Journal of Pharmaceutical and Biomedical Analysis Open最新文献

{"title":"Recent advances in molecular imprinting techniques for the electrochemical analysis of chiral compounds","authors":"Sevda Hasanova ,&nbsp;Abdellatif Ait Lahcen ,&nbsp;Erhan Zor","doi":"10.1016/j.jpbao.2024.100046","DOIUrl":"10.1016/j.jpbao.2024.100046","url":null,"abstract":"<div><div>Molecular imprinting technology has emerged as a powerful tool for creating highly selective recognition elements, known as molecularly imprinted polymers (MIPs). These synthetic polymers possess tailor-made binding sites with high affinity and specificity for target molecules, making them ideal for various analytical applications, including detecting and separating chiral compounds. This review provides a comprehensive overview of recent advances in the design, synthesis, and application of MIPs for chiral analysis. Key developments in using novel monomers, innovative polymerization techniques, and advanced characterization methods are discussed. Additionally, integrating MIPs with cutting-edge materials such as metal-organic frameworks (MOFs) and nanomaterials is explored, highlighting their impact on improving sensor performance. The novelty of our review lies in its profound discussion of the recent advancement of electrochemical sensors-based MIPs that exhibit significant improvements in sensor miniaturization, rapid response times, and portability. The progress made in this fieldmarks a significant leap forward in the development of cost-effective, sustainable sensing devices for chiral analysis in complex matrices. Additionally, this review critically evaluates the pros and cons of various approaches, providing a comprehensive guide to future research in the field. The discussed techniques have strong potential for application in pharmaceutical quality control, clinical diagnosis, and environmental monitoring. This review aims to provide researchers and practitioners in MIPs with valuable insights into the current state and future directions of this technology for chiral compound analysis.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review for cortisol sensing in medical applications","authors":"Gaye Ezgi Yılmaz,&nbsp;Yeşeren Saylan,&nbsp;Adil Denizli","doi":"10.1016/j.jpbao.2024.100045","DOIUrl":"10.1016/j.jpbao.2024.100045","url":null,"abstract":"<div><div>Cortisol, one of the most important glucocorticoids, plays a critical role in various physiological processes. Elevated cortisol levels have been associated with chronic stress, increased vulnerability to anxiety, depression, cardiovascular disease, and weakened immune responses. Consequently, the development of reliable, effective, and rapid cortisol detection methods is invaluable for understanding the dynamic stress-response profile of individuals, enabling comprehensive self-monitoring, personalized healthcare, and effective health management. Cortisol sensors offer limitless possibilities in terms of their applications, featuring straightforward sensor preparation and wide detection limits. To sum, the future of cortisol sensing in medical applications holds immense assure for transforming stress management, mental health care, chronic disease management, athletic performance optimization, and personalized medicine, with significant benefits for individuals and healthcare providers alike. This review gives a wide overview of current state of cortisol hormone sensors, encompassing their working mechanisms and diverse applications. By examining the advancements in cortisol sensing technology, this review aims to provide insights into the potential of cortisol sensing in healthcare and its implications for improved patient outcomes.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142660804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of novel semi-covalent molecularly imprinted polymer for highly improved adsorption performance of tetracycline in aqueous medium","authors":"Luana Rianne da Rocha ,&nbsp;Mariana Gava Segatelli ,&nbsp;César Ricardo Teixeira Tarley","doi":"10.1016/j.jpbao.2024.100044","DOIUrl":"10.1016/j.jpbao.2024.100044","url":null,"abstract":"<div><div>In the present study, a novel tetracycline-imprinted polymer for tetracycline (TC) adsorption in an aqueous medium was synthesized using a semi-covalent imprinting method for the first time. In this approach, the template-monomer complex was synthesized by the reaction of 3-isopropenyl-α,α-dimethylbenzyl isocyanate (IPDMBI) as the functional monomer and TC as a template, forming a thermally reversible urethane bond (covalent bond). The polymer was characterized by Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), nitrogen adsorption/desorption measurements, and determination of point zero charge (PCZ). The equilibrium time of TC onto MIP was reached in 15 min, which was described by the non-linear pseud second-order kinetic model. Adsorption isotherm was described as a dual-site Langmuir-Freundlich model and the maximum adsorption capacity, determined at pH 5.0, was found to be 76.74 mg g⁻¹ for MIP, exhibiting higher adsorption capacity when compared with other adsorbent materials previously reported in the literature for TC. Based on the increment relative selectivity coefficient the MIP showed higher selectivity towards TC and some structurally similar compounds belonging to the tetracyclines family (oxytetracycline and chlorotetracycline), when compared with NIP (non-imprinted polymer). The obtained outcomes in terms of selectivity, maximum adsorption capacity, and fast kinetic make this imprinted polymer an outstanding material for future application in molecularly imprinted solid phase extraction for analytical purposes.