The Relationship between the Progression of Chronic Kidney Disease and Beta Cell Function in Non-Diabetic Korean Adults

Received August 23, 2020 Revised 1 August 30, 2020 Revised 2 August 31, 2020 Accepted September 1, 2020 This study examined the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) in nondiabetic Korean adults. This study included 4,380 adults aged 20 or older (50.32±16.14) using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents the national data in Korea. The present study had several key findings. First, in terms of HOMA-IR, after adjusting for the related variables (Model 4), the HOMA-IR (M±SE, 95% confidence interval [CI]) in group 1 (G1; estimated glomerular filtration rate [eGFR], ≥90 mL/min/1.73 m), group 2 (G2; eGFR, 60∼89 mL/min/1.73 m), group 3a (G3a; eGFR, 30∼59 mL/min/1.73 m), and ≥group 3b (≥G3b; eGFR, <30 mL/min/1.73 m) were 1.78±0.03 (1.73∼1.83), 1.87±0.03 (1.81∼1.93), 2.16±0.13 (1.91∼2.42), and 2.59±0.24 (2.12∼3.06), respectively. The HOMA-IR was positively associated with the progression of CKD (P<0.001). Second, in terms of the HOMA-B, after adjusting for the related variables (Model 4), the HOMA-B (M±SE, 95% CI) in G1, G2, G3a, and ≥G3b were 87.46±1.21 (85.08∼89.84), 89.11±1.38 (86.40∼91.81), 104.82±5.91 (93.23∼116.42), and 123.97±10.87 (102.66∼145.29), respectively. HOMA-B was positively associated with the progression of CKD (P<0.001). Both insulin resistance and the beta-cell function were positively associated with CKD in non-diabetic Korean adults. Copyright C 2020 The Korean Society for Clinical Laboratory Science. All rights reserved.