WFUMB Ultrasound Open最新文献

{"title":"Volumetric sonographic depiction of the fallopian tube lumen for the early detection of tubal abnormalities: A work in progress","authors":"Jessica P. Miller ,&nbsp;Ryan G. Morrison ,&nbsp;Emily Mechling ,&nbsp;Karen Tisdale ,&nbsp;Katherine Frederick-Dyer ,&nbsp;Brannan B. Griffin ,&nbsp;Ben H. Park ,&nbsp;Lauren S. Prescott ,&nbsp;Marta A. Crispens ,&nbsp;Ronald Alvarez ,&nbsp;Arthur Fleischer","doi":"10.1016/j.wfumbo.2023.100031","DOIUrl":"10.1016/j.wfumbo.2023.100031","url":null,"abstract":"<div><h3>Objectives</h3><p>The fallopian tube (FT) has emerged as an important imaging target in the detection of early ovarian cancer, which has remained an evasive challenge in the field of medicine. Recent understanding of ovarian cancer has identified the distal FT as the site of early tumorigenesis. Evaluation of the FT poses challenges due to the small size and variable anatomic position. This study outlines image acquisition and analysis techniques for volumetric depiction of the FT lumen.</p></div><div><h3>Methods</h3><p>Women with <em>BRCA+</em> ​mutations undergoing risk reduction salpingo-ophorectomy were imaged using contrast-enhanced 3D transvaginal ultrasound (n ​= ​7). Sono-salpingography was conducted with intraluminal contrast instilled through the cervix for improved imaging of the FT lumen. Three-dimensional volumetric data was collected for qualitative and quantitative image analysis. Pathologic correlation was conducted using the Sectioning and Extensively Examining the Fimbriated End Protocol (SEE-FIM).</p></div><div><h3>Results</h3><p>Study subjects underwent 3D imaging with <em>trans</em>-cervical FT lumen contrast enhancement at the time of our interim reporting. None of the subjects in our initial study had serous tubal intraepithelial carcinoma (STIC) lesions, however one had acute inflammation of the FT. The 3D quantitative image analysis demonstrated areas of luminal irregularity corresponding to the regions of inflammation on pathology.</p></div><div><h3>Conclusions</h3><p>Our study shows promise in the detailed evaluation of the FT lumen for the detection of luminal abnormalities. We continue to optimize image acquisition and analysis techniques for the detection of STIC lesions as we enroll additional patients.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 1","pages":"Article 100031"},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000319/pdfft?md5=aa3ec194c44eb5150c491bbd19e25ff9&pid=1-s2.0-S2949668323000319-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138993051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on cerebral emboli detection algorithms","authors":"Ab Waheed Lone ,&nbsp;Ahmet Elbir ,&nbsp;Nizamettin Aydin","doi":"10.1016/j.wfumbo.2023.100030","DOIUrl":"10.1016/j.wfumbo.2023.100030","url":null,"abstract":"<div><p>The increasing availability of biomedical data has attracted the interest of many researchers to understand and perform analysis on extracted patterns from data. Stroke is considered as one of the main causes of deaths worldwide. A considerable amount of work has been performed related to the cause of stroke and other physiological effects. Cerebral emboli is considered as one of the main sources of stroke. Algorithms from one of the traditional subjects called signal processing have been used in cerebral emboli detection and lot of researchers have performed emboli detection and classification using Fourier transform based algorithms and different filtering approaches.</p><p>In this paper, we discuss the physics of Doppler ultrasound and perform review of cerebral emboli detection algorithms and some animal models used in understanding the behaviour, size, and composition of emboli development. Ranging from Fourier transform, wavelet transform based emboli detection to neural network architectures trained with Doppler signal spectra, we performed comprehensive review of signal processing based cerebral emboli detection works and provide some basic understanding of related terms in emboli detection. With natural arterial structural relation between humans and some animals, we highlight some of the animal models used for understanding the nature of emboli development process.