Environmental Chemistry and Ecotoxicology最新文献

{"title":"Modelling the association between the El Niño Southern Oscillation and levels of legacy pollutants in Alaskan seabird eggs from 1999 to 2010","authors":"Caitlin A. McConaghy ,&nbsp;Vrinda Kalia ,&nbsp;Amina Salamova ,&nbsp;Lance A. Waller ,&nbsp;Matthew O. Gribble","doi":"10.1016/j.enceco.2024.11.004","DOIUrl":"10.1016/j.enceco.2024.11.004","url":null,"abstract":"<div><h3>Background</h3><div>The circumpolar north has long been a sink for legacy persistent organic pollutants (POPs). Under a warmer climate, these contaminants are predicted to remobilize within environmental media where they are subject to climate processes, underscoring the need to examine the effects of large-scale climate oscillations on the fate of legacy POPs.</div></div><div><h3>Methods</h3><div>We apply piecewise log-linear spline regression models with non-parametric bootstrapping to measure the association between the El Niño Southern Oscillation (ENSO), a measure of Pacific sea surface temperature variability, and levels of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and polybrominated diphenyl ethers (PBDEs) measured in common murre (<em>Uria aalge</em>) and thick-billed murre (<em>Uria lomvia)</em> eggs collected from the Gulf of Alaska and Bering Sea between 1999 and 2010.</div></div><div><h3>Results</h3><div>In thick-billed murres, average PCB concentrations increased 143 % per unit increase in ONI during the warm phase of the ENSO, with a meta-regression pooled estimate of 0.887 (95 % CI: 0.674, 1.099). Similarly, average PBDE concentrations increased 562 % per unit increase in ONI during the warm phase, with a pooled estimate of 1.890 (95 % CI: 0.647, 3.133). During the cool phase, average PCB concentrations decreased 59 % per unit increase in ONI, with a pooled estimate of −0.892 (95 % CI: −1.400, −0.384). In common murres, average PCB concentrations decreased 51.4 % per unit increase in ONI during the warm phase, with a meta-regression pooled estimate of −0.722 (95 % CI: −0.894, −0.549), and increased 39.5 % per unit increase in ONI during the cool phase, with a pooled estimate of 0.333 (95 % CI: 0.185, 0.481). Average PBDE concentrations decreased 79.2 % per unit increase in ONI during the warm phase, with a pooled estimate of −1.572 (95 % CI: −2.357, −0.787).</div></div><div><h3>Conclusion</h3><div>Our results indicate associations between the ENSO and PCB and PBDE loads in Alaskan murre eggs, suggesting the ENSO may be an important factor in the fate of legacy POPs within Alaskan marine food webs. To our knowledge, this is the first paper to link the ENSO and levels of legacy POPs in Alaska's environment and may be relevant to health and food security in this region.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 174-181"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative environmental impacts analysis of technologies for recovering critical metals from copper anode slime: Insights from LCA","authors":"Yu Li ,&nbsp;Jenny Baker ,&nbsp;Yaxi Fang ,&nbsp;Haizhou Cao ,&nbsp;Cameron Pleydell-Pearce ,&nbsp;Trystan Watson ,&nbsp;Sha Chen ,&nbsp;Guangling Zhao","doi":"10.1016/j.enceco.2025.01.005","DOIUrl":"10.1016/j.enceco.2025.01.005","url":null,"abstract":"<div><div>Copper anode slime (CAS) is a byproduct produced during copper electrorefining process. It contains metals such as gold, silver, copper, selenium, tellurium etc. Without proper treatment, CAS posed significant environmental hazard due to its toxic components. Recovering critical metals from CAS not only mitigates environmental risks but also serves as an important source of these valuable materials. Recycling of critical metals can significantly enhance metal recycling efficiency and support the advancement of a circular economy. However, this process could introduce potential environmental impacts due to the increased consumption of energy, chemical material, and water. The process requires comprehensive assessment. In this study, life cycle assessment is employed to evaluate the potential environmental impact of the four resource recovery processes for copper anode slime: pyrometallurgy, hydrometallurgy, semi-hydrometallurgy, and combining bio-hydrometallurgy and semi-hydrometallurgy (CBS). The functional unit is 1 kg of copper anode slime. 