Revista Colombiana de Reumatología (English Edition)最新文献

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Disease relapse in idiopathic inflammatory myopathies: A 10-year registry-based follow-up multicentre study in Colombia 特发性炎性肌病的疾病复发:哥伦比亚一项为期10年的基于登记的随访多中心研究
Revista Colombiana de Reumatología (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1016/j.rcreue.2025.102162
Pablo Arango Guerra , Alejandro Echavarría Cross , Manuel Alejandro Giraldo Delgado , Mauricio Murillo Moreno , María Pérez-Restrepo , Juan Camilo Díaz-Coronado , Diego Fernando Rojas-Gualdrón , Neil Pertuz
{"title":"Disease relapse in idiopathic inflammatory myopathies: A 10-year registry-based follow-up multicentre study in Colombia","authors":"Pablo Arango Guerra ,&nbsp;Alejandro Echavarría Cross ,&nbsp;Manuel Alejandro Giraldo Delgado ,&nbsp;Mauricio Murillo Moreno ,&nbsp;María Pérez-Restrepo ,&nbsp;Juan Camilo Díaz-Coronado ,&nbsp;Diego Fernando Rojas-Gualdrón ,&nbsp;Neil Pertuz","doi":"10.1016/j.rcreue.2025.102162","DOIUrl":"10.1016/j.rcreue.2025.102162","url":null,"abstract":"<div><h3>Introduction</h3><div>Disease relapses of idiopathic inflammatory myopathies (IIM) play a significant role in the burden of disease. However, Colombian studies with long-term follow-ups are scarce.</div></div><div><h3>Objective</h3><div>To estimate the ten-year relapse-free survival in patients with idiopathic inflammatory myopathy treated at a specialized medical center for autoimmune diseases with presence in different cities in Colombia.</div></div><div><h3>Method</h3><div>This is a retrospective follow-up study based on medical records. All patients diagnosed with idiopathic inflammatory myopathy treated between January 2012 and June 2022 were included. The time to relapse was defined as the outcome variable. Additionally, demographic, clinical, laboratory, and treatment variables were characterized. Analyses were performed using Weibull survival regression for interval-censored data.</div></div><div><h3>Results</h3><div>A total of 278 patients followed for a mean of 6.60 years were included. Of these, 70.9% were women, with a median age of 57 (IQR 40–66) years. Dermatomyositis (60.1%) and polymyositis (28.1%) were the most frequent phenotypes. Relapse-free survival at one year was 86.3%, and at five years, 68.3%, with a median relapse-free time of 13.8 years. By phenotype, the lowest median relapse-free survival rates were observed for antisynthetase syndrome at 3 years, immune-mediated necrotizing myopathy at 6 years, and juvenile dermatomyositis at 7.3 years.</div></div><div><h3>Conclusion</h3><div>Relapse-free survival is highly heterogeneous according to the clinical phenotype of idiopathic inflammatory myopathy, being lowest in patients with antisynthetase syndrome.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102162"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Profile of use and cost of care in knee osteoarthritis 膝关节骨关节炎的使用概况和护理费用
Revista Colombiana de Reumatología (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-01-15 DOI: 10.1016/j.rcreue.2025.102158
Erick Baltazar Pano Nogueda , Enrique Villarreal Ríos , Liliana Galicia Rodríguez , Mireya Franco Saldaña , Mariana Del Rayo Guerrero Mancera , Laura Alicia Cu Flores
{"title":"Profile of use and cost of care in knee osteoarthritis","authors":"Erick Baltazar Pano Nogueda ,&nbsp;Enrique Villarreal Ríos ,&nbsp;Liliana Galicia Rodríguez ,&nbsp;Mireya Franco Saldaña ,&nbsp;Mariana Del Rayo Guerrero Mancera ,&nbsp;Laura Alicia Cu Flores","doi":"10.1016/j.rcreue.2025.102158","DOIUrl":"10.1016/j.rcreue.2025.102158","url":null,"abstract":"<div><h3>Introduction</h3><div>The profile of health service use in the care of knee osteoarthritis determines the cost of care.</div></div><div><h3>Objective</h3><div>To determine the profile of use and cost of care in knee osteoarthritis.</div></div><div><h3>Materials and methods</h3><div>Study of health service profile of use and cost, 258 clinical records were studied. The profile of use identified the type and number of services used in 1 year. The average annual cost was determined by identifying the fixed unit cost, estimated using the time and motion technique, and the variable unit cost, identified using the micro-costing technique, the sum of both resulted in the average unit cost and was multiplied by the profile of use to identify the average annual cost. With this result, projections were made adopting assumptions for specific populations.