Revista Colombiana de Reumatología (English Edition)最新文献

{"title":"Schnitzler syndrome: A deep insight into a rare medical disorder","authors":"Luisa Fernanda Jiménez Arcia ,&nbsp;Gloria Vásquez Duque","doi":"10.1016/j.rcreue.2026.102164","DOIUrl":"10.1016/j.rcreue.2026.102164","url":null,"abstract":"<div><div>Schnitzler syndrome is a rare autoinflammatory syndrome, in most cases, its characteristic features are chronic urticaria and monoclonal gammopathy. Over 300 cases have been reported worldwide since its discovery, more frequently in Europe than other regions such as North America, Japan, and Latin America. No predisposing conditions or inheritance pattern associated with this disease have been identified to date. However, it seems that disruption of interleukin 1 (IL-1) homeostasis plays an important role as the main pathophysiological mechanism. The main complications described associated with this disease are malignant lymphoproliferative disorders or the development of amyloidosis. Treatment consists primarily of IL-1 blockade and this has shown significant control of clinical symptoms. In this review we aim to take an in-depth look at the possible pathophysiological mechanisms of this rare entity.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102164"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of implementing a pharmaceutical service in consultations with patients with rheumatoid arthritis","authors":"Sebastián Ospina Pérez ,&nbsp;Evanny S. Valencia Patiño ,&nbsp;Daniel Efrén Rodríguez Ariza ,&nbsp;Juan C. Díaz Coronado ,&nbsp;Carolina Pérez Ríos","doi":"10.1016/j.rcreue.2025.102185","DOIUrl":"10.1016/j.rcreue.2025.102185","url":null,"abstract":"<div><h3>Introduction</h3><div>Rheumatoid arthritis (RA) is an autoimmune, chronic disease with significant morbidity, often hindered by access barriers to therapy.</div></div><div><h3>Objective</h3><div>To assess the effect of a pharmaceutical service in an outpatient rheumatology unit that dispensed medications at the end of the consultation.</div></div><div><h3>Material and methods</h3><div>An observational-analytical, retrospective study tracking a cohort of RA patients (before and after the introduction of the pharmacy service). Bivariate analysis was conducted using the Chi-square test, and multivariate analysis using a regression model with the variables disease remission (DAS28 (ESR) &lt; 2.6) and moderate-to-high RA activity (DAS28 (ESR) &gt; 3.2).</div></div><div><h3>Results</h3><div>A total of 544 patients were included, of which 435 (80.0%) were female. Remission was observed in 266 (48.9%) patients before and 384 (70.6%) after implementation of the pharmaceutical service. Factors associated with RA remission included biological therapy (HR .37 95% CI .25–.56), corticosteroid therapy (HR .31 95% CI .21–.44), leflunomide (HR .55 95% CI .42–.72), sulfasalazine (HR .60 95% CI .42–.86), and having access to the pharmaceutical service (HR 2.93 95% CI 2.23–3.85).</div></div><div><h3>Conclusions</h3><div>Implementing a pharmaceutical service that dispenses medications for rheumatoid arthritis immediately after consultation was associated with disease remission.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102185"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative review: Mesenchymal stem cells derived from the umbilical cord and osteoarthritis","authors":"Sofía Arias-Correal ,&nbsp;Ana María Santos ,&nbsp;María Helena Pedraza ,&nbsp;John Londoño ,&nbsp;Igor Rueda-Cárdenas ,&nbsp;Keisy Orduz-Uribe ,&nbsp;Laura Manuela Olarte-Bermúdez ,&nbsp;Luz Mabel Ávila-Portillo","doi":"10.1016/j.rcreue.2026.504859","DOIUrl":"10.1016/j.rcreue.2026.504859","url":null,"abstract":"<div><div>Osteoarthritis (OA) is the leading cause of articular pain in adult patients, with a high worldwide prevalence and a trend towards increasing. By 2050, 642 million people are expected to suffer from knee OA. Current treatment focuses on measures to prevent progressive joint wear and control symptoms such as pain. Research in regenerative medicine, including the infiltration of platelet-rich plasma, has not yet provided solid evidence for its efficacy. With the advent of cellular therapy, the isolation and expansion of mesenchymal stem cells (MSCs) from various origins have shown promise in reducing inflammation and creating a suitable environment for the regeneration of articular cartilage. This narrative review focuses on umbilical cord-derived mesenchymal stem cells (UC-MSCs), which have certain advantages over other types of MSCs. It summarizes the various clinical trials conducted in recent years, based on a search of multiple databases.