5 metals are recycled during the process named: cupper (Cu), tellurium (Te), selenium (Se), gold (Au), and silver (Ag). Six impact categories—climate change, freshwater ecotoxicity, marine ecotoxicity, terrestrial ecotoxicity, human toxicity (cancer), and human toxicity (non-cancer)—were assessed and compared across the four recycling technologies. The LCA results show that CBS has the lowest environmental impact among all the assessed impact categories. CBS process demonstrated superior metal recovery rates. Hydrometallurgy has the lowest energy and material costs. CBS incurs higher total costs due to the use of expensive chemicals like potassium iodide.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 275-285"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggregate exposure pathways for 6PPD-quinone: A source-to-target site continuum integrating exposure and human health","authors":"Edmond Sanganyado","doi":"10.1016/j.enceco.2025.02.002","DOIUrl":"10.1016/j.enceco.2025.02.002","url":null,"abstract":"<div><div><em>N</em>-(1,3-Dimethylbutyl)-<em>N</em>′-phenyl-<em>p</em>-phenylenediamine quinone (6PPD-Q), a transformation product of the tire additive 6PPD, has been increasingly detected in environmental compartments, yet its cumulative risk remains poorly characterized. This study developed an Aggregate Exposure Pathway (AEP) framework to assess the mechanistic transport of 6PPD-Q from environmental sources to neuronal mitochondria in humans, focusing on the Pearl River Delta. A Weight of Evidence assessment identified key exposure states (KES) across air, road dust, surface runoff, surface water, and biota, highlighting critical data gaps in mass flux estimates, partitioning coefficients, and uptake rates. The study identified significant data gaps in atmospheric deposition, sludge-soil partitioning, groundwater leaching, oral and respiratory bioaccessibility and bioavailabity, and blood-cerebrospinal fluid permeability of 6PPD-Q. A Weight of Evidence assessment revealed significant gaps in the empirical support and quantitative understanding in 60 % of the key transitional relationships, particularly in intermediate media, external exposure and internal exposure. The findings emphasize the need for quantitative models incorporating mass fluxes and phase transfer dynamics to refine exposure predictions. Future research should focus on experimentally determining partitioning coefficients, uptake and accumulation rates, and the flux of 6PPD-Q in environmental and biological systems to enhance quantitative AEP modeling. By systematically integrating mechanistic exposure data, AEPs provide a structured approach for improving cumulative risk assessment and guiding targeted mitigation strategies.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 394-406"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apportioning and modeling the anthropogenic fingerprints in a Himalayan freshwater lake over the last ∼ 3.7 ka: Insights into pollution chronology and future policy implications","authors":"Shahnawaz Hassan ,&nbsp;Bikram Singh Bali ,&nbsp;Prachita Arora ,&nbsp;Sheikh Nawaz Ali ,&nbsp;P. Morthekai ,&nbsp;Wani Muneer ,&nbsp;Abid Hussain Wani ,&nbsp;Sabreena ,&nbsp;Aarif Yaseen ,&nbsp;Muzafar Zaman ,&nbsp;Bashir Ahmad Ganai","doi":"10.1016/j.enceco.2025.02.015","DOIUrl":"10.1016/j.enceco.2025.02.015","url":null,"abstract":"<div><div>Lack of systematic monitoring and increasing pollution trends in Himalayan Lake sediments highlights the need for evaluating increasing anthropogenic fingerprints with advanced multi-dimensional analytical approaches to understand potential risks to aquatic life and broader ecosystem. Therefore, this study investigated and modelled the chronological and quantitative shifts in heavy metals and bulk organic parameters in Dal Lake core sediments for last ∼3700 years using optically stimulated luminescence (OSL) dating, inductively coupled plasma mass spectrophotometry (ICP-MS), elemental and time series forecasting analysis. Due to the limited scientific literature available on