</div></div><div><h3>Results</h3><div>The average annual cost of knee osteoarthrosis care was USD $ 205.82; the highest cost corresponds to the fixed cost of consultation and hospitalization services. The total projected cost for 6408 patients with osteoarthritis is USD $ 1,318,917 and for 4644 patients with osteoarthrosis is USD $ 955,844,529.</div></div><div><h3>Conclusion</h3><div>The cost of care for knee osteoarthritis is high, the projections for the average cost of care for knee osteoarthritis are worrying, this scenario will be true as long as the adopted assumptions are met.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102158"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of osteoporosis in patients with ankylosing spondylitis: systematic review, and meta-analysis 强直性脊柱炎患者骨质疏松症的诊断:系统回顾和荟萃分析
Revista Colombiana de Reumatología (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-02-27 DOI: 10.1016/j.rcreue.2026.102175
Pedro Arbey Quevedo Mayorga , Andrés Alfonso González , Javier Mauricio Mora Méndez , Juan Carlos Vela Quevedo , Lilian Marcela Estupiñán Moya , Angelica María Quintero , Carlos Eduardo García Morón , César Augusto Cantillo Moreno
{"title":"Diagnosis of osteoporosis in patients with ankylosing spondylitis: systematic review, and meta-analysis","authors":"Pedro Arbey Quevedo Mayorga ,&nbsp;Andrés Alfonso González ,&nbsp;Javier Mauricio Mora Méndez ,&nbsp;Juan Carlos Vela Quevedo ,&nbsp;Lilian Marcela Estupiñán Moya ,&nbsp;Angelica María Quintero ,&nbsp;Carlos Eduardo García Morón ,&nbsp;César Augusto Cantillo Moreno","doi":"10.1016/j.rcreue.2026.102175","DOIUrl":"10.1016/j.rcreue.2026.102175","url":null,"abstract":"<div><h3>Introduction</h3><div>The variability in the identification of osteopenia and osteoporosis in AS (ankylosing spondylitis) is related to the possible overestimation of BMD (bone mineral density) identified by DXA (dual x-ray absorptiometry) in the lumbar spine (LS) and femoral neck (FN) due to changes in bone neoformation in the anterior vertebral ligament and enthesis, which leads to the under-identification of alterations in the BMD of this group of patients. This justifies evaluating different BMD estimation techniques such as QCT (quantitative dual-energy tomography) to optimize the identification of this complication. Our objective was to evaluate the available evidence regarding the identification of osteoporosis and osteopenia through DXA versus QCT techniques in patients with AS.</div></div><div><h3>Methodology</h3><div>A systematic review and meta-analysis were carried out following the PRISMA-P checklist 2015 methodology. The databases consulted were MEDLINE CENTRAL (Cochrane Central Register of Controlled Trials), EMBASE, LILACS, GOOGLE SCHOLAR, SCIELO from 2010 to December 2021; we included randomized clinical trials, cohort studies, cases and controls, as well as cross-sectional studies in PROSPERO (CRD42023472431) on both methods. The effect was estimated from fixed or random effects models according to the estimation of heterogeneity by I<sup>2</sup>.</div></div><div><h3>Results</h3><div>The search yielded 287 studies, of which only 3 were included. There were 109 patients in total, the mean age was 49.5±4.8, a greater probability of OP was evident (RR = 1.91 95% CI .65–5.62 p = .23) and osteopenia (RR = 1.44 95% CI = .86–2.42 p = .16) with QCT vs. DXA, without statistical significance. The difference in means in the bone density was significant between the two techniques, being lower in QCT (MD = −833 Z = −8.38 p = .001).</div></div><div><h3>Conclusions</h3><div>QCT is a useful technique in determining BMD in these patients, but the available evidence is still insufficient to conclude which is the least effective technique for diagnosing OP in AS.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102175"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond expectations: Concurrent presence of beta thalassemia and Sjögren's syndrome 超出预期:同时存在-地中海贫血和Sjögren综合征
Revista Colombiana de Reumatología (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-13 DOI: 10.1016/j.rcreue.2026.102168
