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Laboratory Robotics and Automation最新文献

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Information processing issues and solutions associated with microarray technology 与微阵列技术相关的信息处理问题和解决方案
Laboratory Robotics and Automation Pub Date : 2000-01-01 DOI: 10.1002/1098-2728(2000)12:6<317::AID-LRA8>3.0.CO;2-#
A. Kuklin, Shishir Shah, B. Hoff, S. Shams
{"title":"Information processing issues and solutions associated with microarray technology","authors":"A. Kuklin, Shishir Shah, B. Hoff, S. Shams","doi":"10.1002/1098-2728(2000)12:6<317::AID-LRA8>3.0.CO;2-#","DOIUrl":"https://doi.org/10.1002/1098-2728(2000)12:6<317::AID-LRA8>3.0.CO;2-#","url":null,"abstract":"Managing vast amounts of information associated with DNA array technology presents a challenge. This article describes a synergistic analy- sis management (SAM) system, which integrates mi- croarray and laboratory data along with analysis steps to present a synergistic view to the researcher. We describe tools for data management in array fab- rication, automated image analysis, and array data mining. All the described modules allow for seamless flow of information and are connected through a da- tabase. SAM will enhance microarray projects at pharmaceutical and academic institutions, which face the problems of high throughput microarray data management. � 2000 John Wiley & Sons, Inc. Lab Robotics and Automation 12:317-327, 2000","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"50 1","pages":"317-327"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88880950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Editorial notes 社论指出
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<311::AID-LRA1>3.0.CO;2-%23
W. Jeffrey Hurst
{"title":"Editorial notes","authors":"W. Jeffrey Hurst","doi":"10.1002/(SICI)1098-2728(1999)11:6<311::AID-LRA1>3.0.CO;2-%23","DOIUrl":"https://doi.org/10.1002/(SICI)1098-2728(1999)11:6<311::AID-LRA1>3.0.CO;2-%23","url":null,"abstract":"","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"311"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137624856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three HTRF methods provide sensitivity for miniaturization in high-throughput screening 三种HTRF方法为高通量筛选的小型化提供了灵敏度
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<324::AID-LRA5>3.0.CO;2-E
Loraine V. Upham
{"title":"Three HTRF methods provide sensitivity for miniaturization in high-throughput screening","authors":"Loraine V. Upham","doi":"10.1002/(SICI)1098-2728(1999)11:6<324::AID-LRA5>3.0.CO;2-E","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:6<324::AID-LRA5>3.0.CO;2-E","url":null,"abstract":"<p>Homogeneous time-resolved fluorescence (HTRF®) assays are ideal for miniaturization in high-throughput screening. HTRF assays can be scaled down from 200 μL reactions to 25 to 70 μL reactions without loss of sensitivity. Three assay formats using proprietary europium cryptate, (Eu)K, and XL665 are described. An HTRF tyrosine kinase assay illustrates the indirect assay format. Inhibition can be detected with enzyme concentrations as low as 20 pM. An HTRF receptor-ligand binding assay is used to show a direct assay format. Reproducibility and stability are shown by a comparison of competitive binding curves under varying assay conditions. An HTRF reverse transcriptase assay is described to show the semidirect assay format. Enzyme concentrations were varied and compared with a typical [<sup>32</sup>P]-labeled assay. All three assay formats have been optimized using HTRF reagents. Results, measured in the highly sensitive Discovery® HTRF microplate analyzer, show that the sensitivity of HTRF is maintained when converting from 96-well format to 384-well format, despite the decrease in volume of reagents. © 1999 John Wiley &amp; Sons, Inc. Lab Robotics and Automation 11: 324–329, 1999</p>","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"324-329"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:6<324::AID-LRA5>3.0.CO;2-E","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86740574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Design of a laboratory automation system for a large clinical laboratory in São Paulo, Brazil 巴西圣保罗一家大型临床实验室实验室自动化系统的设计
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<335::AID-LRA7>3.0.CO;2-4
José Gilberto H. Vieira, José de Sá, Maria Tereza Guiringuello, Roque F. M. Barros, Neuza S. W. Okayama, Cecília Y. Terada, Izabel E. Ono
