Reaction screening and optimization by an automated workstation-based system

Laboratory Robotics and Automation Pub Date : 1999-08-31 DOI:10.1002/(SICI)1098-2728(1999)11:4<186::AID-LRA2>3.0.CO;2-N

Leo C. Hsu, Li-Jen Ping, Edward C. Webb, Thomas J. Wrzosek

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引用次数: 1

Abstract

The shortening of drug development timelines has caused SmithKline Beecham Chemical Development to rethink its strategies for product development. One approach has been to incorporate robotics and automation with statistical experimental design into new drug development paradigms. This paper will discuss the hardware and the chromatographic configuration required for the screening and optimization of a Suzuki coupling reaction. The reactions were done in a STEM block and the samples were transferred to a Zymark BenchMate workstation for further sample preparation which included dilution and filtration. The treated samples were then analyzed by a HPLC system that was directly connected to the BenchMate workstation. Finally, the chromatographic system was configured so that data can be shared between Synthetic Chemistry and the Environmental Research Laboratory via SB internal network. This automated approach has the potential for accelerating drug development and process optimization in Chemical Development. © 1999 John Wiley & Sons, Inc. Lab Robotics and Automation 11: 186–192, 1999

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反应筛选和优化的自动化工作站为基础的系统

药物开发时间的缩短导致SmithKline Beecham Chemical development重新考虑其产品开发策略。一种方法是将机器人和自动化与统计实验设计结合到新的药物开发范例中。本文将讨论筛选和优化铃木偶联反应所需的硬件和色谱配置。反应在STEM模块中完成，样品被转移到Zymark BenchMate工作站进行进一步的样品制备，包括稀释和过滤。处理后的样品然后通过直接连接到BenchMate工作站的高效液相色谱系统进行分析。最后，对色谱系统进行了配置，使合成化学和环境研究实验室之间的数据可以通过SB内部网络共享。这种自动化方法具有加速药物开发和化学开发过程优化的潜力。©1999 John Wiley &儿子,Inc。实验室机器人与自动化11:186-192,1999

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Laboratory Robotics and Automation

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