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"2 1","pages":"Article 100030"},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000307/pdfft?md5=4d7790d8c5ac67d5efe220f308f7292c&pid=1-s2.0-S2949668323000307-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate hemodynamic effects of transcatheter aortic valve replacement on left ventricular stroke volume and carotid artery blood flow","authors":"Joris van Houte ,&nbsp;Rob Eerdekens ,&nbsp;Erik Dieters ,&nbsp;Mariska te Pas ,&nbsp;Inge Wijnbergen ,&nbsp;Pim Tonino ,&nbsp;Arthur Bouwman","doi":"10.1016/j.wfumbo.2023.100008","DOIUrl":"10.1016/j.wfumbo.2023.100008","url":null,"abstract":"<div><h3>Introduction</h3><p>Transcatheter aortic valve replacement (TAVR) is performed in selected patients with severe aortic valve stenosis, leading to immediate relief of left ventricular outflow obstruction. The purpose of this study was to evaluate the immediate hemodynamic effects of TAVR on left ventricular stroke volume (SV_LVOT) and common carotid artery stroke volume (SV_CCA).</p></div><div><h3>Material and methods</h3><p>Twenty-five TAVR patients were included in this prospective observational study. Patients were treated under either local, or general anesthesia. Echocardiographic, and carotid ultrasound measurements were performed in the operating room pre (T1), and post (T2) TAVR. Changes in SV_LVOT, SV_CCA, carotid peak systolic velocity (PSV), pulsatility index (PI) and other carotid Doppler parameters were evaluated.</p></div><div><h3>Results</h3><p>Following TAVR, the aortic valve area (AVA) increased from 0.8 [0.6–0.9] to 1.9 [1.6–2.3] cm² (p &lt; 0.001), and the peak transvalvular gradient (PG_AV) decreased from 70 [65–81] to 15 [11-18] mm Hg (p &lt; 0.001) from T1 to T2. SV_LVOT increased from 58 ± 17 to 69 ± 24 ml, p &lt; 0.01, whereas SV_CCA remained unchanged (from 10 [7-11] to 10 [8-11] ml, p = 0.50). Δ SV_LVOT was 19 [7–31] % and Δ SV_CCA was 1 [-7-20] %, p &lt; 0.05. PSV increased from 68 ± 17 to 81 ± 17 cm/s, p &lt; 0.001, and PI increased from 1.7 [1.5–2.2] to 2.2 [1.7–2.6], p &lt; 0.001.</p></div><div><h3>Conclusion</h3><p>Successful TAVR resulted in immediate improvement of left ventricular stroke volume, whereas carotid stroke volume remained unchanged.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100008"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000083/pdfft?md5=1f9ea753cecedbdc889544d8d4da2747&pid=1-s2.0-S2949668323000083-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88898639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on how Australian rheumatologists use musculoskeletal ultrasound (MSUS), including challenges and unmet needs","authors":"Zoe Brown ,&nbsp;Fredrick Joshua ,&nbsp;Helen Keen ,&nbsp;Anita Lee","doi":"10.1016/j.wfumbo.2023.100028","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100028","url":null,"abstract":"<div><h3>Objective</h3><p>Worldwide there is increasing use of musculoskeletal ultrasound (MSUS) in clinical practice, particularly by rheumatologists. Despite reported high levels of interest in the use of MSUS, lack of education and experience are often reported as barriers to rheumatologists performing MSUS in clinical practice. To evaluate current MSUS practices in Australia, we undertook a survey of rheumatologists who are current members of an Australian MSUS special interest group.</p></div><div><h3>Methods</h3><p>Descriptive and summary statistics of responses to a web-based survey to rheumatologists who had attended a workshop with the Australian Musculoskeletal Imaging Special Interest Group (AMISIG) were undertaken.</p></div><div><h3>Results</h3><p>Of thirty-six respondents, 97.2 % reported using MSUS as part of clinical care, and more than a quarter also use MSUS for research and teaching. The most frequent indication for MSUS use in 94.4 % of clinicians was for early diagnosis of rheumatic diseases, followed by monitoring response to treatment. Barriers to use of MSUS were identified, including time constraints, costs and lack of training post courses and experience. To support MSUS use in Australia, respondents nominated more “hands-on” supervised training courses and supervision of advanced trainees.</p></div><div><h3>Conclusion</h3><p>MSUS use by surveyed Australian rheumatologists is most frequently to make an early diagnosis of rheumatic diseases as well as in monitoring response to treatments, in research and in teaching activities. Australian clinicians identified that increased clinical education in MSUS, particularly for rheumatology trainees, was needed.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100028"},"PeriodicalIF":0.0,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000289/pdfft?md5=170b032f5667aa2e8c683a5d349ebc34&pid=1-s2.0-S2949668323000289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138396763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative contrast-enhanced ultrasound evaluates the hemodynamic change of cerebral revascularization in adult moyamoya disease: Preliminary results","authors":"Xiandi Zhang ,&nbsp;Wei Ni ,&nbsp;Yinhui Deng ,&nbsp;Yuanxin Xie ,&nbsp;Yu Lei ,&nbsp;Jiabin Su ,&nbsp;Chao Gao ,&nbsp;Liqiong Zhang ,&nbsp;Jinhua Yu ,&nbsp;Yuxiang Gu ,&nbsp;Hong Ding","doi":"10.1016/j.wfumbo.2023.100025","DOIUrl":"10.1016/j.wfumbo.2023.100025","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to determine the feasibility of using intraoperative contrast-enhanced ultrasound (CEUS) to assess subcortical hemodynamic changes in moyamoya disease patients who had undergone combined revascularization. It also aimed to investigate the correlation between quantitative CEUS parameters and post-operative neural functional recovery.