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of LC/MS/MS quantification method for plantaricins in culture supernatant","authors":"Yumi Komori,&nbsp;Hiroshi Kuwahara,&nbsp;Mikio Aoki","doi":"10.1016/j.jpbao.2024.100043","DOIUrl":"10.1016/j.jpbao.2024.100043","url":null,"abstract":"<div><div>Bacteriocins are a group of small antimicrobial peptides that are ribosomally synthesized and secreted by lactic acid bacteria (LAB). These peptides exhibit high inhibitory activity at low concentrations in the nanomolar range and possess relatively narrow-spectrum antimicrobial activity, making them attractive for various applications, especially as natural food preservatives. Here, we report a novel nanoflow LC/MS/MS-based analysis method for the simultaneous quantification of plantaricin E, F, J, and K in the culture supernatants of their producer LAB strain ABG0035. This method enables accurate quantification of the bacteriocins of interest, even in the presence of high concentrations of sample matrices commonly found in the culture medium. Furthermore, this approach is promising for the analysis of bacteriocins in diverse environments, including cultured bacteria and food matrices.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of ultra-sensitive and disposable electrochemical biosensor: Detection of kidney injury molecule-1 protein in urine for diagnosis of kidney injury","authors":"Elif Ceren Ankara,&nbsp;Sude Aras,&nbsp;Burçak Demirbakan,&nbsp;Mustafa Kemal Sezgintürk","doi":"10.1016/j.jpbao.2024.100042","DOIUrl":"10.1016/j.jpbao.2024.100042","url":null,"abstract":"<div><div>This research study indicates the development of the indium tin oxide-polyethylene terephthalate (ITO-PET) coated electrode-based electrochemical biosensor system to sensitively and specifically detect kidney injury molecule-1 (KIM-1), an acute kidney injury (AKI) biomarker. The ITO-PET electrode surface was modified with 3-(Trimethoxysilyl)-1-propanethiol (3-TMESP) silane agent. Electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and single frequency impedance (SFI) techniques were utilized to examine the interactions between anti-KIM-1 antibody and KIM-1 antigen. The ITO-PET electrode surface was observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM) to analyze the morphological characterization at each electrode development stage. Optimization studies have been conducted to determine the optimal concentrations for detecting the 3-TMESP silane agent, the NHS crosslinker, the anti-KIM-1 antibody, and the optimum incubation period for the anti-KIM-1 antibody and the KIM-1 antigen. Analytical characteristic properties of the developed biosensor, including linear determination range, and the studies of reproducibility, regeneration, repeatability, storage life, and selectivity were investigated. The KIM-1 biosensor system, based on 3-TMESP, has a broad linear range and is capable of providing sensitive measurements between 0.1 fg/mL and 1000 fg/mL. The values of low limits of detection (0.26 fg/mL) and of quantification (0.87 fg/mL) were calculated, highlighting its high sensitivity and precision in detecting KIM-1. In addition, five different commercially purchased human urine samples were tested to validate the practicability of the developed biosensor.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142433952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An intriguing future is approaching: Artificial intelligence meets molecularly imprinted polymers","authors":"Tunca Karasu ,&nbsp;Fatih Çalışır ,&nbsp;Sena Pişkin ,&nbsp;Erdoğan Özgür ,&nbsp;Canan Armutcu ,&nbsp;Mehmet Emin Çorman ,&nbsp;Lokman Uzun","doi":"10.1016/j.jpbao.2024.100041","DOIUrl":"10.1016/j.jpbao.2024.100041","url":null,"abstract":"<div><p>Artificial intelligence (AI) is developing and expanding rapidly beyond the expectations of engineers who develop it as well. It is evaluated that it has/will have great potential not only in terms of software but also in terms of material science, data analysis, and decision-making. On the other hand; molecularly imprinted polymers (MIPs) still attract researchers’ attention with their superior features in terms of wide range of design options and application fields. In this review, the combination of AI and MIP applications and their potential contributions to the future were compiled. In this context, firstly, a brief introduction to MIPs were given in a combination with recent sensor design approaches. Subsequently, the subject of artificial intelligence, in other commonly used words, machine learning, was discussed while summarizing the commonly used algorithms. In the last section, pioneering studies involving the combination of AI and MIPs are highlighted. This review will be the first article compiling AI and MIPs as well as it is thought to be an important main resource for researchers and enthusiasts.