Dermatological Reviews最新文献

{"title":"Energy-based devices for melasma and postinflammatory hyperpigmentation","authors":"Shane Reynal,&nbsp;Elise Martin,&nbsp;Girish Munavalli","doi":"10.1002/der2.177","DOIUrl":"https://doi.org/10.1002/der2.177","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Melasma and postinflammatory hyperpigmentation (PIH) are conditions commonly encountered by dermatologists, and they are often distressing to patients. While PIH can improve with time once the inflammatory process is controlled, melasma is a condition that often requires prolonged treatment and maintenance. There are numerous treatment options, ranging from UV protection and topical therapies (such as hydroquinone), to more procedural-based options (chemical peels, micro-needling, and energy-based devices).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This review will focus on the treatment of melasma and PIH with various energy-based therapies, including laser devices, intense pulsed light (IPL), high-frequency ultrasound, and radiofrequency devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>References were collected by using Pubmed with search terms of “laser”, “melasma”, “post-inflammatory hyperpigmentation”, and “energy-based devices.”</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Findings</h3>\u0000 \u0000 <p>Lasers and IPL target pigment in the epidermis and dermis by using the appropriate wavelengths and principles such as thermal relaxation time and photoacoustic damage. Other lasers, such as pulsed-dye laser (PDL), target the vascular component of melasma. Used alone or in combination with topical treatments, these devices provide improvement in melasma and PIH. In addition, some authors have studied the use of these devices, such as fractionated lasers, in device-assisted drug delivery of topical therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While there is a benefit to the use of these devices, this change is usually temporary and balanced against the side effects of dyspigmentation and scarring. Therefore, these treatments are best used in combination, with a maintenance program that employs both topical therapies, procedures, and energy-based devices.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 1","pages":"58-66"},"PeriodicalIF":0.0,"publicationDate":"2023-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50124844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperpigmentation and melasma—From A to Z","authors":"Michael H. Gold","doi":"10.1002/der2.175","DOIUrl":"https://doi.org/10.1002/der2.175","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 1","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50118910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest editor's introduction: Hyperpigmentation and melasma—from A to Z","authors":"Karan Lal,&nbsp;David Goldberg","doi":"10.1002/der2.176","DOIUrl":"https://doi.org/10.1002/der2.176","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 1","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2023-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50118923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial radiation therapy for nonmelanoma skin cancer: A review","authors":"Haowei Han,&nbsp;Anita Gade,&nbsp;Francesca M. Ceci,&nbsp;Alec Lawson,&nbsp;Sloane Auerbach,&nbsp;Mark S. Nestor","doi":"10.1002/der2.174","DOIUrl":"10.1002/der2.174","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The high prevalence of nonmelanoma skin cancer (NMSC) has become a global health-care burden. Various modalities have been established to treat NMSC, with surgery being the mainstay approach. Superficial radiation therapy (SRT) has been in use for over a century to treat various conditions. Recent discussion among the dermatological community has promoted the use of SRT for the treatment of NMSC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A literature search was conducted using electronic databases (Medline, Pubmed, Embase, CINAHL, EBSCO) and textbooks, in addition to the authors' clinical experience with SRT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Multiple retrospective medical record reviews have deemed SRT to be highly effective and associated with minimal side effects. Moreover, SRT yields superior cosmetic results. Over the past decade, SRT has become a mainstay of dermatologist treatment of NMSC due to the new technological advances of the devices. These advances include improved controllability, precision in delivery, additional safety precautions, and have sparked a resurgence in research and clinical evidence on SRT. Most recent data have revealed that the NMSC cure rate is about 93%–100% with excellent 5-year follow-up data. Image-guided SRT using ultrasound guidance may additionally improve cure rates in the future.