Diffuse alveolar hemorrhage secondary to anti-synthetase syndrome

María Fernanda Castillo López , Eric Andrey Rodríguez Vega , Mayra Edith Mejía Ávila , Jorge Rojas Serrano
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Abstract

Introduction

Alveolar hemorrhage syndrome can be secondary to multiple autoimmune disorders. The objective is to describe three diffuse alveolar hemorrhage (DAH) cases secondary to anti-synthetase syndrome (ASSD).

Presentation of the case

Three cases of ADH secondary to ASSD are described: one positive to anti-PL7, another positive to anti-PL12, and the last patient with double positivity to anti-Jo1 and anti-OJ. The patients presented improvement after receiving immunosuppressive treatment.

Discussion

The evolution with therapeutic response and resolution of DAH supports the conclusion that ASSD is a potentially treatable cause of DAH and should be considered within the differential diagnosis in diagnosing DAH.

Conclusion

The described cases contribute to the knowledge of DAH, where ASSD should be considered in diagnosing DAH.

继发于抗合成酶综合征的弥漫性肺泡出血
导言肺泡出血综合征可继发于多种自身免疫性疾病。病例介绍本文介绍了三例继发于抗合成酶综合征(ASSD)的弥漫性肺泡出血(DAH)病例:一例患者抗PL7阳性,另一例患者抗PL12阳性,最后一例患者抗Jo1和抗OJ双阳性。这些患者在接受免疫抑制治疗后病情有所好转。讨论随着治疗反应的变化和 DAH 的缓解,支持了 ASSD 是 DAH 潜在的可治疗病因的结论,在诊断 DAH 时应将其作为鉴别诊断的一部分。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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