Intelligent Pharmacy最新文献

{"title":"Chitosan fortified repaglinide gastro-retentive mucoadhesive microsphere with improved anti-diabetic attribute","authors":"Anil Pawar ,&nbsp;Pranjal Lohakane ,&nbsp;Ramdas Pandhare ,&nbsp;Popat Mohite ,&nbsp;Shubham Munde ,&nbsp;Sudarshan Singh ,&nbsp;Vijay Chidrawar","doi":"10.1016/j.ipha.2024.01.012","DOIUrl":"10.1016/j.ipha.2024.01.012","url":null,"abstract":"<div><p>Repaglinide (RPG) has a high rate of absorption from the gastrointestinal system after oral administration due to low log <em>P</em> value. Hence, in this study the inotropic gelation process was used to fabricate mucoadhesive microspheres of RPG using biodegradable polymers such as guar gum, chitosan, and fenugreek seed mucilage. The mucoadhesive microspheres were characterized and tested <em>in vitro</em> followed with oral glucose tolerance test on animals. Scanning electron microscopy images demonstrated that the fabricated microspheres were smooth and spherical with lack of pores. The particle size and polydispersity index (PDI) of microsphere was observed as 300 ​μm and 0.349, respectively with high positive zeta potential of 38.4 ​mV. The results of percentage yield and swelling index analysis demonstrated 87.04 % and 90.65 %, respectively for optimized formulation with an <em>in vitro</em> release capability of 95.20 % in 10 ​h. In addition, the results suggested that the mucoadhesive microspheres successfully entrapped 94.86 ​± ​4.25 % of the RPG. These results clearly indicated that the optimized formulation of RPG fortified mucoadhesive microspheres reduced the blood glucose level (hyperglycemia due to glucose load 2 ​g/kg) significantly, compared to marketed RPG formulation (0.25 ​mg/kg) after 2 ​h of oral administration. Additionally, RPG incorporated microspheres enable the regulated blood glucose level over a 10 ​h. Hence, the formulation demonstrated overall improvement in anti-diabetic efficacy.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X24000224/pdfft?md5=3b0ca9f262b5e390472892b8c57f954f&pid=1-s2.0-S2949866X24000224-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles: The future of therapeutics and drug delivery systems","authors":"Md Jamir Uddin ,&nbsp;Popat Mohite ,&nbsp;Shubham Munde ,&nbsp;Nitin Ade ,&nbsp;Tosin Ayodeji Oladosu ,&nbsp;Vijay R. Chidrawar ,&nbsp;Ravish Patel ,&nbsp;Sankha Bhattacharya ,&nbsp;Himanshu Paliwal ,&nbsp;Sudarshan Singh","doi":"10.1016/j.ipha.2024.02.004","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.02.004","url":null,"abstract":"<div><p>Extracellular vesicles (EVs) are nanometric size, a cell-derived drug delivery carrier composed of membrane-bound structures, release into the cellular medium and found in body fluids. EVs serve a dual purpose, acting as a means of disposing of redundant material and a method of communication between cells. Their natural origin, biocompatibility, protein, and nucleic acid composition boosts superior targeting capabilities. While strong safety profile, intrinsic pleiotropic therapeutic effects, ability to accommodate both lipophilic and hydrophilic agents, and pass through blood–brain barrier makes them exceptional nanocarrier. Several synthetic drug delivery methods have been fabricated and introduced to the market throughout the previous few decades. However, their inefficiency, cytotoxicity, and/or immunogenicity hinder their applications. Evidence demonstrates that EVs play a critical role in major physiological and pathological processes, such as cellular homeostasis, infection propagation, cancer progression, and cardiovascular diseases. Moreover, EVs offer a range of advantages over traditional synthetic carriers, thus paving the way for innovative drug delivery approaches. Although therapeutic applications as carrier is limited due to lack of scalable isolation techniques and efficient drug loading, EVs serve great potential as nanocarriers. The review summarizes and discuss recent progress and challenges associated with development of EVs as nanocarrier.