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 504859"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic diarrhea as initial manifestation of polyarteritis nodosa: A case-based review","authors":"Paul J. Tejada-Llacsa ,&nbsp;Julia Sumire Umes ,&nbsp;Manuel Francisco Ugarte-Gil ,&nbsp;Graciela S. Alarcón ,&nbsp;Víctor Román Pimentel-Quiroz","doi":"10.1016/j.rcreue.2026.102174","DOIUrl":"10.1016/j.rcreue.2026.102174","url":null,"abstract":"<div><h3>Introduction</h3><div>Polyarteritis nodosa is a rare form of vasculitis which affects medium and small arteries. Gastrointestinal involvement occurs in 14–65% of patients, the most common symptom being abdominal pain; in a few cases, intestinal perforation may occur. Chronic diarrhea at disease onset is, however, very uncommon.</div></div><div><h3>Objective</h3><div>To present the case of an elderly man with chronic diarrhea as the main manifestation of polyarteritis nodosa that progressed to intestinal perforation.</div></div><div><h3>Material and methods</h3><div>The diagnosis of polyarteritis nodosa was made by intestinal biopsy; cyclophosphamide was administered as induction treatment with progressive clinical improvement. Furthermore, a PubMed literature review was conducted.</div></div><div><h3>Results</h3><div>Three communications on which diarrhea was reported as a manifestation of polyarteritis nodosa; in one of these patients, a 13-year-old girl, chronic diarrhea was the main manifestation.</div></div><div><h3>Conclusion</h3><div>This case illustrates the diagnostic complexity of polyarteritis nodosa due to non-specific symptoms and atypical presentation such as diarrhea, underscoring the importance for early recognition and intervention.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102174"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silicone breast implant-related illness or breast implant-related “ASIA” syndrome: Expert consensus","authors":"Andrés A. Hormaza-Jaramillo ,&nbsp;Damaris Romero Chamorro ,&nbsp;Yeison Santamaría Alza ,&nbsp;Alejandro Duque Restrepo ,&nbsp;David Enrique Guarín Sastre ,&nbsp;Jaime Eduardo Pachón Suárez ,&nbsp;María Isabel Cadena Ríos ,&nbsp;Diana Rocío Gil Calderón ,&nbsp;Daniel G. Fernández-Ávila ,&nbsp;Felipe Mesa Betancur ,&nbsp;Gloria María Vásquez D. ,&nbsp;Héctor Ernesto Barbosa Landínez ,&nbsp;Adriana Rojas-Villarraga","doi":"10.1016/j.rcreue.2026.102186","DOIUrl":"10.1016/j.rcreue.2026.102186","url":null,"abstract":"<div><h3>Introduction</h3><div>Breast augmentation surgeries are very common, but in recent years there has been a growing interest in their possible relationship with the appearance of nonspecific symptoms and signs, as well as the development of autoimmune disorders. The lack of a consensus about the syndrome is a controversial issue for the scientific community and generates uncertainty among women with breast implants in Colombia.</div></div><div><h3>Objective</h3><div>To provide guidelines for the evaluation, approach, and follow-up of silicone breast implant-related disease, or ASIA syndrome, based on evidence and clinical expert opinion.</div></div><div><h3>Methods</h3><div>Experts from the Colombian Society of Rheumatology and the Colombian Society of Plastic Surgery and an independent methodological team developed a systematic literature review and consensus using a modified Delphi method.</div></div><div><h3>Results</h3><div>The evidence for an association between silicone breast implants and the development of symptoms, autoimmune or rheumatic diseases is limited, and a definitive causal relationship has not been demonstrated. The low certainty of the evidence is due to bias, study heterogeneity, and non-specific, self-reported symptoms. On this basis, 22 consensus statements were formulated, highlighting the importance of an individualized medical approach, comprehensive evaluation, and effective communication with patients about risks and expectations before implantation and explantation procedures.</div></div><div><h3>Conclusions</h3><div>Evaluation and therapeutic decisions in women with suspected silicone implant-associated disease should be based on available scientific evidence. Future research should explore the causality of the syndrome and improve disease characterization.