临床检验杂志最新文献

{"title":"Study on Legal Issues and Scope of Medical Technologist’s Practice","authors":"M. Shim, Bon-Kyeong Koo, Chang-Eun Park","doi":"10.15324/KJCLS.2017.49.2.55","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.55","url":null,"abstract":"최근 과학과 의료기술의 발전으로 의료행위에 있어 많은 변화를 가져왔으며 환자의 치료에 있어 그 역할이 강조되고 있다. 특히 임상병리사의 경우, 역할과 중요성이 의료과학 분야가 발달함에 따라 증가되고 있으며, 이에 따른 책임감 역시 증가하고 있다. 임상병리사의 전문성과 독립성의 증가로 더 이상 의사의 보조로만 여기지 않고, 의사의 진료와 의료기사 등의 의료 보조행위에 기초하여 현대 의료서비스는 보다 조직화되고 복잡화, 전문화 되고 있다. 그러나 “의료기사 등에 관한 법률”에서는 의료기사는 의사 또는 치과의사의 지도하에서만 면허범위 내의 행위가 가능하도록 규정하고 있다. 그래서 본 연구에서는 각종의료행위에 있어서 임상병리사를 중심으로 하여 “의료기사 등에 관한 법률”에서 나타나는 문제점과 그 중에서도 의료업무, 의료지도에 관한 부분 등에 관해 살펴보았다. 결론으로 “의료기사 등에 관한 법률”에 명시된 의사의 지도에 대한 명확한 해석이 필요하며, 국가면허시험의 자격과 역할을 “의료기사 등에 관한 법률”에 명시하고, 임상병리사의 역할에 대해 보건의료인들과의 소통 또한 필요하며, 독립된 법제정으로 임상병리사들의 영역 확대와 전문성을 확대 강화하는 것이 필요할 것이라고 생각한다.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"49 1","pages":"55-68"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76788502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Inhibitory Effects of Cordycepin on Phosphoproteins including PI3K, Akt, and p38","authors":"Hyuk-Woo Kwon, Dong-Ha Lee","doi":"10.15324/KJCLS.2017.49.2.99","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.99","url":null,"abstract":"A species of Cordyceps, an ingredient in Chinese traditional medicine well-known for its major component, cordycepin (3'-deoxyadenosine), has been known to have antiplatelet effects; however, its effects on regulation of phosphoprotein have not been fully elucidated. In this study, we investigated how cordycepin regulates the phosphoprotein, including phosphatidylinositol 3-kinase (PI3K)/Akt and p38, to inhibit platelet aggregation, which are concerned with fibrinogen binding to glycoprotein IIb/IIIa (IIb/3) and granule secretion in platelets. Our finding suggests that cordycepin inhibits collagen-induced platelet aggregation with 261.1 M of IC50 and also inhibits fibrinogen binding to IIb/3 by a suppression of PI3K/Akt phosphorylation in a dose dependent manner. In addition, cordycepin further showed to inhibit collagen-induced p38 phosphorylation, reducing granule secretion (i.e. ATPand serotonin-release) and thromboxane A2 (TXA2) production without regulating cyclooxygenase-1 (COX-1) and thromboxane A synthase (TXAS) activities, as well as phospholipase C-2 (PLC-2) phosphorylation. In conclusion, these results demonstrate that cordycepin-mediated antiplatelet effects were due to the inhibition of fibrinogen binding to IIb/3 via the suppression of PI3K/Akt phosphorylation and inhibition of granule secretion & TXA2 production by suppressing p38 phosphorylation. These results strongly indicate that cordycepin might have therapeutic or preventive potential for platelet aggregation-mediated disorders, regulating the phosphoprotein, including PI3K/Akt and p38.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"387 1","pages":"99-107"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84989818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey on the Education System and National Licensing Examination for Fostering Competent Medical Technologists","authors":"H. Kim, P. Kwon, Ji-Hyuk Kang, Man-Gil Yang, Jong O Park, Dae-Joong Kim, Won Shik Kim, Sei-Ick Joo, Eun-Joong Kim, Sun Kyung Lee, Sang Hee Lee, S. Jekal","doi":"10.15324/KJCLS.2017.49.2.161","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.161","url":null,"abstract":"Department of Medical Laboratory Science, Korea Nazarene University, Cheonan, Korea Department of Clinical Laboratory Science, Wonkwang Health Science University, lksan, Korea Department of Biomedical Laboratory Science, DaeJeon University, Daejeon, Korea Department of Research & Experiments, Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea Department of Laboratory Medicine, Bundang Jesaeng Hospital, Seongnam, Korea Department of Clinical Laboratory Science, Daejeon Health Institute of Technology, Daejeon, Korea Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea Department of Clinical Laboratory Science, Chungbuk Health and Science University, Cheongju, Korea Department of Clinical Laboratory Science, Dongkang College, Gwangju, Korea Department of Clinical Laboratory, Asan Medical Center, Seoul, Korea","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"8 1","pages":"161-170"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85336917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of College Adjustment and Social Support on Career Development Level of College Students Who Majors in Health or Social Welfare","authors":"Jung-yeon Park, Soon-mi Park","doi":"10.15324/KJCLS.2017.49.2.180","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.180","url":null,"abstract":"본 연구에서는 보건 복지전공 대학생의 대학생활적응과 사회적 지지가 진로발달수준에 어떤 영향을 미치는지에 대해 검증하였다. 