Mechanobiology in Medicine最新文献_第2页

Mechanobiological research fueling the advancement of mechanotherapy and mechanohealth 机械生物学研究推动机械治疗和机械健康的发展。

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2026-03-11 DOI: 10.1016/j.mbm.2026.100180

Peixiang Ma , Zhifeng Yu , Ning Wang , X. Ed Guo , Guy M. Genin , Ling Qin , Dennis E. Discher , Zonglai Jiang , Jie Zhao , Yi-Xian Qin

{"title":"Mechanobiological research fueling the advancement of mechanotherapy and mechanohealth","authors":"Peixiang Ma , Zhifeng Yu , Ning Wang , X. Ed Guo , Guy M. Genin , Ling Qin , Dennis E. Discher , Zonglai Jiang , Jie Zhao , Yi-Xian Qin","doi":"10.1016/j.mbm.2026.100180","DOIUrl":"10.1016/j.mbm.2026.100180","url":null,"abstract":"<div><div>Integrating mechanobiological principles into disease pathogenesis, therapeutic development, and tissue engineering is reshaping our understanding of biological systems and accelerating the advancement of mechanotherapy and mechanohealth. This field reveals how mechanical cues regulate cellular behavior, such as force transmission along integrin-nucleus pathways and collective cell migration, and tissue functions. In doing so, mechanobiology connects fundamental research with clinical applications, from limiting cancer metastasis and fibrosis to promoting bone regeneration and maintaining vascular homeostasis. Building on discussion from the Inaugural International Conference on Mechanobiology (ICM) 2025, integrating mechanobiological research with clinical strategies offers new opportunities to address unmet needs, including personalized anti-fibrotic interventions or precision bone regenerative therapies. At the same time, it supports the broader concept of mechanohealth -- a paradigm focused on preserving the physiological mechanical balance within tissues.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"4 1","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function 细胞骨架预应力稳态是支配活细胞结构和功能的生物学原理

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2026-03-03 DOI: 10.1016/j.mbm.2026.100179

Fazlur Rashid , Ning Wang

{"title":"Cytoskeletal prestress homeostasis is a biological principle that governs living cell structure and function","authors":"Fazlur Rashid , Ning Wang","doi":"10.1016/j.mbm.2026.100179","DOIUrl":"10.1016/j.mbm.2026.100179","url":null,"abstract":"<div><div>Over the last few decades, physical principles have been proposed to explain some biological processes and functions. However, biological principles remain elusive. A biological principle is a governing rule that guides the structure and functions of cells. Biological principles are built upon the laws of physics and chemistry, but they go beyond these laws and are unique to living matter. Here, we discuss what differentiates a biological principle from a physical principle and discuss candidates for biological principles. We review evidence from literature that regulation of cytoskeletal prestress (endogenous cytoskeletal pre-existing tensile stress) is essential for governing biological structures and functions of living cells. We propose that, in addition to the biological principles of Central Dogma and metabolism, cytoskeletal prestress homeostasis is a biological principle of a living cell across all domains of life. We propose that living cells regulate their stress and modulus to limit maximum strain on the cells. Homeostasis of endogenous energy-dependent, stress-supported systems that use cytoskeletal (CSK) prestress (the force of life) to stabilize structure represents a biological principle of a living cell that is not observed in inorganic systems, whereas other basic principles (e.g., self-assembly) are required for living systems but are also found in simpler nonliving systems. Leveraging biological principles of cells may have far-reaching implications in understanding the essence of cell life and designing effective interventions for therapeutics to advance medicine and enhance human health.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"4 1","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penicillin–streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation1 青霉素-链霉素对巨噬细胞力学特性和微环境力学感觉的影响1

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2025-12-31 DOI: 10.1016/j.mbm.2025.100173

Shiqi Hu , Buwei Hu , Jing Yang , Rui Liu , Yang Song , Yufan Zheng

{"title":"Penicillin–streptomycin influences macrophage mechanical properties and microenvironment mechano-sensation1","authors":"Shiqi Hu , Buwei Hu , Jing Yang , Rui Liu , Yang Song , Yufan Zheng","doi":"10.1016/j.mbm.2025.100173","DOIUrl":"10.1016/j.mbm.2025.100173","url":null,"abstract":"<div><div>Penicillin–streptomycin (pen-strep) is routinely included in cell culture media, yet its impact on macrophage mechanics has not been systematically examined. Here, we show that pen-strep treatment increases macrophage stiffness in a time-dependent manner, while adhesion strength is only transiently affected. Morphological analysis revealed that pen-strep promotes cell spreading on PDMS rubber, collagen I, laminin, poly-amino acids, and poly-RGD peptides, but reduces spreading on type IV collagen, indicating altered extracellular matrix sensing in a context-dependent fashion. Gene expression assays further demonstrated upregulation of YAP-1 and TAZ and downregulation of β1 integrin, consistent with reprogramming of mechanotransduction pathways. Consequently, pen-strep elevated intracellular ROS, suppressed the M1 gene spectrum, induced heterogeneous M2-associated responses, and impaired phagocytic capacity. Collectively, these findings identify pen-strep as a modulator of macrophage stiffness, ECM mechano-sensation, polarization, and key immune functions, raising concerns about its routine use in mechanobiology research and clinical applications.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"4 1","pages":"Article 100173"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145939110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechano-regulation of cancer cell memory in tumor progression and therapy 肿瘤进展和治疗中癌细胞记忆的机械调节

