临床检验杂志 Pub Date : 2021-03-31 DOI: 10.15324/KJCLS.2021.53.1.32

Jun Ho Lee

引用次数: 0

Cathepsin B Is Implicated in Triglyceride (TG)-Induced Cell Death of Macrophage 组织蛋白酶B与甘油三酯诱导的巨噬细胞死亡有关

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.245

Byung Chul Jung, Jaewon Lim, Sung Hoon Kim, Y. Kim

引用次数: 0

The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults 韩国非糖尿病成人慢性肾脏疾病进展与β细胞功能的关系

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.165

H. Kim

{"title":"The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults","authors":"H. Kim","doi":"10.15324/KJCLS.2020.52.3.165","DOIUrl":"https://doi.org/10.15324/KJCLS.2020.52.3.165","url":null,"abstract":"Received August 23, 2020 Revised 1 August 30, 2020 Revised 2 August 31, 2020 Accepted September 1, 2020 This study examined the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in nondiabetic Korean adults. This study included 4,380 adults aged 20 or older (50.32±16.14) using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents the national data in Korea. The present study had several key findings. First, in terms of HOMA-IR, after adjusting for the related variables (Model 4), the HOMA-IR (M±SE, 95% confidence interval [CI]) in group 1 (G1; estimated glomerular filtration rate [eGFR], ≥90 mL/min/1.73 m), group 2 (G2; eGFR, 60∼89 mL/min/1.73 m), group 3a (G3a; eGFR, 30∼59 mL/min/1.73 m), and ≥group 3b (≥G3b; eGFR, <30 mL/min/1.73 m) were 1.78±0.03 (1.73∼1.83), 1.87±0.03 (1.81∼1.93), 2.16±0.13 (1.91∼2.42), and 2.59±0.24 (2.12∼3.06), respectively. The HOMA-IR was positively associated with the progression of CKD (P<0.001). Second, in terms of the HOMA-B, after adjusting for the related variables (Model 4), the HOMA-B (M±SE, 95% CI) in G1, G2, G3a, and ≥G3b were 87.46±1.21 (85.08∼89.84), 89.11±1.38 (86.40∼91.81), 104.82±5.91 (93.23∼116.42), and 123.97±10.87 (102.66∼145.29), respectively. HOMA-B was positively associated with the progression of CKD (P<0.001). Both insulin resistance and the beta-cell function were positively associated with CKD in non-diabetic Korean adults. Copyright C 2020 The Korean Society for Clinical Laboratory Science. All rights reserved.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"25 1","pages":"165-171"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86912563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Mismatch Negativity Using Frequency Difference in Healthy Young Adults: Latency and Amplitude 在健康年轻人中使用频率差异的错配负性:潜伏期和振幅

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.194

Seokwon Jung, Young-Soo Kim, Tae-won Yang, Do-Hyung Kim, Min Su Kim, Sang Hyeon Bae, Ga-In Kim, O. Kwon

引用次数: 0

Risk of Stroke according to the Duration of Diabetes Mellitus with Hypertension 糖尿病合并高血压病程与脑卒中风险的关系

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.188

H. Kim

{"title":"Risk of Stroke according to the Duration of Diabetes Mellitus with Hypertension","authors":"H. Kim","doi":"10.15324/KJCLS.2020.52.3.188","DOIUrl":"https://doi.org/10.15324/KJCLS.2020.52.3.188","url":null,"abstract":"Received June 22, 2020 Revised 1 July 29, 2020 Revised 2 August 13, 2020 Revised 3 August 24, 2020 Accepted August 25, 2020 Stroke is a major cause of death and disorder, and diabetes mellitus (DM) is a significant risk factor of stroke. This study examined the importance of target blood pressure (<140/<90 mmHg) management in patients with DM. Based on the data of the 6th National Health and Nutrition Examination Survey, a total of 16,389 patients aged 18 to under 80 were assessed through regression analysis to estimate the risk of stroke through blood pressure control. The prevalence of stroke according to the presence or absence of DM was higher in the diabetic group, and a longer duration of DM indicated a higher risk of hypertension and stroke. The hazard ratio of stroke was lower in the maintenance group (0.57) of target blood pressure (<140/<90 mmHg) compared to the high blood pressure group(>140/>90 mmHg). Despite the accompanying treatment for DM and hypertension, the frequency of hypertension increased, and the prevalence of stroke increased after five years of DM. Hence, effective blood pressure management at this time is important. The risk of stroke should be reduced by continuously managing blood pressure in DM. Copyright C 2020 The Korean Society for Clinical Laboratory Science. All rights reserved.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"46 1","pages":"188-193"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74734066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metformin or α-Lipoic Acid Attenuate Inflammatory Response and NLRP3 Inflammasome in BV-2 Microglial Cells 二甲双胍或α-硫辛酸可减弱BV-2小胶质细胞的炎症反应和NLRP3炎性体

