Laboratory Robotics and Automation最新文献_第7页

Automation in flow-injection analysis: Simultaneous determination of chloride and total iron 流动注射分析中的自动化:氯化物和总铁的同时测定

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<260::AID-LRA3>3.0.CO;2-Y

José Y. Neira, Joaquim A. Nóbrega

引用次数: 2

Editorial notes 社论指出

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<249::AID-LRA1>3.0.CO;2-F

W. Jeffrey Hurst

引用次数: 0

Robotic system for analytical method development with on-line quantification and a graphical interface 具有在线定量和图形界面的分析方法开发机器人系统

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<289::AID-LRA8>3.0.CO;2-R

John D. Manley, M. Christina Díaz Cachero, Denys A. R. Dugendre, Jeremy B. Lewis, Robert H. Unsworth, Raj Gill

{"title":"Robotic system for analytical method development with on-line quantification and a graphical interface","authors":"John D. Manley, M. Christina Díaz Cachero, Denys A. R. Dugendre, Jeremy B. Lewis, Robert H. Unsworth, Raj Gill","doi":"10.1002/(SICI)1098-2728(1999)11:5<289::AID-LRA8>3.0.CO;2-R","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:5<289::AID-LRA8>3.0.CO;2-R","url":null,"abstract":"A robotic system that automates method development and performs simultaneous multiple-method, routine sample analysis was jointly developed between Rhône-Poulenc Agriculture Limited (RPAL) and Middlesex University. The system consists of 21 discrete workstations of varying complexity. Three different types were used: those that were ready to use and did not require modification, those that required modification, and those that were purpose-built. In order to achieve such a system, many of the discrete processes in the analytical laboratory were automated in separate work cells. A programmable logic controller and serial interfaces are used to control and communicate with a distributed controlling computer system. A small industrial robot mounted on a six meter length of track functions as a pick- and place-manipulator for the workstations. The control system gives the analyst full control of all the parameters associated with each workstation. A graphical user interface (GUI) allows analysts to use the system with minimal training and to graphically represent the process in a familiar form. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 289–298, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 5","pages":"289-298"},"PeriodicalIF":0.0,"publicationDate":"1999-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:5<289::AID-LRA8>3.0.CO;2-R","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74574085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An engineering evaluation of four fluid transfer devices for automated 384-well high throughput screening 384井高通量筛分四种流体输送装置的工程评价

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<250::AID-LRA2>3.0.CO;2-1

Ted A. Bateman, Reed A. Ayers, R. Bryan Greenway

{"title":"An engineering evaluation of four fluid transfer devices for automated 384-well high throughput screening","authors":"Ted A. Bateman, Reed A. Ayers, R. Bryan Greenway","doi":"10.1002/(SICI)1098-2728(1999)11:5<250::AID-LRA2>3.0.CO;2-1","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:5<250::AID-LRA2>3.0.CO;2-1","url":null,"abstract":"As high throughput screening (HTS) evolves toward plate densities greater than 96 wells, the ability of fluid-handling devices to accurately transfer proportionately smaller volumes of liquid is challenged. This article examines the performance of four methods for plate-to-plate transfer of fluid volumes ranging from 10 nL to 10 μL. These volumes enable screening assays with plate densities of 384 wells or greater. The hardware are: (1) Zymark's Rapid Plate-96™ modified with an XY-stage, (2) Robbins Scientific's Hydra 384™, (3) Cartesian Engineering's PixSys™, and (4) Packard's BioChip™. The criteria that were chosen to quantitatively evaluate the liquid-handling devices are precision/coefficient of variation and the time to complete a transfer from one 384-well plate to another. In addition, a more subjective discussion is presented on the maintainability of the hardware, reagent waste minimization, general hardware “robustness,” and the capability and ease for integration into an HTS system. These criteria are evaluated from the standpoint of using the hardware in an integrated, fully automated HTS robotic system. This engineering evaluation concluded that the modified Rapid Plate-96™ and Hydra 384™ are best suited for immediate use in an automated HTS system, and the newer technologies employed by the PixSys and BioChip require improvements in reliability, speed, and ease of use. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 250–259, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 5","pages":"250-259"},"PeriodicalIF":0.0,"publicationDate":"1999-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:5<250::AID-LRA2>3.0.CO;2-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80983903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Basic kinematic characteristics of humanoid manipulators 类人机械臂的基本运动学特性

