Spanish Journal of Psychiatry and Mental Health最新文献

{"title":"Negative symptoms and sex differences in first episode schizophrenia: What's their role in the functional outcome? A longitudinal study","authors":"Silvia Amoretti ,&nbsp;Gisela Mezquida ,&nbsp;Norma Verdolini ,&nbsp;Miquel Bioque ,&nbsp;Ana M. Sánchez-Torres ,&nbsp;Laura Pina-Camacho ,&nbsp;Iñaki Zorrilla ,&nbsp;Amira Trabsa ,&nbsp;Roberto Rodriguez-Jimenez ,&nbsp;Iluminada Corripio ,&nbsp;Salvador Sarró ,&nbsp;Angela Ibañez ,&nbsp;Judith Usall ,&nbsp;Rafael Segarra ,&nbsp;Eduard Vieta ,&nbsp;Natalia Roberto ,&nbsp;Josep Antoni Ramos-Quiroga ,&nbsp;Alfonso Tortorella ,&nbsp;Giulia Menculini ,&nbsp;Manuel J. Cuesta ,&nbsp;M. Paz Portilla","doi":"10.1016/j.sjpmh.2023.04.001","DOIUrl":"10.1016/j.sjpmh.2023.04.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect and are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted affect and alogia) and amotivation/pleasure (MAP) (anhedonia, avolition, asociality). The aim of this article was to examine potential sex differences among first-episode schizophrenia (FES) patients and analyze sex-related predictors of two NS symptoms factors (EXP and MAP) and functional outcome.</div></div><div><h3>Material and methods</h3><div>Two hundred and twenty-three FES (71 females and 152 males) were included and evaluated at baseline, six-months and one-year. Repeated measures ANOVA was used to examine the effects of time and sex on NS and a multiple linear regression backward elimination was performed to predict NS factors (MAP-EXP) and functioning.</div></div><div><h3>Results</h3><div>Females showed fewer NS (<em>p</em> <!-->=<!--> <!-->0.031; Cohen's <em>d</em> <!-->=<!--> <!-->−0.312), especially those related to EXP (<em>p</em> <!-->=<!--> <!-->0.024; Cohen's <em>d</em> <!-->=<!--> <!-->−0.326) rather than MAP (<em>p</em> <!-->=<!--> <!-->0.086), than males. In both male and female group, worse premorbid adjustment and higher depressive symptoms made a significant contribution to the presence of higher deficits in EXP at one-year follow-up, while positive and depressive symptoms predicted alterations in MAP. Finally, in females, lower deficits in MAP and better premorbid adjustment predicted better functioning at one-year follow-up (<em>R</em>² <!-->=<!--> <!-->0.494; <em>p</em> <!-->&lt;<!--> <!-->0.001), while only higher deficits in MAP predicted worse functioning in males (<em>R</em>² <!-->=<!--> <!-->0.088; <em>p</em> <!-->=<!--> <!-->0.012).</div></div><div><h3>Conclusions</h3><div>Slightly sex differences have been found in this study. Our results lead us to consider that early interventions of NS, especially those focusing on motivation and pleasure symptoms, could improve functional outcomes.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 91-99"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schizophrenia and the COVID-19 pandemic: A narrative review from the biomedical perspective","authors":"Krzysztof Kowalski,&nbsp;Błażej Misiak","doi":"10.1016/j.rpsm.2023.04.002","DOIUrl":"10.1016/j.rpsm.2023.04.002","url":null,"abstract":"<div><div>The outbreak of the Coronavirus Disease 2019 (COVID-19) pandemic in 2020 caused a rapid worsening of global mental health. Patients with severe mental disorders, including schizophrenia, are at higher risk of being infected. The neuroinvasive potential of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has been confirmed. The aim of this article was to present a narrative and comprehensive review of multidimensional associations between schizophrenia and COVID-19 with special emphasis on common biological pathways. Online searches were performed in the PubMed database and covered the publication period until September 17, 2022. Search terms included “psychosis”, “schizophrenia”, “inflammation” and “COVID-19”. Viewed as a neuroinflammatory state, schizophrenia shares several neurobiological mechanisms with the COVID-19. Environmental stress, common comorbidities of schizophrenia and adverse effects of antipsychotic treatment are associated with the higher severity and mortality of the COVID-19. Additionally, more frequent relapses of psychosis have been observed, and might be related to lower treatment adherence. In the context of clinical manifestation, higher level of negative symptoms has been identified among patients with schizophrenia during the pandemic. Improvements in mental health care policy and treatment adjustment are necessary to protect people with schizophrenia who are the population that is particularly vulnerable to the consequences of the COVID-19 pandemic. Future research will show if prenatal infection with the SARS-CoV-2 increases a risk of psychosis.