M. Moscosa-Santillan, C. Bondoux, C. Porte, A. Delacroix, R. Besselievre, S. Cortial
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引用次数: 2
Abstract
It is well known that reliable and accurate control during biochemical processes is important, but sequential and continuous treatment requirements of bioreactors make this task difficult to achieve. In this paper, we report the development of a supervisory PLC-based control system that ensures complete bioreactor operation. Sequential phases founded during sterilization are accomplished by the programmable controller, while continuous regulation of main parameters (pH, temperature, and pressure) is achieved by control units using a PID (Proportional, Integral, Derivative) algorithm with feed-forward circuitry and auto-tuning feature. Finally, an operator graphic interface was developed in FIX MMI™'s intellution ® software, the man-machine interface provides supervisory and data acquisition functions. This system was successfully tested in E. coli and termophiles cultures; satisfactory control precisions of ±0.5°C, ±0.001 bar and ±0.1 pH unit were observed. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 197–206, 1999
应用于发酵过程监测的混合plc控制系统的开发
众所周知,在生化过程中可靠和准确的控制是重要的,但生物反应器的顺序和连续处理要求使得这一任务难以实现。在本文中,我们报告了一种基于plc的监控系统的开发,以确保生物反应器的完整运行。灭菌过程中建立的顺序相位由可编程控制器完成,而主要参数(pH,温度和压力)的连续调节由控制单元使用具有前馈电路和自动调谐功能的PID(比例,积分,导数)算法实现。最后,在FIX MMI™的intelligent®软件中开发了操作员图形界面,人机界面提供了监控和数据采集功能。该系统在大肠杆菌和嗜冷菌培养中成功测试;控制精度为±0.5°C,±0.001 bar和±0.1 pH单位。©1999 John Wiley &儿子,Inc。实验室机器人与自动化11:197-206,1999
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