Eye & ENT Research最新文献

{"title":"Effect of pharyngeal wall compliance on passive collapsibility of retropalatal airway in patients with obstructive sleep apnea","authors":"Hongyi Tian,&nbsp;Yanru Li,&nbsp;Na Lin,&nbsp;Jianhong Liao,&nbsp;Yunhan Shi,&nbsp;Dan Kang,&nbsp;Xiu Ding,&nbsp;Hongguang Li,&nbsp;Demin Han","doi":"10.1002/eer3.6","DOIUrl":"10.1002/eer3.6","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the pharyngeal compliance of patients with obstructive sleep apnea with complete muscle relaxation. And to study the relationship between the pharyngeal wall compliance and the mechanical load of the retropalatal airway.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The static mechanical load of the retropalatal pharynx was determined by critical closing pressure (<i>P</i>_crit) of the segment during general anesthesia in 30 patients. The size/dimensions of the pharynx were measured while intraluminal pressure was controlled at 3–20 cmH₂O.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 30 participants (age: 37.6 ± 7.6 years, 27 males) were studied. The mean apnea-hypopnea index was 51.6 ± 23.9 events/h. The retropalatal mean <i>P</i>_crit was 12.68 ± 4.13 cmH₂O. There was a significant difference in the length of the obstruction segment (<i>F</i> = 26.028, <i>p</i> &lt; 0.001) among groups with different pharyngeal collapsibility. The correlation between the mechanical load of retropalatal airway and pharyngeal compliance in the level of the hard palate (<i>r</i> = −0.448, <i>p</i> = 0.015) and the uvula level (<i>r</i> = −0.462, <i>p</i> = 0.026) were significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Increased retropalatal mechanical loads were related to abnormal passive compliance of the pharyngeal wall. The contribution of each pharyngeal wall to airway collapse was varied.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"49-55"},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective analysis of 350 cases of parotid gland tumors and the value of ultrasound in the diagnosis of benign and malignant parotid gland tumors","authors":"Wen Gao,&nbsp;Lifei Feng,&nbsp;Zishi Huang,&nbsp;Duoxuan Chen,&nbsp;Wei Guo,&nbsp;Gaofei Yin,&nbsp;Yang Zhang,&nbsp;Zhigang Huang","doi":"10.1002/eer3.7","DOIUrl":"10.1002/eer3.7","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To retrospective analysis of the epidemiological and clinical characteristics of parotid gland tumors, and to explore the value of ultrasound in the differentiation of benign and malignant parotid gland tumors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The clinical data of 350 patients with parotid gland tumors in our hospital from 2002 to 2022 were retrospectively analyzed. These patients were examined by ultrasound. The postoperative pathological test results were used as the “gold standard” to verify and analyze the value of color Doppler ultrasound in the differential diagnosis of benign and malignant parotid tumors (PT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The male-to-female ratio of 350 patients with parotid gland tumors was 1.16:1. The age of patients ranged from 12 to 87 years old. Patients aged 40–65 years accounted for 54.6%, which was the most common age of parotid gland tumors. Among 350 cases, 259 were benign and 91 were malignant. The top three benign PTs were pleomorphic adenoma, Warthin tumor, and basal cell adenoma. The top three malignant tumors were mucoepidermoid carcinoma, acinar cell carcinoma, and adenoid cystic carcinoma. The specificity, sensitivity, accuracy, positive predictive value, and negative predictive value of ultrasonography in the diagnosis of benign and malignant parotid masses were 96.53%, 69.23%, 89.43%, 87.50%, and 87.72%, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The pathological types of parotid gland tumors are complex and diverse. Ultrasonography has high accuracy in the diagnosis of PT, which can provide important evidence for the differentiation of benign and malignant PT, and then assist in the clinical selection of individualized surgical programs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"56-63"},"PeriodicalIF":0.0,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The next-generation therapies in ophthalmology for blindness worldwide","authors":"Jie Xu,&nbsp;Chang-Jun Zhang,&nbsp;Jia-Yi Jiang,&nbsp;Zi-Bing Jin","doi":"10.1002/eer3.4","DOIUrl":"10.1002/eer3.4","url":null,"abstract":"<p>With the rapid and groundbreaking development in 21st century medicine on a global scale, new possibilities have emerged for addressing eye diseases, that can be blindness, and that conventional pharmaceuticals and surgical interventions have not hitherto been able to adequately treat. Gene enhancement/supplementation, gene editing, and stem cell therapies have now emerged as key subdisciplines. Here we discuss the current state and prospects of regenerative therapy in the field of ophthalmology, with a primary focus on diseases affecting the cornea, retina, and optic nerve. Our review summarizes the latest advances, challenges, and opportunities in these fields, as well as the potential applications and limitations of different strategies. The review also highlights the importance of interdisciplinary and collaborative innovation models for achieving breakthroughs in therapeutic development for sight-loss diseases worldwide.</p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"20-38"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Dual-pressure theory” in pathogenesis of glaucomatous optic neuropathy from the Beijing intracranial and intraocular pressure study","authors":"Ying Cheng,&nbsp;Mayinuer Yusufu,&nbsp;Robert N. Weinreb,&nbsp;Ningli Wang","doi":"10.1002/eer3.3","DOIUrl":"10.1002/eer3.3","url":null,"abstract":"<p>The mechanical theory of glaucoma indicates that high intraocular pressure (IOP) leads to glaucomatous optic nerve damage. However, nearly half of primary open-angle glaucoma patients with normal intraocular pressure also exhibit progression of what appears to be glaucomatous optic nerve damage. Our earlier prospective study identified for the first time that the relatively low intracranial pressure (ICP) is also an important risk factor for progressive glaucomatous injury of normal-tension glaucoma. When considering the results of studies in nonhuman primates, clinical research, large-scale natural-population studies, and basic laboratory investigations, a new understanding of the pathophysiology of glaucoma, the “Dual-Pressure Theory”, has been proposed. This theory states that “either high IOP or low ICP contributes to increasing the translaminar cribrosa pressure difference; it is the pressure difference rather than the IOP alone that results in the glaucomatous optic neuropathy”. Here, we provide a systematic introduction to Dual-Pressure Theory relating to glaucoma, the form of a research map, an outline of basic laboratory investigations, the main methodology, and research updates.