Mateo Aguirre Flórez , Daniel Toro Restrepo , Lina María Saldarriaga Rivera , Henry Idrobo Quintero , Laura Alejandra Jiménez Osorio , Valeria López Pulgarín , Daniel Millán Morales
{"title":"Beyond expectations: Concurrent presence of beta thalassemia and Sjögren's syndrome","authors":"Mateo Aguirre Flórez ,&nbsp;Daniel Toro Restrepo ,&nbsp;Lina María Saldarriaga Rivera ,&nbsp;Henry Idrobo Quintero ,&nbsp;Laura Alejandra Jiménez Osorio ,&nbsp;Valeria López Pulgarín ,&nbsp;Daniel Millán Morales","doi":"10.1016/j.rcreue.2026.102168","DOIUrl":"10.1016/j.rcreue.2026.102168","url":null,"abstract":"<div><h3>Background</h3><div>Beta thalassaemia and Sjögren's syndrome are rare diseases with distinct aetiologies. Beta thalassaemia is an inherited haemoglobinopathy that causes chronic anemia, while Sjögren's syndrome is an autoimmune disease that affects exocrine glands.</div></div><div><h3>Case report</h3><div>We present a 45-year-old female with beta-thalassaemia diagnosed by genetic testing who developed Sjögren's syndrome symptoms. The diagnosis was confirmed by clinical, serological, and histopathological criteria. This is the first documented case in a Colombian tertiary institution.</div></div><div><h3>Conclusions</h3><div>Beta-thalassaemia and Sjögren's syndrome coexistence is extremely rare, highlighting the need for a multidisciplinary diagnostic approach. Further investigation into possible molecular and genetic links is needed.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102168"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular risk factors related to arterial stiffness in patients with rheumatoid arthritis in low disease activity 低疾病活动度类风湿关节炎患者动脉僵硬相关的心血管危险因素
Revista Colombiana de Reumatología (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-01-19 DOI: 10.1016/j.rcreue.2025.102146
Gabriel-Santiago Rodríguez-Vargas , Jaime-Andrés Rubio-Rubio , Pedro Santos-Moreno , Darío Echeverri , Luz-Dary Gutiérrez-Castañeda , Paula-Katherine Bautista-Niño , Adriana Rojas-Villarraga
{"title":"Cardiovascular risk factors related to arterial stiffness in patients with rheumatoid arthritis in low disease activity","authors":"Gabriel-Santiago Rodríguez-Vargas ,&nbsp;Jaime-Andrés Rubio-Rubio ,&nbsp;Pedro Santos-Moreno ,&nbsp;Darío Echeverri ,&nbsp;Luz-Dary Gutiérrez-Castañeda ,&nbsp;Paula-Katherine Bautista-Niño ,&nbsp;Adriana Rojas-Villarraga","doi":"10.1016/j.rcreue.2025.102146","DOIUrl":"10.1016/j.rcreue.2025.102146","url":null,"abstract":"<div><h3>Introduction</h3><div>Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular disease associated with the chronic inflammatory state.</div></div><div><h3>Objective</h3><div>The objective was to describe arterial stiffness in RA patients with low disease activity and its relationship with cardiovascular risk factors.</div></div><div><h3>Materials and methods</h3><div>Case series study. Consecutive inclusion of patients with RA in low disease activity. Sociodemographic, clinical and laboratory data, and disease activity score-28 were captured. Arterial stiffness [pulse wave velocity (PWV), oscillometric method] was assessed. Univariate and bivariate analyses, correlations (Rho Spearman), and principal component analysis.</div></div><div><h3>Results</h3><div>52 patients (76.9% women) were included. Median age 57 years (interquartile range-IQR 9). Median disease activity score-28 (DAS28) 2.6 (IQR-1.3), low activity. Mean PWV 8.45 (Standard deviation 3.1) m/sec. PWV in patients treated with methotrexate was lower (<em>p</em> = .013). Age was correlated with PWV (<em>p</em> = .006). Aortic augmentation index was higher in women (<em>p</em> = .015) and in patients with familial autoimmunity (<em>p</em> = .05). Framingham cardiovascular risk score correlated with pulse pressures. The number of cups of coffee consumed was correlated (inversely) with the aortic augmentation index (<em>p</em> = .042). Principal component analysis (4 components) explained 70.1% of the variance.</div></div><div><h3>Conclusions</h3><div>PWV levels in patients with RA in low disease activity were similar to those reported in the population without RA. Despite not being elevated, they correlate with traditional and non-traditional cardiovascular risk factors (methotrexate, familial autoimmunity, coffee consumption).</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102146"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of life of patients with fibromyalgia presenting headache and/or depressive symptoms 出现头痛和/或抑郁症状的纤维肌痛患者的生活质量
