{"title":"Artificial Neural Network Prediction on negative and positive activation energy of magnetohydrodynamic nanofluid flow with multiple slips","authors":"Shovan Sarkar , Hiranmoy Mondal , Prabir Kumar Kundu","doi":"10.1016/j.hybadv.2025.100452","DOIUrl":"10.1016/j.hybadv.2025.100452","url":null,"abstract":"<div><div>In this study, the non-Newtonian magnetohydrodynamic stagnation point nanofluid flow with negative and positive activation energy and multiple slip boundary conditions over a slippery surface has been investigated and an artificial neural network model has been developed to predict the Sherwood number (mass transfer rate). This study can be helpful to identify the optimal conditions for heat and mass transfer enhancement in magnetohydrodynamic nanofluid flow with multiple slips. Artificial neural network model can provide real-time predictions, so it can play an important role in process control, optimization and reducing computational cost. All of the previous study has focused on positive activation energy but in our current study we have considered the negative and positive activation energy together. Thus, our study is unique. Through the use of similarity transformations, the system of non-linear partial differential equations that represent the fluid flow has been converted into a system of non-linear ordinary differential equations and then solved numerically with the help of Spectral Quasi-linearization Method. It has been seen that, velocity increases and temperature, concentration decreases for the increasing values of velocity slip parameter. Concentration of the fluid decreases for the rising values of thermal slip parameter and concentration slip parameter. For the rising values of positive activation energy, concentration of the fluid first decreases then increases and opposite behaviour has been seen for the rising values of negative activation energy. It is also seen that, for the rising values of activation energy from 0.5 to 2.5, Skin friction coefficient and Sherwood number are increased by 0.65 % and 4.64 % respectively while Nusselt number is decreased by 3.65 %. When activation energy goes from <span><math><mrow><mo>−</mo><mn>0.5</mn><mo>−</mo><mn>2.5</mn></mrow></math></span>, Skin friction coefficient and Sherwood number are decreased by 1.74 % and 17.47 % respectively while Nusselt number is increased by 12.40 %. This investigation can take a key role in the field of biochemical engineering, medical and thermal management such as heat exchangers, cooling systems, tissue engineering, protein production etc. Another important matter to discuss here that we have used feed-forward back-propagation multilayer perceptron artificial neural network with Levenberg-Marquard algorithm as the training algorithm to predict the Sherwood number for both activation energy values 1 and -1. We have analysed Mean Square Error, Root Mean Square Error, Coefficient of correlation, Mean and Standard deviation of errors to justify the accuracy of the designed artificial neural network model. From our observations, we can conclude that artificial neural network model is an ideal tool which can be employed for the prediction of magnetohydrodynamic nanofluid flow behaviours.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100452"},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2025-03-22DOI: 10.1016/j.hybadv.2025.100457
Idowu David Ibrahim
{"title":"Improvement of mechanical and wear behaviour of fiber-reinforced polypropylene composites for the rail industry","authors":"Idowu David Ibrahim","doi":"10.1016/j.hybadv.2025.100457","DOIUrl":"10.1016/j.hybadv.2025.100457","url":null,"abstract":"<div><div>There is a growing need for advanced composite materials due to increasing areas of applications that are unachievable by single materials. Material surfaces are prone to wear due to contact with other materials, applied load and the nature of the material itself, thus the need for improved composite materials. The influence of applied load on the wear behaviour of polymeric-based composites, produced with several fillers and fibers as reinforcements, is reported in studies. The reinforcing fiber was alkaline treated (5 wt% NaOH) for improved strength and interfacial adhesion between the polymer matrix and the fiber. The reinforced composites were developed by extrusion, followed by compressive molding. The wear analysis was done by varying the applied load (5, 10, and 20 N). Based on the findings of this study, there was an increase of between 51 and 79 % in the wear rate as the applied load increased from 5 to 20 N due to a higher coefficient of friction with increasing load. Increasing fiber loading from 10 to 40 wt% led to a decrease of 75, 38 and 36 % in the wear rate of the reinforced composites for applied load of 5, 10 and 20 N, respectively. The impact strength and water absorption rate were observed to have increased with increasing fiber contents. The study shows that reinforced polypropylene composites recorded improved wear resistance, which means that the properties of reinforced composites largely depend on the fiber content, interfacial bonding between the polymer matrix and the reinforcing fibers and applied load. This makes the composite material ideal for the transport industry.