Revista Colombiana de Reumatología (English Edition)最新文献

{"title":"Protective effect of propolis against oxidative stress induced by hydrogen peroxide in vitro peripheral blood mononuclear cells","authors":"Luz Elena Triana Vidal,&nbsp;Armando Lucumi Moreno,&nbsp;Ivonne Valeria Ortiz","doi":"10.1016/j.rcreue.2025.06.001","DOIUrl":"10.1016/j.rcreue.2025.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and cellular antioxidant activity. Overproduction of ROS causes oxidative damage to major macromolecules, alters homeostasis and leads to the generation of different pathologies. At present, there is no totally effective treatment to counteract these diseases involved with oxidative stress, so it is necessary to investigate new treatment alternatives that suppress the ROS generated. One promising alternative is the use of plant extracts, which have demonstrated a potent antioxidant effect. Efficient cells for the study of pathological diseases related to reactive oxygen species are T lymphocytes, which share systems with neurons such as: the dopaminergic system, death signaling and survival. <em>In vitro</em> lymphocytes are an optimal model for the evaluation of oxidative mechanisms.</div></div><div><h3>Objective</h3><div>To determine the protective effect of ethanolic extract of propolis against oxidative damage induced by hydrogen peroxide (H₂O₂) in human lymphocytes <em>in vitro</em>, by means of the cell viability test with trypan blue.</div></div><div><h3>Results</h3><div>Anova test shows that the concentrations of 0.0225 and 0.045 mg/mL of ethanolic extract of propolis, present protective activity against cell damage caused by H₂O₂.</div></div><div><h3>Conclusion</h3><div>This study proposes the ethanolic extract of propolis as a potential pharmacological, useful for treatments against autoinmune disorders.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 315-320"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Errata in articles published in the journal Revista Colombiana de Reumatología in 2023 and 2024","authors":"","doi":"10.1016/j.rcreue.2025.07.003","DOIUrl":"10.1016/j.rcreue.2025.07.003","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 421-422"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practical perspective on gastrointestinal manifestations of systemic lupus erythematosus","authors":"Juan Camilo Santacruz ,&nbsp;Marta Juliana Mantilla ,&nbsp;Sandra Pulido ,&nbsp;Ferney Africano ,&nbsp;Carlos Alberto Agudelo ,&nbsp;Rubén Darío Mantilla ,&nbsp;Ángelo Arzuaga ,&nbsp;John Londoño","doi":"10.1016/j.rcreue.2025.08.003","DOIUrl":"10.1016/j.rcreue.2025.08.003","url":null,"abstract":"<div><div>Systemic lupus erythematosus is an autoimmune disease with a tendency to wax and wane. Unlike other autoimmune conditions, disease activity in the gastrointestinal system is relatively rare, and its approach can vary, according to different points of view. Despite its low prevalence, gastrointestinal manifestations can be potentially fatal, as occurs in cases of intestinal vasculitis and the consequent mesenteric ischaemia. The spectrum of gastrointestinal involvement in this disease is broad, and includes disease activity, infection associated with immunosuppression, adverse effects of some medications, or other intercurrent processes such as lupus cystitis. The clinical symptoms and laboratory findings are highly diverse, which leads to a delay in diagnosis with consequent organ dysfunction. Early diagnosis can be a challenge because a large proportion of patients present with nonspecific constitutional symptoms associated with nausea, emesis, and abdominal pain. These numerous factors have been an obstacle to further research in this field, making a unified diagnostic and therapeutic approach difficult. Therefore, an advanced search of the literature will be undertaken to obtain the most evidence available on the diagnostic methods and treatments currently available, providing the clinician with more tools to achieve a comprehensive approach.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 385-393"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement in quantifying the extension of autoimmune-associated interstitial lung disease using the Goh method","authors":"Luis Javier Cajas Santana ,&nbsp;Santiago Cuero ,&nbsp;Gabriela Guerrero ,&nbsp;Mayelin Ceballos ,&nbsp;María Carolina Torres ,&nbsp;Diana Rocio Gil ,&nbsp;Yimy F. Medina ,&nbsp;Ana Milena Callejas ,&nbsp;Javier Leonardo Galindo ,&nbsp;Cesar Riascos ,&nbsp;Wilmer Aponte ,&nbsp;Diana Ochoa ,&nbsp;Jennifer Delgadillo","doi":"10.1016/j.rcreue.2025.09.005","DOIUrl":"10.1016/j.rcreue.2025.09.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Interstitial lung disease (ILD) is one of the leading causes of mortality in autoimmune diseases. The extent of the disease is a determining factor in the prognosis and treatment initiation and monitoring. Quantification using the Goh method is the most commonly used method; however, it is subjective. So far, no studies have evaluated the level of agreement among various readers.</div></div><div><h3>Objective</h3><div>The study's objective is to determine the interobserver and intra-observer variability in using ILD quantification among physicians from various specialties and levels of experience.