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SRT has shown to be an effective option for NMSC. It can also be effectively used in the management of keloids. The limitations across most studies encompass localized patient selection and a predominance of retrospective reviews in the literature. Additional research is warranted to further support SRT's efficacy in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"3 6","pages":"409-417"},"PeriodicalIF":0.0,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78875744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest editor's introduction: Actinic keratoses and skin cancer update","authors":"George Martin","doi":"10.1002/der2.173","DOIUrl":"10.1002/der2.173","url":null,"abstract":"albinism and the immunosuppressed, particularly those with HIV. Melanoma remains one of the most lethal skin cancers seen by healthcare providers from all disciplines in medicine. In their article Cutaneous Melanoma: An Update on Pathogenesis, Prevention, and Treatment the authors provide a broad overview of melanoma pathogenesis, diagnosis, surgical intervention and treatment of advanced melanoma. Early detection is key to melanoma survival. Artificial intelligence, still in development for melanoma detection, is discussed as it offers promise as a valid tool for early and accurate detection. The authors focus on the latest in melanoma imaging, the status of wide local excision and sentinel lymph node biopsy in melanoma management, genetic testing, immune and targeted therapy which are all critical in melanoma management. These topics are discussed in the context of the latest data and most current recommendations. Finally, the rapidly evolving treatment regimens for advanced melanoma, which have turned a once hopelessly fatal disease into a chronic disease, are discussed. In Update on immune checkpoint therapy for melanoma the authors summarize the latest updates in each of the major areas of immune checkpoint therapy for metastatic melanoma. In addition to highlighting the pivotal clinical trials that have led to the approval of these therapies in metastatic melanoma they also discuss therapy ‐ related adverse events. They examine the importance of developing predictive biomarkers and their role in melanoma management. Last, the authors identify the future directions necessary to advance the field of immunotherapy in advanced melanoma.","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"3 6","pages":"353"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84677209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actinic keratoses and skin cancer update","authors":"Michael H. Gold","doi":"10.1002/der2.172","DOIUrl":"10.1002/der2.172","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"3 6","pages":"354"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76867416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical notes and pharmacological overview of traditional plant: Adhatoda vasica","authors":"Avadh Biharee,&nbsp;Sudha Bhartiya,&nbsp;Dheeraj Dubey,&nbsp;Raju P. Yadav,&nbsp;Arun Sharma,&nbsp;Sachchidanand Pathak,&nbsp;Anu Chaudhary,&nbsp;Arpita Yadav","doi":"10.1002/der2.170","DOIUrl":"https://doi.org/10.1002/der2.170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Adhatoda vasica</i> (Nees.) of the Acanthaceae family has excellent medicinal properties. It is a crucial ingredient in a number of formulations that have been used for decades in India to treat a wide range of health-related difficulties, including fever, jaundice, headaches, colds, cough, whooping cough, asthma, dyspnea, phthisis, chronic bronchitis, and diarrhea. In our country (India) and other countries, the <i>A. vasica</i> plant has great medicinal importance. In the Ayurveda system of treatment, this plant is frequently employed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this comprehensive study is to provide updated information on the phytochemical and pharmacological activity of <i>A. vasica</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The stated objectives are to collect systematic data on the botanical description, phytochemistry, pharmacology, and toxicity of <i>A. vasica</i>, as well as detailed information on the many formulations that have conventionally been available on the Indian market.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The relevant information was obtained from a variety of peer-reviewed journals. Google Scholar, PubMed, ScienceDirect, and SciFinder were used to retrieve the journals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p><i>A. vasica</i> is a rich source of therapeutic agents that may have the potential to treat a variety of illnesses, while a detailed investigation of pharmacological activity is needed to confirm the contributing mechanism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p><i>A. vasica</i> is an important medicinal shrub, abundantly found across India, and a rich source of several alkaloids, terpenoids, carbohydrates, and terpenoids that may be used therapeutically in the medical system for treating a range of illnesses. It is a key ingredient in several Ayurvedic and Unani preparations available on the Indian market that are being used to treat a variety of illnesses.