Dermatological Reviews最新文献

{"title":"A clinical update on fungal disease of human skin","authors":"Kevin M. Burningham,&nbsp;Juliana H. Kim,&nbsp;Alisha Kashyap,&nbsp;Stephen K. Tyring","doi":"10.1002/der2.224","DOIUrl":"https://doi.org/10.1002/der2.224","url":null,"abstract":"<p>Fungi cause cutaneous pathology in humans in three broad categories: superficial mycoses, subcutaneous mycoses, and systemic or opportunistic mycoses. In this chapter, we will discuss recent updates in treatment for dermatological diagnoses in each of these categories. We will also discuss dermatologically relevant emerging fungal pathogens.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139704735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatological reviews—Introduction: Cosmeceuticals I","authors":"Michael H. Gold","doi":"10.1002/der2.223","DOIUrl":"10.1002/der2.223","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 6","pages":"245"},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138954386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging skin infections: A clinical update","authors":"Hamza Malick,&nbsp;Sheeva Shahinfar,&nbsp;Mohamad Jabin,&nbsp;Kevin M. Burningham,&nbsp;Mojahed M. K. Shalabi,&nbsp;Stephen K. Tyring","doi":"10.1002/der2.222","DOIUrl":"10.1002/der2.222","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139007779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and skin manifestations","authors":"Ramlah Khan,&nbsp;Hamza Malick,&nbsp;Kevin M. Burningham,&nbsp;Mojahed M. K. Shalabi,&nbsp;Stephen K. Tyring","doi":"10.1002/der2.221","DOIUrl":"10.1002/der2.221","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139008045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthropods and the skin","authors":"Mohamad Jabin,&nbsp;Yousef Salem,&nbsp;Kevin Burningham,&nbsp;Mojahed Mohammad K. Shalabi,&nbsp;Stephen K. Tyring","doi":"10.1002/der2.220","DOIUrl":"10.1002/der2.220","url":null,"abstract":"<p>Arthropods are responsible for most of the animal-related emergency room visits each year, and nonvenomous arthropods cause the greatest number of animal-related deaths in the emergency setting. Physicians should recognize the sequela of common and lethal arthropod bites and stings as they can range from asymptomatic or mild pruritus to fatal anaphylactic reactions. This chapter provides an update on recent advancements in the dermatological manifestations, pathophysiology, and management of conditions caused by arthropod bites and stings. Key topics include emerging treatments for pediculosis, characteristic rashes of mosquito-borne viral diseases, cutaneous lesions in Chagas disease, new Lyme disease vaccine development, topical Spinosad for scabies, and Loxosceles venom composition and early use of antivenom. Recent research reveals progress in understanding arthropod-related dermatologic diseases but also persistent knowledge gaps in the literature. This focused update delivers a concise overview of current concepts and developments at the intersection of arthropods and dermatology for clinicians.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138616017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of cosmeceuticals","authors":"Maya Firsowicz,&nbsp;Delfina Bur,&nbsp;Ted Lain","doi":"10.1002/der2.219","DOIUrl":"10.1002/der2.219","url":null,"abstract":"<p>The present state of skincare addresses the consequences of photodamage, hormonal influences, and the cumulative impact of exposome exposure throughout a person's life. Treatments within the aesthetic domain either harness biological pathways to achieve rejuvenation, such as retinoids and antioxidants, or suppress them, like lightening ingredients. Emerging advancements encompass techniques that stimulate the differentiation of stem cells to generate younger keratinocytes and fibroblasts, activate macrophages to diminish proinflammatory cellular waste, and restore glycosaminoglycans within the dermal matrix. While these innovations have significantly enhanced the potential of skincare to revitalize the skin in recent years, obstacles to their adoption remain substantial, including complex multistep regimens, the elevated cost of novel technologies, and limited accessibility for a majority of consumers. The next phase of skincare innovation targets the root cause of aging, at the genetic and epigenetic level. By reversing the effect of the exposome at this level, it is conceivable that biological age and chronological age might no longer correlate. Additionally, the integration of artificial intelligence, the identification of biomarkers, and improved accessibility to genetic predisposition lab testing will combine to allow for greater personalization of skincare recommendations.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 6","pages":"284-289"},"PeriodicalIF":0.0,"publicationDate":"2023-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139264587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hydroxy acids: Where have we been and what's new?","authors":"Caitlin Egli,&nbsp;Mildred Min,&nbsp;Nasima Afzal,&nbsp;Raja K. Sivamani","doi":"10.1002/der2.217","DOIUrl":"10.1002/der2.217","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hydroxy Acids (HAs) have been used for the treatment of a variety of skin conditions over the past several decades. The use of HAs in both pharmaceutical and cosmetic products has increased dramatically, and recent studies have been undertaken to better understand their applications and therapeutic benefits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The objective of this review is to study the uses of HAs and the emerging ingredients in the area of skin care. Relevant studies were reviewed and categorized by their molecular structure into alpha HAs (AHAs) beta HAs (BHAs) and poly HAs (PHAs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search on the use of HAs was performed and articles for review were selected from more recent dermatological studies published from 2018 to 2023. Older research was compared to the results of newer studies to identify the more recent developments in the application of HAs in skin care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The