연구를 위해서 경상남도 G지역과 J지역에 소재한 전문대학내 보건 복지전공 대학생을 대상으로 설문조사가 실시되었고, 총 203부가 분석에 사용되었다. 연구결과를 살펴보면, 우선 각 변인의 ...","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"11 1","pages":"180-186"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82548136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S100A8 and S100A9 Secreted by Allergens in Monocytes Inhibit Spontaneous Apoptosis of Normal and Asthmatic Neutrophils via the Lyn/Akt/ERK Pathway","authors":"I. Kim, Ji-Sook Lee","doi":"10.15324/KJCLS.2017.49.2.128","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.128","url":null,"abstract":"Der p 1과 Der p 2는 알레르기 질환과 관련된 집먼지 진드기의 핵심적인 알러젠이다. 본 연구에서는 Der p 1과 Der p 2가 단구에서 S100A8과 S10A9을 분비시키는지를 확인하였고, 분비된 S100A8과 S10A9이 호중구의 세포고사 조절기전에 작용하는지를 연구하였다. Der p 1과 Der p 2는 정상인의 단구에서 S100A8과 S10A9을 유의하게 증가시켰고, S100A8과 S10A9은 정상인과 알레르기 질환 호중구의 자발적 세포고사를 억제시켰다. 호중구의 Lyn, Akt, ERK는 S100A8과 S10A9을 시간별로 처리하였을 때 활성화하였다. 본 연구를 통하여 단구와 호중구에서 Der p 1과 Der p 2의 역할을 규명하였고, 나아가 관련된 알레르기 병인기전을 이해하는데 유용할 것이다.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"206 1","pages":"128-134"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76963577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Method to Detect Cattle Material from Processed Meat Products Using a Polymerase Chain Reaction","authors":"Young Chul Kwon, Do-Yun Hah, Yunwi Heo, Tae-kyu Kim, Yoo-Jeong Choi, D. Jo, Sang-Yun Nam, Byeong-Guk Son, Bo-Won Hwang, B. Yang, Euikyung Kim","doi":"10.15324/KJCLS.2017.49.2.135","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.135","url":null,"abstract":"중합효소연쇄반응법을 이용한 축산물 가공식품 내에 존재하는 소고기 성분을 특이적으로 검출할 수 있는 방법을 개발하기 위하여 축산물 가공식품 78종류를 무작위로 선별하였다. 가공식품으로부터 추출한 genomic DNA를 이용하여 소의 미토콘드리아 16S rRNA 염기서열을 이용하여 strain-specific primer를 직접 제작하여 중합효소연쇄반응을 수행한 후, 증폭된 반응산물의 염기서열을 분석 하였다. 축산물 가공식품 내 소고기 성분 검출을 위한 중합효소연쇄반응 수행 결과, 소고기 성분이 함유되어 있는 17개의 축산물 가공식품이 정확히 증폭되었고, 증폭산물의 DNA 염기서열 분석 결과 소의 미토콘드리아 16S rRNA 서열과 95% 이상의 상동성을 보였다. \u0000본 실험에서 제시된 방법으로 축산물 가공식품 내 소고기 성분검출을 적용하였을 시, 소고기 성분이 함유된 축산물 가공식품을 정확하게 감별할 수 있었으며, 나아가 식품 원재료의 허위기재 등에 의한 불량식품 유통 근절 및 종교적 이유로 인한 금기 식품감별 등과 같은 과학적 식품 감시에 기여할 수 있다고 사료된다.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"1 1","pages":"135-140"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76978273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analytical Validation of the GenesWell™ BCT Multigene Prognostic Test in Patients with Early Breast Cancer","authors":"김지은, 강병일, 배승민, 한새봄, 전아름, 한진일, 조민아, 최윤라, 이종흔, 문영호","doi":"10.15324/KJCLS.2017.49.2.79","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.79","url":null,"abstract":"GenesWell $^{TM}$ BCT는 호르몬 수용체 양성, HER2 음성, 및 pN0 또는 1인 조기 유방암 환자의 10년내 타 장기 전이 재발 위험도를 제시하는 다지표 예후 예측 검사로, 예후에 대한 위험을 BCT Score로 제시한다. 본 연구에서는 GenesWell $^{TM}$ BCT의 분석적 성능을 검사하였다. 조기 유방암 환자의 FFPE 검체로 부...","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"27 1","pages":"79-87"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84537584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of Retirement Expectation among Medical Technologists in Korea","authors":"Yoon-kyung Jo, D. Lee, H. Sung","doi":"10.15324/KJCLS.2017.49.2.171","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.171","url":null,"abstract":"This study investigated the influence factors of retirement expectations among medical technologists at medical centers in Seoul and Gyeonggi area, Korea. Subjects were 158 medical technologists. Using a sampling survey method, data was analyzed between July 2015 and December 2016. There was a negative correlation between educational level and economic preparation, but gender and monthly income did not reach retirement expectation level. Conversely, we found no change in the trends with respect to gender, monthly income; nonetheless, we observed that frustration gradually increased with age and working duration. In conclusion, our findings show that there are four factors that significantly influence retirement expectation and preparation: age, level of education, working duration, and family condition. This study contributes to understanding retirement expectations and can be a reference for retirement preparation in medical technologists.