Journal of Pharmaceutical and Biomedical Analysis Open最新文献

筛选
英文 中文
Design of a MIP-based electrochemical sensor for sensitive and selective detection of anti-cancer drug ibrutinib in pharmaceutical dosage forms and biological fluids
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2025-01-27 DOI: 10.1016/j.jpbao.2025.100055
Tuba Arif , Ahmet Cetinkaya , Mehmet Altay Unal , Esen Bellur Atici , Sibel A. Ozkan
{"title":"Design of a MIP-based electrochemical sensor for sensitive and selective detection of anti-cancer drug ibrutinib in pharmaceutical dosage forms and biological fluids","authors":"Tuba Arif ,&nbsp;Ahmet Cetinkaya ,&nbsp;Mehmet Altay Unal ,&nbsp;Esen Bellur Atici ,&nbsp;Sibel A. Ozkan","doi":"10.1016/j.jpbao.2025.100055","DOIUrl":"10.1016/j.jpbao.2025.100055","url":null,"abstract":"<div><div>Ibrutinib (IBR) is a Bruton's Tyrosine Kinase (BTK) inhibitor that is being used to treat refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). Detecting lower levels of IBR in humans could significantly contribute to different areas of research, such as drug delivery. In this work, an electrochemical sensor was designed using a molecularly imprinted polymer on a glassy carbon electrode (GCE) for the selective and sensitive determination of IBR. A polymeric film was obtained on the GCE surface by photopolymerization (PP) method using template molecule IBR, 2-hydroxyethyl methacrylate (HEMA), ethylene glycol dimethacrylate (EGDMA), and 4-aminobenzoic acid (4-ABA). Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and scanning electron microscopy (SEM) were used to examine the sensor's morphological and electrochemical characteristics. In addition, the parameters affecting the MIP were optimized. For the first time, a MIP-based electrochemical sensor was designed to determine IBR. Low limit of detection (LOD) and limit of quantification (LOQ) values of 6.13 × 10<sup>−14</sup> and 2.04 × 10<sup>−13</sup> M were obtained, respectively. The developed sensor detected IBR at least 3 times more selectively than similar substances (pemetrexed (PEM), tofacitinib (TOF), and ruxolitinib (RUX)). IBR detection was investigated in biological samples and pharmaceutical dosage forms. Furthermore, the sensor successfully distinguished IBR from compounds with similar structures, demonstrating great selectivity.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is surface-enhanced Raman spectroscopy (SERS) a good alternative to separation techniques for nicotine dosage in e-liquid boosters?
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2025-01-16 DOI: 10.1016/j.jpbao.2025.100054
Charlotte De Bleye , Pierre Beckers , Kevser Kemik , Julie Horne , Kenza Lahrichi , Pierre-Yves Sacré , Philippe Hubert , Eric Ziemons
{"title":"Is surface-enhanced Raman spectroscopy (SERS) a good alternative to separation techniques for nicotine dosage in e-liquid boosters?","authors":"Charlotte De Bleye ,&nbsp;Pierre Beckers ,&nbsp;Kevser Kemik ,&nbsp;Julie Horne ,&nbsp;Kenza Lahrichi ,&nbsp;Pierre-Yves Sacré ,&nbsp;Philippe Hubert ,&nbsp;Eric Ziemons","doi":"10.1016/j.jpbao.2025.100054","DOIUrl":"10.1016/j.jpbao.2025.100054","url":null,"abstract":"<div><div>Since 2014, electronic cigarettes must follow the European Directive on tobacco products. In Belgium, the transposition of this directive requires that nicotine-containing e-liquid boosters cannot exceed a concentration of 20 mg mL<sup>−1</sup> to ensure consumers safety. Nowadays, accurate analytical methods available to measure nicotine levels in e-liquid products involve chromatography. The development of alternative analytical tools being faster, greener and adaptable to in-field analyses are therefore required. Surface-enhanced Raman scattering is a spectroscopic technique that significantly enhances inherent Raman scattering signals, improving detection limits, when analytes are adsorbed onto metallic nanostructures such as gold nanoparticles (AuNPs). This study introduces new SERS methods for quantifying nicotine in e-liquid boosters using two different Raman spectrophotometers based on a transmission (SETRS) and a backscattering detection mode. The transmission Raman spectrophotometer has a better sample representativity, which