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X24000273/pdfft?md5=fc15256de188ba137c11be7de0fceab3&pid=1-s2.0-S2949866X24000273-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141243819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QSAR, molecular docking, and molecular designs of some anti-epilepsy compounds","authors":"Usman Abdulfatai ,&nbsp;Stephen Ejeh ,&nbsp;Abduljelil Ajala ,&nbsp;Samuel Ndaghiya Adawara ,&nbsp;Olasupo Sabitu Babatunde ,&nbsp;Zakari Ya'u Ibrahim","doi":"10.1016/j.ipha.2023.11.011","DOIUrl":"10.1016/j.ipha.2023.11.011","url":null,"abstract":"<div><p>Epilepsy is a non-communicable central nervous system (CNS) disease that accounts for approximately 0.8–1.2 % of the global population at any time. The hyper-activities of gamma butyric acid aminotransferase (GABA_AT) enzyme have been confirmed to be largely responsible for seizure/epilepsy. Because of this special function, the GABA_AT enzyme has been the main target of many anti-epilepsy drugs (AEDs). To date, many discovered AEDs have not eradicated this neurological disease. Since experimental determinations of modern drugs are usually costly and sometimes non-eco-friendly, in-silco quantitative structure–activity relationship (QSAR)-machine learning, docking and pharmacokinetics (PMK) techniques were used to design and test the oral bio-availabilities of all the designed AEDs. QSAR models were generated, and the predictive properties of R²int = 0.9827, R²ext = 0.9407, and R²adj of 0.9667 indicate the evidence that the developed model was not by chance. Six (6) new AEDs were newly designed, and they were found to have better anti-epileptic activities values of 2.146799, 2.224866, 2.31479, 2.450313, 2.301474, and 2.618303 than the standard AED, Vigabatrin (0.40672). Also, the docked new compounds shows excellent binding energies of −127.001, −129.071, −130.515, −126.881, −130.771, and −126.974 kcal/mol compared to the referenced AED (−76.9173 kcal/mol). The PMK and absorption, distribution, metabolism, excretion, and toxicity (ADMET) investigations also revealed that all the designed compounds were found to be bio-available for human administration. 'Therefore, the newly designed analogues (AEDs) could be considered as potential drug candidates for the treatment of epilepsy.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001259/pdfft?md5=b5d5a294d721cc4faafe33be21511ebc&pid=1-s2.0-S2949866X23001259-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138627236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the competence of ChatGPT for customer and patient service management","authors":"Abid Haleem ,&nbsp;Mohd Javaid ,&nbsp;Ravi Pratap Singh","doi":"10.1016/j.ipha.2024.03.002","DOIUrl":"10.1016/j.ipha.2024.03.002","url":null,"abstract":"<div><p>The modern language generation model ChatGPT, created by Open Artificial Intelligence (AI), is recognised for its capacity to comprehend context and produce pertinent content. This model is built on the transformer architecture, which enables it to process massive volumes of data and produce text that is both cohesive and illuminating. Service is a crucial component everywhere as it provides the basis for establishing client rapport and offering aid and support. In healthcare, the application of ChatGPT for patient service support has been one of the most significant advances in recent years. ChatGPT can help overcome language obstacles and improve patient satisfaction by facilitating communication with healthcare personnel and understanding of care. It can assist in enhancing the entire patient experience by offering personalised information and support to patients and making it more straightforward for them to communicate with healthcare professionals. Its goal can be to expedite and streamline service by promptly and accurately responding to customers. Businesses of all sizes increasingly use ChatGPT since it allows them to provide 24/7 customer support without requiring human contact. This paper briefly discusses ChatGPT and the need for better services. Various perspectives on improving customer and patient services through ChatGPT are discussed. The article also discussed the major key enablers of ChatGPT for refining customer and patient assistance. Further, the paper identifies and discusses the critical application areas of ChatGPT for customer and patient service. With its ability to handle several requests simultaneously, respond quickly and accurately to client questions, and gain knowledge from every interaction, ChatGPT is revolutionising customer and patient service. Its accessibility and compatibility with various communication channels make it a desirable solution for businesses looking to improve support. As technology advances, ChatGPT is positioned to become an essential tool for businesses wishing to provide speedy and customised service. Although ChatGPT may give convincing solutions, the chance of providing accurate and updated information poses a problem for its usage in service jobs that need accurate and up-to-date information. In future, various services will become better and more efficient due to ChatGPT and AI.