Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Cognitive performance as a health indicator: Lessons from the Spanish version of the mini-mental","authors":"Antonio Lobo M.D., Ph.D. Emeritus Professor","doi":"10.1016/j.sjpmh.2025.04.001","DOIUrl":"10.1016/j.sjpmh.2025.04.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 2","pages":"Pages 82-83"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic pathways and mortality across psychotic disorders: Evidence from Catalonia integrated health records","authors":"Santiago Madero,&nbsp;Gerard Anmella,&nbsp;Michele De Prisco,&nbsp;Vincenzo Oliva,&nbsp;Clàudia Valenzuela-Pascual,&nbsp;Ariadna Mas,&nbsp;Giovanna Fico,&nbsp;Andrea Murru,&nbsp;Marc Valentí,&nbsp;Jordi Blanch,&nbsp;Clemente Garcia-Rizo,&nbsp;Vicent Llorca-Bofí,&nbsp;Silvia Amoretti,&nbsp;Norma Verdolini,&nbsp;Miquel Bioque,&nbsp;Eduard Parellada,&nbsp;Eduard Vieta,&nbsp;Diego Hidalgo-Mazzei","doi":"10.1016/j.sjpmh.2025.02.001","DOIUrl":"10.1016/j.sjpmh.2025.02.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Although psychotic disorders are associated with significant morbidity and mortality, the diagnostic trajectories and mortality risks across the spectrum of these disorders remain poorly understood. This study aimed to characterize diagnostic pathways and compare mortality outcomes across psychotic disorders in Catalonia.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study using electronic health records of 357,007 adults accessing mental health services in Catalonia from 2015 through 2019. Diagnostic categories included schizophrenia, bipolar disorder, schizoaffective disorder, delusional disorder, other non-organic psychoses, unipolar psychotic depression, and other mental health diagnoses. Cox proportional hazards models assessed mortality risk, adjusting for sociodemographic factors and comorbidities.</div></div><div><h3>Results</h3><div>About one-third of the sample received their first psychotic disorder diagnosis in specialized care. All psychotic disorders showed elevated mortality risk vs other mental health conditions. Schizophrenia had the highest risk (HR, 2.63; 95%CI, 2.46–2.81, <em>p</em> <!-->&lt;<!--> <!-->0.001 followed by schizoaffective (HR, 1.99; 95%CI, 1.77–2.24, <em>p</em> <!-->&lt;<!--> <!-->0.001) and delusional disorders (HR, 1.92; 95%CI, 1.66–2.21, <em>p</em> <!-->&lt;<!--> <!-->0.001). Low socioeconomic status (HR, 3.69; 95%CI, 3.48–3.92, <em>p</em> <!-->&lt;<!--> <!-->0.001) and comorbidities (HR, 1.82 per comorbidity; 95%CI, 1.81–1.83, <em>p</em> <!-->&lt;<!--> <!-->0.001) were significant predictors of mortality across diagnoses. Gradient boosting machine modeling identified comorbidities (56.07%) and diagnostic category (24.51%) as top predictors of mortality risk.</div></div><div><h3>Conclusions</h3><div>This study demonstrates significantly elevated mortality risk across the spectrum of psychotic disorders in a Southern European context, with socioeconomic factors and medical comorbidities emerging as critical determinants. These findings underscore the need for integrated care approaches addressing both mental and physical health needs in psychotic disorders.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 2","pages":"Pages 89-98"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of prolactin levels and sexual dysfunction in patients on long-acting risperidone ISM vs monthly paliperidone palmitate","authors":"Javier Labad,&nbsp;Vanesa Gálvez,&nbsp;Miriam Gregorio,&nbsp;Ana Palacio,&nbsp;Yolanda Manzano,&nbsp;Rosa Gabernet,&nbsp;Mireia Borràs,&nbsp;Marta Niubó,&nbsp;Sara Silles,&nbsp;Alba Toll,&nbsp;Alicia Ruiz,&nbsp;Miquel Ragull,&nbsp;Rosa Hernández-Ribas","doi":"10.1016/j.sjpmh.2025.10.001","DOIUrl":"10.1016/j.sjpmh.2025.10.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Hyperprolactinaemia and sexual dysfunction are common adverse effects of antipsychotic drugs, particularly with dopamine D2 receptor antagonists. Long-acting injectables such as paliperidone palmitate (PP) and risperidone ISM may differ in their endocrine safety profiles, especially across sexes. We aimed to compare prolactin levels and clinically significant sexual dysfunction in patients treated with risperidone ISM vs monthly PP.