</p></div><div><h3>Methods</h3><p>This study included seventeen patients diagnosed with moyamoya disease, confirmed through cerebral angiography, who underwent combined revascularization. Intraoperative subcortical hemodynamics were assessed using CEUS before and immediately after cerebrovascular bypass. Hemodynamic parameters were calculated by analyzing the time-intensity curve generated from a defined region of interest in each CEUS video. Post-operative neurological symptoms, computed tomography records, and short-term modified Rankin Scale (mRS) scores were also recorded.</p></div><div><h3>Results</h3><p>During the post-operative follow-up, 29.4 % of the patients experienced new neurological symptoms, including epilepsy, dyskinesia, and language impairment. Overall, CEUS quantitative parameters suggested that blood supply improved after surgery. And certain hemodynamic parameters exhibited a stronger correlation with the mRS scores, with correlation coefficients ranging up to 0.73 (<em>p</em> &lt; 0.01). However, no statistically significant differences were observed among the different functional groups. The advanced parameter of wash-out intensity (<span><math><mrow><mi>δ</mi></mrow></math></span> WOI), which signifies the rate of change at the point when blood flow is completely washed out, demonstrated a significant difference between two functional groups (<em>p</em> = 0.02) and exhibited a correlation with mRS scores (correlation coefficients: 0.55, <em>p</em> = 0.02).</p></div><div><h3>Conclusions</h3><p>This preliminary study suggests that quantitative intraoperative CEUS can measure subcortical hemodynamic changes. It provides a novel non-invasive method that may predict the short-term post-operative neural functional recovery of combined revascularization in moyamoya disease patients.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100025"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000253/pdfft?md5=c78038aef31638604a0df3095b2143e0&pid=1-s2.0-S2949668323000253-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135765654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pupillary clonus - an abnormal pupillary unrest on POCUS of pupil in patients with altered sensorium","authors":"Priyanka Modi,&nbsp;Sanjeev Bhoi,&nbsp;Savan Pandey","doi":"10.1016/j.wfumbo.2023.100027","DOIUrl":"10.1016/j.wfumbo.2023.100027","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100027"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000277/pdfft?md5=3e2a7e669c2eb3c023bb16eefd6b44a7&pid=1-s2.0-S2949668323000277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135764399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sono-clinical decision rule for repeat head computed tomography scan in traumatic brain injury in emergency settings","authors":"Priyanka Modi,&nbsp;Sanjeev Bhoi,&nbsp;Savan Pandey","doi":"10.1016/j.wfumbo.2023.100026","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100026","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100026"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949668323000265/pdfft?md5=b87593cd0197f2499620bc45a438816b&pid=1-s2.0-S2949668323000265-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92149048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric contrast-enhanced ultrasound in Nordic hospitals","authors":"Alvaro Torres ,&nbsp;Björn Fischler ,&nbsp;Seppo K. Koskinen","doi":"10.1016/j.wfumbo.2023.100024","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100024","url":null,"abstract":"","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The updated roles of new ultrasound imaging techniques in assessing carotid vulnerable plaques","authors":"Yangyang Cheng ,&nbsp;Aidi Wu ,&nbsp;Michael Ying ,&nbsp;Xiangyan Chen","doi":"10.1016/j.wfumbo.2023.100023","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100023","url":null,"abstract":"<div><p>Carotid atherosclerosis, a subtype of large artery atherosclerosis, is a significant contributor to ischemic stroke events. Considering the pivotal role of ultrasound in assessing carotid artery pathology, this review emphasizes its application in visualizing