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 141-148"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9946312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empowering the future of psychiatry: The development of the young psychiatrists section of the Spanish Society of Psychiatry and Mental Health","authors":"Gonzalo Salazar de Pablo ,&nbsp;Claudia Aymerich ,&nbsp;Justo Pinzón-Espinosa","doi":"10.1016/j.sjpmh.2024.09.003","DOIUrl":"10.1016/j.sjpmh.2024.09.003","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 149-151"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142335938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex and substance use in first episode psychosis: Impact on clinical symptoms, psychosocial functioning and cognitive performance","authors":"Gemma Safont ,&nbsp;Marina Garriga ,&nbsp;Silvia Amoretti ,&nbsp;Manuel J. Cuesta ,&nbsp;Mara Parellada ,&nbsp;Ana González-Pinto ,&nbsp;Daniel Bergé ,&nbsp;Roberto Rodriguez-Jimenez ,&nbsp;Alexandra Roldán Bejarano ,&nbsp;Salvador Sarró ,&nbsp;Ángela Ibáñez ,&nbsp;Judith Usall ,&nbsp;Miguel Gutiérrez ,&nbsp;Eduard Vieta ,&nbsp;Belén Arranz ,&nbsp;Esther Berrocoso ,&nbsp;Norma Verdolini ,&nbsp;Miguel Bernardo ,&nbsp;2EPS Group","doi":"10.1016/j.rpsm.2022.03.002","DOIUrl":"10.1016/j.rpsm.2022.03.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Sex differences in first episode of psychosis (FEP) have been widely studied. However, the existence of controversial results may be attributable to not considering relevant factors such as substance use. Cannabis use is associated with an earlier age of onset of psychosis and rates of cannabis use are consistently higher among men. The main objective of this study was to analyze and describe sex differences while considering the presence of substance use and its potential role when predicting age at onset of psychosis.</div></div><div><h3>Material and methods</h3><div>A cross-sectional study of 223 non-affective FEP patients was performed. Participants were divided into “current substance users”, defined as those who reported having used a substance in the past 30 days, and those who did not as “not current substance users”. Descriptive analyses, general linear modeling and multiple regression modeling were used.</div></div><div><h3>Results</h3><div>In the current substance group, women were older, with an older age of onset, a better premorbid adjustment and a higher cognitive reserve while presenting less clinical severity, a better functioning and a better verbal memory performance in comparison with men. In males, but not in females, lifetime of cannabis use and accumulative lifetime substance use was associated with age of onset.</div></div><div><h3>Conclusions</h3><div>Clinical presentation of FEP varies by sex and especially when considering substance use. Our results suggest that early interventions need to be tailored to the different clinical needs of males and females and according to substance consumption in FEP.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 80-90"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85104668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Luis Martín-Santos: A multidimensional psychiatrist","authors":"José Lázaro","doi":"10.1016/j.sjpmh.2024.09.002","DOIUrl":"10.1016/j.sjpmh.2024.09.002","url":null,"abstract":"","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 70-71"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clozapine use in the first two years after first-episode psychosis in a real-world clinical sample","authors":"Emilio Pechuán ,&nbsp;Alba Toll ,&nbsp;Daniel Bergé ,&nbsp;Teresa Legido ,&nbsp;Laura Martínez-Sadurní ,&nbsp;Amira Trabsa ,&nbsp;Gonzalo De Iturbe ,&nbsp;Sara García Fernández ,&nbsp;Beltran Jiménez-Fernández ,&nbsp;Aurea Fernández ,&nbsp;Víctor Pérez-Solà ,&nbsp;Anna Mané","doi":"10.1016/j.sjpmh.2024.06.001","DOIUrl":"10.1016/j.sjpmh.2024.06.001","url":null,"abstract":"<div><h3>Background</h3><div>Approximately 20–30% of patients with schizophrenia fail to respond to antipsychotic<span> treatment and are considered treatment resistant (TR). Although clozapine is the treatment of choice in these patients, in real-world clinical settings, clinicians often delay clozapine initiation, especially in first-episode psychosis (FEP).</span></div></div><div><h3>Aim</h3><div>The main aim of this study was to describe prescription patterns for clozapine in a sample of patients diagnosed with FEP and receiving specialized treatment at a university hospital. More specifically, we aimed to determine the following: (1) the proportion of patients who received clozapine within two years of disease onset, (2) baseline predictors of clozapine use, (3) time from starting the first antipsychotic to clozapine initiation, (4) concomitant medications, and (5) clozapine-related adverse effects.</div></div><div><h3>Methods</h3><div>All patients admitted to a specialized FEP treatment unit at our hospital between April 2013 and July 2020 were included and followed for two years. The following variables were assessed: baseline sociodemographic characteristics; medications prescribed during follow-up; clozapine-related adverse effects; and baseline predictors of clozapine use. We classified the sample into three groups: clozapine users, clozapine-eligible, and non-treatment resistant (TR).</div></div><div><h3>Results</h3><div>A total of 255 patients were consecutively included. Of these, 20 (7.8%) received clozapine, 57 (22.4%) were clozapine-eligible, and 178 (69.8%) were non-TR. The only significant variable associated with clozapine use at baseline was the Global Assessment of Functioning (GAF) score (<em>R</em>² <!-->=<!--> <!-->0.09, <em>B</em> <!-->=<!--> <!-->−0.07; OR<!--> <!-->=<!--> <!-->0.94; 95% CI: 0.88–0.99; <em>p</em> <!-->=<!--> <span>0.019). The median time to clozapine initiation was 55.0 (93.3) days. The most common side effect was sedation.</span></div></div><div><h3>Conclusions</h3><div>A significant proportion (30.2%) of patients in this cohort were treatment resistant and eligible for clozapine. However, only 7.8% of the sample received clozapine, indicating that this medication was underprescribed. A lower baseline GAF score was associated with clozapine use within two years, suggesting that it could be used to facilitate the early identification of patients who will need treatment with clozapine, which could in turn improve treatment outcomes.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 2","pages":"Pages 125-132"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal thickness: A window into cognitive impairment in bipolar disorder.","authors":"Juan Pablo Chart-Pascual, Guillermo Cano-Escalera, Manuel Graña, Iñaki Zorrilla, Purificacion Lopez-Peña, Carmen Martin Requena, Andrea Flores Ceballos, Irene Perez Landaluce, Haritz Urcola, Miguel Angel Alvarez-Mon, Hilary P Blumberg, Joaquim Radua, Ana Gonzalez-Pinto","doi":"10.1016/j.sjpmh.2025.01.001","DOIUrl":"10.1016/j.sjpmh.2025.01.001","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive impairment (CI) in bipolar disorder (BD) significantly impacts overall functioning and quality of life. A better understanding of the neurobiological mechanisms associated with CI is needed. Studies on neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, have revealed promising findings related to retinal thickness alterations using optical coherence tomography (OCT). Similarly, retinal differences between healthy controls and individuals with BD or schizophrenia have been described. This study explores the utility of OCT in discerning retinal changes possibly associated with CI in BD to enhance our understanding of the biological markers of BD and provide additional information to neuropsychological testing.