Tetrahedron Green Chem最新文献

{"title":"Photocatalysed eosin Y mediated synthesis of biologically potent 4 (3H)-quinazolinone","authors":"Pravin Kumar Singh ,&nbsp;Rohit Kumar ,&nbsp;Vishal Srivastava ,&nbsp;Praveen Pratap Singh","doi":"10.1016/j.tgchem.2024.100053","DOIUrl":"10.1016/j.tgchem.2024.100053","url":null,"abstract":"<div><p>An environmentally benign green and metal-free visible light mediated approach for the synthesis of biologically potent 4(3<em>H</em>)-quinazolinone through multicomponent reaction of readily available starting materials potassium salt of anthranilic acid, aryl carboxylic acid, aliphatic/aromatic amine catalyzed by Eosin-Y has been developed with wide range of applications in pharmaceutical. Integrated process reduces the mechanical loss of the intermediate during the process of isolation.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"4 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000189/pdfft?md5=b970972161ba3791712b7c51a6eac168&pid=1-s2.0-S2773223124000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent-free microwave reactions towards significant organic transformations: A green approach","authors":"Animesh Mondal ,&nbsp;Chhanda Mukhopadhyay","doi":"10.1016/j.tgchem.2024.100054","DOIUrl":"10.1016/j.tgchem.2024.100054","url":null,"abstract":"<div><p>The electromagnetic radiation from microwave irradiation has been widely employed as a heating source in various significant organic transformations over the past two decades. The method, without adding any solvent while tied to microwave treatment, is acompletely environmentally benign platform with conspicuous advancements and has resulted in copious advantages with regards to rate of reaction and yield of the products compared to the other classical techniques. Therefore, in this review, we have attempted to summarize some recently developed organic reactions based on microwave-radiated solvent-free protocols, which would be very efficient for academic and industrial use without affecting the principles of green chemistry.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"4 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000190/pdfft?md5=13bc8931d179a06382febe54ab35a9c3&pid=1-s2.0-S2773223124000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142171959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pd-catalysed one-pot and three-component sequential chemoselective double cross-coupling: Synthesis of novel 2-aryl-1,3-azoles from 4-bromophenyl tosylate","authors":"Imamhusen Jamadar ,&nbsp;Athmanand Anchi ,&nbsp;Sunita Kurahatti ,&nbsp;Vinod S. Jadhav ,&nbsp;Shruti S. Malunavar ,&nbsp;Rajesh G. Kalkhambkar ,&nbsp;Mahaveer D. Kurkuri","doi":"10.1016/j.tgchem.2024.100051","DOIUrl":"10.1016/j.tgchem.2024.100051","url":null,"abstract":"<div><p>One of the principles of green and sustainable chemistry is to use green solvents and one-pot synthetic methods which can eliminate the need for drawn-out separation procedures, purification of intermediate compounds, and the production of waste by-products. Considering these concepts of green and sustainable chemistry, an efficient and novel chemoselective one-pot strategy has been developed for the novel synthesis of 2-Aryl-1,3-azoles <em>via</em> Suzuki and Heck cross-coupling reactions via C-2 arylation of azoles under the discriminate temperature using an ionic liquid as green solvent, promoter and ligand. The chemoselective one-pot synthesis, wide substrate scope, moderate to excellent isolated yield of pure products, mild reaction conditions and recycling/reuse of ionic liquid are highlights of this work.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"4 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000165/pdfft?md5=83298baeb1565f71e0c2df6bace58243&pid=1-s2.0-S2773223124000165-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organobase catalyzed synthesis of pyranopyrazoles with X-ray crystallography, docking and ADME studies","authors":"Md. Musawwer Khan ,&nbsp;Bhoomika Singh ,&nbsp;Anam Arif ,&nbsp;Saigal ,&nbsp;Subash C. Sahoo","doi":"10.1016/j.tgchem.2024.100050","DOIUrl":"10.1016/j.tgchem.2024.100050","url":null,"abstract":"<div><p>An organobase assisted approach is adopted to synthesize pyranopyrazole derivatives in one pot. Three-component condensation reaction of 3-methylpyrazolin-5-ones, aromatic aldehydes and malononitrile were catalyzed by 5 mol% of 4-dimethylaminopyridine (DMAP) in ethanol at room temperature. Key aspects of this approach are simple filtration without the need of time-consuming column purification; good yields; cost-effectiveness and use of easily available solid organo-base as a catalyst. A broad substrate scope and variety of functional group tolerance permit diversity generation in a one pot operation. In silico, molecular-docking studies of the compounds were performed with anti-inflammatory active drugs <em>i.e. indomethacin</em> and <em>celecoxib</em> and the compounds were also studied for their pharmacokinetic properties absorption, distribution, metabolism, and excretion (ADME). The results obtained for most of the synthesized compounds are promising and all of them comply well satisfying the Lipinski rule of 5 (RO5) with 0 violation.