MedComm – Biomaterials and Applications最新文献_第6页

Multiple biomaterials for immediate implant placement tissue repair: Current status and future perspectives 用于即刻植入组织修复的多种生物材料：现状与未来展望

MedComm – Biomaterials and Applications Pub Date : 2024-02-29 DOI: 10.1002/mba2.69

Xiaoqi Su, Shasha Jia, Xueya Wang, Baodong Zhao, Guowei Wang, Xiaojing Wang

{"title":"Multiple biomaterials for immediate implant placement tissue repair: Current status and future perspectives","authors":"Xiaoqi Su, Shasha Jia, Xueya Wang, Baodong Zhao, Guowei Wang, Xiaojing Wang","doi":"10.1002/mba2.69","DOIUrl":"https://doi.org/10.1002/mba2.69","url":null,"abstract":"Immediate oral implant placement is a widely accepted technique, known for its efficacy in reducing treatment duration, surgical visits, and overall healing time. One of the primary challenges associated with immediate implant placement is the attainment of initial stability. The inevitable loss of bone and soft tissue after extraction poses a risk to implant osseointegration in both vertical and horizontal dimensions. Guided tissue regeneration/guided bone regeneration (GTR/GBR) is a well-established method for periodontal regeneration. However, current GTR/GBR membranes lack tissue inherent regeneration properties and necessitate combination with grafts to enhance tissue recovery. In this context, biomaterials have emerged as a promising option due to their good biocompatibility, biodegradability, and bioactive properties. They present a potential alternative to standard autologous/allograft procedures. The field of biomaterials for bone regeneration has rapidly evolved, developing new guiding materials and engineering techniques. These advances have become integral in addressing tissue defects at the immediate implant site. Various materials such as bioceramics, natural polymers, and synthetic polymers have been used for tissue repair. This article undertakes an etiological examination of tissue deficiency associated with immediate implant placement. Additionally, it reviews the advantages and disadvantages of a variety of biomaterials, aiming to provide references for clinical treatment and areas for further investigation.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.69","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140000724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise tumor treatment: pH-responsive nanoparticles for modulating and real-time monitoring tumor microenvironment 精确治疗肿瘤：用于调节和实时监测肿瘤微环境的 pH 响应纳米粒子

MedComm – Biomaterials and Applications Pub Date : 2024-02-25 DOI: 10.1002/mba2.73

Xinming Su, Zehua Wang, Shiwei Duan

{"title":"Precise tumor treatment: pH-responsive nanoparticles for modulating and real-time monitoring tumor microenvironment","authors":"Xinming Su, Zehua Wang, Shiwei Duan","doi":"10.1002/mba2.73","DOIUrl":"https://doi.org/10.1002/mba2.73","url":null,"abstract":"The tumor microenvironment (TME) presents a unique and complex milieu, characterized by spatial and temporal heterogeneity that significantly hinders cancer treatment strategies. Nanoparticles emerge as a versatile solution, potentially overcoming these challenges by enabling targeted therapy and real-time, concurrent assessment of therapeutic effectiveness under abnormal physiological and biochemical conditions. A recent study by Lu et al. introduces a significant innovation in the form of pH-responsive companion diagnostics (CDx) reagent, comprising core-satellite semiconducting polymer nanoparticles @ cobalt hydroxide oxide (SPNs@CoOOH). This novel structure demonstrates a specific affinity for TME targeting, while effectively combining chemiluminescence with reactive oxygen species (ROS)-mediated therapy. This synergy facilitates efficient tumor treatment alongside real-time monitoring, using only water as a resource in the body. As research in nanoparticle-based strategies progresses, the incorporation of pH-responsive systems heralds new possibilities for personalized and more effective cancer therapies.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.73","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139976572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardization of 3D printing parameters to control the size and shape of pores in Polylactic acid scaffolds 控制聚乳酸支架中孔隙大小和形状的 3D 打印参数标准化

MedComm – Biomaterials and Applications Pub Date : 2024-02-13 DOI: 10.1002/mba2.74

Lucía Pérez-Sánchez, Misael A. Ortiz de la O, Marco A. Álvarez-Pérez, Monserrat Llaguno-Munive, Osmar A. Chanes-Cuevas, Janeth Serrano-Bello

