology as either malignant or benign (i.e., hematoma) as hematomas are non-vascular lesions and do not show any enhancement as opposed to bladder cancers which tend to be highly vascular. CEUS holds several advantages such as being widely available, quick, and cost-efficient. CEUS is also suitable for patients who have contraindications to undergo CT, MRI, and/or conventional cystoscopy. Additionally, CEUS can be safely performed in patients with renal failure as UCAs are not nephrotoxic and not deposited in tissues as they are blood pool agents and are metabolized and excreted via pulmonary breathing.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49733761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pei Sun , Qing Lu , Luxia Jing , Cuixian Li , Jiexian Wen , Cong Li , Jingjing Wang , Hongli Cao , Beijian Huang
{"title":"Contrast enhanced ultrasound diagnosis of complex cystic renal mass: Interobserver variability based on different Bosniak classification systems","authors":"Pei Sun , Qing Lu , Luxia Jing , Cuixian Li , Jiexian Wen , Cong Li , Jingjing Wang , Hongli Cao , Beijian Huang","doi":"10.1016/j.wfumbo.2023.100007","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100007","url":null,"abstract":"<div><p>The diagnostic value of Bosniak classification based on contrast enhanced ultrasound (CEUS) on complex cystic renal mass (CRM) was compared among different observers. From 2012 to 2022, 212 complex CRMs, confirmed by pathology or at least 1-year imaging follow-up, were enrolled. The CEUS images of CRM were retrospectively analyzed by two reviewers with different experience in kidney CEUS examination, and each lesion was given the categorizations according the Bosniak ver. 2015 and ver. 2019, respectively. There was good inter-observer agreement (<em>k</em> = 0.689; <em>p</em> < 0.05) for Bosniak ver. 2019. With Bosniak ver. 2019, senior and junior reviewer correctly classified 44 (83.02%), 40 (75.47%) benign lesions as low grade (Ⅰ ∼ ⅡF), and 94 (94.95%), 80 (80.81%) malignant tumors as high grade (Ⅲ or Ⅳ), respectively. Meanwhile, the combination of Bosniak 2019 and senior reviewer demonstrated the highest area under the receiver operating characteristic curve (Az: 0.875, all <em>p</em> < 0.05) than other groups, with the highest specificity (81.10%) and sensitivity (93.90%) among all the groups (95% CI, 0.807–0.943; <em>p</em> < 0.05), respectively. Overall, the senior reviewer combined with Bosniak ver. 2019 was the best choice for the diagnosis of complex CRM.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49761686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Solvin , S. Sajadi , M. Lippert , R. Massey , H. Holmstrøm , O. Elle , K. Mathiassen , H. Brun
{"title":"Feasibility of teleoperated robotic echocardiography – A pilot study","authors":"H. Solvin , S. Sajadi , M. Lippert , R. Massey , H. Holmstrøm , O. Elle , K. Mathiassen , H. Brun","doi":"10.1016/j.wfumbo.2023.100018","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100018","url":null,"abstract":"<div><h3>Purpose</h3><p>Echocardiography is dependent on highly specialized healthcare professionals. Teleoperated examinations could provide higher availability of specialized care for patients living in rural areas. The objective of this study was to evaluate the feasibility of a teleoperated robotic echocardiography system.</p></div><div><h3>Methods</h3><p>Twenty-three healthy volunteers underwent teleoperated echocardiography, compared to standard bedside echocardiography. Examination time, image quality, ability to assess cardiac structures, measurements of left ventricular fractional shortening and blood flow velocities were compared. Image quality was rated on a scale from 0 to 3.</p></div><div><h3>Results</h3><p>Approximately 90% of robotically acquired images were rated as medium quality or better and approximately 80% of cardiac structures were evaluated as assessable by at least one evaluator. Mean image quality was lower for robotic (1.6 ± 0.3) compared to standard clinical examinations (2.5 ± 0.4) (p = 0.001). Left ventricular fractional shortening from the robotic examinations was 2.2%, p = 0.160 (absolute value) lower compared to the reference and showed a variation coefficient of 19%. The calculated Doppler insonation angles deviated from the reference by more than 25° for three of four blood flow velocity measurements. The teleoperated examinations had a mean examination time of 26.4 min and were 1.9 times longer compared to the reference (p = 0.001).</p></div><div><h3>Conclusion</h3><p>This feasibility study of teleoperated echocardiography shows promising results for the presented system. Clinically satisfactory imaging, particularly measurements of dimension and velocities, requires further development of the system.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100018"},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49726936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}