the temporal trends and forecasting of heavy metals and nutrients in the bottom sediments of the lake, incorporating such a multi-dimensional approach facilitates accurate historical reconstruction, detailed elemental characterization, and predictive insights into future contamination, providing a thorough understanding of sediment composition and environmental changes over time. The findings of study revealed substantial variations in heavy metals and organic parameters within the lake from ∼12.5 to ∼3719 years before present (BP). Sediment pollution indices showed anthropogenic pressures on lake between ∼567 to ∼12.5 years BP, indicating moderate to strong pollution in upper sediment layers. Potential ecological risk index highlighted moderate risks up to ∼216 years BP and low risks from ∼285 to ∼3719 years BP. Organic parameters, such as total organic carbon, nitrogen, phosphorus, and C/N ratios indicated rising eutrophication from ∼476 to ∼12.5 years BP. Multivariate statistical analysis highlighted a strong positive relationship between heavy metals and organic parameters, depicting common environmental pathways and sources of contamination in Dal lake. Time series analysis using auto-regressive moving average model confirmed continuous anthropogenic alterations on lake and predicted increasing pollution trends in the coming decades. The model forecasted zinc concentration in Dal Lake over next 35 years to increase by ∼15 times, iron (∼35), manganese (∼24), lead (∼76), arsenic (∼239), mercury (∼100), cadmium (∼16), chromium (∼5), molybdenum (∼27), copper (∼10), cobalt and nickel (∼14) times from current observed concentrations. Similarly, total organic carbon in Dal Lake top sediment layers is expected to increase by ∼20 times, total nitrogen ∼37 and total phosphorous ∼36 times, indicating potential hyper-eutrophic conditions in coming decades. Novel insights provided by present study could have significant policy implications beyond regional context offering a framework for understanding the long-term anthropogenic fingerprints in Himalayan and global lake ecosystems.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 547-564"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aged polystyrene microplastics exacerbate cadmium-induced hepatotoxicity in zebrafish through gut-liver axis metabolic dysregulation","authors":"Xue Li,&nbsp;Kexin Jing,&nbsp;Ping Song,&nbsp;Jing Yu","doi":"10.1016/j.enceco.2025.05.001","DOIUrl":"10.1016/j.enceco.2025.05.001","url":null,"abstract":"<div><div>Microplastics (MPs) are ubiquitous environmental contaminants that can adsorb heavy metals, with aging enhancing adsorption capacity. This intensifies the threat posed to aquatic organisms and complicates liver toxicity. Herein, zebrafish were exposed to polystyrene (PS) or aged PS (APS) (200 μg/L) and cadmium (Cd) (10 μg/L) for 21 days, either singly or in combination, to investigate hepatotoxicity and underlying mechanisms, focusing on the gut-liver axis. Results indicated that co-exposure to APS and Cd caused more severe liver damage. Aging of PS significantly enhanced its ability to adsorb Cd, leading to greater Cd accumulation. Oxidative stress (ROS, SOD, MDA, and CAT levels increased by 1.73, 0.90, 1.08, and 0.89-fold, respectively), inflammation (TNF-α level increased by 1.30-fold), and lipid accumulation (TG and T-CHO contents increased by 0.83 and 1.48-fold, respectively) were exacerbated in the liver. The expression levels of the corresponding genes in the liver were also significantly up-regulated. Metabolomic analysis revealed that PS+Cd co-toxicity was associated with cellular senescence pathway, while APS+Cd co-exposure induced lipid accumulation via the sphingolipid, PPP, and protein digestion and absorption metabolisms. Furthermore, APS+Cd exposure significantly reduced the expression of <em>ZO-1</em>, <em>Occludin</em>, and <em>MUC2</em>, leading to gut barrier disruption and gut microbial composition changes in gut microbial composition, including increased Firmicutes and <em>Paracoccus</em>, along with decreased Fusobacteriota, which contributed to stronger synergistic toxicity via the gut-liver axis, interacting with metabolites such as tetradecanoic acid. This study facilitated valuable insights into the broader implications of PS contamination and its interaction with heavy metals.