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100457"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A state-of-the-art review on SiC and MWCNTs reinforced hybrid metal matrix composites: Processing, properties, and applications","authors":"Sanoj Divakar , Santanu Sardar , Satesh Sah , Debdulal Das","doi":"10.1016/j.hybadv.2025.100454","DOIUrl":"10.1016/j.hybadv.2025.100454","url":null,"abstract":"<div><div>In recent years, the focus of material scientists has been moving from single to hybrid metal matrix composites (HMMCs) in order to fulfil the ever-increasing industrial demand for low-cost and lightweight materials with comprehensive mechanical performances. Discontinuous HMMCs, often with multi-scaled reinforcements with contrasting properties, are relatively simple to manufacture. They offer exciting property combinations like great specific-strength, acceptable formability and toughness, and outstanding wear resistance, making them potential candidates for a wide range of applications in the aerospace, automotive, and military sectors. Metal matrix reinforced with one hard ceramic and another carbonaceous material are the most researched hybrid composites; among these, silicon carbide (SiC) and multi-walled carbon nanotubes (MWCNTs) reinforced ones are the most promising. Therefore, the current article presented a comprehensive review of the processing, microstructures, properties, and applications of SiC plus MWCNTs reinforced light metal matrix hybrid composites, emphasizing the recent advancements, current challenges, and future directions. Various fabrication methods were compared in terms of microstructural characteristics and mechanical properties, while the role of different processing parameters was identified. The emerging steps to overcome the challenges of dispersion of reinforcements, damage of MWCNTs, and interfacial reaction during processing were explicitly addressed. New understandings of the thermal, electrical, tensile, tribological, and corrosion properties of the selected composite system were systematically highlighted.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100454"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2025-03-22DOI: 10.1016/j.hybadv.2025.100456
Rui He , Inpyo Hong , Sangmo Kim , Chung Wung Bark
{"title":"Review on recent developments in the ferroelectric material SrMnO3","authors":"Rui He , Inpyo Hong , Sangmo Kim , Chung Wung Bark","doi":"10.1016/j.hybadv.2025.100456","DOIUrl":"10.1016/j.hybadv.2025.100456","url":null,"abstract":"<div><div>Strontium manganese oxide (SrMnO<sub>3</sub>), a perovskite multifunctional oxide material, has emerged as an ideal candidate for next-generation memory devices and energy conversion systems owing to its unique ferroelectricity, antiferromagnetism, and magnetoelectric coupling effect. SrMnO<sub>3</sub> films show great potential for ferroelectric memories (e.g., Fe random-access memory) and energy storage devices (e.g., capacitors and lithium-ion batteries). In recent years, with the development of advanced film preparation technologies and characterization methods, considerable progress has been made in the preparation and structural regulation of SrMnO<sub>3</sub> films, as well as in understanding their physical properties and functional applications. Studies have shown that the ferroelectric, magnetic, and electrical properties can be significantly improved by regulating the thickness, stress state, and doping of the film. This paper systematically reviews the research status of bulk SrMnO<sub>3</sub> and SrMnO<sub>3</sub> thin films, including preparation technologies and optimization strategies, focusing on their structure, ferroelectricity, magnetism, and electrical transport properties. In addition, the influence of doping and interface engineering on film performance and the application potential of SrMnO<sub>3</sub> thin films in energy storage devices and ferroelectric memories have been analyzed. Based on the results, we summarize the current research breakthroughs in SrMnO<sub>3</sub> thin films, highlight the persisting challenges associated with practical applications, and outline possible research directions for the future.