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2025-11-21 DOI: 10.1016/j.mbm.2025.100165

Yunjia Qu , Jiaxin Cui , Zhuohang Wu , Peixiang He , Fan Wei , Tianze Guo , Yixuan Huang , Xi Yu , Mishel Tsoy , Kunshu Liu , Ziyue Zhu , Yiming Zhang , Yingxiao Wang , Longwei Liu

{"title":"Mechano-regulation of cancer cell memory in tumor progression and therapy","authors":"Yunjia Qu , Jiaxin Cui , Zhuohang Wu , Peixiang He , Fan Wei , Tianze Guo , Yixuan Huang , Xi Yu , Mishel Tsoy , Kunshu Liu , Ziyue Zhu , Yiming Zhang , Yingxiao Wang , Longwei Liu","doi":"10.1016/j.mbm.2025.100165","DOIUrl":"10.1016/j.mbm.2025.100165","url":null,"abstract":"<div><div>Cancer cell memory, the ability to retain responses to prior environmental stimuli, has emerged as a key driver of tumor progression, therapeutic resistance, and immune evasion. Mechanical cues within the tumor microenvironment (TME), including matrix stiffness, viscoelasticity, and compressive stress, are increasingly recognized as critical regulators of such memory. These biophysical inputs not only influence immediate cellular behavior but also induce long-lasting transcriptional, epigenetic, and phenotypic changes that sustain cancer cell aggressive traits. In this review, we specifically highlight mechanobiology in shaping cancer cell memory. We summarize how extracellular matrix (ECM) composition and remodeling encodes mechanical inputs into stable gene expression programs that promote tumor progression, and highlight how mechano-regulated plasticity, membrane tension, chromatin remodeling, and epigenetic changes govern self-renewal, differentiation, and drug and immune resistance, underscoring how physical suppression contributes to chemo-, radio-, and targeted therapies failure. We further discuss emerging mechano-targeted strategies, including ECM-degrading agents, sonogenetic engineered cells, and stiffness-responsive nanoparticles, that seek to rewire cancer cell memory and improve treatment outcomes.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"4 1","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TCR-pMHC recognition mediates target phagocytosis by T cells TCR-pMHC识别介导T细胞靶向吞噬

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI: 10.1016/j.mbm.2026.100177

Xiangcheng Chen , Maximilian Wang , Ning Jiang

{"title":"TCR-pMHC recognition mediates target phagocytosis by T cells","authors":"Xiangcheng Chen , Maximilian Wang , Ning Jiang","doi":"10.1016/j.mbm.2026.100177","DOIUrl":"10.1016/j.mbm.2026.100177","url":null,"abstract":"<div><div>T cells are traditionally viewed as non-phagocytic lymphocytes that recognize antigens via the T cell receptor (TCR) and mediate cytotoxicity at the immunological synapse, while phagocytosis is performed by professional phagocytes such as macrophages and dendritic cells. Here we show that peptide–MHC (pMHC) recognition alone is sufficient to drive rapid, antigen-specific phagocytosis by Jurkat T cells. We generated CD8<sup>+</sup> Jurkat cells expressing a class I–restricted human TCR (SVAR16) with intermediate-to-high 2-dimensional (2D) affinity for the SARS-CoV-2 epitope HLA∗A2:01–YLQ and used a micropipette system to control and image T cell interaction with pMHC coated beads. Upon contact with cognate YLQ-coated beads, SVAR16 transduced CD8<sup>+</sup> Jurkat cells consistently formed phagosomes within minutes and completely internalized beads with consistent kinetics. These results demonstrate that appropriately tuned TCR–pMHC interactions, supported by CD8 co-receptors, can convert a canonical CD4<sup>+</sup> T cell line into an antigen-specific phagocyte. This work reports a novel effector function of T cells and suggests that TCR-engineering could convert CD4<sup>+</sup> T cells into phagocytes, potentially revealing a new approach to T cell-based cancer immunotherapy.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"4 1","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portable electronic devices for mechanotherapy and operative treatment of osteoarthritis 用于骨关节炎机械治疗和手术治疗的便携式电子设备

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI: 10.1016/j.mbm.2026.100176

Ran Xu , Xu Jiang , Yushun Tao , Shikun Fang , Jie Li , Fan Zhao , Fujun Wang , Liao Wang , Jun Zhang