</p><p><strong>Material and methods: </strong>Optical coherence tomography (OCT) was employed to measure retinal thickness in the macular ganglion cell layer (GCL), inner plexiform layer (IPL), retinal nerve fiber layer (RNFL), and peripapillary RNFL (pRNFL) in 50 individuals with bipolar disorder (BD). Associations with cognitive impairments were analyzed using cross-validated Random Forest models.</p><p><strong>Results: </strong>The analysis revealed significant associations between retinal thinning in various segments of the macular GCL, IPL, and RNFL and cognitive impairment (CI) in BD, with particular relevance to executive function deficits (AUC>0.8).</p><p><strong>Conclusions: </strong>Thinning of the GCL, IPL, and RNFL was significantly associated with worse cognitive performance in individuals with BD. Similar patterns have been observed in schizophrenia, highlighting an innovative and promising field for research and clinical application.</p>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and validity of proxy reports of impulsivity and aggression: An evidence-based assessment approach to psychological autopsy methods","authors":"Sergio Sanz-Gómez ,&nbsp;Adrían Alacreu-Crespo ,&nbsp;Julio Antonio Guija ,&nbsp;Lucas Giner","doi":"10.1016/j.sjpmh.2023.10.003","DOIUrl":"10.1016/j.sjpmh.2023.10.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Psychological autopsy methods often include measures of impulsivity and aggression. The aim is to assess their reliability and validity in a Spanish sample.</div></div><div><h3>Methods</h3><div>Cross-sectional web-based survey was fulfilled by 184 proband and proxy pairs. Data was collected on sociodemographic characteristics, impulsivity through Barratt Impulsiveness Scale (BIS-11), aggression through Buss–Perry Aggression Questionnaire (BPAQ), and history of suicide ideation. Proxies filled out BIS-11, BPAQ and suicide ideation with the responses they would expect from the probands. Reliability was assessed using intraclass correlation coefficients (ICC) between proband and proxies. Logistic regression analysis was performed to assess the predictive validity of proxy reports in predicting probands’ suicide ideation.</div></div><div><h3>Results</h3><div>Bivariate analysis showed differences in BPAQ (Median 68 vs. 62; <em>p</em> <!-->=<!--> <!-->0.001), but not in BIS-11 (<em>p</em> <!-->&gt;<!--> <!-->.050). BIS-11 showed good concordance (ICC<!--> <!-->=<!--> <!-->0.754; CI 95% 0.671–0.816) and BPAQ acceptable (ICC<!--> <!-->=<!--> <!-->0.592; CI 95% 0.442–0.699). In the probands regression model BPAQ predicted suicide ideation (OR 1.038; CI 95% 1.016–1.061) but not BIS-11 (OR 0.991; CI 95% 0.958–1.025). In the proxy-report model BPAQ also predicted probands’ suicide ideation (OR 1.036; CI 95% 1.014–1.058) but not BIS-11 (OR 0.973; CI 95% 0.942–1.004).</div></div><div><h3>Conclusion</h3><div>Used as proxy-reported assessment tools, BIS-11 showed better reliability than the BPAQ. However, both showed validity in Spanish population and could be included in psychological autopsy protocols.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 28-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138049125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in clinical response to deep brain stimulation in resistant obsessive-compulsive disorder","authors":"Lorea Mar-Barrutia ,&nbsp;Oliver Ibarrondo ,&nbsp;Javier Mar ,&nbsp;Eva Real ,&nbsp;Cinto Segalàs ,&nbsp;Sara Bertolín ,&nbsp;Marco Alberto Aparicio ,&nbsp;Gerard Plans ,&nbsp;José Manuel Menchón ,&nbsp;Pino Alonso","doi":"10.1016/j.sjpmh.2024.01.006","DOIUrl":"10.1016/j.sjpmh.2024.01.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep brain stimulation (DBS) is an effective alternative to treat severe refractory obsessive-compulsive disorder (OCD), although little is known on factors predicting response. The objective of this study was to explore potential sex differences in the pattern of response to DBS in OCD patients.