Mechanobiology in Medicine最新文献_第2页

Early diabetes screening via red blood cell mechanics using microfluidic chip integration 利用微流控芯片集成红细胞力学进行早期糖尿病筛查

Mechanobiology in Medicine Pub Date : 2025-05-29 DOI: 10.1016/j.mbm.2025.100136

Yibo Feng , Bingchen Che , Yonggang Liu , Cangmin Zhang , Jiameng Niu , Jiangcun Yang , Guangyin Jing , Dan Sun , Xiaobo Gong , Ce Zhang

{"title":"Early diabetes screening via red blood cell mechanics using microfluidic chip integration","authors":"Yibo Feng , Bingchen Che , Yonggang Liu , Cangmin Zhang , Jiameng Niu , Jiangcun Yang , Guangyin Jing , Dan Sun , Xiaobo Gong , Ce Zhang","doi":"10.1016/j.mbm.2025.100136","DOIUrl":"10.1016/j.mbm.2025.100136","url":null,"abstract":"<div><div>Early diagnosis of diabetes is crucial, as diabetes, particularly type 2, can eventually lead to irreversible changes and complications. Conventional techniques, such as the Fasting Plasma Glucose (FPG) Test and Hemoglobin A1c (HbA1c) Test, measure blood glucose levels, which fluctuate over time and are insensitive to early stages. In this study, we focus on measuring the mechanical properties of red blood cells, as their irreversible changes can indicate early pathological impacts of diabetes. We developed a microfluidic chip with a symmetrical hyperbolic structure. By periodically altering the state of the valve membrane, we generate a reciprocating shear flow field that repeatedly acts on groups of RBCs. We then quantify the morphological parameters of the RBCs, establishing a correlation between the reciprocating shear flow field and the morphological changes of the cells. Using the developed microfluidic chip, we investigated the resistance of blood cells from 20 healthy volunteers to mechanical stimuli. The results indicated a significant correlation between the deformability of red blood cells and age, while no such correlation was found among individuals of the same gender. This study highlights the potential of utilizing the mechanical properties of red blood cells as an early diagnostic tool for diabetes. Furthermore, given the ease of integration of microfluidic chips, they present a promising high-throughput diagnostic solution for large-scale clinical screening.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 3","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanosensitive nuclear checkpoint: nuclear envelope as a sensor of chromosomal instability and driver of cell fate 机械敏感核检查点：核包膜作为染色体不稳定性的传感器和细胞命运的驱动因素

Mechanobiology in Medicine Pub Date : 2025-05-21 DOI: 10.1016/j.mbm.2025.100135

Chenyang Ji, Junwei Chen, Fuxiang Wei

引用次数: 0

Neuromorphic chips for biomedical engineering 生物医学工程用神经形态芯片

Mechanobiology in Medicine Pub Date : 2025-05-15 DOI: 10.1016/j.mbm.2025.100133

Kaiyang Wang , Shuhui Ren , Yunfang Jia , Xiaobing Yan , Lizhen Wang , Yubo Fan

{"title":"Neuromorphic chips for biomedical engineering","authors":"Kaiyang Wang , Shuhui Ren , Yunfang Jia , Xiaobing Yan , Lizhen Wang , Yubo Fan","doi":"10.1016/j.mbm.2025.100133","DOIUrl":"10.1016/j.mbm.2025.100133","url":null,"abstract":"<div><div>The modern medical field faces two critical challenges: the dramatic increase in data complexity and the explosive growth in data size. Especially in current research, medical diagnostic, and data processing devices relying on traditional computer architecture are increasingly showing limitations when faced with dynamic temporal and spatial processing requirements, as well as high-dimensional data processing tasks. Neuromorphic devices provide a new way for biomedical data processing due to their low energy consumption and high dynamic information processing capabilities. This paper aims to reveal the advantages of neuromorphic devices in biomedical applications. First, this review emphasizes the urgent need of biomedical engineering for diversify clinical diagnostic techniques. Secondly, the feasibility of the application in biomedical engineering is demonstrated by reviewing the historical development of neuromorphic devices from basic modeling to multimodal signal processing. In addition, this paper demonstrates the great potential of neuromorphic chips for application in the fields of biosensing technology, medical image processing and generation, rehabilitation medical engineering, and brain-computer interfaces. Finally, this review provides the pathways for constructing standardized experimental protocols using biocompatible technologies, personalized treatment strategies, and systematic clinical validation. In summary, neuromorphic devices will drive technological innovation in the biomedical field and make significant contributions to life health.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 3","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sex-specific effects of RAGE signaling and type 2 diabetes on mouse cortical bone mechanics, structure, and material properties RAGE信号和2型糖尿病对小鼠皮质骨力学、结构和材料特性的性别特异性影响