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"4 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000153/pdfft?md5=ae89f53e86e94845b5ee25e5c6f88d4f&pid=1-s2.0-S2773223124000153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in the catalytic applications of tin dioxide-based materials in the synthesis of bioactive heterocyclic compounds","authors":"Bhaskarjyoti Borah ,&nbsp;Sushmita Banerjee ,&nbsp;Bharat Kumar Allam","doi":"10.1016/j.tgchem.2024.100048","DOIUrl":"https://doi.org/10.1016/j.tgchem.2024.100048","url":null,"abstract":"<div><p>Metal oxides are versatile catalysts in organic synthesis, exhibiting diverse properties such as acidity, basicity, redox behaviour, and stability. Among these, tin dioxide (SnO₂) stands out for its resilience and durability, making it a preferred catalyst. The reduced ionic character and high oxidation state (+4) of tin dioxide contribute to its heightened acidity. Tin dioxide based materials have gained significant attention as catalysts in heterocycle synthesis, cross-coupling, decarboxylation, ring-opening and ring-closing reactions, biodiesel synthesis, and glycerol transformations. Additionally, SnO₂-based materials are also employed as photocatalysts and photo-electrocatalysts.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"4 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277322312400013X/pdfft?md5=e464c211732f4e99caf946b503a3538a&pid=1-s2.0-S277322312400013X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141480487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular electro- and photocatalytic approach to artificial nitrogen fixation for the synthesis of green ammonia","authors":"Ottavia Bettucci ,&nbsp;Giorgia Salerno ,&nbsp;Norberto Manfredi ,&nbsp;Alessandro Abbotto","doi":"10.1016/j.tgchem.2024.100040","DOIUrl":"https://doi.org/10.1016/j.tgchem.2024.100040","url":null,"abstract":"<div><p>Ammonia (NH₃) stands as a cornerstone compound across industries, pivotal in agriculture, chemicals, and energy sectors. However, the conventional Haber-Bosch process demands high pressures, temperatures, and fossil fuels, calling for sustainable alternatives. Electrocatalytic Nitrogen Reduction Reactions (E-NRRs) and Photocatalytic Nitrogen Reduction Reactions (Photo-NRRs) present innovative routes, leveraging electricity and direct sunlight to convert nitrogen (N₂) to NH₃ under mild conditions, reducing emissions and softening energy requirements. Catalysts play a strategic role in these approaches, overcoming activation barriers and enhancing efficiency. However, some challenges still need to be addressed. Indeed, noble metals exhibit limits and their scarcity, geopolitical involvement, and often fluctuating costs inhibit large-scale use. Non-noble metals offer promise but require optimization and face durability concerns. Finally, carbon-based catalysts present challenges in optimization and doping. In this scenario, a molecular-based approach, comprising both specific single coordination-based molecules with transition metal centres and either metal centre coordination-based or fully organic multi-dimensional networks originating from direct molecular organic precursors, overcomes these issues while keeping the benefits of the previously mentioned classes of compounds. This mini-review explores the molecular approach to E-NRRs and Photo-NRRs from coordination compounds carrying porphyrins and phthalocyanines as organic ligands to polymeric networks based on coordination compounds between metallic centres and organic ligands (Metal-Organic Frameworks), and to networks of molecular organic units into multi-dimensional structures (Covalent Organic Frameworks). Mechanistic insights into E-NRRs and Photo-NRRs pathways elucidate N₂ conversion to NH₃. A critical comparative evaluation of reported catalysts has been carried out to highlight the limits and the possibilities of each class of compounds. Although challenges persist in terms of stability, cost and complexity of the synthesis, the use of a molecular approach in NRRs represents one of the most promising routes towards the sustainable preparation of ammonia.