Intelligent Pharmacy最新文献

{"title":"A systematic review on the effectiveness of Zingiber officinale in reducing dental caries","authors":"Raghu Dhanapal ,&nbsp;Subramani Parasuraman ,&nbsp;Mohammed Zahedul Islam Nizami ,&nbsp;Galvin Sim Siang Lin ,&nbsp;Jogikalmat Krithikadatta","doi":"10.1016/j.ipha.2024.08.001","DOIUrl":"10.1016/j.ipha.2024.08.001","url":null,"abstract":"<div><div>According to the Global Burden of Disease Study and the World Health Organization, dental caries is one of the most prevalent oral diseases globally. It is well known that dental caries are associated with cariogenic bacteria and their biofilm. Many preventive strategies and therapeutic compounds have been proposed for decades. Among them, various plant-based phytochemical compounds have been investigated against cariogenic bacteria. In this review, we plan to show the effectiveness of <em>Zingiber officinale</em> to reduce dental caries. <em>Z. officinale</em> in ginger is a bioactive spice compound that shows antimicrobial activity. Therefore, it is reasonable to consider the antimicrobials and biofilm inhibition properties of bioactive <em>Z. officinale</em> to rationalize its potential in reducing dental caries. While the literature highlights the general antimicrobial properties of <em>Z. officinale</em>, this review focuses on <em>Z. officinale</em>’s capability against cariogenic microbes and their biofilms. Reported results of minimum inhibition concentration (MIC), minimum bactericidal concentration (MBC), and biofilm inhibition (glucans and adhesion) were systematically reviewed. Common search engines like PubMed, Science Direct, and the Web of Science database are used to retrieve data using the keywords “<em>Zingiber officinale” and</em> “dental caries”. Out of 122 resulting reports, 11 of them were included in this review. It can be concluded that <em>Z. officinale</em> effect against cariogenic bacteria varies depending on microbial and analytical factors. However, translational advanced studies have not yet been conducted to verify its clinical application.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 638-642"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sea buckthorn: A potential dietary supplement with multifaceted therapeutic activities","authors":"","doi":"10.1016/j.ipha.2023.12.003","DOIUrl":"10.1016/j.ipha.2023.12.003","url":null,"abstract":"<div><div>Sea buckthorn (<em>Hippophae rhamnoides</em> L.) is a plant with various nutritional and medicinal properties. It contains vitamins, carotenoids, polyphenols, fatty acids, and phytosterols, which have antioxidant, anticancer, anti-hyperlipidemic, anti-obesity, anti-inflammatory, antimicrobial, antiviral, dermatological, neuroprotective, and hepatoprotective effects. Sea buckthorn can be used as a functional food or a dietary supplement for the prevention and treatment of chronic diseases. This review summarizes the phytochemistry, health benefits, and food applications of sea buckthorn, and highlights the potential and challenges for its further development and utilization. Sea buckthorn not only has greatmedicinal and therapeutic potential, but also is a promising economic plant. The potential of seabuckthorn in the human food industry has attracted the research interest of researchers and pro- ducers. The present review mainly summarizes the phytochemistry, nutrients, health benefits, andfood applications of sea buckthorn. Overall, sea buckthorn is a dietary source of bioactive ingredi- ents with the potential to be developed into functional foods or dietary supplements for the pre- vention and treatment of certain chronic diseases, which deserves further research.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 681-687"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in anti-dengue drug development","authors":"","doi":"10.1016/j.ipha.2024.01.006","DOIUrl":"10.1016/j.ipha.2024.01.006","url":null,"abstract":"<div><div>Dengue fever is a mosquito-borne illness that affects millions of people worldwide. Artificial intelligence (AI) is being employed in the battle against it. AI is being used to analyse dengue immune repertoires, which may yield hitherto unheard-of insights into the complexities of dengue adaptive immunity, help in the development of novel treatments, and influence the creation of vaccines. This AI-driven strategy may contribute to the creation of dengue fever therapies that are more potent.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 721-722"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review on the chemical composition and pharmacological activities of ACACIA ARABICA","authors":"","doi":"10.1016/j.ipha.2024.01.008","DOIUrl":"10.1016/j.ipha.2024.01.008","url":null,"abstract":"<div><div>Since the dawn of time, people have used herbal medications to both prevent and treat a variety of illnesses. Numerous illnesses, including diabetes, skin conditions, and most seriously cancer, have been claimed to be successfully treated by <em>Acacia Arabica</em>. According to Indian traditional medicine, the fresh sections of <em>Acacia Arabica have</em> beneficial nutritional properties as well as astringent, demulcent, aphrodisiac, anthelmintic, antibacterial, and antidiarrheal properties. The ethnobotanical and therapeutic benefits of <em>Acacia Arabica</em> are briefly reviewed in this article along with information about the plants. This is an attempt to gather and record data regarding many facets of <em>Acacia Arabica</em> and its prospective applications. Before using <em>Acacia Arabica</em>'s therapeutic potential, more research is required.