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study including 59 patients with psychotic disorders (27 on risperidone ISM, 32 on PP). Clinically significant hyperprolactinaemia was defined as prolactin levels above sex-specific thresholds along with hypogonadism and/or sexual dysfunction. The Arizona Sexual Experience Scale was used to assess sexual function. Hormonal assays included prolactin, testosterone, and oestradiol. Prolactin values were log-transformed for regression models. Multiple linear regression assessed predictors of prolactin, including treatment, sex, age, dose, co-treatment with aripiprazole or other antipsychotics, and sex-by-treatment interaction. An exploratory logistic regression examined predictors of clinically significant hyperprolactinemia (with either hypogonadism or sexual dysfunction).</div></div><div><h3>Results</h3><div>Women on PP showed significantly higher prolactin levels vs those on risperidone ISM (interaction between female sex and PP; <em>p</em> <!-->=<!--> <!-->0.002). Aripiprazole co-treatment was associated with lower prolactin levels (<em>p</em> <!-->=<!--> <!-->0.020). Clinically significant hyperprolactinaemia was present in 55.6% of the risperidone ISM group vs 68.8% of the PP group. The exploratory logistic regression model revealed no significant predictors of clinically significant hyperprolactinaemia.</div></div><div><h3>Conclusion</h3><div>Risperidone ISM may be associated with a more favourable prolactin profile in women vs PP. Findings support the relevance of sex and adjunctive strategies in managing antipsychotic-induced endocrine side effects.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 2","pages":"Pages 84-88"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of innovation: Challenges and perspectives in mental health","authors":"Marina Díaz-Marsá","doi":"10.1016/j.sjpmh.2026.03.003","DOIUrl":"10.1016/j.sjpmh.2026.03.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 2","pages":"Pages 75-78"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood-based immune biomarkers and functional outcomes in acute schizophrenia: A retrospective cohort study","authors":"Vicent Llorca-Bofí,&nbsp;Miquel Bioque,&nbsp;Samuel Pàmpols-Pérez,&nbsp;Esther Buil-Riné,&nbsp;Marina Adrados-Pérez,&nbsp;Eugènia Nicolau-Subires,&nbsp;Lucia Ibarra-Pertusa,&nbsp;Carla Albert-Porcar,&nbsp;Andrea Jiménez-Mayoral,&nbsp;Belén Resa-Pérez,&nbsp;Maria Font,&nbsp;Maria Mur","doi":"10.1016/j.sjpmh.2026.02.006","DOIUrl":"10.1016/j.sjpmh.2026.02.006","url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia is a chronic psychiatric disorder characterized by acute relapses and significant functional impairment. While antipsychotic medications are effective in managing acute episodes, many patients fail to achieve functional remission. Recent research suggests that immune mechanisms may influence treatment outcomes, yet studies focusing on the relationship between immune biomarkers and functional recovery are limited.</div></div><div><h3>Objective</h3><div>This study aims to evaluate whether blood-based immune biomarkers can predict functional response and remission in patients with acute schizophrenia.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted with 354 inpatients diagnosed with schizophrenia, admitted to an acute psychiatric unit between January 2010 and December 2020. Sociodemographic, clinical, and immune biomarker data were extracted from electronic records. Functional outcomes were measured using Global Assessment of Functioning (GAF) scores at admission and discharge. Immune biomarkers assessed included white blood cell counts, ratios and C-reactive protein. Functional response was defined as a GAF score improvement &gt;40 points, while functional remission was defined as a GAF score ≥70 at discharge.</div></div><div><h3>Results</h3><div>Higher leukocyte counts increased the risk of non-functional response, while a higher platelet–lymphocyte ratio (PLR) was a protective factor. Additionally, Higher lymphocyte and platelet counts were protective against non-functional remission. However, the predictive performance for both functional response and remission was limited, with an AUC ranging from 0.53 to 0.61.