</div></div><div><h3>Methods</h3><div>Images from chest computed tomography of patients with rheumatoid arthritis (RA) or systemic sclerosis (SSc) and ILD were collected. The five necessary cuts described by Goh were extracted to be evaluated by pulmonologists, rheumatologists, radiologists, fellows, and a thoracic radiologist (gold standard). The interobserver and intra-observer variability values were calculated using the intraclass correlation coefficient test or Cohen's Kappa test, depending on the nature of the variable, between each group of medical specialties and in comparison with the gold standard.</div></div><div><h3>Results</h3><div>Seventy-nine patients were selected, primarily women, 56% having SSc. A total of 1098 CT scans were performed. The intraclass correlation coefficient was .75 (95% CI: .67–.81), including all nine readers. The best correlation with the gold standard was found among pulmonologists (CCI .83) and rheumatologists (CCI .81). According to severity (more significant or less than 20% extension), the Kappa coefficient was .64 among the nine readers. The intraclass correlation coefficient for the average intra-observer correlation of all readers was .89 (95% CI: .81–.93), and the Kappa coefficient was .82.</div></div><div><h3>Conclusion</h3><div>The Goh method is valuable and highly correlated among a diverse group of specialties that manage ILD, making it a practical tool for assessing the extent of the disease.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 368-373"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of inequalities and correction model of the Goh method used in quantifying interstitial lung disease","authors":"Luis Javier Cajas Santana ,&nbsp;Daniela Rojas Carvajal ,&nbsp;Wendy Torres Chazatar ,&nbsp;Laura Mendoza Galindo ,&nbsp;Yensi Romero Díaz ,&nbsp;Daniel Ramírez Muñoz ,&nbsp;Gisella Fernández Salamanca","doi":"10.1016/j.rcreue.2025.06.003","DOIUrl":"10.1016/j.rcreue.2025.06.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Interstitial lung disease is a significant complication in autoimmune diseases. The extent of involvement is crucial in determining both onset and treatment response. While there are computational methods for this calculation, manual methods, such as the Goh method, remain the most commonly used. However, it has some disadvantages, such as presuming that areas across the lung are equivalent and thus influence the calculation equally. The aim of this study is to analyse these difficulties and find a mathematical correction method.</div></div><div><h3>Materials and methods</h3><div>High-resolution chest tomography images were obtained from patients with and without ILD. Pulmonary areas were analysed and compared in the slices referenced in the Goh method. Through geometric analysis of lung structure, the slice closest to the average of its areas was identified for comparison with other measurements. Based on this, a correction equation was formulated, and through simulation of various interstitial involvement patterns, the degree of variation was determined.</div></div><div><h3>Results</h3><div>Images from 80 patients were analysed, mostly women diagnosed with systemic sclerosis. It was found that apical areas (slices 1 and 2) and the sum of left-sided pulmonary areas were 20% smaller compared to basal and right-sided areas, respectively. Simulation with different involvement components found that apical or left-sided disease overestimates extension by 5% to 10%, especially when it exceeds 15%. The third slice was determined to be closest to the average of the areas, and a correction formula was devised based on this.</div></div><div><h3>Conclusions</h3><div>The Goh method incorrectly assumes the equivalence of pulmonary areas, which can impact calculations. We propose a mathematical correction for this purpose.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 328-334"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blau syndrome as a cause of fever of unknown origin in adults: A case report","authors":"Edgar Santiago Castro Prieto ,&nbsp;Carlos Mauricio Martínez Montalvo ,&nbsp;Sandra Ximena Ramírez ,&nbsp;Valentina Ramírez Vega ,&nbsp;Carlos Ernesto Artega Unigarro ,&nbsp;Cristian Ivan Aparicio Neisa","doi":"10.1016/j.rcreue.2025.06.002","DOIUrl":"10.1016/j.rcreue.2025.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>We present the first case reported in Colombia of Blau syndrome manifested in adults associated with a de novo mutation in the NOD2 gene in the context of a case of fever of unknown origin.</div></div><div><h3>Case summary</h3><div>44-year-old female patient presenting with a condition of approximately 4 years of evolution consisting of cyclical episodes of quantified fever lasting approximately 20 days, with remission intervals of 6–8 months, accompanied by generalized abdominal pain, polymyalgia, polyarthralgia, and general discomfort. Her medical history included treated liver tuberculosis (TB), anterior uveitis, appearance of erythema nodosum in the lower limbs with spontaneous remission, and an episode of peripheral facial paralysis. During the aetiological studies, hepatic granulomas were documented, which were taken to biopsy where multiple non-caseating granulomas were found. Angiotensin-converting enzyme levels were measured, which were found within normal limits, and molecular and microbiological limits for tuberculosis in the biopsy were negative. Subsequently, an autoinflammatory syndrome was considered a suspected diagnostic diagnosis given the persistence of the condition, so genetic studies were performed where a de novo heterozygous mutation was detected in the NOD2 gene, which is associated with Blau syndrome.