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X24000480/pdfft?md5=486c0b1deb623f0ab297c68f59356065&pid=1-s2.0-S2949866X24000480-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140272095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“A review on electromedicine its various properties and emerging application in various fields”","authors":"Vaibhavi Vijay Kshatriya, M. Kumbhare, Shraddha Vikas Jadhav, P. Thorat, Rushikesh Gajanan Bhambarge","doi":"10.1016/j.ipha.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.05.001","url":null,"abstract":"","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141054625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaphorical investigation of aqueous distillate of Cichorium intybus, Foeniculum vulgare and Solanum nigrum along with atorvastatin and orlistat in experimental rodent models of dyslipidaemia and obesity","authors":"Rufaida Wasim,&nbsp;Tarique Mahmood,&nbsp;Arshiya Shamim,&nbsp;Farogh Ahsan,&nbsp;Aditya Singh","doi":"10.1016/j.ipha.2023.08.011","DOIUrl":"10.1016/j.ipha.2023.08.011","url":null,"abstract":"<div><h3>Background</h3><p>Arq is a traditional Unani liquid formulation. In this study we explored Arq-Makoh, Arq-Badiyan and Arq-Kasni for their pharmacological potential to alleviate the symptoms of hyperlipidaemia and obesity and develop an amalgamation with modern drugs that have clinically well reported antihyperlipidaemic and antiobesity potential.</p></div><div><h3>Materials and methods</h3><p>Rats were fed High Fat Diet for 4 weeks. 10 ​ml/kg of each of the three arqs were given alone and along with atorvastatin and orlistat daily for 28 days P.O. During the course of treatment body weight and food intake were carefully observed and after the end of the study, liver weight, heart weight, plasma lipid profile, blood glucose level, insulin and leptin level, serum lipase, lactate dehydrogenase, and antioxidant activity were studied in all treatment groups.</p></div><div><h3>Result</h3><p>Both Arqs and Atorvastatin and Orlistat significantly reduced body weight, lipid profile in HFD fed rats. Arqs when given along with Atorvastatin and Orlistat produced more significant decrease in the serum lipid profile, serum lipase, atherogenic index, lactate Dehydrogenase and TBARS compared with HFD Control group and elevated the levels of HDL-C and SOD. Apart from antihyperlipidaemic and antiobesity effects the treatment groups showed a significant reduction in elevated fasting blood glucose levels (as a result of HFD model used in the study). The above parameters were further confirmed by histopathological studies.</p></div><div><h3>Conclusion</h3><p>The present study indicates that Arq-Makoh, Arq-Badiyan and Arq-Kasni has lipid lowering potential and could potentiate the antihyperlipidaemic and antiobesity potential of Atorvastatin and Orlistat.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23000709/pdfft?md5=3d04078bbf3cab1f4e08abace1f45b82&pid=1-s2.0-S2949866X23000709-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135388914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling the influenza virus inhibitory potential: Ligand-based docking, pharmacophore, MM-GBSA, and molecular dynamic simulation of phytochemicals and cyanobacteria metabolites","authors":"John Maria Jancy Rani ,&nbsp;Karunanithi Kalaimathi ,&nbsp;Srinivasan Prabhu ,&nbsp;Muniappan Ayyanar ,&nbsp;Shine Kadaikunnan ,&nbsp;Subramaniyan Vijayakumar ,&nbsp;Sathammai Priya ,&nbsp;Jayasree Sheshadri ,&nbsp;Singamoorthy Amalraj ,&nbsp;Muthu Thiruvengadam ,&nbsp;Stanislaus Antony Ceasar","doi":"10.1016/j.ipha.2023.10.011","DOIUrl":"10.1016/j.ipha.2023.10.011","url":null,"abstract":"<div><p>Viral outbreaks facilitated by global travel and modernity pose significant threats to global health. Influenza viruses, particularly α-influenza and β-influenza strains, have been plaguing human populations since time immemorial. Despite their long-standing impact, effective drugs are yet to be developed, and co-infection with these viruses can lead to severe health complications. In light of these challenges, this study aimed to investigate the potential antiviral molecules sourced from cyanobacteria and herbs. We conducted virtual screening using ligand-based docking to identify potential phytochemicals and cyanobacterial metabolites as candidates for further evaluation. Subsequently, pharmacophore modeling was employed to validate the binding modes of the selected compounds, followed by MM-GBSA calculations to assess their binding affinities and stabilities within the viral target. Among the molecules investigated, the cyanobacterial