Eye & ENT Research最新文献

{"title":"IL-4/IL-13 pathway in nasal type 2 inflammation: The central role and targeted therapy","authors":"Zhiqiu Zhu,&nbsp;Chaoran Zhao,&nbsp;Ming Wang","doi":"10.1002/eer3.5","DOIUrl":"10.1002/eer3.5","url":null,"abstract":"<p>Type 2 dominant inflammation in nasal mucosa is the key underlying pathophysiological mechanism of allergic rhinitis (AR) and most presentations of chronic rhinosinusitis with nasal polyps (CRSwNP). Interleukin-4 (IL-4) and IL-13 share common receptor subunits and signaling molecules, which lead to various pathological changes in different cells, playing key roles in the pathogenesis of nasal type 2 inflammation. Numerous clinical trials have shown that biologics targeting key molecules of the IL-4/IL-13 pathway, especially IL-4 receptor alpha, can treat CRSwNP and AR with high efficacy, and are generally well tolerated. Several biologics have been approved for the treatment of difficult-to-control CRSwNP, while others also show promising results. Here, we review the IL-4/IL-13 pathway, its role in nasal type 2 inflammation, and current targeted therapies related to the IL-4/IL-13 pathway, with a focus on AR and CRSwNP.</p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of corneal endothelial cell regeneration and replacement","authors":"Zongyi Li,&nbsp;Haoyun Duan,&nbsp;Qingjun Zhou","doi":"10.1002/eer3.2","DOIUrl":"10.1002/eer3.2","url":null,"abstract":"<p>Corneal endothelial cells (CECs) are crucial for the maintenance of corneal transparency and normal visual function. Corneal endothelial dysfunction can lead to corneal edema, opacity, and even blindness. Due to the limited proliferative capacity of human CECs and the global shortage of donor cornea, corneal endothelial regeneration and replacement always represent the most challenge in the basic research and clinical treatment of corneal diseases. Although there is a potential existence of corneal endothelial progenitor cells, the efficiency of Descemet stripping without endothelial keratoplasty remains controversial. In recent years, significant advancements have been made in the field of cultured endothelial cell regeneration and artificial material replacement. Here, we reviewed the current research and clinical progress of corneal endothelial cell regeneration and replacement, including the in vitro cultivation of primary human CECs, in vitro differentiation of stem cell-derived CECs, tissue-engineered corneal endothelium, and fabrication of artificial corneal endothelium. We also discussed the remaining questions regarding innovating clinical preventive and therapeutic strategies for corneal endothelial dysfunction.</p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"2-10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new journal for broad sensory medicine","authors":"Zi-Bing Jin,&nbsp;Luo Zhang","doi":"10.1002/eer3.1","DOIUrl":"10.1002/eer3.1","url":null,"abstract":"<p>As the inaugural editors of <i>Eye and ENT Research</i>, a new academic journal in the field of sensory medicine, we are deeply honored to share our vision and commitment with our esteemed readers and contributors at this important juncture. The collaborative efforts of Beijing Tongren Hospital with the Higher Education Press have enabled us to present this landmark inaugural issue to our extensive readership. Beijing Tongren Hospital's profound clinical experience and research achievements in ophthalmology and otolaryngology, and especially its national key disciplinary status not just in those fields but also in allergology and traditional Chinese ophthalmology, have made a significant contribution to medical research in China and globally.</p><p>We find ourselves in an era of remarkable growth in China's scientific research investment and output. Since 1981, China's investment in scientific research has increased by an astounding factor of 400, with a 3.5-fold increase in just the past decade, far surpassing the growth rates of Western nations. This surge in investment not only signifies China's rise on the global scientific stage but also heralds its future dominance in technological innovations. Research is international and open, and Chinese researchers are increasingly prominent in key scientific areas. Their prolific output in high-quality, original academic papers, producing over 1000 highly cited papers annually, not only showcases their capabilities but also opens new avenues for global scientific research collaboration. Similarly, the leadership of our researchers in critical fields like ophthalmology and otolaryngology is becoming increasingly evident. We encourage domestic researchers to publish their work in international journals, not only to highlight their achievements but also to enhance the international impact of our academic publications. We are also committed to creating a robust and open platform to attract the latest and best research from around the world.</p><p>The mission of <i>Eye and ENT Research</i> is to gather and present the wisdom and experience of researchers and practitioners in the fields of ophthalmology and otolaryngology, to foster scientific development in these areas, and to reflect the latest research achievements globally, especially from the Asia-Pacific region. By sharing the latest research findings, innovative methodologies, and clinical practices, we are dedicated to guiding scientific advancement in these fields to new heights.</p><p>We look forward to <i>Eye and ENT Research</i> becoming an essential platform for ophthalmology and otolaryngology researchers, clinicians, and related experts to exchange ideas and share the latest research findings. We firmly believe that through collective wisdom and collaboration, we can contribute insights and strengths to global medical research, advancing the science of human health.</p><p></p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}