临床检验杂志 Pub Date : 2017-06-30 DOI: 10.15324/KJCLS.2017.49.2.150

S. Jekal, M. Park, D. Kim

引用次数: 3

The Cutoff Value of HbA1c in Predicting Diabetes and Impaired Fasting Glucose HbA1c在预测糖尿病和空腹血糖受损中的临界值

临床检验杂志 Pub Date : 2017-06-30 DOI: 10.15324/KJCLS.2017.49.2.114

Seyoung Kwon, Youngak Na

引用次数: 4

The Relationship between Metabolic Syndrome Risk Factors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women 老年腹部肥胖妇女代谢综合征危险因素与高敏c反应蛋白的关系

临床检验杂志 Pub Date : 2017-06-30 DOI: 10.15324/KJCLS.2017.49.2.121

신경아

{"title":"The Relationship between Metabolic Syndrome Risk Factors and High Sensitive C-reactive Protein in Abdominal Obesity Elderly Women","authors":"신경아","doi":"10.15324/KJCLS.2017.49.2.121","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.121","url":null,"abstract":"이 연구에서는 복부비만을 가진 고령여성을 대상으로 대사증후군 동반 유무에 따른 대사증후군 위험요인과 hs-CRP와의 관련성에 대해 알아보고자 하였다. 대사증후군 진단은 AHA/NHLBI (American Heart Association/National Heart, Lung and Blood Institute) 2005년 기준에 따라 5가지 기준 중3개 이상 해당되는 경우 대사증후군 진단군(MetS, N=77), 2개이하의 위험요인에 해당하는 경우 대조군(Absent, N=97)으로 분류하였다. hs-CRP 농도는 대사증후군 위험요인과 밀접한 관련이 있으며, 특히 복부비만(r=0.190, p=0.014), 공복혈당(r=0.240, p=0.002), HDL-콜레스테롤(r=-0.164, p=0.035)과 연관이 있음을 확인할 수 있었다. 또한 대조군보다 대사증후군 진단군에서 hs-CRP가 높게 나타났으며(p=0.007), 복부비만 상태일지라도 높은 혈당(p=0.006)과 낮은 HDL-콜레스테롤혈증(p=0.010)의 위험요인이 있는군에서 hs-CRP가 높았다. 결론적으로 복부비만이 있더라도 대사증후군 위험요인의 동반유무에 따라 염증관련 위험도가 달라짐을 알 수 있었다.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"23 1","pages":"121-127"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90756915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Epidemiological Study on Acute Diarrheal Disease of Children and Adolescents in the Jeju Region Using a Multiplex-PCR 济州地区儿童青少年急性腹泻病的多重pcr流行病学研究

临床检验杂志 Pub Date : 2017-06-30 DOI: 10.15324/KJCLS.2017.49.2.141

Kyutaeg Lee, Sunmi Kim, M. Chong

引用次数: 3

C-Reactive Protein and Respiratory Viral Infection c反应蛋白与呼吸道病毒感染

临床检验杂志 Pub Date : 2017-03-31 DOI: 10.15324/KJCLS.2017.49.1.15

Jae-Sik Jeon, I. Rheem, J. K. Kim

引用次数: 23

Enhancing the Effects of Zerumbone on THP-1 Cell Activation 增强Zerumbone对THP-1细胞活化的作用