{"title":"Portable electronic devices for mechanotherapy and operative treatment of osteoarthritis","authors":"Ran Xu , Xu Jiang , Yushun Tao , Shikun Fang , Jie Li , Fan Zhao , Fujun Wang , Liao Wang , Jun Zhang","doi":"10.1016/j.mbm.2026.100176","DOIUrl":"10.1016/j.mbm.2026.100176","url":null,"abstract":"<div><div>Knee osteoarthritis (KOA) is fundamentally driven by abnormal mechanical loading and the subsequent loss of joint homeostasis. Effective therapeutic strategies, whether conservative or surgical, depend on the precise restoration of physiological kinematics and load distribution. This review synthesizes recent advances in sensor technologies designed to quantify the mechanobiological environment of the knee. In non-surgical management, wearable systems utilizing inertial measurement units (IMU) and flexible pressure sensors enable the continuous monitoring of gait cycles, joint angles, and muscle activation, providing objective data for neuromuscular rehabilitation. In surgical contexts, we analyze the evolution of intraoperative sensing from rigid force-sensing spacers to emerging soft electronics in total knee arthroplasty (TKA). A critical challenge remains in developing sensors with mechanical compliance similar to biological tissues and minimal thickness to fit the constrained joint space during joint-preserving procedures. We highlight the potential of novel transduction mechanisms—including piezoresistive, capacitive, piezoelectric, and triboelectric systems—to overcome these limitations. The integration of these flexible, self-powered technologies with data-driven analytics offers a pathway toward an integrated data-driven treatment framework, which could facilitate optimal biomechanical alignment and functional recovery.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"4 1","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147396142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogen-host infection modulated by mechanobiological cues in tissue microenvironments 组织微环境中由机械生物学线索调控的病原体-宿主感染。

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2026-02-18 DOI: 10.1016/j.mbm.2026.100175

Yiming Han , Xiaocen Duan , Shuyi Wang , Shuqiang Huang , Kui Zhu , Jianyong Huang

引用次数: 0

Mechanoimmunology: past, present, and future perspectives 机械免疫学：过去，现在和未来的观点

Mechanobiology in Medicine Pub Date : 2026-03-01 Epub Date: 2025-12-02 DOI: 10.1016/j.mbm.2025.100166

Cheng Zhu

引用次数: 0

Theta-shaking mitigates cognitive-emotional decline via subiculum and ventral septum metabolic plasticity 脑波震动通过枕下和腹隔代谢可塑性减轻认知情绪下降

Mechanobiology in Medicine Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1016/j.mbm.2025.100148

Runhong Yao , Kouji Yamada , Hirohide Sawada , Takeshi Chihara , Naoki Aizu , Kazuhiro Nishii

{"title":"Theta-shaking mitigates cognitive-emotional decline via subiculum and ventral septum metabolic plasticity","authors":"Runhong Yao , Kouji Yamada , Hirohide Sawada , Takeshi Chihara , Naoki Aizu , Kazuhiro Nishii","doi":"10.1016/j.mbm.2025.100148","DOIUrl":"10.1016/j.mbm.2025.100148","url":null,"abstract":"<div><div>Aging-associated cognitive decline remains a major challenge in gerontology; few non-invasive interventions provide both mechanistic insight and translational feasibility. We investigated whether low-frequency “theta-shaking” whole-body vibration (5 Hz) could modulate cognitive function, emotional behavior, and metabolic plasticity in a senescence-accelerated mouse model. Senescence-accelerated mouse prone-10 mice were exposed to theta-shaking stimulation for 30 weeks. Spatial memory was assessed using Y-maze spontaneous alternation test, and anxiety-related behavior was evaluated using marble burying test. Histological and immunohistochemical analyses were conducted to assess neuronal density and protein expression in specific brain regions. Theta-shaking subjected mice exhibited delayed yet significant improvements in spatial memory at 20 (p = 0.017) and 30 (p = 0.018) weeks. Anxiety-related behavior shows a biphasic pattern: an initial increase at 20 weeks (p < 0.001) followed by stabilization at 30 weeks. Histological analysis revealed preserved neuronal density in the subiculum (p < 0.001) and elevated proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) expression in the Cornu Ammonis 1, subiculum, and lateral septum (all p < 0.05). Notably, mitochondrial biogenesis appeared to be intervention's primary target, as shown by robust PGC1α upregulation, while brain-derived neurotrophic factor revealed a trend-level increase (p = 0.062), and neurotrophin-3 expression remained unchanged. Frequency-tuned mechanical stimulation induced region-specific neural neurometabolic adaptations, supporting theta-shaking as a non-pharmacological, low-exertion strategy to counteract brain aging. These findings offer promising translational potential, especially for individuals with limited mobility.</div></div>","PeriodicalId":100900,"journal":{"name":"Mechanobiology in Medicine","volume":"3 4","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanotransduction in neutrophil: Mechanosensing and immune function regulation 中性粒细胞的机械转导：机械感应和免疫功能调节

Mechanobiology in Medicine Pub Date : 2025-12-01 Epub Date: 2025-09-07 DOI: 10.1016/j.mbm.2025.100157

Wenying Zhao, Jin Wang, Jing Wang

引用次数: 0