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102186"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can cardiovascular risk factors affect the result of nailfold videocapillaroscopy? A retrospective multicentre study","authors":"Eva Álvarez Andrés ,&nbsp;Eugenio de Miguel ,&nbsp;Laura Nuño Nuño ,&nbsp;Paloma García de la Peña Lefebvre ,&nbsp;Itsaso Losantos ,&nbsp;Alejandro Balsa ,&nbsp;Paloma Turiel ,&nbsp;Nuria Garvin ,&nbsp;Manuel Beladiez ,&nbsp;Camila Tapia ,&nbsp;Cristina Zamora ,&nbsp;Ana Belén Rodriguez ,&nbsp;Clara Sangüesa ,&nbsp;Patricia López ,&nbsp;Rocío Mustienes ,&nbsp;Ana Cruz","doi":"10.1016/j.rcreue.2026.102171","DOIUrl":"10.1016/j.rcreue.2026.102171","url":null,"abstract":"<div><h3>Objectives</h3><div>Nailfold capillaroscopy (NC) is used in the study of Raynaud’s phenomenon (RPh). Many people have cardiovascular risk factors (CVRF): tobacco (TOB), diabetes (DM), alcohol (ALC), dyslipidaemia (DL), arterial hypertension (HT), and obesity (OBE). The objective of the work was to investigate whether CVRF produce capillaroscopic alterations, which could influence their final interpretation.</div></div><div><h3>Methods</h3><div>Multicentre descriptive retrospective study of patients referred to CP consultation for RPh or suspected connective tissue disease in two Madrid hospitals between 2015 and 2018. 200x videocapillaroscopy (Dinolite®) was used. Analytical, clinical, therapeutic variables, CVRF, and capillaroscopic alterations (tortuosities, ramifications, dilations, giant capillaries, decreased density, and haemorrhages) were collected. For the statistical study, parametric and non-parametric tests were used (statistical significance at p &lt; .05).</div></div><div><h3>Results</h3><div>340 medical records were reviewed, 286 (84.1%), mean age of 52.36±16.97 years; 270 had RPh (79.4%) and 212 (62.4%) CVRF: 108 TOB (31.8%), 108 DL (31.8%), 62 H T (18.2%), 20 DM (5.8%), 8 ALC (2.4%). Three groups were formed: 155 primary RPh (45.6%), 123 with connective tissue disease (36.2%) and 62 with other osteoarticular diseases (18.2%). The statistical study showed an association between all capillaroscopic alterations and CVRF (p &lt; .001), as well as between: decreased density with HT (p = 0.006); tortuosities with HT (p &lt; .001) and hypercholesterolaemia (p = .006); Dilations, ramifications, haemorrhages with HT (p &lt; .001, p = .019, and p = .008) and TOB (p &lt; .001, p = .019, and p = .002); giant capillaries with TOB (p = .034).</div></div><div><h3>Conclusions</h3><div>This work shows the association between capillaroscopic alterations and CVRF, which should be considered for correct CP interpretation.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102171"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relapses in idiopathic inflammatory myopathies: a perspective from the Colombian clinical experience","authors":"Andrés Hormaza-Jaramillo","doi":"10.1016/j.rcreue.2026.504881","DOIUrl":"10.1016/j.rcreue.2026.504881","url":null,"abstract":"","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 504881"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147454075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the classification criteria for antiphospholipid syndrome (APS) of ACR/EULAR 2023 vs. Sidney criteria 2006 in a sample of pregnant women with APS","authors":"Laura Vela Valle ,&nbsp;Jorge Perbech Larraz ,&nbsp;Margarita Míriam Lesta Colmenero ,&nbsp;Maria Patricia Solana Hidalgo ,&nbsp;Borja del Carmelo Gracia Tello ,&nbsp;Mercedes Pilar Pérez Conesa ,&nbsp;Luis Sáez Comet","doi":"10.1016/j.rcreue.2026.102189","DOIUrl":"10.1016/j.rcreue.2026.102189","url":null,"abstract":"<div><h3>Introduction</h3><div>Antiphospholipid antibody syndrome (APS) is characterized by the presence of thrombosis and obstetric pathology.</div></div><div><h3>Objective</h3><div>To analyze the diagnostic validity of the APS classification criteria published in 2023 by the American College of Rheumatology (ACR) together with the European Alliance of Associations for Rheumatology (EULAR) and to compare them with the 2006 Sydney criteria in pregnant women with suspected APS.</div></div><div><h3>Material and methods</h3><div>Retrospective observational cohort study based on the follow-up of 754 pregnancies by the Autoimmune Diseases Unit of the Miguel Servet University Hospital in Zaragoza. The diagnosis of its specialist doctors was considered to be gold-standard. Sensitivity, specificity, positive and negative predictive values, and area under the curve (AUC) were calculated for the Sydney and ACR/ELAR criteria, with a value of <em>P</em> &lt; .05.