is very interesting to perform SERS on liquids samples, and an autosampler offering facilities for routine analyses as a benchtop equipment while the second spectrophotometer was a handheld Raman device allowing to expand the use of the developed SERS method to in-field analyses. These SERS analyses were performed using lab-synthetized AuNps and by adding an isotope-edited internal standards (IEISs) being nicotine-d4 to mitigate some repeatability issues. These methods were finally validated according to the ICH Q2 (R2) guidelines for a working range from 100 to 300 µg L<sup>−1</sup> of nicotine concentrations using a total error risk-based approach considering the acceptance limits fixed at 15 % and a risk level of 5 %.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional high-performance liquid chromatographic determination of serine, threonine and allothreonine enantiomers in mouse tissues and physiological fluids
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2025-01-13 DOI: 10.1016/j.jpbao.2025.100053
Mai Oyaide , Takeyuki Akita , Chiharu Ishii , Masashi Mita , Kenji Hamase
{"title":"Three-dimensional high-performance liquid chromatographic determination of serine, threonine and allothreonine enantiomers in mouse tissues and physiological fluids","authors":"Mai Oyaide ,&nbsp;Takeyuki Akita ,&nbsp;Chiharu Ishii ,&nbsp;Masashi Mita ,&nbsp;Kenji Hamase","doi":"10.1016/j.jpbao.2025.100053","DOIUrl":"10.1016/j.jpbao.2025.100053","url":null,"abstract":"<div><div>The amounts of serine (Ser), threonine (Thr) and allothreonine (aThr) enantiomers in 6 tissues (cerebrum, cerebellum, medulla oblongata, pancreas, liver and kidney) and 2 physiological fluids (plasma and urine) of mice were determined using a highly-selective three-dimensional high-performance liquid chromatographic (3D-HPLC) system. The 3D-HPLC system was composed of reversed-phase (Singularity RP18), anion-exchange (Singularity AX) and chiral separation (Singularity CSP-013S) columns, and the amino acids derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole were determined. To analyze the mouse tissues and physiological fluids, the separation conditions were re-investigated from those reported in our previous study, and the method was validated using the tissue/physiological fluid samples. For Ser, the presence of the <span>d</span>-form could be determined in all the tissues and physiological fluids (1.77 ± 0.09–266.5 ± 11.3 nmol/g or mL). For <span>d</span>-Thr and <span>d</span>-aThr, the presence in the cerebrum and urine was clearly demonstrated (0.28 ± 0.01–1.44 ± 0.56 for <span>d</span>-Thr and 4.63 ± 1.44–6.44 ± 0.36 nmol/g or mL for <span>d</span>-aThr). Trace levels of <span>d</span>-Thr and <span>d</span>-aThr were detected in the other tissues and plasma. The results indicate that the target 3 hydroxy <span>d</span>-amino acids are widely present in mammalian tissues and physiological fluids, and further investigations focusing on their physiological significance are expected.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoplasmonic sensing as a rapid and sensitive methodology to investigate tolvaptan loaded plant-derived nanovesicles and liposomes
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2025-01-06 DOI: 10.1016/j.jpbao.2025.100052
Shishir Jaikishan , Ramila Mammadova , Rui Chen , Feby Pratiwi , Gabriella Pocsfalvi , Seppo J. Vainio , Susanne K. Wiedmer
{"title":"Nanoplasmonic sensing as a rapid and sensitive methodology to investigate tolvaptan loaded plant-derived nanovesicles and liposomes","authors":"Shishir Jaikishan ,&nbsp;Ramila Mammadova ,&nbsp;Rui Chen ,&nbsp;Feby Pratiwi ,&nbsp;Gabriella Pocsfalvi ,&nbsp;Seppo J. Vainio ,&nbsp;Susanne K. Wiedmer","doi":"10.1016/j.jpbao.2025.100052","DOIUrl":"10.1016/j.jpbao.2025.100052","url":null,"abstract":"<div><div>Plant-derived nanovesicles (PDNVs) are potential next generation carriers for drug delivery. However, the systemic incorporation of drugs into PDNVs and their quality control still needs extensive research. Previous works showed that <em>Solanum lycopersicum</em> (tomato) fruit is an excellent resource for the high yield manufacturing of tomato PDNVs. Tomato PDNVs have anti-inflammatory activity <em>in vitro</em> which could be further increased by the loading of a lipophilic natural compound, like curcumin. Recently, tolvaptan, a synthetic selective vasopressin V2-receptor antagonist drug was also successfully loaded into tomato PDNVs. In this work, we have advanced the analysis of native and loaded PDNVs and compared them with liposomes using nanoplasmonic sensing (NPS). Tolvaptan was loaded into liposomes composed of phosphatidyl choline (1-palmitoyl-2-oleoyl-<em>sn</em>-glycero-3-phosphocholine or 1,2-dipalmitoyl-<em>sn</em>-glycero-3-phosphocholine) and 1,2-palmitoyl-oleoyl-<em>sn</em>-glycero-3-phosphoserine with and without cholesterol. In addition to NPS, micro differential scanning calorimetry was used to get a deeper understanding of the interactions between tolvaptan and the various liposome compositions. The result of the comparative NPS study showed that tolvaptan can be successfully incorporated both into PDNVs and liposomes of different compositions. The PDNV/tolvaptan and liposome/tolvaptan systems were found to be stable. Due to the low water solubility of tolvaptan, the developed PDNV/tolvaptan or liposome/tolvaptan nanoparticle complexes may present a novel and effective strategy for nanodrug delivery.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100052"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chitosan and carbon nanotube modified DNA biosensor for determination of drug-DNA interaction
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2025-01-03 DOI: 10.1016/j.jpbao.2025.100050
Selen Soyalp , Ece Eksin , Arzum Erdem
{"title":"Chitosan and carbon nanotube modified DNA biosensor for determination of drug-DNA interaction","authors":"Selen Soyalp ,&nbsp;Ece Eksin ,&nbsp;Arzum Erdem","doi":"10.1016/j.jpbao.2025.100050","DOIUrl":"10.1016/j.jpbao.2025.100050","url":null,"abstract":"<div><div>In the present study Chitosan (CHIT) and Multiwalled carbon nanotube (MWCNT) modified pencil graphite electrodes (MWCNT-CHIT-PGEs) were developed for enhanced electrochemical monitoring of nucleic acid, and the interaction of the anticancer drug Mitomycin C (MC) and calf thymus double stranded DNA (ctdsDNA). The microscopic characterization of PGE and MWCNT-CHIT-PGE surfaces was carried out by scanning electron microscopy (SEM). Cyclic Voltammetry (CV) and Electrochemical Impedance Spectroscopy (EIS) techniques were used to evaluate the electrochemical performance of the MWCNT-CHIT-PGEs. The interaction between MC and ctdsDNA was investigated by measuring the oxidation signals of both MC and guanine in the same voltammetric scale using Differential pulse voltammetry (DPV) technique. The experimental parameters, dsDNA and MC concentration and the interaction time were optimized to enhance the overall efficiency of the experimental process.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advancements in novel electrochemical sensors for disease-associated molecule determination
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2025-01-03 DOI: 10.1016/j.jpbao.2025.100051
Seyda Nur Samanci , Goksu Ozcelikay-Akyildiz , S. Irem Kaya , Sibel A. Ozkan
{"title":"Recent advancements in novel electrochemical sensors for disease-associated molecule determination","authors":"Seyda Nur Samanci ,&nbsp;Goksu Ozcelikay-Akyildiz ,&nbsp;S. Irem Kaya ,&nbsp;Sibel A. Ozkan","doi":"10.1016/j.jpbao.2025.100051","DOIUrl":"10.1016/j.jpbao.2025.100051","url":null,"abstract":"<div><div>Disease-associated molecules (biomarkers) provide clinically important information for diagnosing, monitoring, and treating diseases common in society, such as cancer, neurodegenerative, metabolic, and infectious diseases. Reliable sensor platforms are required for sensitive, rapid, and selective determination of these molecules in biological fluids. Electrochemical sensors are popular options used effectively to determine many analytes in complex matrices to meet this need. One of the key points in assay of these clinically important molecules is to obtain sensitive responses even at low concentrations. Therefore, integration with materials such as nanomaterials, composites, carbon-based materials, and molecularly imprinted polymers (MIPs) is widely applied to improve the