{"title":"Design of a laboratory automation system for a large clinical laboratory in São Paulo, Brazil","authors":"José Gilberto H. Vieira,&nbsp;José de Sá,&nbsp;Maria Tereza Guiringuello,&nbsp;Roque F. M. Barros,&nbsp;Neuza S. W. Okayama,&nbsp;Cecília Y. Terada,&nbsp;Izabel E. Ono","doi":"10.1002/(SICI)1098-2728(1999)11:6<335::AID-LRA7>3.0.CO;2-4","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:6<335::AID-LRA7>3.0.CO;2-4","url":null,"abstract":"<p>Laboratório Fleury is a reference clinical laboratory performing more than 1,200 different laboratory tests, with a workload of 3.5 million tests in 1998. With 60% of this workload directed to our clinical chemistry section, we started a project three years ago to evaluate the possibility of an automation system to fulfill our needs of quality, increased productivity, and as a base for further increases in workload. A workforce was assembled, and after detailed studies of our necessities and possibilities as well as an extensive program of visits and contacts in the U.S., Europe, and Japan, a final solution was settled.The system is being manufactured by IDS, Japan, and will be delivered by April 1999. It includes an inlet unit, an error lane, a decapper, a waiting line, a retrieve unit, a sorting table, a recapper unit, and an outlet unit. One of the main characteristics of our system is that it can be easily upgraded in order to receive more machines and/or more samples. © 1999 John Wiley &amp; Sons, Inc. Lab Robotics and Automation 11: 335–337, 1999</p>","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"335-337"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:6<335::AID-LRA7>3.0.CO;2-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76764109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computer-simulation modeling of clinical laboratories 临床实验室计算机模拟建模
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<312::AID-LRA2>3.0.CO;2-U
Kristine A. Bailey, Sebastian D'Angelo
{"title":"Computer-simulation modeling of clinical laboratories","authors":"Kristine A. Bailey,&nbsp;Sebastian D'Angelo","doi":"10.1002/(SICI)1098-2728(1999)11:6<312::AID-LRA2>3.0.CO;2-U","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:6<312::AID-LRA2>3.0.CO;2-U","url":null,"abstract":"<p>In the manufacturing sector, computer simulation has been used for many years to support complex decisions such as automation of processes or planning new factories. Clinical laboratories and diagnostic manufacturers are also faced with the challenges of automation and process redesign that will fundamentally change the way work is performed and the net economic impact of those changes. The question arises as to how we can minimize the risks, explore options, and make the right decisions. In this report, we present an overview of how simulation modeling can assist with laboratory decision making. © 1999 John Wiley &amp; Sons, Inc. Lab Robotics and Automation 11: 312–315, 1999</p>","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"312-315"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:6<312::AID-LRA2>3.0.CO;2-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80579849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Olympus automated laboratory system at the St. Marianna University School of Medicine in Tokyo: An interview with Shigetaka Matsuo, Director of 37 Mitsubishi Branch Laboratories in Japan, Conducted by Prof. Georg Hoffmann on April 9, 1998 东京圣玛丽安娜大学医学院的奥林巴斯自动化实验室系统:1998年4月9日，Georg Hoffmann教授对日本37家三菱分公司实验室主任Shigetaka Matsuo的采访
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<320::AID-LRA4>3.0.CO;2-T
Shigetaka Matsuo, Georg Hoffmann
{"title":"Olympus automated laboratory system at the St. Marianna University School of Medicine in Tokyo: An interview with Shigetaka Matsuo, Director of 37 Mitsubishi Branch Laboratories in Japan, Conducted by Prof. Georg Hoffmann on April 9, 1998","authors":"Shigetaka Matsuo,&nbsp;Georg Hoffmann","doi":"10.1002/(SICI)1098-2728(1999)11:6<320::AID-LRA4>3.0.CO;2-T","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:6<320::AID-LRA4>3.0.CO;2-T","url":null,"abstract":"","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"320-323"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:6<320::AID-LRA4>3.0.CO;2-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91145889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic approaches to technology adoption 采用技术的战略方法
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<330::AID-LRA6>3.0.CO;2-M
Steven D. Goldby
{"title":"Strategic approaches to technology adoption","authors":"Steven D. Goldby","doi":"10.1002/(SICI)1098-2728(1999)11:6<330::AID-LRA6>3.0.CO;2-M","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:6<330::AID-LRA6>3.0.CO;2-M","url":null,"abstract":"<p>Knowing how and when to implement new technology is an ongoing challenge in highly competitive, innovation-driven industries such as chemicals and electronics. Using the emerging field of combinatorial materials science as the primary example, this discussion enumerates, describes, and illustrates the seven specific stages a company must go through in the successful adoption and assimilation of innovation. These stages, as depicted over a single S curve, include: awareness, acquisition, application, acceptance, communication, assimilation, and incremental iteration. The competitive advantages of early technology adoption are described, as are the issues involved in implementing a combinatorial, or high-speed, approach to new materials discovery. © 1999 John Wiley &amp; Sons, Inc. Lab Robotics and Automation 11: 330–334, 1999</p>","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"330-334"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:6<330::AID-LRA6>3.0.CO;2-M","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90339718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The BioRobot 96OO automates front-end procedures of high-throughput DNA sequencing projects BioRobot 96OO自动化高通量DNA测序项目的前端程序