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 859-871"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-, medium- and long-chain chlorinated paraffins from indoor/outdoor air in Guanzhong Plain, China: Characteristics, distribution and human exposure risks","authors":"Xiuqun Liu ,&nbsp;Han Song ,&nbsp;Jingzhi Wang ,&nbsp;Xiaomei Huang ,&nbsp;Li Xing ,&nbsp;Xi Li ,&nbsp;Ge Ma ,&nbsp;Zhibao Dong ,&nbsp;Yongming Han ,&nbsp;Junji Cao","doi":"10.1016/j.enceco.2025.05.013","DOIUrl":"10.1016/j.enceco.2025.05.013","url":null,"abstract":"<div><div>Research on the environment of long chain chlorinated paraffins (LCCPs) in the fine particulate matter (PM_2.5) and gas phase is still scarce, particularly in indoors. It limits the comprehensive investigation into the gas-particle partitioning behavior and health risk assessment of CPs. In this study, short-, medium- and long-chain chlorinated paraffins (SCCPs, MCCPs and LCCPs) of outdoor and indoor PM_2.5/gas phases were simultaneously studied in two rural villages in Guanzhong Plain of 2021. CPs were mainly accumulated in the gas phases, especially indoors. However, the indoor and outdoor distribution of CPs in PM_2.5 was affected by many factors, such as the sandstorm events, different fuel usage and living habits, etc. Moreover, the concentrations of MCCPs (from 0.7 to 16.1 ng/m³) in PM_2.5 were higher than SCCPs (from 0.3 to 5.6 ng/m³) and LCCPs (from 0.3 to 1.8 ng/m³). However, in gas phase, the concentrations of SCCPs were highest, then followed by MCCPs and LCCPs. The shorter carbon chain of SCCPs (C_10~11) and MCCPs (C₁₄) were the most abundant groups, while the higher carbon chain (C₂₉) dominated in the LCCPs. The lower chlorinated groups (Cl_5~6) were dominated for SCCPs, MCCPs and LCCPs. Principal component analysis (PCA) showed that there were no obviously different sources of the CPs in the two sampling sites. However, the CPs in gaseous phase and CPs in PM_2.5 displayed different sources. Human exposure risk assessment indicated that the CPs had no significant risks to different age groups basing on the inhalation. However, considering their persistence and bioaccumulation, CPs exposure should be monitored continually in this region.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 1085-1094"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of tetrabromobisphenol A and its related compounds in an anthropogenic impacted soil-groundwater system: Concern for understudied derivatives","authors":"Shuang Cao ,&nbsp;Aifeng Liu ,&nbsp;Feng Guo ,&nbsp;Minggang Zheng ,&nbsp;Ling Wang ,&nbsp;Jiaxin Wang ,&nbsp;Guangbo Qu","doi":"10.1016/j.enceco.2025.02.013","DOIUrl":"10.1016/j.enceco.2025.02.013","url":null,"abstract":"<div><div>Globally, excessive extraction along with environmental pollution pose substantial threats to both the quantity and quality of groundwater. In this study, environmental occurrence and potential risks of bisphenol A (BPA), tetrabromobisphenol A (TBBPA), 20 byproducts and transformation products were investigated by UHPLC-Orbitrap-HRMS in the soil-groundwater system of Laizhou Bay, China. The results revealed that the concentrations of the 22 target substances in soil and groundwater were 8.77 × 10⁻¹-1.01 × 10⁴ ng/g dry weight (dw) (average 380 ng/g dw) and not detected (nd)-3.99 × 10⁴ ng/L (average 731 ng/L), respectively. For the groundwater samples, the detection rate of byproducts and transformation products is up to 88 %, and the concentration range is nd-3.98 × 10⁴ ng/L, which exceeds those of the parent compounds, TBBPA and BPA. Byproduct TBBPA mono (allyl ether) (TBBPA-MAE) is the predominant pollutant. Another 9 transformation products were tentatively identified, and commonly found in both matrices (with detection frequencies of &gt;75 %). The risk quotients of 3 transformation products and BPA were greater than 0.1, indicating a moderate or high degree of health risk. This represents the first in-depth investigation of TBBPA and its analogs in the soil-groundwater system within typical halogen industrial areas, highlighting that the associated risks of emerging pollutants to the local environment cannot be overlooked.