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 5","pages":"211-222"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68179907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical peels for the management of melasma and hyperpigmentation","authors":"Maria Karim,&nbsp;Darlene Diep,&nbsp;Omobola Onikoyi,&nbsp;Shereen Teymour,&nbsp;Karan Lal","doi":"10.1002/der2.169","DOIUrl":"https://doi.org/10.1002/der2.169","url":null,"abstract":"<p>Melasma is often a difficult disease to treat, and can be psychologically distressing to patients. Currently, the gold standard for the treatment of melasma is hydroquinone. While this treatment has been used for many years, it does not come without risks with overuse. Chemical peels have also become an option for the treatment of melasma, but their efficacy and safety in comparison to hydroquinone has not yet been established. This review aims to investigate the various types, efficacy, and safety of chemical peels used to treat melasma.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"4 1","pages":"53-57"},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50134378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest editors' introduction—Vitiligo and hypopigmentation","authors":"Somesh Gupta,&nbsp;Venkatram Mysore","doi":"10.1002/der2.171","DOIUrl":"10.1002/der2.171","url":null,"abstract":"Editorial We are living in an exciting era of vitiligo research. There has been an unprecedented focus on vitiligo in the field of dermatology, pharmaceutical and publishing industry, as well as among academic institutions. Partly, this is due to economic growth in countries with people of skin of color where vitiligo has a significant impact on quality of life, and therefore, a rise in the demand for treatment of vitiligo as the purchasing power of patients improves. Still, in most countries, the treatment of vitiligo as a disease is not covered in the health insurance and the treatment of vitiligo becomes burdensome for the patients. Till recently, the only topical cream approved by US ‐ FDA for treatment of vitiligo, was monobenzyl ether of hydroquinone, a depigmenting cream which is used for bleaching of residual pigment when repigmentation is not a realistic goal due to widespread body surface area involvement in vitiligo. However, in a first, US ‐ FDA has recently approved, in the year 2022, Ruxolitinib as a repigmenting topical agent for treatment of vitiligo. This is a sign of paradigm shift in the approach, where vitiligo is not merely considered a cosmetic nuisance but, more realistically, an autoimmune disease with significant psychosocial problems. The current issue of Dermatological reviews is a welcome addition in the existing literature on vitiligo. Many renowned researchers from across the world have contributed to this issue. The issue comprehensively covers the basic science, psychological aspects, clinical science, clinical signs and biomarkers of disease activity and disease stability, recent advances in the medical treatment, and surgical approaches of treatment for vitiligo. Rarely, we do get such an extensive discussion on vitiligo in any dermatology journals. Therefore, this issue will be a valuable resource on recent advances in the science related to vitiligo. We hope you will enjoy reading these papers.","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"3 5","pages":"259"},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84420662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers and clinical indicators of disease activity in vitiligo","authors":"Liesbeth Delbaere,&nbsp;Reinhart Speeckaert,&nbsp;Sandrine Herbelet,&nbsp;Arno Belpaire,&nbsp;Jolien Duponselle,&nbsp;Nanja van Geel","doi":"10.1002/der2.168","DOIUrl":"10.1002/der2.168","url":null,"abstract":"<p><b>Background</b>: The management of vitiligo is guided by the assessment of disease activity. However, this assessment is hampered by the absence of a highly feasible and reliable single marker to evaluate activity. Furthermore, the need for an objective, easy, preferably noninvasive marker is further stressed by the increased amount of research performed on new treatment strategies for vitiligo.</p><p><b>Objectives</b>: In this review, the available research on clinical signs linked to disease activity, and biomarkers in tissues and blood are summarized.</p><p><b>Results</b>: In the group of clinical signs, the Koebner phenomenon has the strongest evidence of an association with disease activity, while confetti-like depigmentation is gaining importance and seems to outweigh this role. For the tissue markers, the most evidence is available for histopathological findings, such as epidermal spongiosis with vacuolar degeneration in the basal cells and inflammatory infiltrate. Circulating biomarkers such as interleukin-1β (IL-1β), IL-17, interferon-γ, tumor growth factor-β, soluble cluster of differentiation 25, autoantibodies, and oxidative stress markers show the most promising results. Nevertheless, none of them are currently regarded as the gold standard.</p><p><b>Discussion</b>: In conclusion, we encourage researchers to investigate various biomarkers and clinical signs in their trials in a standardized manner to get insight into their exact value, so they can be used to optimize treatment selection, gain insight into the disease, and predict future disease progression.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"3 5","pages":"289-307"},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78336522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}