Revista Colombiana de Reumatología (English Edition) Pub Date : 2026-01-01 Epub Date: 2026-03-13 DOI: 10.1016/j.rcreue.2026.102152
Yasmine Fortes , Wallyson Souza , Adriana Soares , Maria das Graças Sousa , Bruna Castro , Raimundo Silva-Néto , Gabriela Uchôa
{"title":"Quality of life of patients with fibromyalgia presenting headache and/or depressive symptoms","authors":"Yasmine Fortes ,&nbsp;Wallyson Souza ,&nbsp;Adriana Soares ,&nbsp;Maria das Graças Sousa ,&nbsp;Bruna Castro ,&nbsp;Raimundo Silva-Néto ,&nbsp;Gabriela Uchôa","doi":"10.1016/j.rcreue.2026.102152","DOIUrl":"10.1016/j.rcreue.2026.102152","url":null,"abstract":"<div><h3>Introduction</h3><div>Fibromyalgia has a high degree of co-occurrence with a number of conditions. The association of fibromyalgia, headache and mood disorders is well observed.</div></div><div><h3>Objective</h3><div>To analyze the relationship between these manifestations, exploring whether the quality of life in patients with fibromyalgia is influenced by the presence of depressive symptoms and chronification of headache.</div></div><div><h3>Materials and methods</h3><div>A retrospective observational cross-sectional study was carried out to determine the quality of life of patients with fibromyalgia presenting with headache and/or depressive symptoms. The samples were evaluated using the Widespread Pain Index (WPI) and Symptom Severity (SS) questionnaires to confirm the diagnosis of fibromyalgia. Quality of life and level of depressive symptoms were assessed, respectively, by the Fibromyalgia Impact Questionnaire (FIQ) and the Patient Health Questionnaire-9 (PHQ-9).</div></div><div><h3>Results</h3><div>A total of 120 patients (3 men and 117 women) diagnosed with fibromyalgia were interviewed, with ages ranging from 23 to 65 years. The most common primary headache was chronic migraine (45%). While depressive symptoms was observed in 118 patients (98.33%). The factors degree of depressive symptoms and headache chronicity were marginally significant in explaining the quality of life of patients with fibromyalgia.</div></div><div><h3>Conclusions</h3><div>Faced with a disease with such a possibility of being associated with other complex conditions, multidisciplinary monitoring becomes a preponderant factor in the treatment of the entire patient.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102152"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-TIF1γ-positive dermatomyositis with interstitial lung involvement: Report of two cases 抗tif1 γ阳性累及肺间质性皮肌炎2例报告
Revista Colombiana de Reumatología (English Edition) Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI: 10.1016/j.rcreue.2025.06.012
Pablo Arango Guerra , Santiago Monsalve Yepes , Andrés Chavarriaga Restrepo , Carlos Jaime Velásquez
{"title":"Anti-TIF1γ-positive dermatomyositis with interstitial lung involvement: Report of two cases","authors":"Pablo Arango Guerra ,&nbsp;Santiago Monsalve Yepes ,&nbsp;Andrés Chavarriaga Restrepo ,&nbsp;Carlos Jaime Velásquez","doi":"10.1016/j.rcreue.2025.06.012","DOIUrl":"10.1016/j.rcreue.2025.06.012","url":null,"abstract":"<div><h3>Introduction</h3><div>The association of certain myositis-specific antibodies (MSA) with the development of interstitial lung disease (ILD) in relation to inflammatory myopathies, such as antisynthetase syndrome and anti-MDA5, is well known. However, the potential relationship with the anti-TIF1γ antibody is not well understood, as the reported cases to date are few and have not allowed for solid confirmation of this association. Most of the literature has focused primarily on the association with malignant neoplasms. We aim to include two new cases in the existing literature to support the assertion of the link despite its infrequency.</div></div><div><h3>Objective</h3><div>To report two cases of ILD associated with anti-TIF1γ positive dermatomyositis (DM).</div></div><div><h3>Materials and methods</h3><div>A description of the clinical characteristics of two cases of anti-TIF1γ positive DM with ILD and a comparison with analogous cases.