</div></div><div><h3>Conclusion</h3><div>Immune biomarkers, particularly leukocyte counts, PLR, and lymphocyte counts, show significant associations with functional outcomes in acute schizophrenia. However, their predictive value for clinical practice remains limited.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"19 2","pages":"Pages 119-126"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic stigma in mental health: When burden and investment diverge.","authors":"Lucas Giner, Diego de la Vega, Philippe Courtet","doi":"10.1016/j.sjpmh.2026.02.005","DOIUrl":"10.1016/j.sjpmh.2026.02.005","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147505878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between social cognition and inflammatory markers in eating disorders and borderline personality disorder.","authors":"Carla da Vila, Karina MacDowell, Jorge Álvarez, Pablo Mola, Álvaro Carrasco, Juan Carlos Leza, José Luis Carrasco, Celia Hernández, Alejandro de la Torre-Luque, Marina Díaz Marsá","doi":"10.1016/j.sjpmh.2026.02.003","DOIUrl":"10.1016/j.sjpmh.2026.02.003","url":null,"abstract":"<p><strong>Introduction/objectives: </strong>Eating disorders (EDs) and borderline personality disorder (BPD) are severe psychiatric conditions characterized by emotional dysregulation and impairments in social cognition. Growing evidence suggests that inflammatory and oxidative stress pathways may contribute to their pathophysiology. The present study aimed to explore the association between social cognition performance and immune-inflammatory and oxidative stress biomarkers in individuals with BPD, restrictive ED (EDR), and purging ED (EDP) vs healthy controls (HC), using a pathway-based psychoneuroimmunological approach.</p><p><strong>Methods: </strong>We studied a total of 100 adult women (EDR, EDP, BPD, and HC) using the Movie for the Assessment of Social Cognition (MASC) and a comprehensive clinical battery. Blood samples were drawn to quantify inflammatory, oxidative stress, and antioxidant biomarkers, including intracellular signaling pathways. Group comparisons and group-specific Bayesian Lasso regression analyses were conducted to examine within-group associations between biomarkers and social cognition outcomes, controlling for relevant clinical and demographic covariates.</p><p><strong>Results: </strong>Participants with BPD and EDP showed greater psychological dysregulation, higher impulsivity, and increased activation of pro-inflammatory and oxidative stress pathways vs HC. The EDR group displayed an intermediate biological and clinical profile. Social cognition impairments were observed across clinical groups, with BPD participants exhibiting the highest hypomentalization. Exploratory regression analyses revealed diagnosis-specific associations between social cognition performance and immune-inflammatory pathways, particularly involving markers related to p38 MAPK, JNK, COX-2, and oxidative stress, with no significant associations observed in healthy controls.</p><p><strong>Conclusions: </strong>The findings support a psychoneuroimmunological model in which social cognition impairments are associated with diagnosis-specific interactions between immune-inflammatory regulation and clinical phenotype in EDs and BPD. Because of the exploratory and cross-sectional design, these results should be considered hypothesis-generating and warrant replication in longitudinal studies.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147367963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Francesc Tosquelles: Pioneer of institutional psychotherapy.","authors":"Antonio Labad","doi":"10.1016/j.sjpmh.2026.02.001","DOIUrl":"10.1016/j.sjpmh.2026.02.001","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of suicidal ideation and suicide attempts among medical professionals in Argentina: A cross-sectional, observational study.","authors":"Julieta Ramirez, Ricardo Corral, Alejo Corrales, Federico Rebok","doi":"10.1016/j.sjpmh.2026.01.004","DOIUrl":"10.1016/j.sjpmh.2026.01.004","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disruption in Access to Essential Drugs: The Anafranil Shortage in Spain.","authors":"Carolina Donat-Vargas, Emilio Pol-Yanguas, Carlos Chiclana","doi":"10.1016/j.sjpmh.2025.12.006","DOIUrl":"10.1016/j.sjpmh.2025.12.006","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146151693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}