performance of electrochemical sensors. Another essential expectation in determining disease-related molecules is the ability to perform point-of-care analysis with portable devices. This way, it is possible to obtain results that the patient can follow and convey to healthcare professionals without losing time. This review discusses the most current and novel electrochemical sensor approaches in disease-associated molecule determination. These studies were overviewed regarding the relevant disease, sensor type, electrochemical method, linear range, LOD, sample, and recovery values. This review aims to shed light on current studies in this field and provide researchers with a resource for future applications.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upconversion nanoparticles in biomedical applications: Its potential for early diagnosis of cancer and telomeric activity
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2024-12-04 DOI: 10.1016/j.jpbao.2024.100049
Mesut Kaplan , Lokman Uzun
{"title":"Upconversion nanoparticles in biomedical applications: Its potential for early diagnosis of cancer and telomeric activity","authors":"Mesut Kaplan ,&nbsp;Lokman Uzun","doi":"10.1016/j.jpbao.2024.100049","DOIUrl":"10.1016/j.jpbao.2024.100049","url":null,"abstract":"<div><div>In this review, we have focused our attention on figuring out the intriguing potential of upconversion nanoparticles. For this aim, the properties of upconversion nanoparticles were summarized in terms of photoelectrochemical analysis and their sensing and treating cancers. Furthermore, the basic principles and advantages of their luminescent properties were pointed out as well as emphasizing their possibilities to incorporate into the emerging composite materials. Moreover, the strategies for their surface functionalities for targeting cancer tissues and simultaneous imaging and treating methods. In the end, the potential of telomerase concerning early cancer diagnosis was compiled.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spotlights of MIP-sensors for drugs and protein biomarkers
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2024-11-28 DOI: 10.1016/j.jpbao.2024.100048
Aysu Yarman , Aysel Oktay , Melis Işık Toksoy , Sivoney Ferreira de Souza , João Ameixa , Ilko Bald , Cem Bulent Ustundag , Frieder W. Scheller
{"title":"Spotlights of MIP-sensors for drugs and protein biomarkers","authors":"Aysu Yarman ,&nbsp;Aysel Oktay ,&nbsp;Melis Işık Toksoy ,&nbsp;Sivoney Ferreira de Souza ,&nbsp;João Ameixa ,&nbsp;Ilko Bald ,&nbsp;Cem Bulent Ustundag ,&nbsp;Frieder W. Scheller","doi":"10.1016/j.jpbao.2024.100048","DOIUrl":"10.1016/j.jpbao.2024.100048","url":null,"abstract":"<div><div>Molecularly Imprinted Polymers (MIPs) are potential tools in pharmaceutical analysis and for determining protein biomarkers. This review presents a comprehensive comparison of MIP synthesis concepts, i.e., segment <em>vs.</em> whole template imprinting and polymerization of the template/monomer mixture <em>vs.</em> “hierarchical (oriented) imprinting” and combinations of MIPs with enzymes, antibodies, and aptamers, respectively. For low-molecular-weight substances such as drugs and biomacromolecules, the hierarchical polymer synthesis around the oriented template results in MIPs with higher affinity than MIPs prepared by polymerizing a mixture of the template and functional monomers. Application of the target molecule fragments as the template, so-called epitopes, gives MIPs that possess comparable affinity towards the whole analyte as the “Whole-molecule”-MIPs, but the synthesis costs are considerably lower. The combination of MIPs with enzymes, antibodies, and aptamers allows the expansion of the analyte spectrum, amplifies the signal, and suppresses interfering substances. Catalytically active MIPs may, in the future, substitute enzymes and catalyze unnatural reactions.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100048"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive analysis of screening assays for identifying pyruvate kinase M2 modulators
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2024-11-26 DOI: 10.1016/j.jpbao.2024.100047
Moumita Ghosh Chowdhury, Venkatesh Muthukumar, Rudradip Das, Amit Shard