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"3 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000050/pdfft?md5=601c1bf44d21dd9b1e68d936859e2200&pid=1-s2.0-S2773223124000050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalyst-free synthesis of substituted benzimidazoles and benzothiazoles in a sustainable solvent","authors":"R. Bernadett Vlocskó ,&nbsp;Manisha Mishra ,&nbsp;A. Ioana Stoica,&nbsp;Leila Gustin,&nbsp;Béla Török","doi":"10.1016/j.tgchem.2023.100035","DOIUrl":"https://doi.org/10.1016/j.tgchem.2023.100035","url":null,"abstract":"<div><p>A catalyst-free synthesis of various 2-alkyl or aryl-substituted benzothiazoles and benzimidazoles has been developed at room temperature by simply combining alkyl or arylaldehydes with <em>ortho</em>-phenylenediamines and 2-aminothiophenols, respectively. The synthesis of these widely applicable fused heterocycles is often challenging and requires additives. The advantages of this new benign procedure include: products with nearly quantitative yields, high atom economy and no toxic waste formation, catalyst-free process with no need for catalyst separation and/or recycling, the use of a green and sustainable solvent, ethanol, and mostly room temperature reactions with moderate reaction times to ensure that the protocol is energetically favorable.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"3 ","pages":"Article 100035"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223123000341/pdfft?md5=9a34f2c34f02019aae2627073cea49a2&pid=1-s2.0-S2773223123000341-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valorization of biomass platform molecules through one-pot cascade processes using heterogeneous catalysts","authors":"Karen S. Arias,&nbsp;Alexandra Velty,&nbsp;Maria J. Climent,&nbsp;Sara Iborra","doi":"10.1016/j.tgchem.2024.100037","DOIUrl":"https://doi.org/10.1016/j.tgchem.2024.100037","url":null,"abstract":"<div><p>The transformation of biomass derived platform molecules is an interesting approach to produce valuable chemicals from biomass. In addition, process intensification by reducing the number of steps for final chemicals production by performing cascade-type catalytic reactions in one-pot mode is largely desirable in a biorefinery facility. In this review the possibilities of valorization of representative platform molecules such as sugars, itaconic and levulinic acids and furanic aldehydes through one-pot cascade processes using mono and multifunctional heterogeneous catalysts are illustrated through selected examples.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"3 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000025/pdfft?md5=bf0bd60a02807bbc335bd69d8e72e07a&pid=1-s2.0-S2773223124000025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"K2CO3-catalyzed highly efficient O and N-acylation under mild conditions","authors":"Haiyang Wang ,&nbsp;Jing Lu ,&nbsp;Mingjiang Wu ,&nbsp;Yumei Zhang","doi":"10.1016/j.tgchem.2024.100041","DOIUrl":"https://doi.org/10.1016/j.tgchem.2024.100041","url":null,"abstract":"<div><p>An eco-friendly, mild and efficient acylation of various nucleophiles with alkenyl carboxylates via inorganic base catalysis is described. Among five inorganic base species examined, K₂CO₃ was proved to be the most efficient catalyst for the acylation. A broad variety of acylated products were achieved within 15 min at room temperature in high yields. In addition, we found that the 3-position of indoles should have a suitable substituent group under this procedure.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"3 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000062/pdfft?md5=3dee0134e624e47cdb0172e74320ed1d&pid=1-s2.0-S2773223124000062-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140918499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ionic liquid Mediated Pd-catalyzed sonochemistry for facile synthesis of carbazoles: Molecular Modelling and antimicrobial studies","authors":"Imamhusen Jamadar ,&nbsp;Athmanand Anchi ,&nbsp;Shruti S. Malunavar ,&nbsp;Rajesh G. Kalkhambkar ,&nbsp;Suraj M. Sutar ,&nbsp;Shrinivas D. Joshi","doi":"10.1016/j.tgchem.2024.100038","DOIUrl":"https://doi.org/10.1016/j.tgchem.2024.100038","url":null,"abstract":"<div><p>Herein we have described the Pd-catalyzed sonochemistry driven by [BMIM]-IL as re-useable solvent to synthesize various carbazole scaffolds from 2,2′-dibromodiphenyl. Diverse primary amines were utilised as coupling partners in the presence of [PAIM][NTf₂], which exhibits an impactful promoter in the IL medium, thereby avoiding the need for hazardous VOC's. The recyclability of ionic liquids highlights the green approach of the reaction. Further, the synthesized carbazole scaffolds were assessed for antimicrobial activity. Compounds 3e and 3g are found to be highly active. The most probable binding sites for these scaffolds were screened through a computer-simulated docking method with targeted protein.</p></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"3 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773223124000037/pdfft?md5=5a7903c8226622d3fc4bd6ab46008779&pid=1-s2.0-S2773223124000037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139743278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}