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 729-736"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140521854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mimusops elengi: A comprehensive review","authors":"","doi":"10.1016/j.ipha.2023.11.007","DOIUrl":"10.1016/j.ipha.2023.11.007","url":null,"abstract":"<div><div><em>Mimusops elengi</em>, a widely distributed tree species in tropical regions, has been used for centuries in traditional medicine due to its numerous therapeutic properties. In this study, we conducted a comprehensive analysis of the phytocompounds present in various parts of <em>Mimusops elengi</em>, including leaves, bark, and flowers using advanced analytical techniques. The objective was to identify and quantify the bioactive compounds responsible for the plant's medicinal attributes. Our findings revealed a diverse range of phytochemicals in <em>Mimusops elengi</em>. The analysis detected various classes of compounds, including alkaloids, flavonoids, tannins, phenolic compounds, terpenoids and glycosides. Notably, the leaves contained a significant concentration of alkaloids, particularly elengioside, which has demonstrated potential anti-inflammatory and analgesic properties. Additionally, the flowers were rich in flavonoids and tannins, such as quercetin and catechin, known for their antioxidant and anti-cancer activities. Furthermore, the bark of <em>Mimusops elengi</em> exhibited the presence of terpenoids, including lupeol and betulinic acid, which have been associated with anti-inflammatory and antiviral properties. These compounds may contribute to the plant's traditional use for treating various ailments, including skin disorders and respiratory issues. This review provides valuable insights into the phytochemical composition <em>of Mimusops elengi,</em> shedding light on its potential therapeutic applications. <em>Mimusops elengi</em> holds promise as a valuable source of natural compounds with health-promoting benefits.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 672-680"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139292832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design of some potent non-toxic Autoimmune disorder inhibitors based on 2D-QSAR, CoMFA, molecular docking, and molecular dynamics investigations","authors":"","doi":"10.1016/j.ipha.2023.12.009","DOIUrl":"10.1016/j.ipha.2023.12.009","url":null,"abstract":"<div><div>Current clinical research suggests that inhibitors of protein arginine deiminase 4 (PAD4), major histocompatibility complex (MHC) class II HLA-DQ-ALPHA chain, and thyrotropin receptor (or TSH receptor) which are of biological and therapeutic interest, may show potential in treating rheumatoid arthritis, type 1 diabetes, Graves' disease and other autoimmune disorder. In the present study, a comprehensive analysis was conducted on a collection of 32 compounds concerning their anti-rheumatoid arthritis activity as inhibitors of PAD4. This analysis represents the first instance in which these compounds were computationally examined, employing an <em>in-silico</em> approach that considered 2D-3D QSAR modeling, and molecular docking and was further validated through molecular dynamics and ADMET properties assessment. A credible 2D QSAR (Q_LOO^2 ​= ​0.6611 and R^2 ​= ​0.7535) model was constructed and verified using an external validation test set, Y-randomization, variance inflation factor (VIF), mean effect (MF), and William's plot applicability domain (AD). Ligand-based alignment was implemented in the 3D-QSAR examination. The outcomes demonstrated that CoMFA (uvepls) (Q²LOO ​= ​0.5877; <em>R</em>² ​= ​0.9983) possess remarkable stability and foresight. The internal validation indicated that CoMFA (uvepls) MIFs display superior predictive capability compared to COMFA (ffdsel). Structural criteria determined by the contour maps of the model and molecular docking simulations were strategically employed to computationally develop 10 new, non-toxic autoimmune disease inhibitors with increased efficacy. Docking tests were done on the newly developed compounds to illustrate their binding mechanism and to identify critical interaction residues inside the active region of rheumatoid arthritis (PDB id: 3BLU). In addition, docking results of the selected designed compounds inside the active sites of type 1 diabetes receptor (6DFX), and Graves' disease receptor (4QT5) demonstrated their rheumatoid arthritis (PDB id: 3BLU) selectivity. A molecular dynamics simulation and binding free energy calculations using the MM/GBSA technique confirmed the stability of the proposed compound D4 inside the rheumatoid arthritis (3BLU) receptor active site. In summary, the results of our investigation might give considerable insight into the future design and development of new autoimmune disease inhibitors.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 688-706"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of Vernonia cinerea L. ethno-medicinal uses and pharmacology shows that it could be a useful plant for medical purposes","authors":"","doi":"10.1016/j.ipha.2023.11.005","DOIUrl":"10.1016/j.ipha.2023.11.005","url":null,"abstract":"<div><div><em>Vernonia cinerea</em> L.