</p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-4/IL-13 pathway in nasal type 2 inflammation: The central role and targeted therapy","authors":"Zhiqiu Zhu,&nbsp;Chaoran Zhao,&nbsp;Ming Wang","doi":"10.1002/eer3.5","DOIUrl":"10.1002/eer3.5","url":null,"abstract":"<p>Type 2 dominant inflammation in nasal mucosa is the key underlying pathophysiological mechanism of allergic rhinitis (AR) and most presentations of chronic rhinosinusitis with nasal polyps (CRSwNP). Interleukin-4 (IL-4) and IL-13 share common receptor subunits and signaling molecules, which lead to various pathological changes in different cells, playing key roles in the pathogenesis of nasal type 2 inflammation. Numerous clinical trials have shown that biologics targeting key molecules of the IL-4/IL-13 pathway, especially IL-4 receptor alpha, can treat CRSwNP and AR with high efficacy, and are generally well tolerated. Several biologics have been approved for the treatment of difficult-to-control CRSwNP, while others also show promising results. Here, we review the IL-4/IL-13 pathway, its role in nasal type 2 inflammation, and current targeted therapies related to the IL-4/IL-13 pathway, with a focus on AR and CRSwNP.</p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of corneal endothelial cell regeneration and replacement","authors":"Zongyi Li,&nbsp;Haoyun Duan,&nbsp;Qingjun Zhou","doi":"10.1002/eer3.2","DOIUrl":"10.1002/eer3.2","url":null,"abstract":"<p>Corneal endothelial cells (CECs) are crucial for the maintenance of corneal transparency and normal visual function. Corneal endothelial dysfunction can lead to corneal edema, opacity, and even blindness. Due to the limited proliferative capacity of human CECs and the global shortage of donor cornea, corneal endothelial regeneration and replacement always represent the most challenge in the basic research and clinical treatment of corneal diseases. Although there is a potential existence of corneal endothelial progenitor cells, the efficiency of Descemet stripping without endothelial keratoplasty remains controversial. In recent years, significant advancements have been made in the field of cultured endothelial cell regeneration and artificial material replacement. Here, we reviewed the current research and clinical progress of corneal endothelial cell regeneration and replacement, including the in vitro cultivation of primary human CECs, in vitro differentiation of stem cell-derived CECs, tissue-engineered corneal endothelium, and fabrication of artificial corneal endothelium. We also discussed the remaining questions regarding innovating clinical preventive and therapeutic strategies for corneal endothelial dysfunction.</p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"2-10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new journal for broad sensory medicine","authors":"Zi-Bing Jin,&nbsp;Luo Zhang","doi":"10.1002/eer3.1","DOIUrl":"10.1002/eer3.1","url":null,"abstract":"<p>As the inaugural editors of <i>Eye and ENT Research</i>, a new academic journal in the field of sensory medicine, we are deeply honored to share our vision and commitment with our esteemed readers and contributors at this important juncture. The collaborative efforts of Beijing Tongren Hospital with the Higher Education Press have enabled us to present this landmark inaugural issue to our extensive readership. Beijing Tongren Hospital's profound clinical experience and research achievements in ophthalmology and otolaryngology, and especially its national key disciplinary status not just in those fields but also in allergology and traditional Chinese ophthalmology, have made a significant contribution to medical research in China and globally.</p><p>We find ourselves in an era of remarkable growth in China's scientific research investment and output. Since 1981, China's investment in scientific research has increased by an astounding factor of 400, with a 3.5-fold increase in just the past decade, far surpassing the growth rates of Western nations. This surge in investment not only signifies China's rise on the global scientific stage but also heralds its future dominance in technological innovations. Research is international and open, and Chinese researchers are increasingly prominent in key scientific areas. Their prolific output in high-quality, original academic papers, producing over 1000 highly cited papers annually, not only showcases their capabilities but also opens new avenues for global scientific research collaboration. Similarly, the leadership of our researchers in critical fields like ophthalmology and otolaryngology is becoming increasingly evident. We encourage domestic researchers to publish their work in international journals, not only to highlight their achievements but also to enhance the international impact of our academic publications. We are also committed to creating a robust and open platform to attract the latest and best research from around the world.</p><p>The mission of <i>Eye and ENT Research</i> is to gather and present the wisdom and experience of researchers and practitioners in the fields of ophthalmology and otolaryngology, to foster scientific development in these areas, and to reflect the latest research achievements globally, especially from the Asia-Pacific region. By sharing the latest research findings, innovative methodologies, and clinical practices, we are dedicated to guiding scientific advancement in these fields to new heights.</p><p>We look forward to <i>Eye and ENT Research</i> becoming an essential platform for ophthalmology and otolaryngology researchers, clinicians, and related experts to exchange ideas and share the latest research findings. We firmly believe that through collective wisdom and collaboration, we can contribute insights and strengths to global medical research, advancing the science of human health.</p><p></p>","PeriodicalId":100519,"journal":{"name":"Eye & ENT Research","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eer3.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}