{"title":"Standardization of 3D printing parameters to control the size and shape of pores in Polylactic acid scaffolds","authors":"Lucía Pérez-Sánchez, Misael A. Ortiz de la O, Marco A. Álvarez-Pérez, Monserrat Llaguno-Munive, Osmar A. Chanes-Cuevas, Janeth Serrano-Bello","doi":"10.1002/mba2.74","DOIUrl":"https://doi.org/10.1002/mba2.74","url":null,"abstract":"The challenge of three-dimensional (3D) printing by polymeric extrusion in tissue bioengineering is to control with precision the microarchitecture and porous interconnectivity of scaffolds, as well as search for models that allow and facilitate the development of personalized constructs that meet optimal characteristics for the regeneration of significant bone defects. In this study, anatomically accurate scaffolds were designed and printed to a critical size defect from a microtomography image of the rat calvaria. Different software is used to design a scaffold with exact anatomy. With Ultimaker Cura software, distinct printing parameters were standardized, permitting the printing of different types of pores and graded porosity scaffolds, with exact adaptation to the bone defect, utilizing a commercial 3D printer with a fused deposition modeling technique and compensating for the limitations of the method. The scaffolds were characterized by evaluating their mechanical properties and surface characteristics (pore size and porosity), employing scanning electron microscopy images, verifying that the size and shape of the pores were controlled, and evaluating cell viability and cell distribution on the 3D printed scaffold. Therefore, this work proves that by standardizing the printing parameters, it was possible to print a unique customized scaffold, controlling the shape and size of pores.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.74","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective 使用天然生物材料及其衍生物治疗周围神经损伤：进展与前景

MedComm – Biomaterials and Applications Pub Date : 2024-02-03 DOI: 10.1002/mba2.72

Suraj Kumar, Rishabha Malviya, Sonali Sundram

{"title":"Management of peripheral nerve injuries using natural based biomaterials and their derivatives: Advances and prospective","authors":"Suraj Kumar, Rishabha Malviya, Sonali Sundram","doi":"10.1002/mba2.72","DOIUrl":"https://doi.org/10.1002/mba2.72","url":null,"abstract":"The management of peripheral nerve injuries is an important concern due to the their incidence of nerve lesions and inappropriate regeneration that follows severe injuries, which ultimately reduces the lives of patients with this condition. Different strategies have been investigated to repair severe nerve injuries with the improvement of motor and sensory regeneration. Although autograft remains the gold standard technique, an emerging number of research articles concerning nerve conduit use have been reported in the last few years. Nerve conduits aim to overcome autograft disadvantages, but they satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural-based biomaterials have great potential to be used to produce nerve guides. Although they have many characteristics with synthetic biomaterials, natural-based biomaterials are preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review highlights the recent progress in the development of natural-based biomaterials and their derivatives for the management of peripheral nerve injuries.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.72","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139676730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal omics of life energy: Towards medicine of frequencies and terahertz drugs 生命能量的时空全息学：迈向频率和太赫兹药物医学

MedComm – Biomaterials and Applications Pub Date : 2024-01-23 DOI: 10.1002/mba2.71

Li-Ping Wang, Feng Gao, Zhou-Xiang Zhao, Shi-hao Liu, Rui-Song Xu, Jun Guo, Feng Zhang

{"title":"Spatiotemporal omics of life energy: Towards medicine of frequencies and terahertz drugs","authors":"Li-Ping Wang, Feng Gao, Zhou-Xiang Zhao, Shi-hao Liu, Rui-Song Xu, Jun Guo, Feng Zhang","doi":"10.1002/mba2.71","DOIUrl":"https://doi.org/10.1002/mba2.71","url":null,"abstract":"The quantum mechanisms how life efficiently utilizes energy and transmits information remain unclear yet. Frequency medicine, an emerging cross-discipline of both quantum mechanics and biomedicine, is a promising turning point for biomaterials and medicine developing from the matter level to the energy level. Recognizing the pivotal role of molecular vibrational frequencies in resonant energy coupling and transmission underscores the potential of frequency medicine to precisely regulate biomaterial vibrations, influencing interactions and reactions in living organisms. At present, scientists have unveiled sophisticated phototherapeutics; nevertheless, their advancement necessitates the precise mapping of the life energy. In contrast to genomics, proteomics, and metabolomics studied on the matter level, omics of frequencies related to medicine should be on the energy level. Herein, starting from the history of frequency medicine, and followed by the introduction of vibrational strong coupling applications in life sciences, we emphasize the significance, necessity, and urgency of studying spatiotemporal omics of medicine frequencies. By decoding the energy atlas of life, we can acquire profound insights into the quantum mechanisms that govern life processes from an energy standpoint. We anticipate that the integration of biomaterials with spatiotemporal frequency omics related to medical research will contribute significantly to advancing the goals of precision medicine, potentially revolutionizing pharmaceuticals, such as terahertz drugs.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.71","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139550505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-based CRISPR/Cas9 delivery system for genome editing in cancer treatment 基于纳米技术的 CRISPR/Cas9 传递系统用于癌症治疗中的基因组编辑