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100456"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-process manufacturing framework: A cost-effective approach for pediatric prosthetic knee joints in above-knee amputations","authors":"Pratisthit Lal Shrestha, Sudan Baral, Isha Acharya, Bhola Thapa","doi":"10.1016/j.hybadv.2025.100450","DOIUrl":"10.1016/j.hybadv.2025.100450","url":null,"abstract":"<div><div>Existing manufacturing methods for pediatric knee joints can be expensive and resource-intensive, which makes them inaccessible to low and middle-income countries. This challenge is further complicated for toddlers aged 3–5, which is a crucial time for their rapid growth and may necessitate frequent knee joint replacements. This issue demands a framework that can suggest a suitable combination of manufacturing methods for reliable pediatric prosthetic knee joints at an affordable price. This study investigated a multi-process manufacturing approach for a typical polycentric 4-bar knee joint based on Geometric Complexity Score (GCS), Mechanical Strength Requirements (MSR), and Affordability. The GCS matrix identified Additive Manufacturing (AM) as preferable for highly complex parts and Subtractive Manufacturing (SM) for moderately and least complex parts. The MSR analysis categorized components based on stress levels, with the highest stress observed in the pin (147.27 MPa under loading condition 1 and 108.07 MPa under loading condition 2) and the lowest in the washer (4.1384 MPa and 2.71 MPa, respectively). The affordability study evaluated that the production cost index for AM, SM, and the hybrid approach was 0.186, 1, and 0.277, respectively. The results demonstrated that a multi-process manufacturing approach, utilizing AM for complex geometries and SM for simpler components, offers an optimal balance of affordability, strength, and manufacturability. This study paves the way for creating cost-effective, pediatric prosthetic knee joints, enhancing accessibility and quality of life for amputees. Further research is required to refine the design and assess long-term performance through clinical trials.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100450"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2025-03-22DOI: 10.1016/j.hybadv.2025.100446
Arpita Mandal , Arindam Sarkar
{"title":"Effect of Coriolis force on thermally radiative rotating hybrid nanofluid flow over a bi-directional stretching sheet","authors":"Arpita Mandal , Arindam Sarkar","doi":"10.1016/j.hybadv.2025.100446","DOIUrl":"10.1016/j.hybadv.2025.100446","url":null,"abstract":"<div><div>This paper aims to investigate the flow of 3-dimensional hydromagnetic hybrid nanofluids throughout a stretching surface. The combination of titanium and its compounds with water results in an effective hybrid nanofluid that is proficient at efficiently allowing the transfer of heat and mass. Thermal radiation is considered using convective boundary conditions. The theoretical formulation of the physical model is done by examining a system of partial differential equations. Upon implementing appropriate similarity transformations, the framework was transformed into a corresponding system of ordinary differential equations (ODEs). The Spectral Quasi-linearization Method (SQLM) is employed to solve and analyze the system numerically. Furthermore, the physical interest coefficients of skin friction and the Nusselt number for heat transfer have been determined both numerically and graphically. The stability, convergence, and accuracy of the numerical system are confirmed by calculating residual errors. Additionally, the Bejan number has been shown to generate entropy. Both the axial and normal velocities decrease with an increase of the magnetic parameter, while the thermal layout is increased. It is found that Coriolis force creates a secondary flow effect, which enhances the velocity gradients near the wall and results in the enhancement in the skin-friction and the axial skin friction increases by about 7.4972 %. The Nusselt number is reduced by about 19.3735 % when the rotational parameter enhances from 0.1 to 0.4<span><math><mrow><mtext>.</mtext></mrow></math></span> By the incrementation of the radiation parameter, the Nusselt number decreased by about 44.7271 %<span><math><mrow><mtext>.