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.253

Hye-Rim Choi, Ji-Sun Ha, I. Kim, S. Yang

{"title":"Metformin or α-Lipoic Acid Attenuate Inflammatory Response and NLRP3 Inflammasome in BV-2 Microglial Cells","authors":"Hye-Rim Choi, Ji-Sun Ha, I. Kim, S. Yang","doi":"10.15324/KJCLS.2020.52.3.253","DOIUrl":"https://doi.org/10.15324/KJCLS.2020.52.3.253","url":null,"abstract":"Received August 18, 2020 Revised 1 August 25, 2020 Revised 2 August 31, 2020 Accepted August 31, 2020 Alzheimer’s disease (AD) is a chronic and progressive neurodegenerative disease that can be described by the occurrence of dementia due to a decline in cognitive function. The disease is characterized by the formation of extracellular and intracellular amyloid plaques. Amyloid beta (Aβ) is a hallmark of AD, and microglia can be activated in the presence of Aβ. Activated microglia secrete pro-inflammatory cytokines. Furthermore, S100A9 is an important innate immunity pro-inflammatory contributor in inflammation and a potential contributor to AD. This study examined the effects of metformin and α-LA on the inflammatory response and NLRP3 inflammasome activation in Aβand S100A9-induced BV-2 microglial cells. Metformin and α-LA attenuated inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). In addition, metformin and α-LA inhibited the phosphorylation of JNK, ERK, and p38. They activated the nuclear factor kappa B (NF-κ B) pathway and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Moreover, metformin and α-LA reduced the marker levels of the M1 phenotype, ICAM1, whereas the M2 phenotype, ARG1, was increased. These findings suggest that metformin and α-LA are therapeutic agents against the Aβand S100A9-induced neuroinflammatory responses. Copyright C 2020 The Korean Society for Clinical Laboratory Science. All rights reserved.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"202 1","pages":"253-260"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80199497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Case of Treatment Using Adaptive Servo-Ventilation in a Patient with Central Sleep Apnea after a Lateral Medullary Infarction 应用自适应伺服通气治疗外侧髓梗死后中枢性睡眠呼吸暂停1例

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.278

D. Kim, J. Cho, Hyun Woo Kim, J. S. Choi, S. Mun

引用次数: 0

Study on the Relationship between Pro-Brain Natriuretic Peptide and Routine Blood Test Factors at a General Hospital in Gyeonggi-do 京畿道某综合医院血常规检查因子与前脑利钠肽关系的研究

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.172

D. Park, Sang-Su Kim, H. Sung, C. Park

引用次数: 0

Investigation of Bacterial Contamination of Liquid Soaps Used in Public Restroom 公共厕所液体肥皂细菌污染调查

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.214

S. Hong

{"title":"Investigation of Bacterial Contamination of Liquid Soaps Used in Public Restroom","authors":"S. Hong","doi":"10.15324/KJCLS.2020.52.3.214","DOIUrl":"https://doi.org/10.15324/KJCLS.2020.52.3.214","url":null,"abstract":"Received August 18, 2020 Revised 1 August 21, 2020 Revised 2 August 21, 2020 Accepted August 21, 2020 Handwashing with soap is an important practice to reduce the transmission of potentially pathogenic microorganisms, but liquid soaps with refillable dispensers are prone to extrinsic bacterial contamination. This study investigated the bacterial contamination of liquid soaps in 58 public restrooms in six buildings. The bacteria were identified by a biochemical test and MALDI-TOF mass spectrophotometry. The antimicrobial susceptibility was determined using the Vitek II system. Of the 58 restrooms examined, 27(46.55%) were using a refill dispenser, of which 25(92.59%) were contaminated with bacteria. The bacteria recovered from the soaps ranged from 1.6x10 to 2.7×10 CFU/mL. Serratia liquefaciens (12), Achromobacter xylosoxidans (9), S. marcescens (4), Staphylococcus pastueri (1), and Achromobacter spanius (1) were isolated. Except for one A. xylosoxidans, bacteria of the same species isolated in the same building showed a unique resistance pattern. In conclusion, handwashing with contaminated soap may play a role in the transmission of bacteria in public health settings. Therefore, it is necessary to limit the use of refillable liquid soaps in the restrooms of hospitals used by patients with reduced immunity. Copyright C 2020 The Korean Society for Clinical Laboratory Science. All rights reserved.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"29 1","pages":"214-220"},"PeriodicalIF":0.0,"publicationDate":"2020-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79083627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey on Sexually Transmitted Infection Test of One Referral Laboratory in Seoul: Focused on Multiple Sexually Transmitted Diseases 首尔某转诊实验室性传播感染检测调查:以多种性传播疾病为重点

临床检验杂志 Pub Date : 2020-09-30 DOI: 10.15324/KJCLS.2020.52.3.237

Dong-In Seok, H. Sung, C. Park

引用次数: 1

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