</div></div><div><h3>Results</h3><div>Two cases are described, the first of a 47-year-old man and the second of a 57-year-old woman, both diagnosed with anti-TIF1γ positive DM with the presence of ILD. Underlying malignancy was ruled out due to the presence of the MSA in question, and other potential causes of ILD were excluded, leading to the initiation of immunosuppressive treatment in both cases.</div></div><div><h3>Conclusion</h3><div>It is essential to further investigate the relationship between inflammatory myopathy and how different MSAs, other than antisynthetase and anti-MDA5 are also associated with ILD. Finding two cases related to anti-TIF1γ and knowing that there are analogous cases generates this hypothesis.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 409-415"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The coexistence of rheumatoid arthritis and ankylosing spondylitis: Case series and literature review 类风湿关节炎和强直性脊柱炎共存:病例系列和文献回顾
Revista Colombiana de Reumatología (English Edition) Pub Date : 2025-10-01 Epub Date: 2025-10-21 DOI: 10.1016/j.rcreue.2025.09.004
Hanene Lassoued Ferjani , Ben Ayed Hiba , Dorra Ben Nessib , Dhia Kaffel , Kaouther Maatallah , Wafa Hamdi
{"title":"The coexistence of rheumatoid arthritis and ankylosing spondylitis: Case series and literature review","authors":"Hanene Lassoued Ferjani ,&nbsp;Ben Ayed Hiba ,&nbsp;Dorra Ben Nessib ,&nbsp;Dhia Kaffel ,&nbsp;Kaouther Maatallah ,&nbsp;Wafa Hamdi","doi":"10.1016/j.rcreue.2025.09.004","DOIUrl":"10.1016/j.rcreue.2025.09.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis and ankylosing spondylitis are among the most common rheumatic diseases. The coexistence of both affections in a single patient is highly infrequent but seems to be underestimated in clinical practice.</div></div><div><h3>Materials and methods</h3><div>We described the clinical, biological, and radiological characteristics of 12 patients with concomitant rheumatoid arthritis and ankylosing spondylitis diagnosed at our hospital. The 28 disease activity score (DAS28), the Bath ankylosing spondylitis disease activity index (BASDAI), and the Ankylosing Spondylitis Disease Activity Score (ASDAS) were used as outcome measures.</div></div><div><h3>Results</h3><div>Twelve patients with a male-to-female ratio of 0.71 and a mean age of 62.1<!--> <!-->±<!--> <!-->12.8 years were included. Rheumatoid arthritis was the first disease diagnosed in seven patients. The mean duration of rheumatoid arthritis diagnosis at the time of ankylosing spondylitis diagnosis was 20.2<!--> <!-->±<!--> <!-->25 months. The first sign of ankylosing spondylitis in rheumatoid arthritis patients was incidental radiological sacroiliitis in four patients, inflammatory low back pain in three patients, and distal interphalangeal joint involvement in hands radiographs in two patients. Rheumatoid arthritis was seronegative in four patients. Erosions were observed on radiographs of the hands and/or feet in 66% of the cases and almost all the patients (11/12) had sacroiliitis on imaging studies. The mean values of the DAS28, ASDAS, and BASDAI scores at the initial diagnosis of rheumatoid arthritis/ankylosing spondylitis were 4.54<!--> <!-->±<!--> <!-->1.22, 3.1<!--> <!-->±<!--> <!-->0.72, and 4.1<!--> <!-->±<!--> <!-->0.5, respectively.</div></div><div><h3>Conclusion</h3><div>The coexistence of Rheumatoid arthritis and ankylosing spondylitis is uncommon but should be considered. We could not draw a conclusion about whether the association of both disease conditions confers different characteristics.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 394-400"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systematic review and meta-analysis of the low-dose versus high-dose cyclophosphamide regimen for induction treatment in lupus nephritis patients, evidence update 2010–2023 低剂量与高剂量环磷酰胺方案诱导治疗狼疮性肾炎患者的系统评价和荟萃分析,证据更新2010-2023
Revista Colombiana de Reumatología (English Edition) Pub Date : 2025-10-01 Epub Date: 2025-08-26 DOI: 10.1016/j.rcreue.2025.08.001
Pedro Arbey Quevedo Mayorga , Javier Mauricio Mora Méndez , Alejandro Aristizábal , Lilian Marcela Estupiñan Moya , Diana Muñoz