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<272::AID-LRA5>3.0.CO;2-L

Jadran Lenarčič

引用次数: 13

Spectrophotometric flow-injection method for determination of sorbic acid in wines 分光光度流动注射法测定酒中山梨酸

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<299::AID-LRA9>3.0.CO;2-N

A. Rivero Molina, E. Vereda Alonso, M. T. Siles Cordero, A. García de Torres, J. M. Cano Pavón

{"title":"Spectrophotometric flow-injection method for determination of sorbic acid in wines","authors":"A. Rivero Molina, E. Vereda Alonso, M. T. Siles Cordero, A. García de Torres, J. M. Cano Pavón","doi":"10.1002/(SICI)1098-2728(1999)11:5<299::AID-LRA9>3.0.CO;2-N","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:5<299::AID-LRA9>3.0.CO;2-N","url":null,"abstract":"A simple, rapid, and accurate spectrophotometric flow-injection method was developed for the determination of sorbic acid in wines based on the oxidation of sorbic acid with K2Cr2O7/H2SO4 at 100°C, followed by reaction of the resulting malonaldehyde with thiobarbituric acid, also at 100°C, to give a red product, the absorbance of which is measured at 532 nm. The method requires no prior distillation of the wine and allows a sampling rate of 40 per hour. The calibration graph was linear from 0 to at least 15 μg mL−1 (the linear correlation coefficient was 0.9997), and the detection limit (signal-to-noise ratio, 3) was 0.14 μg mL−1. The relative standard deviation of ten replicate determinations was 1.58%. The method was applied successfully to the determination of sorbic acid in red and white wines. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 299–303, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 5","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"1999-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:5<299::AID-LRA9>3.0.CO;2-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79266996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Reversible intermittent flow-injection determination of mercury in sediments and vinasses by cold vapor atomic absorption spectrometry 可逆间歇流动注射冷蒸汽原子吸收光谱法测定沉积物和葡萄酒中的汞

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<304::AID-LRA10>3.0.CO;2-C

José Anchieta Gomes Neto, Luis Fabrício Zara, Ademir Santos, Julio Cesar Rocha, Arnaldo Alves Cardoso

{"title":"Reversible intermittent flow-injection determination of mercury in sediments and vinasses by cold vapor atomic absorption spectrometry","authors":"José Anchieta Gomes Neto, Luis Fabrício Zara, Ademir Santos, Julio Cesar Rocha, Arnaldo Alves Cardoso","doi":"10.1002/(SICI)1098-2728(1999)11:5<304::AID-LRA10>3.0.CO;2-C","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:5<304::AID-LRA10>3.0.CO;2-C","url":null,"abstract":"A reversible intermittent flow-injection procedure is proposed for the automated determination of mercury in sediments and vinasses by cold vapor atomic absorption spectrometry, CVAAS. Solutions of sample and stannous chloride are carried by two air streams and sequentially injected into the generator/separator chamber in a segmented asynchronous merging zone configuration. The intermittent flow in the forward direction carries the mercury vapor through the flow cell, and in the backward direction, it aspirates the remaining solution from the vessel to waste. We investigated composition and concentration of reagents, flow rates, commutation times, reactor configuration, and conditions for mercury release. The accuracy was checked by mercury determination in a certified sediment and spiked vinasses and river waters. The system handles about 100 samples per hour (0.50–5.00 μg L−1), consuming ca. 2.5 mL of sample and 50 mg of SnCl2 per determination. Good recoveries (92–103%) were obtained with spiked samples. Results are precise (RSD <3% for 2.5 μg Hg L−1, n = 12) and in agreement with values for certified reference material at 95% confidence level. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 304–310, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 5","pages":"304-310"},"PeriodicalIF":0.0,"publicationDate":"1999-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:5<304::AID-LRA10>3.0.CO;2-C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89678573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Continuous flow analysis of iron (III) in seawater using a chalcogenide glass ion-selective electrode 用硫系玻璃离子选择电极对海水中铁(III)的连续流动分析

Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<284::AID-LRA7>3.0.CO;2-8

Roland De Marco, Bobby Pejcic, Xue Dong Wang

引用次数: 18

Development of a hybrid PLC-based control system applied to a monitored fermentation process 应用于发酵过程监测的混合plc控制系统的开发

Laboratory Robotics and Automation Pub Date : 1999-08-31 DOI: 10.1002/(SICI)1098-2728(1999)11:4<197::AID-LRA4>3.0.CO;2-D

M. Moscosa-Santillan, C. Bondoux, C. Porte, A. Delacroix, R. Besselievre, S. Cortial

{"title":"Development of a hybrid PLC-based control system applied to a monitored fermentation process","authors":"M. Moscosa-Santillan, C. Bondoux, C. Porte, A. Delacroix, R. Besselievre, S. Cortial","doi":"10.1002/(SICI)1098-2728(1999)11:4<197::AID-LRA4>3.0.CO;2-D","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:4<197::AID-LRA4>3.0.CO;2-D","url":null,"abstract":"It is well known that reliable and accurate control during biochemical processes is important, but sequential and continuous treatment requirements of bioreactors make this task difficult to achieve. In this paper, we report the development of a supervisory PLC-based control system that ensures complete bioreactor operation. Sequential phases founded during sterilization are accomplished by the programmable controller, while continuous regulation of main parameters (pH, temperature, and pressure) is achieved by control units using a PID (Proportional, Integral, Derivative) algorithm with feed-forward circuitry and auto-tuning feature. Finally, an operator graphic interface was developed in FIX MMI™'s intellution ® software, the man-machine interface provides supervisory and data acquisition functions. This system was successfully tested in E. coli and termophiles cultures; satisfactory control precisions of ±0.5°C, ±0.001 bar and ±0.1 pH unit were observed. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 197–206, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 4","pages":"197-206"},"PeriodicalIF":0.0,"publicationDate":"1999-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:4<197::AID-LRA4>3.0.CO;2-D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75222287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Reaction screening and optimization by an automated workstation-based system 反应筛选和优化的自动化工作站为基础的系统

Laboratory Robotics and Automation Pub Date : 1999-08-31 DOI: 10.1002/(SICI)1098-2728(1999)11:4<186::AID-LRA2>3.0.CO;2-N

Leo C. Hsu, Li-Jen Ping, Edward C. Webb, Thomas J. Wrzosek

{"title":"Reaction screening and optimization by an automated workstation-based system","authors":"Leo C. Hsu, Li-Jen Ping, Edward C. Webb, Thomas J. Wrzosek","doi":"10.1002/(SICI)1098-2728(1999)11:4<186::AID-LRA2>3.0.CO;2-N","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:4<186::AID-LRA2>3.0.CO;2-N","url":null,"abstract":"The shortening of drug development timelines has caused SmithKline Beecham Chemical Development to rethink its strategies for product development. One approach has been to incorporate robotics and automation with statistical experimental design into new drug development paradigms. This paper will discuss the hardware and the chromatographic configuration required for the screening and optimization of a Suzuki coupling reaction. The reactions were done in a STEM block and the samples were transferred to a Zymark BenchMate workstation for further sample preparation which included dilution and filtration. The treated samples were then analyzed by a HPLC system that was directly connected to the BenchMate workstation. Finally, the chromatographic system was configured so that data can be shared between Synthetic Chemistry and the Environmental Research Laboratory via SB internal network. This automated approach has the potential for accelerating drug development and process optimization in Chemical Development. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 186–192, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 4","pages":"186-192"},"PeriodicalIF":0.0,"publicationDate":"1999-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:4<186::AID-LRA2>3.0.CO;2-N","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73984916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1