</div></div><div><h3>Conclusions</h3><div>Autoinflammatory syndromes, although they occur mostly in childhood, should not be ruled out in adults. In our country there are no known cases of Blau syndrome manifesting in adulthood, so this case report will help us inform the scientific community about it.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 401-408"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a more accurate quantification of pulmonary fibrosis in scleroderma: Reflections on Goh's method and its geometric correction","authors":"Bibiana Andrea Pinzón Valderrama","doi":"10.1016/j.rcreue.2025.08.002","DOIUrl":"10.1016/j.rcreue.2025.08.002","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 299-300"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristic and outcomes of psoriasis patients in a multicentre outpatient healthcare institution in Colombia","authors":"Julio Roberto Amador ,&nbsp;Carolina Becerra-Arias ,&nbsp;Wilmer Gerardo Rojas-Zuleta ,&nbsp;Juan Raul Castro-Ayarza ,&nbsp;Manuel Franco ,&nbsp;Mario Barbosa-Rengifo ,&nbsp;Jorge Donado-Gómez ,&nbsp;Natalia Duque-Zapata","doi":"10.1016/j.rcreue.2025.09.001","DOIUrl":"10.1016/j.rcreue.2025.09.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Psoriasis is a chronic inflammatory disease characterized by scaly erythematous plaques, systemic inflammation, and an elevated cardiovascular risk. Due to its complexity in treatment and the frequent occurrence of comorbidities, characterizing patients diagnosed with psoriasis enrolled in care programmes becomes paramount for enhancing health outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To provide a comprehensive description of the sociodemographic, clinical features, and outcomes of a cohort of patients diagnosed with psoriasis in a multicentre outpatient healthcare institution in Colombia.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;A cohort study was conducted involving patients diagnosed with psoriasis. Inclusion criteria required a minimum follow-up duration of three months. Quantitative variables were summarized using the median and interquartile range, while qualitative variables were presented with measures of frequency and 95% confidence interval. Changes in the final values of PASI, DLQI, NAPSI, and BSA from baselines were assessed through percentage comparisons, analysed using chi-square test.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 1155 patients were included, with a median age of 53 years and the majority were men (58%). Plaque psoriasis was the predominant type, observed in 78.7%. Psoriatic arthritis was diagnosed in 18.9%. The most prevalent comorbidity was hypertension, identified in 23.0% (95% CI 20.6 to 25.6%), followed by diabetes at 12.5% (95% CI 10.6 to 14.5%) and cardiovascular disease at 10.6%. A significant proportion of patients were classified as overweight and obese, 43.9% (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;479) and 20.9% (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;228), respectively. Regarding treatment modalities, the majority received biological therapies (39%), followed by systemic therapy (22.2%), and topical therapy (17.5%).&lt;/div&gt;&lt;div&gt;During the follow-up period, a considerable percentage of patients experienced some decrease in disease activity. A PASI75 response was achieved by 28.5% (95% CI 25.4% to 31.8%), and PASI90% was achieved by 18% (95% CI 15.4% to 20.9%). A bivariate analysis based on Body Mass Index showed a lower response in patients with overweight or obesity, thought these differences were not statistically significant (p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.937). Notably, a higher percentage of patients with no response were observed among those with hypertension (62.9% p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.123), diabetes mellitus (64.7% p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.393), cardiovascular disease (51.5% p&lt;&lt;!--&gt; &lt;!--&gt;.001), and chronic kidney disease (55.6% p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.014) when compared with patients who achieved therapeutic goals.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;We present the largest psoriasis cohort in Colombia. A majority of our patients showed improvement in disease activity based on clinimetric measures. Nevertheless, the presence of comorbidities significantly reduces the likel","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 301-308"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective evaluation of PARK-7 expression dynamics in systemic sclerosis","authors":"Emine Öztürk ,&nbsp;Dilara Bulut Gökten ,&nbsp;Rıdvan Mercan ,&nbsp;Savaş Güzel","doi":"10.1016/j.rcreue.2025.09.002","DOIUrl":"10.1016/j.rcreue.2025.09.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction/Objective&lt;/h3&gt;&lt;div&gt;In our study, we investigated the role of Parkinsonism-associated protein 7 (PARK-7), known as DJ-1, which is involved in several pathways that counteract oxidative stress. This stress is thought to contribute to the development of fibrosis and vascular damage in patients with systemic sclerosis (SSc). Our study aims to investigate the correlation between PARK-7 levels, laboratory and clinical findings related to SSc and treatment regimens.