carotid atherosclerosis, with a particular interest in distinguishing stable from vulnerable carotid plaques. Recent advancements have improved our understanding of the relationship between plaque stability and ischemic stroke. This has motivated a comparative analysis of cutting-edge ultrasound techniques to evaluate extracranial carotid plaque, particularly focusing on areas of intraplaque vulnerability. The B-Mode remains the standard first-line imaging modality for both detecting carotid plaques and their morphology. However, its diagnostic potential is typically realized during the intermediate to advanced stages of atherosclerosis. In contrast, the latest innovations in ultrasound imaging techniques, such as contrast-enhanced ultrasound (CEUS), shear wave elastography (SWE), grayscale median (GSM), and the refined Doppler method (superb microvascular imaging, SMI), offer a detailed quantitative approach to categorize carotid plaques into “stable” or “vulnerable” categories. Their application, however, is not widespread in outpatient settings due to factors such as exorbitant costs, extended imaging duration, and a prevalent lack of technical knowledge among healthcare providers. Beyond conventional echogenicity markers, both CEUS and SMI imaging possess the capability to evaluate intraplaque neovascularization, illuminating deep and microvessels within hypoechoic plaques. This aids in identifying high-risk plaque attributes, such as morphological irregularities and ulcerations, which are paramount for risk stratification and monitoring therapeutic responses. SWE offers insights into tissue rigidity and carotid plaque constituents, such as the fibrous cap and lipid core by gauging shear wave velocity and quantifying shear deformation with a specificity of 66.7 % which is higher than that of CEUS (58.3 %). Therefore, a multiparametric ultrasound approach offers a viable strategy for a holistic evaluation of carotid plaques. The timely identification of susceptible plaques can tailor therapeutic interventions, potentially averting cerebrovascular incidents, including acute ischemic strokes (AIS) and transient ischemic attacks (TIA).</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound characteristics of Hashimoto’s thyroiditis in the subclinical stages of the disease","authors":"Nikolaos Angelopoulos ,&nbsp;Dimitrios G. Goulis ,&nbsp;Ioannis Chrisogonidis ,&nbsp;Evanthia Giannoula ,&nbsp;Ioannis Iakovou","doi":"10.1016/j.wfumbo.2023.100022","DOIUrl":"https://doi.org/10.1016/j.wfumbo.2023.100022","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the prognostic value of indicators from b-mode ultrasound, color Doppler ultrasound, and strain elastography of the thyroid gland in the diagnosis of Hashimoto's thyroiditis (HT).</p></div><div><h3>Methods</h3><p>In 70 euthyroidal patients with HT, demographic characteristics, serum thyroid profile and ultrasound parameters, including thyroid gland size, vascularity and stiffness (elastography strain index) of the parenchyma, and flow indices of the superior and inferior thyroid artery were recorded. The control group consisted of 70 age and weight matched euthyroid individuals with negative anti-thyroid antibodies (anti-TPO and anti-Tg).</p></div><div><h3>Results</h3><p>A significant difference was observed between the two groups in total thyroid size (ml, median ± standard deviation, SD) 7.86 ± 2.9 in HT vs. 6.35 ± 2.7 ml in controls, p = 0.003) and parenchymal vascularity which was increased in patients with HT (p &lt; 0.001). Tissue strain index was higher in the HT group but without reaching statistical significance In logistic regression, thyroid size (odds ratio 1.20, 95% confidence interval: 1.02–1.41, p = 0.022) demonstrated significant prognostic value for the presence of HT. No differences were found between the two groups, regarding the peak systolic velocity (PSV), end-diastolic volume (EDV), pulsatility index (PI) and resistive index (RI) values of the thyroid arteries. In the ROC analysis (AUC 0.653, p = 0.002), a thyroid size &gt;7.3 ml exhibited sensitivity of 61.43% and specificity of 72.6% for the diagnosis of HT.</p></div><div><h3>Conclusion</h3><p>Patients with HT exhibit larger thyroid size and increased intrathyroidal vascularity on ultrasound prior to the manifestation of hypothyroidism compared to the healthy population. Flow indices of the superior thyroid artery do not have prognostic value in the diagnosis of HT.</p></div>","PeriodicalId":101281,"journal":{"name":"WFUMB Ultrasound Open","volume":"1 2","pages":"Article 100022"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49712288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}