</p></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949771X24000173/pdfft?md5=167be38a8a1ccf3d8345fa82ed16be9d&pid=1-s2.0-S2949771X24000173-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New screening and quantification method by UHPLC-MS/MS of 36 new synthetic cathinones in hair. Application to real cases","authors":"Alfredo Fabrizio Lo Faro ,&nbsp;Anastasio Tini ,&nbsp;Giorgi Kobidze ,&nbsp;Giulio Mannocchi ,&nbsp;Massimo Gottardi ,&nbsp;Francesco Paolo Busardò ,&nbsp;Giuseppe Basile ,&nbsp;Bezhan Chakvetadze","doi":"10.1016/j.jpbao.2024.100040","DOIUrl":"10.1016/j.jpbao.2024.100040","url":null,"abstract":"<div><p>A class of β-keto analogs of phenethylamine known as synthetic cathinones has been identified as the most emergent new class of psychoactive chemicals in the last ten years. Synthetic cathinones (SC) are becoming more varied, which represents a serious danger to social security and public health worldwide. In this work, an analytical technique based on UHPLC-MS/MS was developed for the simultaneously measurement of 36 synthetic cathinones and two metabolites in hair keratin samples. The separation was conducted by Atlantis Premier BEH C18 AX (2.5 μm, 2.1 × 100 mm) column using elution with 5 mM ammonium acetate in water with 0.1 % formic acid (v/v) (mobile phase A) and 2 mM ammonium formate in MeOH/Acetonitrile 50/50, +0.1 % formic acid (v/v) (mobile phase B). The analysis time was 11 min. Mass spectrometer was equipped with electrospray ionization (ESI). Multiple reaction monitoring (MRM) mode was used for the detection and quantification of the studied compounds. The methodology was successfully validated according to the Organization Scientific Area Committee guidelines, with linearity (r² ≥ 0.99) from LOQ to 500 pg/mg concentrations for all the compounds investigated. This method was subsequently applied to nine hair samples positive for ten different synthetic cathinones. The most common SCs identified were 3,4-methylenedioxypyrovalerone (3,4-MDPV), in a concentration range 6.0–1000.0 pg/mg, along with alpha-pyrrolidinopentiophenone (α-PHP (54.0 and 554.0 pg/mg, respectively)), followed by the two positional isomers 3-MMC (556.0 and 5000.0 pg/mg) and 4-MMC (11.5 and 448.0 pg/mg). In conclusion, a validated LC-MS/MS method with high specificity was developed offering an easy and affordable sample preparation, and a run time that makes it suitable for use in a high throughput forensic laboratory for the multi-analyte quantification of 36 novel synthetic cathinones and 2 metabolites in hair.</p></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100040"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949771X24000161/pdfft?md5=958a929ad13f40e45bf901f3a1708ff7&pid=1-s2.0-S2949771X24000161-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absolute purity determination of an organic fluorine pharmaceutical voriconazole via quantitative 19F NMR and method validation","authors":"Nahoko Uchiyama ,&nbsp;Junko Hosoe ,&nbsp;Kohei Kiyota ,&nbsp;Takanori Komatsu ,&nbsp;Naoki Sugimoto ,&nbsp;Kyoko Ishizuki ,&nbsp;Tatsuo Koide ,&nbsp;Mika Murabayashi ,&nbsp;Taeko Shinozaki ,&nbsp;Yoshinori Fujimine ,&nbsp;Katsuya Ofuji ,&nbsp;Hitoshi Shimizu ,&nbsp;Kazuhiro Fujita ,&nbsp;Takashi Hasebe ,&nbsp;Yumi Asai ,&nbsp;Eri Ena ,&nbsp;Yoshinobu Makino ,&nbsp;Toru Miura ,&nbsp;Yasuhiro Muto ,&nbsp;Katsuo Asakura ,&nbsp;Yukihiro Goda","doi":"10.1016/j.jpbao.2024.100039","DOIUrl":"10.1016/j.jpbao.2024.100039","url":null,"abstract":"<div><p>The ¹⁹F NMR spectrum has a smaller number of signals than ¹H NMR, therefore, quantitative ¹⁹F NMR (¹⁹F-qNMR) can replace quantitative ¹H NMR (¹H-qNMR) for the absolute quantitation of organic fluorine-bearing compounds. In this study, we determined the purity of voriconazole (VCZ), an organic fluorine pharmaceutical, using ¹⁹F-qNMR, validated the results in multiple laboratories, and compared them with those obtained using an established ¹H-qNMR method. 3,5-Bis(trifluoromethyl)benzoic acid (3,5-BTFMBA) was selected as the reference standard for both ¹⁹F-qNMR and ¹H-qNMR owing to its solubility characteristics and ¹⁹F-qNMR and ¹H-qNMR chemical shifts.</p><p>Since VCZ contains three fluorines, the ¹⁹F-qNMR spectrum of VCZ showed three major fluorine signals (FA, FB, and FC). ¹⁹F-qNMR measurements were performed under three conditions with each ¹⁹F signal of VCZ (FA, FB, and FC) and the ¹⁹F signal of RS as the center (offset) of each observation. The quantitative values of the three target signals FA, FB, and FC were calculated and were comparable; 99.40 %, 99.66 %, and 99.49 %, respectively.