Mechanobiology in Medicine Pub Date : 2025-05-13 DOI: 10.1016/j.mbm.2025.100132

Timothy Hung , Kaitlyn S. Broz , Remy E. Walk , Simon Y. Tang

{"title":"The sex-specific effects of RAGE signaling and type 2 diabetes on mouse cortical bone mechanics, structure, and material properties","authors":"Timothy Hung , Kaitlyn S. Broz , Remy E. Walk , Simon Y. Tang","doi":"10.1016/j.mbm.2025.100132","DOIUrl":"10.1016/j.mbm.2025.100132","url":null,"abstract":"<div><div>Individuals with type 2 diabetes (T2D) are prone to fracture at numerous skeletal sites despite presenting with a higher bone mineral density (BMD). The accumulation of Advanced Glycation End-products (AGEs) in the bone tissues of patients with T2D could be contributing to this paradox of increased skeletal fragility with higher BMD. AGEs can also impair bone cell homeostasis via the receptor for AGEs (RAGE). To investigate the effects of diabetes, AGE accumulation, and RAGE signaling on mouse cortical bone, we utilized male and female leptin receptor-deficient (db/db) diabetic mice from three age groups ranging from 3 to 12 months of age, which were crossed with mice carrying constitutively active alleles for a RAGE nullifying point mutation (RAGE<sup>−/−</sup>). The morphological, mechanical and material outcomes of bone were measured using microCT, three-point bending, and AGE assays. We observed significant impairments dependent on age and sex to the bone matrix and whole-bone mechanical behavior due to diabetes, with some impairments alleviated by the deletion of RAGE. In older female diabetic mice, the removal of RAGE signaling prevented the deficits in bone mechanics, morphology, and tissue mineral density (TMD). Male diabetic mice without RAGE signaling exhibited improved material properties compared to wild type controls. The study demonstrated that bone impairments associated with T2D can be prevented with RAGE deletion, and T2D complications may be partially reversible with the therapeutic inhibition of RAGE signaling.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 3","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional traction technology and its application in mechanomedicine 三维牵引技术及其在机械医学中的应用

Mechanobiology in Medicine Pub Date : 2025-04-24 DOI: 10.1016/j.mbm.2025.100131

Xinman Chen , Chenyang Ji , Xi Liu , Ning Wang , Fuxiang Wei , Junwei Chen

引用次数: 0

Prognostic assessment of osteolytic lesions and mechanical properties of bones bearing breast cancer using neural network and finite element analysis☆ 基于神经网络和有限元分析的乳腺癌骨溶解病变和力学特性预后评估