{"title":"Systematic review and meta-analysis of the low-dose versus high-dose cyclophosphamide regimen for induction treatment in lupus nephritis patients, evidence update 2010–2023","authors":"Pedro Arbey Quevedo Mayorga ,&nbsp;Javier Mauricio Mora Méndez ,&nbsp;Alejandro Aristizábal ,&nbsp;Lilian Marcela Estupiñan Moya ,&nbsp;Diana Muñoz","doi":"10.1016/j.rcreue.2025.08.001","DOIUrl":"10.1016/j.rcreue.2025.08.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Lupus nephritis is a common complication in patients with systemic lupus erythematosus. Cyclophosphamide in induction treatment has a good efficacy profile, but greater toxicity.</div></div><div><h3>Objective</h3><div>To perform a systematic review and meta-analysis, updating the literature that compares the efficacy and safety of cyclophosphamide at high and low doses.</div></div><div><h3>Materials and methods</h3><div>PRISMA-P methodology, PROSPERO register number CRD42023485477, only randomized clinical trials were included from 2010 to October 2023, in patients over 16 years of age with lupus nephritis class III, IV, V, or V + III, V + IV. Complete response, partial response, relapses, infections, leukopenia, and amenorrhoea were measured, the RR was estimated for a 95% CI, based on the Mantel-Haenszel method, and heterogeneity by I<sup>2</sup> and Q test.</div></div><div><h3>Results</h3><div>415 articles were found, only three were included with 406 patients, 217 for the high dose group and 189 low doses. There were no statistically significant differences with respect to complete response (RR = 0.77, 95% CI 0.60–1.01, p = 0.06), partial response (RR = 0.88, 95% CI 0.67–1.16, p = 0.35), relapses (RR = 2.16, 95% CI 0.18–24.7, p = 0.52) and infections (RR = 0.68, 95% CI 0.45–1.04, p = 0.08), while leukopenia and amenorrhoea were significantly uncommon in the low dose group (RR = 0.41, 95% CI 0.22–0.77, p = 0.01) and (RR = 0.40, 95% CI 0.25–0.64, p = 0.002).</div></div><div><h3>Conclusions</h3><div>The use of low-dose cyclophosphamide is as effective as the high-dose regimen and the probability of leukopenia and amenorrhoea is lower.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 374-384"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of thickened-handled spoon in improving feeding performance in patients with rheumatoid arthritis 加粗柄勺在改善类风湿关节炎患者喂养性能中的应用
Revista Colombiana de Reumatología (English Edition) Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI: 10.1016/j.rcreue.2025.07.002
Kaori Mitchell Gil-Rivasplata, Valeria Katiuska Rojas-Del Aguila, Carlos Manuel Escobar-Galindo, Jesús Martin Trinidad-López
{"title":"Use of thickened-handled spoon in improving feeding performance in patients with rheumatoid arthritis","authors":"Kaori Mitchell Gil-Rivasplata,&nbsp;Valeria Katiuska Rojas-Del Aguila,&nbsp;Carlos Manuel Escobar-Galindo,&nbsp;Jesús Martin Trinidad-López","doi":"10.1016/j.rcreue.2025.07.002","DOIUrl":"10.1016/j.rcreue.2025.07.002","url":null,"abstract":"<div><h3>Introduction/objective</h3><div>Rheumatoid arthritis (RA) primarily affects the hand joints, limiting independence for feeding and requiring the use of assistive technology. The thickening of the handles on the spoon is used as a treatment strategy. However, few studies address how much it helps in RA. Therefore, the study aimed to determine the effect of the use of thickened handle spoons on time, performance quality, and perceived hand effort in the improvement of feeding in users simulating RA with restricted hand movements.</div></div><div><h3>Materials and methods</h3><div>A quasi-experimental design was used in which RA was simulated with a simulator glove, comparing feeding experiences with regular spoons.</div></div><div><h3>Results</h3><div>Using spoons with thickened handles had statistically significant effects on the reduction of perceived effort when eating different foods (p = .005); however, there was no significant difference between the number of times food was dropped and the time to complete the activity (p = .78).</div></div><div><h3>Conclusions</h3><div>Spoons with thickened handles reduce the level of perceived effort, which allows for better joint protection and pain management. It also equals the time and efficiency of eating with a conventional spoon.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"32 4","pages":"Pages 351-358"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145335176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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