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 580-590"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sorption and diffusion studies of radiocesium in soil samples from Ibu Kota Nusantara region of Indonesia","authors":"Hana Fikrinabilah Dely Supratman ,&nbsp;Hendra Adhi Pratama ,&nbsp;Budi Setiawan ,&nbsp;Mochamad Adhiraga Pratama ,&nbsp;Sucipta Sucipta ,&nbsp;Sitti Hijraini Nur ,&nbsp;Nurul Efri Ekaningrum ,&nbsp;Gustri Nurliati ,&nbsp;Moh. Cecep Cepi Hikmat ,&nbsp;Andry Setiawan ,&nbsp;Niken Siwi Pamungkas ,&nbsp;Zico Pratama Putra ,&nbsp;Muhammad Yusuf","doi":"10.1016/j.enceco.2024.12.008","DOIUrl":"10.1016/j.enceco.2024.12.008","url":null,"abstract":"<div><div>A plan by Indonesia to develop a Nuclear Power Plant (NPP) 1750 km from the new capital city, Ibu Kota Nusantara (IKN), has increased the need for radiocesium (radio-Cs) sorption and diffusion studies to reduce environmental concerns during reactor operation and decommissioning. This study provides the first comprehensive assessment of the physical, chemical, and mineral aspects of three soil samples (HA, M, and E) from the IKN region to figure out how these characteristics affect the mobilization of radio-Cs in the soil. To achieve this, radio-Cs apparent diffusion (<span><math><msub><mi>D</mi><mi>a</mi></msub></math></span>) and distribution (<span><math><msub><mi>K</mi><mi>d</mi></msub></math></span>) coefficients were determined for each soil sample. Mineralogical revealed distinct characteristics among the samples, with the E sample having the highest clay content of 46.18 %, followed by HA (36.27 %) and M (23.69 %). The <span><math><msub><mi>D</mi><mi>a</mi></msub></math></span> in groundwater (GW) solvent achieved at 12 × 10⁻¹² m²/s for HA, 5.80 × 10⁻¹² m²/s for M, and 9.91 × 10⁻¹² m²/s for E sample. In Deionized water (DW) solvent, the <span><math><msub><mi>D</mi><mi>a</mi></msub></math></span> obtained at 2.57 × 10⁻¹² m²/s for HA, 3.10 × 10⁻¹² m²/s for M, and 2.79 × 10⁻¹² m²/s for E sample. The lower diffusion rates (<span><math><msub><mi>D</mi><mi>a</mi></msub></math></span>) in DW compared to GW suggest reduced competition from other cations, limiting cesium ion interaction. The <span><math><msub><mi>K</mi><mi>d</mi></msub></math></span> values in GW were valued at 1949.82 mL/g, 1864.60 mL/g, and 3450.83 mL/g, for HA, M, and E samples, respectively. Meanwhile, the <span><math><msub><mi>K</mi><mi>d</mi></msub></math></span> values in DW increased up to 2262.73 mL/g, 2106.14 mL/g, and 3819.23 mL/g for HA, M, and E samples, respectively. The E sample offered the largest distribution coefficient (<span><math><msub><mi>K</mi><mi>d</mi></msub></math></span>) across all solvents, highlighting the significant impact of clay concentration on adsorption capacity. These findings highlight the significant impact of soil features in determining the behavior of radio-Cs, which has important implications for strategies related to environmental monitoring and remediation mitigation in IKN region.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 252-262"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developmental toxicity and mechanistic insights of tralopyril in marine medaka: Epigenetic disruptions and ferroptosis","authors":"Bin Liu,&nbsp;Cun-Long Wang,&nbsp;Teng-Zhou Li,&nbsp;Jian-Xue Feng,&nbsp;Yu-Qing Ma,&nbsp;Ling Liu,&nbsp;Ping Li,&nbsp;Zhi-Hua Li","doi":"10.1016/j.enceco.2025.05.014","DOIUrl":"10.1016/j.enceco.2025.05.014","url":null,"abstract":"<div><div>Tralopyril has emerged as a promising alternative to the banned tributyltin in marine antifouling applications. However, its ecological risks remain underestimated. Through an integrated approach combining behavioral phenotyping, transcriptomics, and whole-genome bisulfite sequencing (WGBS), we demonstrate that tralopyril (0, 1, 10 μg/L) disrupts marine medaka (<em>Oryzias melastigma)</em> development via two interrelated mechanisms: (1) Epigenetic dysregulation: Aberrant CG methylation in key regulatory genes (<em>casr</em>, <em>cacna2d2</em>, <em>dnai1</em>, <em>alox15b</em>, etc.) was