Mechanobiology in Medicine Pub Date : 2025-03-30 DOI: 10.1016/j.mbm.2025.100130

Shubo Wang , Tiankuo Chu , Murtaza Wasi , Rosa M. Guerra , Xu Yuan , Liyun Wang

{"title":"Prognostic assessment of osteolytic lesions and mechanical properties of bones bearing breast cancer using neural network and finite element analysis☆","authors":"Shubo Wang , Tiankuo Chu , Murtaza Wasi , Rosa M. Guerra , Xu Yuan , Liyun Wang","doi":"10.1016/j.mbm.2025.100130","DOIUrl":"10.1016/j.mbm.2025.100130","url":null,"abstract":"<div><div>The management of skeletal-related events (SREs), particularly the prevention of pathological fractures, is crucial for cancer patients. Current clinical assessment of fracture risk is mostly based on medical images, but incorporating sequential images in the assessment remains challenging. This study addressed this issue by leveraging a comprehensive dataset consisting of 260 longitudinal micro-computed tomography (μCT) scans acquired in normal and breast cancer bearing mice. A machine learning (ML) model based on a spatial–temporal neural network was built to forecast bone structures from previous μCT scans, which were found to have an overall similarity coefficient (Dice) of 0.814 with ground truths. Despite the predicted lesion volumes (18.5 % ± 15.3 %) being underestimated by ∼21 % than the ground truths’ (22.1 % ± 14.8 %), the time course of the lesion growth was better represented in the predicted images than the preceding scans (10.8 % ± 6.5 %). Under virtual biomechanical testing using finite element analysis (FEA), the predicted bone structures recapitulated the loading carrying behaviors of the ground truth structures with a positive correlation (y = 0.863x) and a high coefficient of determination (R<sup>2</sup> = 0.955). Interestingly, the compliances of the predicted and ground truth structures demonstrated nearly identical linear relationships with the lesion volumes. In summary, we have demonstrated that bone deterioration could be proficiently predicted using machine learning in our preclinical dataset, suggesting the importance of large longitudinal clinical imaging datasets in fracture risk assessment for cancer bone metastasis.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 2","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overstretch causes lipid accumulation in vascular smooth muscle cells dependent on NADPH oxidase 1 过度拉伸引起血管平滑肌细胞依赖于NADPH氧化酶1的脂质积累

Mechanobiology in Medicine Pub Date : 2025-03-26 DOI: 10.1016/j.mbm.2025.100129

Jiazhen Zhang , Qinfen Li , Suoqi Ding , Wei Xu , Jilei Su , Jingang Cui , Yongsheng Ding

引用次数: 0

Multidimensional excavation of the current status and trends of mechanobiology in cardiovascular homeostasis and remodeling within 20 years 近20年来心血管稳态与重构的力学生物学研究现状与趋势的多维挖掘

Mechanobiology in Medicine Pub Date : 2025-03-19 DOI: 10.1016/j.mbm.2025.100127

Wei Liao , Yuxi Huang , Xiangxiu Wang , Ziqiu Hu , Chuanrong Zhao , Guixue Wang

{"title":"Multidimensional excavation of the current status and trends of mechanobiology in cardiovascular homeostasis and remodeling within 20 years","authors":"Wei Liao , Yuxi Huang , Xiangxiu Wang , Ziqiu Hu , Chuanrong Zhao , Guixue Wang","doi":"10.1016/j.mbm.2025.100127","DOIUrl":"10.1016/j.mbm.2025.100127","url":null,"abstract":"<div><div>Mechanobiology is essential for cardiovascular structure and function and regulates the normal physiological and pathological processes of the cardiovascular system. Cells in the cardiovascular system are extremely sensitive to their mechanical environment, and once mechanical stimulation is abnormal, the homeostasis mechanism is damaged or lost, leading to the occurrence of pathological remodeling diseases. In the past 20 years, many articles concerning the mechanobiology of cardiovascular homeostasis and remodeling have been published. To better understand the current development status, research hotspots and future development trends in the field, this paper uses CiteSpace software for bibliometric analysis, quantifies and visualizes the articles published in this field in the past 20 years, and reviews the research hotspots and emerging trends. The regulatory effects of mechanical stimulation on the biological behavior of endothelial cells, smooth muscle cells and the extracellular matrix, as well as the mechanical-related remodeling mechanism in heart failure, have always been research hotspots in this field. This paper reviews the research advances of these research hotspots in detail. This paper also introduces the research status of emerging hotspots, such as those related to cardiac fibrosis, homeostasis, mechanosensitive transcription factors and mechanosensitive ion channels. We hope to provide a systematic framework and new ideas for follow-up research on mechanobiology in the field of cardiovascular homeostasis and remodeling and promote the discovery of more therapeutic targets and novel markers of mechanobiology in the cardiovascular system.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 2","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanics of horizontal meniscus tear and healing during knee flexion: Finite element analysis 膝关节屈曲时水平半月板撕裂和愈合的生物力学：有限元分析