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"49 1","pages":"171-179"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88942085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Methocarbamol Combination to Prevent Toxicity of Non-steroidal Anti Inflammatory Drugs","authors":"Seungmin Yeom, Min-Seok Kim, Eric A. Lingenfelter, J. Broadwell","doi":"10.15324/KJCLS.2017.49.2.88","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.88","url":null,"abstract":"To prevent toxicity from both robax platinum (methocarbamol, ibuprofen) and robaxacet (methocarbomol, acetaminophen), separately, we used stretches and naproxen as a non-steroidal anti-inflammatory drug (NSAID) to compare each effectiveness. This study used the United States Forces Korea Prescription form (Annex A-Over-The-Counter Prescription) and Alice Rich’s Pain scale with robax platinum, robaxacet including narproxen. The IBM SPSS statics version 24 was used to calculate the data. The combined methocarbamol 500 mg, acetaminophen 325 mg tablet, and ibuprofen 200 mg (or naproxen) tablet can work as well as the combined methocarbamol 500 mg tablet with acetaminophen 325 mg tablet with stretches. Both methods were successful in managing pain. The drug combination of methocarbamol 500 mg, acetaminophen 325 mg and ibuprofen 200 mg tablets yielded similar benefits as the methocarbamol 500 mg and acetaminophen 325 mg tablets paired with physical stretching exercises regarding managing overall pain.","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"64 1","pages":"88-98"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74817788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usefulness of Rapid Triple Test for Cardiac Marker in Forensic Paragnosis of Sudden Cardiac Death","authors":"C. Lim, Jin-Gak Kim","doi":"10.15324/KJCLS.2017.49.2.108","DOIUrl":"https://doi.org/10.15324/KJCLS.2017.49.2.108","url":null,"abstract":"A sudden cardiac death (SCD) is defined as an unnatural sudden death caused by heart disease. To determine the cause of death, observation of the microscopic change in cardiac muscle tissue is suggested, rather than visual postmortem examination. However, this suggestion is time consuming to be applied in the field, is cost-ineffective, and is inconvenient. Therefore, the purpose of this study is to understand whether temporary inspection used to examine the cardiac marker (Myoglobin, CK-MB, cTn I) in postmortem blood via rapid cardiac triple test kit (which is used by clinics to diagnose patients with acute myocardial infarction) can effectively be utilized for the paragnosis of sudden, unnatural cardiac death. The results of postmortem examination and temporary investigation found that 23 groups (76.7%), among the 30 experimental groups, were assumed to be non-traumatic sudden cardiac deaths, which indicated a positive response (according to comparison with forensic autopsy); 4 groups, among the 10 control groups, were assumed to be cerebrovascular disease, which indicated a negative response; 1 group was assumed to be alcoholic and drug poisoning, indicating a positive response; and 1 group was assumed to be oxygen deficiency due to suffocation, indicating a positive response. Hence, it was found that the level of sensitivity and specificity of cardiac marker's temporary inspection showed significant result, 76.7% and 80% respectively. Given this, temporary inspection can be effectively used for the paragnosis of sudden cardiac death when the medical history, situation of the site, and postmortem interval are considered together. With the result of precedent research on time of first revelation and extinction in blood, and difference in concentration over time progress according to the characteristic of cardiac marker's (myoglobin, CK-MB, cTn I) individual material, further research on concentration of cardiac marker per each post time needs to be conducted in order to estimate time science death (which is required to identify the cause of death and investigation).","PeriodicalId":10080,"journal":{"name":"临床检验杂志","volume":"114 1","pages":"108-113"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74892871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}