临床检验杂志 Pub Date : 2017-03-31 DOI: 10.15324/KJCLS.2017.49.1.1

M. H. Lee, Sa Hyun Kim, Sung-Ryul Ryu, Pyeongjae Lee, C. Moon

{"title":"Enhancing the Effects of Zerumbone on THP-1 Cell Activation","authors":"M. H. Lee, Sa Hyun Kim, Sung-Ryul Ryu, Pyeongjae Lee, C. Moon","doi":"10.15324/KJCLS.2017.49.1.1","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.1.1","url":null,"abstract":"Zerumbone은 야생 생강의 일종인 Zingiber zerumbet Smith의 정유(essential oil)에 포함되어 있는 주요성분으로, 다양한 연구를 통해 혈액종양을 포함한 암, 염증질환, 활성산소 감소 등에 이용할 가능성이 꾸준히 제기되어왔다. 또한 면역세포들의 증식과 세포주기진행, 사이토카인의 생성ㆍ발현에도 효과를 나타낸다고 알려져 있다. 이외에도 간보호, 통증완화, 항동맥경화, 항미생물 등 다양한 생물학적 기능이 보고되었다. 본 연구에서는 zerumbone이 단구의 활성과 기능에 어떠한 영향을 미치는지 알아보고자 하였다. 우선, 단구세포주 THP-1세포의 활성이 zerumbone에 의해 증가되는 것을 확인하였다. LPS 처리 후 가장 강한 THP-1 증식 증가는 5 μM의 zerumbone 처리시 나타났으며, 세포 단독 증식 증가는 10 μM의 zerumbone 처리 시 가장 증가하였다. 반면에 50 μM 의 zerumbone 처리 시에는 LPS 존재 여부와 관계없이 급격한 증식 감소가 관찰되었다. LPS의 처리에 의해 유도되는 신호전달 단백질 Erk의 인산화도 zerumbone에 의해 증가되었다. 가장 강한 인산화 증가는 증식 감소가 나타난 50 μM의 zerumbone을 처리했을 때 관찰되었다. 전사인자 NF-κB의 활성은 zerumbone 단독 처리 시에는 큰 변화가 없었지만, LPS 와 동시에 처리했을 경우 증가하는 것으로 관찰되었다. 나아가, NFκB에 의해 발현이 조절되는 염증 사이토카인 TNF-α, IL-8의 전사도 zerumbone 에 의해 증가되는 것을 확인하였다. 이와 같은 결과를 통해 zerumbone이 단핵구의 증식과 활성을 강화시킬 수 있음을 확인하였다. 나아가, zerumbone이 LPS 를 보유한 세균 감염 시 단핵구 활성 증가를 통하여 효과적인 탐식과 면역반응을 강화시켜 효과적인 세균 처리에 도움을 줄 수 있을 것으로 여겨진다.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"200 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76041254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Protective Effect of Rosmarinic Acid on the Aluminum of Dementia Inducer 迷迭香酸对痴呆诱导剂铝的保护作用

临床检验杂志 Pub Date : 2017-03-31 DOI: 10.15324/KJCLS.2017.49.1.8

In-Ju Jung, Y. Seo, S. Jekal

{"title":"The Protective Effect of Rosmarinic Acid on the Aluminum of Dementia Inducer","authors":"In-Ju Jung, Y. Seo, S. Jekal","doi":"10.15324/KJCLS.2017.49.1.8","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.1.8","url":null,"abstract":"To examine the protective effect of rosmarinic acid on the aluminum of dementia inducer, cultured C6 glioma cells were treated with various concentrations of aluminum chloride (AlCl 3 ) or rosmarinic acid. The cell viability, electron donating ability (EDA), superoxide dismutase (SOD)-like activity, and inhibitory activity of lipid peroxidation were evaluated for the antioxidant effect of rosmarinic acid. In these cultures, AlCl 3 sowed a cytotoxic effect by decreasing the cell viability in a dose-dependent manner; then, the XTT 50 value was measured at 142.2  M of AlCl 3 after treating the cultured C6 glioma cells with media containing 120 ∼ 160  M AlCl 3 . Therefore, its toxicity was determined as mid-cytotoxic by Borenfreund and Puerner’s toxic criteria; while, vitamin E of antioxidant markedly increased the cell viability on AlCl 3 – induced cytotoxicity in these cultures. This study showed the antioxidant effect of rosmarinic acid via several assays, such as electron donating activity (EDA), superoxide dismutase (SOD)-like activity, and inhibitory activity of lipid peroxidation. From these findings, it is suggested that the oxidative stress is involved in AlCl 3 -induced cytotoxicity, and rosmarinic acid was effective in the protection of AlCl 3 -induced cytotoxicity by antioxidant activity. In conclusion, natural resources, like rosmarinic acid, may be a putative antioxidant agent for the treatment of reactive oxygen species (ROS)-mediated disease, such","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"26 1","pages":"8-14"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81709515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Correlation between Infection with Multiple Respiratory Viruses and Length of Hospital Stay in Patients from Cheonan, Korea 韩国天安市患者多重呼吸道病毒感染与住院时间的关系