Mechanobiology in Medicine Pub Date : 2025-03-13 DOI: 10.1016/j.mbm.2025.100128

Bingtong Yan , Minmin Lin , Yang Liu , Jiawei Li , Linjing Peng , Yifei Yao , Guangheng Li , Chao Liu

{"title":"Biomechanics of horizontal meniscus tear and healing during knee flexion: Finite element analysis","authors":"Bingtong Yan , Minmin Lin , Yang Liu , Jiawei Li , Linjing Peng , Yifei Yao , Guangheng Li , Chao Liu","doi":"10.1016/j.mbm.2025.100128","DOIUrl":"10.1016/j.mbm.2025.100128","url":null,"abstract":"<div><div>Meniscus horizontal tear is a common injury that mostly occurs in middle-aged and elderly people, and the effect of repair surgery directly affects the functional recovery of the knee joint and prevention of degenerative joint diseases. However, the stress concentration in a horizontal tear is not well understood. The primary objective of this study was to examine the reparative mechanisms involved in addressing horizontal tears of the meniscus and to elucidate the alterations in mechanical behavior throughout the subsequent postoperative healing stages. Based on clinical MRI scan data of normal human knee joint, an accurate three-dimensional finite element model of the knee joint was established to simulate the meniscus at different states: including complete, horizontal torn, repaired and at different degrees of healing. An animal model was established to conduct in vitro loading experiments to assist in validating the model. Static standing simulation revealed the phenomenon of stress concentration in the area of horizontal tears. Knee flexion simulations identified the risk of tear propagation at the endpoints of the horizontal tear. Following suture repair and progressive healing, stress concentration was observed at the site of sutures, while the stress levels decreased at the endpoints of the horizontal tear. As healing progressed, the mechanical function of the meniscus gradually recovered. During progressive healing, the changing trends can provide a reference for patients' postoperative recovery activities. This finding has important implications for guiding clinical treatment strategies and rehabilitation plans for meniscal tears.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 2","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Swimming induces bone loss via regulating mechanical sensing pathways in bone marrow 游泳通过调节骨髓中的机械感应通路诱导骨质流失

Mechanobiology in Medicine Pub Date : 2025-03-12 DOI: 10.1016/j.mbm.2025.100125

Shaotian Fu , Yahong Lu , Wenkun Sun , Wugui Chen , Chengshou Lin , An Qin

{"title":"Swimming induces bone loss via regulating mechanical sensing pathways in bone marrow","authors":"Shaotian Fu , Yahong Lu , Wenkun Sun , Wugui Chen , Chengshou Lin , An Qin","doi":"10.1016/j.mbm.2025.100125","DOIUrl":"10.1016/j.mbm.2025.100125","url":null,"abstract":"<div><div>Bone is an organ capable of perceiving external mechanical stress in real time and responding dynamically via mechanosensing proteins such as Piezo1 and YAP/TAZ. Upon sensing the mechano-signals, cells within the bone matrix collaborate to coordinate bone formation and resorption, while bone marrow cells are also stimulated and mobilized. High-load exercise stimulates osteoblast differentiation and bone formation. However, the mechanism through which the low-load exercises affect bone homeostasis is still unclear. In this work, we established a long-term swimming training model to unload the mechanical stress in mice. Throughout the training model, we observed a significant loss in trabecular bone mass, as evidenced by microCT scanning and histological staining. Single-cell sequencing of the tibial bone marrow tissue revealed a significant increase in the percentage of bone marrow neutrophils, along with alterations in Integrins and the ERK1/2 signaling pathway. Notably, the changes in both Integrins and the ERK1/2 signaling pathway in macrophages were more pronounced than in other cell types, which suggests a mechanical adaptive response in these cells. Moreover, the involvement of Integrins is also critical for the crosstalk between monocyte precusors and macrophages during swimming. Together, this study provides a resource of the alterations of bone marrow cell gene expression profile after swimming and highlights the importance of Integrins and the ERK1/2 signaling pathway in the bone marrow microenvironment after swimming.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 2","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0