new research was concentrated in the area of new uses of the HAs, validating therapeutic concentrations and protocols, and combining different HAs and other chemicals to improve therapeutic outcomes for a variety of skin conditions and diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The articles included for review demonstrate the continuing therapeutic relevance and developments in the application of HAs in skin care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 6","pages":"260-267"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.217","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135243033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin A: It's role in cosmeceuticals for antiaging","authors":"Patricia K. Farris","doi":"10.1002/der2.218","DOIUrl":"10.1002/der2.218","url":null,"abstract":"<p>Topical retinoids are among the most well-studied and widely used cosmeceutical ingredients. Topical retinoids have skin rejuvenating benefits and can soften fine lines and wrinkles, lighten mottled hyperpigmentation, improve skin roughness, sallowness, and overall appearance of photoaged skin. Retinoic acid or tretinoin remains favored among dermatologists because there are a plethora of well-designed clinical trials confirming its efficacy as a topical therapy for treating aging skin. In contrast, cosmeceutical retinoids are regulated as cosmetics and in general are not subjected to the same degree of scientific rigor as prescription retinoids. Despite this difference, there are studies confirming the antiaging benefits of cosmeceutical retinoids and studies comparing their efficacy and tolerability to tretinoin. This review will focus on over-the-counter retinoids including retinol, retinaldehyde, retinyl esters, adapalene, and novel retinoid molecules. Studies on pharmacokinetics, mechanisms of action, clinical benefits, and tolerability will be reviewed.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 6","pages":"268-277"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.218","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135820302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tropical infectious diseases and the skin: Diagnostic and treatment updates since the WHO's integrated campaign against neglected tropical skin diseases","authors":"Juliana H. Kim,&nbsp;Kevin Burningham,&nbsp;Stephen K. Tyring","doi":"10.1002/der2.214","DOIUrl":"10.1002/der2.214","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The World Health Organization (WHO) initiated a unified effort to address skin-related neglected tropical diseases (NTDs) in 2017. This effort increased attention and resources allocated toward decreasing the burden of tropical skin diseases. It emphasized an “integrated approach” to detect and treat multiple co-existing NTDs at once. This article will outline new diagnostic tests, treatment options, and vaccine development for neglected tropical skin diseases since the initiative began.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data Sources</h3>\u0000 \u0000 <p>A PubMed search of clinical trials, randomized controlled trials, systematic reviews, and meta-analyses published since 2017 was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The WHO's initiative has already seen success, increasing the surveillance of leprosy and the distribution of treatment for yaws. It has encouraged the development of new point-of-care tests and better-tolerated treatment options. It has also brought new challenges, with the rise of resistant organisms. Development of point-of-care DNA-RNA-based testing may improve drug resistance monitoring. New vaccines are needed for long-term control of skin NTDs in areas with high transmission rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135869910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast-derived growth factors and exosomes as cosmeceuticals","authors":"Rahul C. Mehta,&nbsp;Kuniko Kadoya,&nbsp;Prithwiraj Maitra,&nbsp;Lisa T. Goberdhan,&nbsp;Elizabeth T. Makino,&nbsp;Gail K. Naughton,&nbsp;Mitchel P. Goldman","doi":"10.1002/der2.215","DOIUrl":"10.1002/der2.215","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Fibroblast (FB)-derived growth factors have been successfully used in skincare to improve the appearance of aged and photodamaged skin for over 20 years. Conditioned media from FB culture, used as a source of growth factors in these early products, also contain extracellular vesicles including bioactive exosomes. Exosomes are tiny extracellular vesicles that have been isolated from the secretome of human-derived mesenchymal stem cells (MSC), adipose-derived stem cells, or fibroblasts for potential clinical application in wound healing, skin rejuvenation, skin disease, pigmentation, and hair growth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Here, we review the potential application of dermal FB-derived growth factors and exosomes in maintaining the structure and function of healthy skin. Specifically, we discuss how to collect and characterize FB-derived exosomes, formulation considerations for skincare products that may contain exosomes, and provide preliminary data to support its clinical use in improving skin quality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Exosomes were successfully isolated from FB secretome and characterized for their content, markers, biological activity, and clinical effects. Condition of growth medium affected exosomes compositions and properties. Product containing 98 billion EVs /mL used twice a day for 12 weeks resulted in statistically significant improvement in all skin aging parameters tested including wrinkles, roughness, sagging and laxity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, active exosomes can be identified along with growth factors in the secretome of dermal fibroblasts and may provide an additional benefit for aging skin if its biological activity remains stable in the product formulation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 6","pages":"250-259"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135168593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}