compound Symplocamide A (−8.042) demonstrated notable outcomes in docking than the herb molecules in the docked ligand. This finding suggests its potential as a therapeutic agent against influenza A virus proteins. Additionally, cyanobacterial molecules such as Lyngbyastatins 3 (−8.001), Lyngbyastatin G1 (−7.501), and Kempenopeptide (−6.128) exhibit stronger binding affinities and more potent docking scores, making them promising candidates for targeting viral proteins in potential therapeutic applications. The present study reveals the possibility of harnessing cyanobacterial molecules as novel antiviral agents against influenza viruses. Ultimately, we believe that this research will serve as a stepping stone in the quest for innovative drugs to combat respiratory diseases caused by viral infections.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X23001028/pdfft?md5=deae6c97c3e2da7f8acfd9ad4a9e4897&pid=1-s2.0-S2949866X23001028-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, development and evaluation of Woodfordia fruticosa and β-sitosterol mediated silver nanoparticles gel for synergistic effect","authors":"Aditya Singh ,&nbsp;Shubhrat Maheshwari","doi":"10.1016/j.ipha.2023.10.012","DOIUrl":"10.1016/j.ipha.2023.10.012","url":null,"abstract":"<div><h3>Background</h3><p>Silver nanoparticles (AgNP) are frequently utilized metallic nanoparticles in healthcare systems. In this investigation, AgNP was produced employing β-sitosterol and <em>Woodfordia fruticosa</em> gel for the purpose of ameliorating wound healing.</p></div><div><h3>Methods</h3><p>The characterization of AgNP was conducted via SEM and spectrophotometry analysis. Simultaneously, a solution with a concentration of 1 ​mM of silver nitrate was prepared by dissolving 16.99 ​mg of silver nitrate in 100 ​ml of distilled water. Subsequently, the API and the silver nitrate solution were utilized in the synthesis of silver nanoparticles. The physicochemical properties, stability, and morphology of the synthesized silver nanoparticles were evaluated through various techniques, such as zeta potential analysis and electron microscopy. These techniques were employed for the purpose of assessing the aforementioned properties. Following the gel preparation, an assessment of the gel was performed.</p></div><div><h3>Result</h3><p>The investigation successfully produced silver nanoparticles (AgNP) using β-sitosterol and <em>Woodfordia fruticosa</em> gel. To characterize the synthesized AgNP, various techniques were employed, including SEM and spectrophotometry analysis. A 1 ​mM solution of silver nitrate was prepared and used in the synthesis process, and the physicochemical properties, stability, and morphology of the AgNP were assessed through zeta potential analysis and electron microscopy.</p></div><div><h3>Conclusion</h3><p>The results of this study indicate the successful synthesis of silver nanoparticles using β-sitosterol and <em>Woodfordia fruticosa</em> gel. The characterization techniques, including SEM and spectrophotometry, confirmed the formation of AgNP. The analysis of physicochemical properties and stability, particularly through zeta potential analysis, provided valuable insights into the stability of the synthesized nanoparticles. These findings have significant implications in the context of wound healing. Silver nanoparticles have been widely studied for their potential wound healing properties due to their antimicrobial and anti-inflammatory characteristics. The utilization of natural compounds like β-sitosterol and botanical sources like <em>Woodfordia fruticosa</em> gel for the synthesis of AgNP is particularly promising as it may reduce potential toxicity and enhance the biocompatibility of these nanoparticles.</p></div>","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949866X2300103X/pdfft?md5=e5b3a1922c1ab6c7626665f1f0890a8f&pid=1-s2.0-S2949866X2300103X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135509936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combat against antibiotic resistance is a challenge in Bangladesh","authors":"M. Roney, A. M. Huq, Mohd Fadhlizil Fasihi Mohd Aluwi","doi":"10.1016/j.ipha.2024.02.002","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.02.002","url":null,"abstract":"","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in anti-dengue drug development","authors":"M. Roney","doi":"10.1016/j.ipha.2024.01.006","DOIUrl":"https://doi.org/10.1016/j.ipha.2024.01.006","url":null,"abstract":"","PeriodicalId":100682,"journal":{"name":"Intelligent Pharmacy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}