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;In our study, we included fifty patients aged 18 years and older diagnosed with SSc and thirty healthy individuals without any systemic, malignant, or autoimmune diseases as a control group. We collected demographic data, clinical manifestations, laboratory and radiological findings, pulmonary function test (PFT), and echocardiography reports, information on comorbidities and prescribed medications from medical records, hospital database analysis, and direct patient interviews. Disease activity was quantified and documented using activity scoring systems developed by the European Scleroderma Study Group (EScSG) and the United Kingdom's (UK) Functional Activity Scoring. PARK-7 levels in venous blood samples from participating patients were quantified by Enzyme-Linked Immunosorbent Assay (ELISA).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The PARK-7 level was 21.26&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;15.83 in the patient group and 16.11&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;11.83 in the control group. There was no significant difference in PARK-7 levels between the patient and control groups (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.22). In terms of disease subtypes, PARK-7 levels were 21.35&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;18.36 in the limited form, 23.18&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;13.83 in the diffuse form. No statistically significant differences were observed between PARK-7 levels, the control group, and the different disease forms (&lt;em&gt;p&lt;/em&gt; &lt;!--&gt;&gt;&lt;!--&gt; &lt;!--&gt;.05). In patients classified as having active disease according to the EScSG scoring system, the PARK-7 level was 25.69&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;18.10 compared to 16.00&lt;!--&gt; &lt;!--&gt;±&lt;!--&gt; &lt;!--&gt;10.91 in the inactive group. No significant correlation was found between the presence of high-resolution computed tomography (HRCT) findings, other systemic involvement, and PARK-7 levels.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;Over the past decade, numerous reports have highlighted the therapeutic potential of PARK-7 and its related molecules for the treatment of various diseases. Whether PARK-7 can be effectively used in the treatment of SSc remains unclear due to the cross-sectional design of our study. We believe that a study measuring PARK-7 levels in patients newly diagnosed or in the early stages of SSc, followed by randomised and prospective follow-up of clinical outcomes with and without treatment, could significantly improve our understanding of the role of PARK-7 in the pathogenesis of SSc and its potential applicability in","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 309-314"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there an association between MBL2 gene polymorphisms and infection susceptibility in patients with systemic lupus erythematosus? An exploratory study in Mexican mestizos","authors":"Miguel Ángel Villarreal-Alarcón ,&nbsp;Jorge Antonio Esquivel-Valerio ,&nbsp;David Vega-Morales ,&nbsp;Jorge Armando Hermosillo-Villafranca ,&nbsp;Rocío Ortiz-López ,&nbsp;Augusto Rojas-Martínez ,&nbsp;Ana Arana-Guajardo ,&nbsp;Mario Alberto Garza-Elizondo ,&nbsp;Berenice Carrillo-Haro ,&nbsp;Alondra Elizabeh Montoya-Montes","doi":"10.1016/j.rcreue.2025.09.006","DOIUrl":"10.1016/j.rcreue.2025.09.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Low mannose-binding lectin (MBL) concentrations in serum are due mainly to the presence of three punctual mutations in the coding region of the MBL2 gene. SLE patients, who are homozygous for MBL allele variants, have a significantly greater risk of developing infections. With the purpose of examining the association of MBL locus haplotypes with disease activity and past history of infection in SLE, we studied a group of patients treated in the Rheumatology Outpatient Clinic of the UANL University Hospital.</div></div><div><h3>Objective</h3><div>Determine the prevalence of MBL2 locus haplotypes and the causal associations between MBL2 locus haplotypes and SLE determining the Hardy–Weinberg law for specific genotypes in both groups of study.</div></div><div><h3>Materials and methods</h3><div>An observational, cross-sectional, retrospective study was performed. Hardy–Weinberg equilibrium for genotypic frequencies was proven with the <em>X</em>² test. The risk of lupus associated with MBL2 genotypes as a genetic factor and the strength of the association of the genotypes with the frequency of clinical characteristics was estimated by calculation of odds ratio with a 95% confidence interval. Statistical significance was taken as a value of <em>P</em> <!-->&lt;<!--> <!-->.05.</div></div><div><h3>Results</h3><div>The findings suggest potential genetic associations between allelic systems and the risk of SLE. A relationship was found regarding the MEX-SLEDAI index, as well as the number of infections among patients with differences in structural gene polymorphisms and promoter gene polymorphisms.</div></div><div><h3>Conclusions</h3><div>There are significant differences in the polymorphisms of the promoter region regarding the risk for developing SLE.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 321-327"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}