</div></div><div><h3>Methods</h3><div>We conducted a prospective observational study in 25 patients with severe resistant OCD. Response to treatment was defined as a ≥35% reduction in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score. Logistic regression models were calculated to measure the likelihood of response at short and long-term follow-up by sex as measured by Y-BOCS score. Similar analyses were carried out to study changes in depressive symptomatology assessed with the Hamilton Depression Rating Scale (HDRS). Additionally, effect sizes were calculated to assess clinical significance.</div></div><div><h3>Results</h3><div>We did not observe significant clinical differences between men and women prior to DBS implantation, nor in the response after one year of stimulation. At long-term follow-up, 76.9% of men could be considered responders to DBS versus only 33.3% of women. The final response odds ratio in men was 10.05 with significant confidence intervals (88.90–1.14). No other predictors of response were identified. The sex difference in Y-BOCS reduction was clinically significant, with an effect size of 3.2. The main limitation was the small sample size.</div></div><div><h3>Conclusions</h3><div>Our results suggest that gender could influence the long-term response to DBS in OCD, a finding that needs to be confirmed in new studies given the paucity of results on predictors of response to DBS.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 34-41"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and fMRI-based response predictors to mindfulness-based cognitive therapy in obsessive-compulsive disorder: Study protocol for a randomised clinical trial","authors":"Neus Miquel-Giner ,&nbsp;Muriel Vicent-Gil ,&nbsp;Ignacio Martínez-Zalacaín ,&nbsp;Daniel Porta-Casteras ,&nbsp;Lorea Mar ,&nbsp;Marina López-Solà ,&nbsp;Jessica R. Andrews-Hanna ,&nbsp;Carles Soriano-Mas ,&nbsp;José Manuel Menchón ,&nbsp;Narcís Cardoner ,&nbsp;Pino Alonso ,&nbsp;Maria Serra-Blasco ,&nbsp;Clara López-Solà","doi":"10.1016/j.rpsm.2022.11.002","DOIUrl":"10.1016/j.rpsm.2022.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Around 40–50% of patients with obsessive-compulsive disorder (OCD) suffer from obsessions and compulsions after receiving first-line treatments. Mindfulness-based cognitive therapy (MBCT) has been proposed as a reasonable augmentation strategy for OCD. MBCT trains to decentre from distressful thoughts and emotions by focusing on them voluntarily and with consciousness. This practice develops alternative ways to deal with obsessions, which could increase non-reactivity behaviours and, in turn, reduce compulsions. This study aims to investigate the efficacy of MBCT to improve OCD symptoms. Secondly, it pursues to investigate which socio-demographic, clinical, and neurobiological characteristics mediate or moderate the MBCT response; and identify potential biomarkers of positive/negative response.</div></div><div><h3>Methods</h3><div>This study is a randomised clinical trial (RCT) of 60 OCD patients who do not respond to first-line treatments. Participants will be randomised to either an MBCT program or treatment as usual. The MBCT group will undergo 10 weekly sessions of 120<!--> <!-->min. <em>Principal outcome</em>: change in OCD severity symptoms using clinician and self-reported measures. Also, participants will undergo a comprehensive evaluation assessing comorbid clinical variables, neuropsychological functioning and thought content. Finally, a comprehensive neuroimaging protocol using structural and functional magnetic resonance imaging will be acquired in a 3T scanner. All data will be obtained at baseline and post-intervention.</div></div><div><h3>Discussion</h3><div>This study will assess the efficacy of mindfulness in OCD patients who do not achieve clinical recovery after usual treatment. It is the first RCT in this subject examining clinical, neuropsychological and neuroimaging variables to examine the neural patterns associated with the MBCT response.</div><div>Clinical trials registration: <span><span>NCT03128749</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":101179,"journal":{"name":"Spanish Journal of Psychiatry and Mental Health","volume":"18 1","pages":"Pages 6-12"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41238294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}