<em>,</em> also known as purple fleabane, is a plant with medicinal properties that have been traditionally used to treat respiratory infections, digestive disorders, and skin conditions. Its antimicrobial and anti-inflammatory properties make it a potential candidate for treating various infections and inflammatory diseases. The plant contains alkaloids, flavonoids, and essential oils, which possess antimicrobial properties, making it a promising candidate for treating bacterial and fungal infections. Its anti-inflammatory properties have shown potential for managing inflammatory diseases like arthritis and dermatitis. Additionally, the plant's analgesic and antipyretic effects suggest its potential for pain management and fever reduction. Its antioxidant properties make it a potential candidate for preventing and treating oxidative stress-related diseases like cardiovascular disorders and neurodegenerative conditions. However, more studies are needed to determine its optimal dosage, safety profile, and potential drug interactions before widespread use in medical practice.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 662-671"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139295892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational transformation in drug discovery: A comprehensive study on molecular docking and quantitative structure activity relationship (QSAR)","authors":"","doi":"10.1016/j.ipha.2024.03.001","DOIUrl":"10.1016/j.ipha.2024.03.001","url":null,"abstract":"<div><div>The procedure for learning and creating a new medicine is widely seen as a drawn-out and costly endeavor. Different rational strategies are considered, depending on their requirements, as potential ways; nevertheless, techniques to designing drugs based on structure and ligands are well acknowledged as very practical and potent tactics in drug discovery. Computational approaches help decrease the need for Medicinal research with animals, helping to develop fresh, safe therapeutic concepts via rational design and positioning of existing products and supporting pharmaceutical scientists and medicinal chemists during the medication development process. Computer-aided drug discovery (CADD) methods are useful for reducing the time and cost of drug discovery and development and understanding the molecular mechanisms of drug action and toxicity. Molecular docking is a technique that predicts a ligand's binding mode and affinity to a target protein. At the same time, QSAR is a technique that establishes mathematical relationships between the structural features and biological activities of a series of compounds. This study reviews the current state and applications of CADD methods, focusing on molecular docking and quantitative structure–activity relationship (QSAR) techniques. This study reviews the principles, advantages, limitations, and challenges of these methods, as well as some recent advances and examples of their applications in drug discovery for various diseases. The study also discusses the future prospects and directions of CADD methods in the era of big data and artificial intelligence.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 589-595"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review on modern techniques of granulation in pharmaceutical solid dosage forms","authors":"","doi":"10.1016/j.ipha.2024.05.006","DOIUrl":"10.1016/j.ipha.2024.05.006","url":null,"abstract":"<div><div>This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. Dry granulation techniques, including slugging, roller compaction, and pneumatic dry granulation, are dissected with thorough analyses of their processing methods, advantages, disadvantages, and diverse applications. The article delves into eleven wet granulation techniques, offering insights into high-shear granulation, low-shear granulation, fluidized bed granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, melt granulation, freeze-dry granulation, foam granulation, thermal adhesion, and twin screw wet granulation. Each method is scrutinized, providing a comprehensive understanding of its processing steps, merits, drawbacks, and practical applications in pharmaceutical manufacturing. The article serves as a valuable resource for researchers, pharmaceutical professionals, and students, offering a nuanced exploration of diverse granulation techniques vital in drug formulation. This synthesis of information aims to enhance the understanding of granulation processes, facilitating informed decision-making in pharmaceutical development and manufacturing.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 609-629"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current approaches in nanostructured biomaterials in treatment of leiomyosarcoma","authors":"","doi":"10.1016/j.ipha.2024.01.009","DOIUrl":"10.1016/j.ipha.2024.01.009","url":null,"abstract":"<div><div>One form of uncommon cancer that develops in the smooth muscles is called leiomyosarcoma, or LMS. The body's hollow organs, such as the stomach, bladder, intestines, and blood vessels, contain smooth muscles. The three main components of conventional therapy are surgery, chemotherapy, and radiotherapy. These treatments have numerous drawbacks, including insufficient surgical resection, drug resistance to chemotherapy, radiotherapy insensitivity, and postoperative bone defects. Because of their easy modification, targeting, and other characteristics, along with their unique physicochemical properties, nanoparticles have been used extensively in research on anti-leiomyosarcoma treatment. Inhibiting the onset and progression of leiomyosarcoma, nanoparticles can have a variety of effects on the growth of leiomyosarcoma cells. We provide a brief overview of the development of nanoparticle research closely associated with leiomyosarcoma treatment in this review.</div></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":"2 5","pages":"Pages 737-741"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139637737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}