associated with developmental toxicity, altering gene expression profiles critical for normal growth. (2) Ferroptosis activation: Tralopyril exposure triggered iron overload and <em>fth1</em> dysregulation, while mitochondrial uncoupling (<em>ucp2</em>) exacerbated oxidative stress, contributing to cellular damage. Notably, epigenetic alterations, such as methylation changes in <em>alox15b</em>, can influence the ferroptosis pathway by regulating genes involved in iron metabolism and oxidative stress. This, in turn, amplified toxic effects and contributed to multiorgan damage. These alterations led to defects such as cardiac remodeling, skeletal malformations, and neuromuscular dysfunction, ultimately resulting in locomotor decline. Inhibitor rescue experiments identified critical molecular targets of tralopyril's toxic effects and demonstrated cross-regulation between <em>ucp2</em> expression and the ferroptosis pathway. These findings elucidate the key molecular mechanisms underlying tralopyril-induced developmental abnormalities and behavioral impairments, emphasizing the synergistic effects of mitochondrial dysfunction and ferroptosis. Overall, this study expands the understanding of mitochondrial function and ferroptosis in environmental toxicology and provides a scientific basis for ecological risk assessment and mitigation strategies for environmental pollutants.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 1046-1058"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic exposure to environmentally relevant concentration of abamectin induces gut toxicity in largemouth bass: Molecular fate, bioaccumulation risk and its potential phytoremediation","authors":"Rabia Tahir ,&nbsp;Haoxiao Yan ,&nbsp;Kuo He ,&nbsp;Abhimanyu Shrestha,&nbsp;Hao Liu,&nbsp;Quanxi Li,&nbsp;Jin Mu,&nbsp;Zaizhao Yang,&nbsp;Lipeng Guo,&nbsp;Chengxian Zhang,&nbsp;Zhihong Li,&nbsp;Liulan Zhao,&nbsp;Song Yang","doi":"10.1016/j.enceco.2025.05.007","DOIUrl":"10.1016/j.enceco.2025.05.007","url":null,"abstract":"<div><div>Abamectin (ABA), one of the most extensively used pesticides, has been increasingly detected in aquatic environment, thereby posing a continuous exposure risk to edible fish. Although organisms are exposed to various pollutants through gut, yet toxic effects of ABA on gut health remain unclear. Henceforth, our study investigated ABA-induced gut toxicity in largemouth bass, widely consumed fish, at environmentally relevant concentration. Chronic exposure of six weeks caused severe tissue damage, including vacuolation, and goblet cell exudation. The reduction of antioxidant enzymes (SOD, GSH-Px and CAT) was triggered by surge in ROS level, resulting in lipid peroxidation (MDA) and dysregulation of <em>pgc-1α, keap1,</em> and <em>nrf2</em>. Disruption in tight junctions (<em>claudin-5, −7, occludin,</em> and <em>zo-1</em>) weakens the gut's protective barrier. Inflammatory response characterized by NF-κb-mediated IκBα degradation, leading to increased cytokines (<em>il-8, il-10, il-15, il-1β, tgf-β1,</em> and <em>tnf-α</em>), and suppressed immunity (ACP and AKP). Dysregulated translation and transcription level of <em>bax, bcl-2, tnfr1</em> and <em>caspases</em> indicated the apoptosis. Excessive autophagic flux, evidenced by increased autophagosome formation by upregulation of <em>atg's</em> and <em>lc3ii, p62</em> degradation, and suppression <em>pi3k, mtor</em>, and <em>akt</em>. HPLC-UV and IBR analysis further confirmed the exposure risk by revealing significant ABA bioaccumulation in gut tissues, indicating its persistent retention. Molecular docking validated that ABA binds to superoxide dismutase isoforms and AKT via hydrogen bonding and hydrophobic interactions. In contrast, aforementioned phenomena were effectively modulated by curcumin (CUR) supplementation by regulation of key biomarkers. Altogether, it highlighted the necessity of including edible fish in regulatory decisions concerning pesticide use.</div></div>","PeriodicalId":100480,"journal":{"name":"Environmental Chemistry and Ecotoxicology","volume":"7 ","pages":"Pages 1011-1026"},"PeriodicalIF":9.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}