</mtext></mrow></math></span></div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Analysis of drilling performance of carbon fiber reinforced polymer with special tool geometries and Raman spectrums","authors":"Rishikesan Visuvamithiran , Arunachalam Narayanaperumal , Velmurugan Ramachandran , Vijayaraghavan Lakshmanan","doi":"10.1016/j.hybadv.2025.100455","DOIUrl":"10.1016/j.hybadv.2025.100455","url":null,"abstract":"<div><div>Carbon fiber reinforced polymer (CFRP) composite is an advanced material used in different industrial domains due to its improved strength-to-weight ratio and high flexural strength. Drilling operations are one of the most inevitable manufacturing processes for fabricating CFRP components. However, drilling CFRP composites often induces critical damage in the vicinity of the drilled holes owing to its anisotropic nature, high brittleness, and other physical properties. Hence, a thorough understanding of material removal mechanisms and selection of proper drill tools with optimized tool geometry is indeed a prior necessity to drill high-quality holes with minimal defects in CFRP composites.</div><div>In this work, an attempt is made to investigate the influence of drill tool point angle on the drilling mechanism and drilled hole quality in CFRP composites. Drills with different point angles such as 90°, 118° and 135° are examined under various drilling settings. Thrust force is employed to analyse the dynamics of the drilling process and material removal mechanism. Residual stresses induced during the drilling operation are examined in detail using micro-Raman spectroscopy analysis. Experimental results show that reducing the point angle to 90° significantly improved drilling performance in CFRP composites compared to the standard 118° drill. At higher feed rates (0.06–0.16 mm/rev), the PA90 tool caused 11.5 % and 17 % less damage than the PA118 and PA135 tools, respectively. The 90° tool also produced fewer residual stresses, as indicated by Raman band shifts. Thus, the 90° point angle tool is suitable for high-speed machining. The point angle is a critical parameter and its impact on damage induction and the quality of the drilled CFRP is demonstrated in detail.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100455"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hybrid AdvancesPub Date : 2025-03-21DOI: 10.1016/j.hybadv.2025.100453
Genet Tewelde Hailu
{"title":"Trends on functional properties improvement of emerging mucilage-based films for food packaging application -A review","authors":"Genet Tewelde Hailu","doi":"10.1016/j.hybadv.2025.100453","DOIUrl":"10.1016/j.hybadv.2025.100453","url":null,"abstract":"<div><div>Mucilage-based films offer a promising approach due to their biodegradability, renewable nature, and ability to enhance food quality protection. Mucilage are made up of hydrophilic molecules that, when combined with water to create gel solutions. They have recently drawn a lot of interest since they offer certain environmental advantages such as being safer, biocompatible and possess good chemical modification flexibility over materials made from petroleum due to this they are highly applicable in various areas, particularly in food packaging. This review focuses on the using of mucilage generated from plants to create biodegradable packaging films. Here, the application of mucilage-based films as packaging materials and strategies for extraction, synthesis, characterization of critical aspects such thermal, mechanical and functional properties were briefly explored. By understanding the effects on physio-mechanical, morphological, barrier, and functional attributes, mucilage-based films hold great potential for advancing sustainable food packaging solutions. It was suggested that mucilage-based packaging films might be cutting-edge biomaterials for preserving food feature, enhancing nutrition and safety, and prolonging product duration. An overview of the findings and possibilities was presented.