MedComm – Biomaterials and Applications Pub Date : 2024-01-14 DOI: 10.1002/mba2.70

Shiyao Zhou, Yingjie Li, Qinjie Wu, Changyang Gong

{"title":"Nanotechnology-based CRISPR/Cas9 delivery system for genome editing in cancer treatment","authors":"Shiyao Zhou, Yingjie Li, Qinjie Wu, Changyang Gong","doi":"10.1002/mba2.70","DOIUrl":"https://doi.org/10.1002/mba2.70","url":null,"abstract":"The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (CRISPR/Cas9) systems initiate a revolution in genome editing, which have a significant potential for treating cancer. A significant amount of research has been conducted regarding genetic modification using CRISPR/Cas9 systems, and 33 clinical trials using ex vivo or in vivo CRISPR/Cas9 gene editing techniques have been carried out to treat cancer. Despite its potential advantages, the main obstacle to convert CRISPR/Cas9 technology into clinical genome editing applications is the safe and efficient transport of genetic material owing to various extra- and intracellular biological hurdles. We outline the characteristics of three forms of CRISPR/Cas9 cargos, plasmids, mRNA/sgRNA, and ribonucleoprotein (RNP) complexes in this review. The recent in vivo nanotechnology-based delivery techniques for these three categories to treat cancer are then reviewed. In the end, we outline the prerequisites for effective and secure in vivo CRISPR/Cas9 delivery in clinical contexts and discuss challenges with current nanocarriers. This review offers a thorough overview of the CRISPR/Cas9 nano-delivery system for the treatment of cancer, serving as a resource for the design and building of CRISPR/Cas9 delivery systems and offering fresh perspectives on the treatment of tumors.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.70","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139468285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress of silk fibroin biomaterials: A bibliometric analysis from 2012 to 2022 丝纤维蛋白生物材料的研究进展：2012 至 2022 年文献计量分析

MedComm – Biomaterials and Applications Pub Date : 2024-01-06 DOI: 10.1002/mba2.68

Peili Luo, Chuanyu Ren, Chao Lu, Xin Pan, Zhengwei Huang

引用次数: 0

Magnetic-based photosensitizer to improve the efficiency of antimicrobial photodynamic therapy against mature dental caries-related biofilms 基于磁性的光敏剂可提高针对成熟龋齿相关生物膜的抗菌光动力疗法的效率

MedComm – Biomaterials and Applications Pub Date : 2023-12-14 DOI: 10.1002/mba2.67

Abdulrahman A. Balhaddad, Lamia Mokeem, Rashed Alsahafi, Michael D. Weir, Hockin H. K. Xu, Mary Anne S. Melo

{"title":"Magnetic-based photosensitizer to improve the efficiency of antimicrobial photodynamic therapy against mature dental caries-related biofilms","authors":"Abdulrahman A. Balhaddad, Lamia Mokeem, Rashed Alsahafi, Michael D. Weir, Hockin H. K. Xu, Mary Anne S. Melo","doi":"10.1002/mba2.67","DOIUrl":"https://doi.org/10.1002/mba2.67","url":null,"abstract":"Antimicrobial photodynamic therapy (aPDT) shows promise in eliminating oral pathogens without inducing microbial resistance. Yet, it faces limited biofilm penetration by the photosensitizer, which hinders its efficacy against mature, thick biofilms. This study assesses the effectiveness of the MagTBO (magnetic nanoparticles and toluidine-blue ortho) nanoplatform against mature Streptococcus mutans biofilms associated with dental caries. The study employs constant-depth film fermenter (CDFF) models, known as “artificial mouth,” to replicate caries processes and allow biofilm growth over teeth. This method enables the evaluation of biofilm-induced mineral loss under cariogenic challenge over 5 and 10 days. The study shows that MagTBO improves aPDT's effectiveness against highly mature and complex biofilms over 5 and 10 days. However, the biofilm reduction unaffected the mineral content in the underlying dentin. This presents a promising approach for clinical aPDT protocols. However, it is crucial to acknowledge that these findings are based on in vitro studies and may necessitate further clinical confirmation. In summary, our data indicate that magnetic-based photosensitizers enhance the modulation of pathogenic oral biofilms by aPDT, offering potential advancements in clinical aPDT protocols.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.67","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138634350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of nanoparticle-based drug delivery system for inflammation treatment and diagnosis 用于炎症治疗和诊断的纳米颗粒给药系统的开发