{"title":"A comprehensive analysis of screening assays for identifying pyruvate kinase M2 modulators","authors":"Moumita Ghosh Chowdhury,&nbsp;Venkatesh Muthukumar,&nbsp;Rudradip Das,&nbsp;Amit Shard","doi":"10.1016/j.jpbao.2024.100047","DOIUrl":"10.1016/j.jpbao.2024.100047","url":null,"abstract":"<div><div>Pyruvate kinase M2 (PKM2) is an essential enzyme in cellular metabolism, playing a key role in regulating glycolysis. It has garnered significant attention in cancer research and is also implicated in the development of various chronic inflammatory conditions. As a result, PKM2 has become a target for drug discovery, with efforts focused on developing inhibitors and activators to modulate its activity. This review discusses various assays used to identify and validate these compounds. Enzyme-based assays help to evaluate PKM2 activity by monitoring substrate conversion. Techniques like dynamic laser light scattering spectrometry and surface plasmon resonance assess the interactions and stability of PKM2 with potential drugs. Cell-based assays measure PKM2 expression levels across different cellular contexts. Additional, methods such as fluorescence titration and mass spectrometry (MS/MS) analyze binding affinity and structural changes of PKM2 upon drug interaction. Metabolic assays, including oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), are employed to evaluate the functional effects of PKM2 modulation on cellular metabolism. This review aims to provide a comprehensive overview of these methodologies to enhance the understanding of PKM2's role and facilitate the discovery of therapeutic agents targeting this important enzyme.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"5 ","pages":"Article 100047"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143143181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in molecular imprinting techniques for the electrochemical analysis of chiral compounds 用于手性化合物电化学分析的分子印迹技术的最新进展
Journal of Pharmaceutical and Biomedical Analysis Open Pub Date : 2024-11-10 DOI: 10.1016/j.jpbao.2024.100046
Sevda Hasanova , Abdellatif Ait Lahcen , Erhan Zor
{"title":"Recent advances in molecular imprinting techniques for the electrochemical analysis of chiral compounds","authors":"Sevda Hasanova ,&nbsp;Abdellatif Ait Lahcen ,&nbsp;Erhan Zor","doi":"10.1016/j.jpbao.2024.100046","DOIUrl":"10.1016/j.jpbao.2024.100046","url":null,"abstract":"<div><div>Molecular imprinting technology has emerged as a powerful tool for creating highly selective recognition elements, known as molecularly imprinted polymers (MIPs). These synthetic polymers possess tailor-made binding sites with high affinity and specificity for target molecules, making them ideal for various analytical applications, including detecting and separating chiral compounds. This review provides a comprehensive overview of recent advances in the design, synthesis, and application of MIPs for chiral analysis. Key developments in using novel monomers, innovative polymerization techniques, and advanced characterization methods are discussed. Additionally, integrating MIPs with cutting-edge materials such as metal-organic frameworks (MOFs) and nanomaterials is explored, highlighting their impact on improving sensor performance. The novelty of our review lies in its profound discussion of the recent advancement of electrochemical sensors-based MIPs that exhibit significant improvements in sensor miniaturization, rapid response times, and portability. The progress made in this fieldmarks a significant leap forward in the development of cost-effective, sustainable sensing devices for chiral analysis in complex matrices. Additionally, this review critically evaluates the pros and cons of various approaches, providing a comprehensive guide to future research in the field. The discussed techniques have strong potential for application in pharmaceutical quality control, clinical diagnosis, and environmental monitoring. This review aims to provide researchers and practitioners in MIPs with valuable insights into the current state and future directions of this technology for chiral compound analysis.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信