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100453"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of deformation characteristics of asphalt mixtures containing Reclaimed Asphalt Pavement (RAP) binders using laboratory simulations","authors":"Idorenyin Ndarake Usanga , Enobong Okon Inyang , Chijioke Christopher Ikeagwuani","doi":"10.1016/j.hybadv.2025.100426","DOIUrl":"10.1016/j.hybadv.2025.100426","url":null,"abstract":"<div><div>Asphalt pavement deterioration, particularly in developing countries such as Nigeria, has led to a significant increase in waste asphalt, presenting environmental and sustainability challenges. Despite the growing application of Reclaimed Asphalt Pavement (RAP) in new asphalt mixtures, the understanding of its performance under varying environmental and loading conditions remains limited. This gap in knowledge is critical, as optimizing RAP utilization could significantly reduce the demand for virgin materials, lower costs, and mitigate environmental impacts. This study investigates the feasibility of incorporating RAP, focusing on the performance of RAP-modified asphalt mixtures under different environmental conditions. Key factors such as stress level, temperature, and moisture content were analyzed to understand the influence on the permanent deformation behavior of these mixtures. To achieve this, virgin and RAP binders were blended at varying RAP contents (15 %, 30 %, and 60 %) and subjected to advanced laboratory tests. These tests included Fourier Transform Infrared Spectroscopy (FTIR) to assess binder blending, Dynamic Shear Rheometer (DSR) and Bending Beam Rheometer (BBR) for rheological properties, Hamburg Wheel Tracking Test (HWTT), and uniaxial repeated loading test to evaluate deformation resistance and durability. Specimens were evaluated under varying stress levels, temperatures, and moisture conditions to simulate real-world scenarios. The results revealed that a 30 % RAP content optimized blending, while higher RAP contents of 60 % improved resistance to permanent deformation at lower stress levels. However, at higher stress levels of 0.6 MPa, the performance improvement became less pronounced. Specifically, at a higher temperature of 60 °C, the number of cycles required to cause permanent deformation increased by 77.7%, 187%, and 288.8% for 15%, 30%, and 60% RAP content, respectively, compared to the virgin binder. Nevertheless, challenges such as moisture infiltration and low temperatures reduced the mixtures' durability. This study underscores the potential of RAP in promoting sustainable asphalt pavement construction and highlights the importance of addressing gaps in current research, particularly in mitigating environmental impacts and enhancing the durability performance of RAP-modified mixtures.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100426"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"3D printing technology in microneedles: An emerging era in transdermal drug delivery","authors":"Manali Prajapat , Amol D. Gholap , Snehal Shinde , Dhvani Padhiyar , Shital Butani , Shreeraj Shah , Amarjitsing Rajput","doi":"10.1016/j.hybadv.2025.100447","DOIUrl":"10.1016/j.hybadv.2025.100447","url":null,"abstract":"<div><div>3D printing technology in microneedle (MN) is revolutionizing the transdermal drug-delivery field. This review introduces 3D printing to MN fabrication and its potential to enhance drug delivery efficiency, thereby overcoming issues of earlier methods. Transdermal drug delivery system (TDDS) offers many advantages, remarkably non-invasive delivery with greater patient compliance, by eliminating problems such as first-pass metabolism and gastrointestinal degradation. MNs are minimally invasive devices designed to penetrate the stratum corneum, thus enabling the delivery of various therapeutic agents, including vaccines and biologics. The review separates MNs into several types: solid, coated, hollow, and dissolving, with their characteristic features and applications. 3D printing enables the exact customization of MNs in shape, size, and drug loading capacity, allowing for tailor-made treatments for individual patients. Additionally, 3D-printed MNs offer advantages such as rapid prototyping, complex structural designs, and precise control over drug release, making them highly promising for clinical applications. On the other hand, some challenges remain, such as manufacturing speed limitations and questions about product quality and intellectual property issues. Future advancements in 3D printing materials, automation, and scalable production techniques are expected to overcome these limitations, paving the way for broader adoption. This review also discusses the wide range of applications involving 3D-printed MNs, such as biosensing, cancer treatment, and chronic disease management. It is this synthesis, therefore, that finally underlines the very promise of 3D printing in MN technology towards a revolutionary form of drug delivery in the creation of a future of personalized medicine, overcoming important challenges within current pharmaceutical practice.</div></div>","PeriodicalId":100614,"journal":{"name":"Hybrid Advances","volume":"10 ","pages":"Article 100447"},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}