MedComm – Biomaterials and Applications Pub Date : 2023-12-06 DOI: 10.1002/mba2.65

Qin Qin, Mao Wang, Yu Zou, Dujiang Yang, Yuchuan Deng, Shuyu Lin, Yiran Song, Rui Li, Yu Zheng

{"title":"Development of nanoparticle-based drug delivery system for inflammation treatment and diagnosis","authors":"Qin Qin, Mao Wang, Yu Zou, Dujiang Yang, Yuchuan Deng, Shuyu Lin, Yiran Song, Rui Li, Yu Zheng","doi":"10.1002/mba2.65","DOIUrl":"https://doi.org/10.1002/mba2.65","url":null,"abstract":"Inflammation is a prevalent pathological process that accompanies the onset and progression of numerous acute and chronic diseases including rheumatoid arthritis, sepsis, pancreatitis, atherosclerosis, ischaemic brain/heart disease and so forth. However, conventional anti-inflammatory drugs have certain disadvantages such as nonspecific tissue distribution, low bioavailability, and a short half-life, resulting in off-target side effects and limited efficacy in disease control. To address these issues, nanoparticles have emerged as a novel therapeutic paradigm in this field to attain inflammation targeting and improve drug pharmacokinetic properties via the well-recognized enhanced permeability and retention (EPR) effect at the inflammatory site. Existing reviews are predominantly centered on inflammatory pathology introduction and vector design. As a necessary complement, this review mainly elaborates on the introduction of inflammation core events, the history of the drug delivery system for anti-inflammatory drugs, the action mechanism of inflammation targeting vectors, nanoparticle classification based on targeting moiety, methods to combine targeting moiety with core nanoparticles, techniques to assess targetability in vitro and in vivo and finally the challenges and prospects in this field. The information provided herein offers practical guidance to researchers seeking to develop and evaluate inflammation targeting vectors rationally.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138502518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-inspired synthesis of bio-hydroxyapatite/synthetic hydroxyapatite hybrid nanosystems 仿生合成生物羟基磷灰石/合成羟基磷灰石杂化纳米体系

MedComm – Biomaterials and Applications Pub Date : 2023-11-28 DOI: 10.1002/mba2.64

Luis F. Zubieta-Otero, Omar M. Gomez-Vazquez, Brandon A. Correa-Piña, Mario E. Rodriguez-Garcia

{"title":"Bio-inspired synthesis of bio-hydroxyapatite/synthetic hydroxyapatite hybrid nanosystems","authors":"Luis F. Zubieta-Otero, Omar M. Gomez-Vazquez, Brandon A. Correa-Piña, Mario E. Rodriguez-Garcia","doi":"10.1002/mba2.64","DOIUrl":"https://doi.org/10.1002/mba2.64","url":null,"abstract":"The current study focuses on the synthesizing of novel hybrid nanosystems of bio-hydroxyapatite (BioHAp)/synthetic-hydroxyapatite (HAp-Syn). Bio-HAp was defatted, deproteinized, and then sonicated to obtain nanoparticles (nBioHAp). Hybrid nanosystems (HNS) were synthesized by wet chemical precipitation using nBioHAp as nucleation sites and applying four different precipitation times of 45, 90, 135, and 180 min. X-ray diffraction (XRD) showed that the patterns of the nBioHAp and HAp-Syn samples have broadened diffraction peaks due to simultaneous elastic and inelastic scattering. Their crystallite size is about 25 nm, while the hybrid nanosystems have a size between 35 and 40 nm. Fourier-transform infrared spectroscopy (FT-IR) revealed the main groups associated with hydroxyapatite (PO32−, OH−, and CO32−), and the nanometer character of the crystals was demonstrated by studying the full width at half maximum (FWHM) of the spectra. Scanning electron microscopy (SEM) revealed the differences between the morphologies of nBioHAp and HAp-Syn. The shape of HNS resembled that of biogenic HAp, which was confirmed by transmission electron microscopy (TEM). Inductively coupled plasma spectroscopy (ICP-OES) and energy dispersive X-ray spectroscopy (EDS) were used to confirm the elemental composition of Mg, Na, K, and Zn as minority ions.","PeriodicalId":100901,"journal":{"name":"MedComm – Biomaterials and Applications","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mba2.64","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138454737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1