临床检验杂志 Pub Date : 2017-03-31 DOI: 10.15324/KJCLS.2017.49.1.22

Jae-Sik Jeon, Jin-wan Park, J. K. Kim

{"title":"Correlation between Infection with Multiple Respiratory Viruses and Length of Hospital Stay in Patients from Cheonan, Korea","authors":"Jae-Sik Jeon, Jin-wan Park, J. K. Kim","doi":"10.15324/KJCLS.2017.49.1.22","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.1.22","url":null,"abstract":"The length of hospital stay (LOS) for patients with respiratory virus infections has been reported to depend the virus type and infection severity. However, the impact of co-infections remains unclear. Patients with suspected respiratory virus infections, who visited Dankook University Hospital between December 2006 and February 2014, were included to examine the relationship between co-infections and LOS. Multiplex reverse transcriptase-polymerase chain reactions were used to identify the causative viruses. LOS was analyzed with respect to sex, age, virus, and co-infection. During this period, 5,310 out of the 8,860 patients (59.9%; median age, 1.5 years) were respiratory virus-positive. In respiratory virus-positive patients with single, double, and three-or-more infections, the average LOS was 7.3, 6.7, and 6.6 days, respectively. Longer LOS was observed for older patients and those with human coronavirus OC43 infections compared with adenovirus or respiratory syncytial virus A infections. LOS differed significantly according to age, virus type, and co-infection, but not between double and three or more infections.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"12 1","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79892104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Expression of Solute carrier family members Genes in Mouse Ovarian Developments 溶质载体家族成员基因在小鼠卵巢发育中的表达

临床检验杂志 Pub Date : 2017-03-31 DOI: 10.15324/KJCLS.2017.49.1.40

O. Lee-Gyun, Chang-Eun Park

引用次数: 1

Global DNA Methylation Patterns and Gene Expression Associated with Obesity-Susceptibility in Offspring of Pregnant Sprague-Dawley Rats Exposed to BDE-47 and BDE-209 暴露于BDE-47和BDE-209的妊娠sd大鼠后代的DNA甲基化模式和基因表达与肥胖易感性相关

临床检验杂志 Pub Date : 2017-03-31 DOI: 10.15324/KJCLS.2017.49.1.28

Byeong-Min Park, Ok-Jin Yoon, Do-Hoon Lee

{"title":"Global DNA Methylation Patterns and Gene Expression Associated with Obesity-Susceptibility in Offspring of Pregnant Sprague-Dawley Rats Exposed to BDE-47 and BDE-209","authors":"Byeong-Min Park, Ok-Jin Yoon, Do-Hoon Lee","doi":"10.15324/KJCLS.2017.49.1.28","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.1.28","url":null,"abstract":"Persistent organic pollutants (POPs) can affect epigenetic mechanisms and obesity development. Polybrominated diphenyl ethers (PBDEs) — widely used to make flames — are one of the important POPs. Prenatal exposure to endocrine disrupting chemicals (EDCs), such as POPs, may affect global DNA methylation in long interspersed nuclear elements (LINE-1), increasing the risk of obesity later in life. Therefore, pregnant Sprague-Dawley (SD) rats were used to elucidate whether BDE-47 and BDE-209 transferred through placenta and breast milk cause epigenetic changes in LINE-1 and increase genetic susceptibility to obesity as obesogen during the developmental periods. Global DNA methylation in LINE-1 and gene expression related to obesity were measured in dams and offspring, using a methylation-sensitive high resolution melting analysis (MS-HRM) and direct bisulfite sequencing and quantitative real time polymerase chain reaction (qPCR), respectively. The results of MS-HRM showed global DNA hypomethylation patterns in LINE-1 of exposed offspring (2 of total 4) at PND 4, but bisulfite sequencing showed no difference in both the exposed and non-exposed groups. Gene expression in dams related to  -oxidation pathway and those related to adipokines showed different patterns between the two groups. On the contrary, gene expressions of offspring showed a similar pattern. Gene expressions related to  -oxidation pathway and obesity were significantly increased when compared with 'at birth', but not PPAR-  . In conclusion, this study demonstrated the possibility that co-exposure to BDE-47 and BDE-209 — via the placenta and breast milk — may affect epigenetic changes and modulate gene expression levels","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"51 1","pages":"28-39"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84583395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

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