Laboratory Robotics and Automation Pub Date : 1999-12-02 DOI: 10.1002/(SICI)1098-2728(1999)11:6<316::AID-LRA3>3.0.CO;2-F
Michael Collasius, Dietrich Hauffe, Andreas Düsterhöft, Helmut Hilbert, Ralf Himmelreich
{"title":"The BioRobot 96OO automates front-end procedures of high-throughput DNA sequencing projects","authors":"Michael Collasius,&nbsp;Dietrich Hauffe,&nbsp;Andreas Düsterhöft,&nbsp;Helmut Hilbert,&nbsp;Ralf Himmelreich","doi":"10.1002/(SICI)1098-2728(1999)11:6<316::AID-LRA3>3.0.CO;2-F","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:6<316::AID-LRA3>3.0.CO;2-F","url":null,"abstract":"<p>Determining the complete DNA sequence of an organism is a complex and time-consuming project. Automation, especially of front-end procedures, has been used to reduce the time and costs of genome projects. The BioRobot™ 96OO is a multipurpose robotic system that facilitates high-throughput genome sequencing by reducing sample handling and integrating multiple steps on the same workstation. © 1999 John Wiley &amp; Sons, Inc. Lab Robotics and Automation 11: 316–319, 1999</p>","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 6","pages":"316-319"},"PeriodicalIF":0.0,"publicationDate":"1999-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:6<316::AID-LRA3>3.0.CO;2-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87175809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flow-injection spectrophotometric determination of yttrium with Arsenazo III 偶氮胂流动注射分光光度法测定钇
Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<279::AID-LRA6>3.0.CO;2-Y
Kate Grudpan, Wiboon Praditweangkum, Ponlayuth Sooksamiti, Robert Edwards
{"title":"Flow-injection spectrophotometric determination of yttrium with Arsenazo III","authors":"Kate Grudpan,&nbsp;Wiboon Praditweangkum,&nbsp;Ponlayuth Sooksamiti,&nbsp;Robert Edwards","doi":"10.1002/(SICI)1098-2728(1999)11:5<279::AID-LRA6>3.0.CO;2-Y","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:5<279::AID-LRA6>3.0.CO;2-Y","url":null,"abstract":"We proposed a simple flow-injection spectrophotometric procedure for the determination of yttrium using Arsenazo III and optimized various conditions (pH for color formation and sample, buffer systems, Arsenazo III concentration, injection volume, flow-rate, and mixing coils). The calibration was linear at least up to 1 mgY/L, with a detection limit (3σ) of 0.02 mgY/L, RSD of 0.8% (n = 11 at 0.40 mgY/L). A throughput of 60 injections h−1 can be achieved. The procedure was applied to ore leachates of reference materials and samples. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 279–283, 1999","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 5","pages":"279-283"},"PeriodicalIF":0.0,"publicationDate":"1999-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:5<279::AID-LRA6>3.0.CO;2-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84305455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Urea determination in FIA mode by a newly designed urease-based biosensor 新设计的脲酶生物传感器在FIA模式下测定尿素
Laboratory Robotics and Automation Pub Date : 1999-10-13 DOI: 10.1002/(SICI)1098-2728(1999)11:5<266::AID-LRA4>3.0.CO;2-D
Stjepan Milardović, I. Kruhak, B. S. Grabarić
{"title":"Urea determination in FIA mode by a newly designed urease-based biosensor","authors":"Stjepan Milardović,&nbsp;I. Kruhak,&nbsp;B. S. Grabarić","doi":"10.1002/(SICI)1098-2728(1999)11:5<266::AID-LRA4>3.0.CO;2-D","DOIUrl":"10.1002/(SICI)1098-2728(1999)11:5<266::AID-LRA4>3.0.CO;2-D","url":null,"abstract":"<p>This article describes a new design of a urea biosensor developed by covalent immobilization of the enzyme urease on the top of a nickel-hexacyanoferrate-modified nickel electrode. The behavior of the electrode was described with respect to several experimental parameters in flow injection mode. Detection of urease-produced NH ion from parent urea at a working potential of 100 mV vs. a Ag/AgCl/2 M NaCl electrode showed linearity in the concentration range of urea in aqueous solutions from 10 μM to 10 mM. The influence of carrier electrolyte concentration, flow rate, and pH on the properties of the transducer were also examined. The selectivity recognition of the transducer was studied with respect to the influence of potentially interfering sodium and potassium ions. The electrode was tested over a period of 45 days. After this period, the biosensor lost only 20% of its sensitivity. © 1999 John Wiley &amp; Sons, Inc. Lab Robotics and Automation 11: 266–271, 1999</p>","PeriodicalId":100863,"journal":{"name":"Laboratory Robotics and Automation","volume":"11 5","pages":"266-271"},"PeriodicalIF":0.0,"publicationDate":"1999-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/(SICI)1098-2728(1999)11:5<266::AID-LRA4>3.0.CO;2-D","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88126241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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