</div></div><div><h3>Results</h3><div>The 2023 ACR/EULAR classification criteria had a sensitivity of 17.47% (AUC 0.583) compared to 74.70% (AUC 0.871) for the Sydney criteria.</div></div><div><h3>Discussion</h3><div>The new ACR/EULAR 2023 criteria are more complex due to the incorporation of new evidence in antiphospholipid syndrome; However, in terms of results, we found a clearly lower sensitivity in the new criteria in agreement with the findings of other studies.</div></div><div><h3>Conclusions</h3><div>The diagnosis of APS continues to be a challenge, due to its multifactorial nature, high prevalence of thrombosis and pregnancy morbidity in the population, broad range of antiphospholipid antibody and the absence of a gold-standard. The results of our study suggest a worse diagnostic performance of the ACR/EULAR criteria compared to the Sydney criteria for the classification of obstetric APS, so further studies are needed to confirm these findings.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102189"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthritis mutilans, not always psoriatic disease. Case report","authors":"Natalia Andrea Uribe-Ruiz ,&nbsp;Santiago José Morón-Serrano ,&nbsp;Gloria Vásquez ,&nbsp;Luis Alonso González-Naranjo ,&nbsp;Carlos Horacio Muñoz-Vahos ,&nbsp;Adriana Lucía Vanegas-García","doi":"10.1016/j.rcreue.2025.102166","DOIUrl":"10.1016/j.rcreue.2025.102166","url":null,"abstract":"<div><h3>Introduction</h3><div>Arthritis mutilans is described in psoriatic arthropathy and as a rare manifestation of systemic sclerosis, but not in overlap syndromes.</div></div><div><h3>Findings and diagnosis</h3><div>We describe the case of a patient with a systemic sclerosis/systemic lupus erythematosus overlap syndrome who initially had non-erosive polyarthritis and progressed to arthritis mutilans requiring immunosuppressive therapy change.</div></div><div><h3>Conclusion</h3><div>Recognition of this complication is essential because of the treatment and prognostic implications.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102166"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of rhupus treated with filgotinib: A promising therapeutic perspective","authors":"Raffaele Barile ,&nbsp;Cinzia Rotondo ,&nbsp;Valeria Rella ,&nbsp;Francesco Paolo Cantatore ,&nbsp;Addolorata Corrado","doi":"10.1016/j.rcreue.2026.102180","DOIUrl":"10.1016/j.rcreue.2026.102180","url":null,"abstract":"<div><h3>Rhupus syndrome</h3><div>Rhupus syndrome, characterized by overlapping clinical features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), presents significant therapeutic challenges due to its complex pathogenesis and limited treatment options. This case report evaluates the efficacy of filgotinib, a selective JAK1 inhibitor, in a patient with refractory rhupus syndrome.</div></div><div><h3>Case presentation</h3><div>A 42-year-old male, initially diagnosed with SLE in 2013, presented with persistent polyarthritis, cutaneous manifestations, and constitutional symptoms. Conventional treatments including hydroxychloroquine, methotrexate, and belimumab failed to achieve adequate disease control.</div></div><div><h3>Diagnosis and treatment</h3><div>In October 2022, the diagnosis was revised to rhupus based on the evolution of clinical manifestations and laboratory findings, leading to the initiation of filgotinib, a JAK1 inhibitor. Disease activity was monitored over 24 months using standardized assessment tools.</div></div><div><h3>Results</h3><div>Significant clinical improvement was observed within weeks of filgotinib initiation, enabling prednisone dose reduction and maintaining low disease activity throughout the 24-month follow-up period.</div></div><div><h3>Conclusion</h3><div>This case highlights the therapeutic potential of filgotinib in managing rhupus syndrome but further research and larger clinical trials are necessary to establish filgotinib's therapeutic potential and safety profile in the management of SLE.</div></div>","PeriodicalId":101099,"journal":{"name":"Revista Colombiana de Reumatología (English Edition)","volume":"33 1","pages":"Article 102180"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147453959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}