</p><p>Owing to a difference of up to 8.8 % between the quantitative values of the two signals other than the targeted quantitative signal, the average FA, FB, and FC quantitative values were considered for purity (%). The purity of VCZ determined by ¹H- and ¹⁹F-qNMR was comparable (99.65±0.29 % and 99.52±0.44 %, respectively), exhibiting variations within an acceptable range. Compared to conventional ¹H-qNMR methods, the developed ¹⁹F-qNMR method has been proven efficient and highly promising for determining the accurate purity of organic fluorine pharmaceuticals.</p></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949771X2400015X/pdfft?md5=f5acbec6128e8e151c576b31ad103517&pid=1-s2.0-S2949771X2400015X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecularly imprinted polymers for pharmaceutical and biomedical analysis","authors":"Mamajan Ovezova ,&nbsp;Fatma Yılmaz ,&nbsp;Ilgım Göktürk ,&nbsp;Kıvılcım Çaktü Güler ,&nbsp;Adil Denizli","doi":"10.1016/j.jpbao.2024.100038","DOIUrl":"10.1016/j.jpbao.2024.100038","url":null,"abstract":"<div><div>Molecularly imprinted polymers (MIPs) are prepared using a technique that allows the formation of binding sites specific to the chosen target molecule. MIPs are materials that can remain stable against changing physical and chemical environmental conditions, possess void structures specific to the target molecule, are easily synthesized, and have a long shelf life. Although initially used primarily for purification and removal processes, MIPs have recently found applications in the medical field as well. In addition to the aforementioned characteristics, their low cost, ease of use, and high accuracy have made them a preferred choice in industrial sectors. MIPs have been widely applied in disease diagnosis and treatment, drug delivery systems, tissue engineering, and industrial drug analysis. Moreover, by integrating with rapidly evolving sensor technologies in addition to traditional methods, MIPs have shortened analysis times, reduced costs, and increased specificity in all conducted analyses. This compilation aims to explain recent studies and advancements in the pharmaceutical field utilizing MIPs, including immunoassays, bioimaging, drug delivery, tissue engineering, cell recognition, and pharmaceutical analyses. Briefly, the scope of this review is to present important scientific and technological advances in molecularly imprinted polymers used for pharmaceutical and biomedical analyses. Although the vast majority of the review focuses on the years 2020–2024, it also addresses current issues and proposed solutions for the use of highly stable molecularly imprinted polymers in pharmaceutical and biomedical analyses since 2010.</div></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949771X24000148/pdfft?md5=26145da75313a743edfc24732d240b8d&pid=1-s2.0-S2949771X24000148-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecularly imprinted polymers in solid-phase microextraction: Enhancing the analysis of pharmaceutical compounds across diverse sample matrices","authors":"Rafael Oliveira Martins,&nbsp;Almir Custodio Batista Junior,&nbsp;Camila Cíntia Sousa Melo Brito,&nbsp;Yuri Arrates Rocha,&nbsp;Andréa Rodrigues Chaves","doi":"10.1016/j.jpbao.2024.100037","DOIUrl":"10.1016/j.jpbao.2024.100037","url":null,"abstract":"<div><p>The biomedicine scientific field has made continuous progress, introducing various pharmaceutical compounds to enhance human life. While these advancements bring benefits, the unregulated use of these compounds raises concerns, particularly regarding their presence in the environment and potential adverse effects on human health. Therefore, the assessment of pharmaceutical compounds by analytical strategies is imperative for comprehending and appraising their potential effects and interactions across diverse matrices. In this sense, solid-based microextraction procedures have shed light on the challenging task of evaluating pharmaceutical compounds in complex and diverse samples. Moreover, miniaturized procedures are firmly rooted in the principles of green analytical chemistry, thereby presenting more environmentally friendly approaches than traditional extraction methods. Consequently, significant endeavors have been undertaken to introduce novel sorbent materials that foster a more selective interaction with target analytes. Having this in mind, molecularly imprinted polymers (MIPs) emerge as a solution, providing selective binding sites capable of interacting with the target analyte within a complex sample. The integration of solid-based microextraction procedures with MIPs as sorbent phases has led to significant strides in advancing the evaluation of pharmaceutical compounds in different samples. Hence, this review endeavors to offer a comprehensive overview of the current applications of solid-based microextraction combined with MIPs in the assessment of pharmaceutical compounds across various samples.</p></div>","PeriodicalId":100822,"journal":{"name":"Journal of Pharmaceutical and Biomedical Analysis Open","volume":"4 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949771X24000136/pdfft?md5=5ce4b0b1b8ca25542029681bdbfea541&pid=1-s2.0-S2949771X24000136-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}