Dermatological Reviews最新文献

{"title":"Treatment of Cutaneous Warts in Immunocompromised Individuals: A Systematic Review","authors":"Abdullah Almeziny,&nbsp;Rahaf Almutairi,&nbsp;Latifah Almehaideb,&nbsp;Renad Almutairi,&nbsp;Amal Altamimi,&nbsp;Khloud Alshehri,&nbsp;Atheer Almutairi,&nbsp;Asem Shadid,&nbsp;Fares Alkhayal,&nbsp;Yasser Alqubaisy","doi":"10.1002/der2.70039","DOIUrl":"https://doi.org/10.1002/der2.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>While existing literature focuses on treating warts in immunocompetent persons, there is a lack of comprehensive recommendations for managing cutaneous warts in immunocompromised (ID) patients. The review aimed to appraise the most effective and safe treatment for cutaneous warts in ID patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The systematic review followed (PRISMA) guidelines. The PubMed, Scopus, and Cochrane databases were employed to search for papers published between January 2015 and May 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two hundred twenty-five studies were found, however this study included 16 studies. Among the reviewed studies, there was one RCT, 11 case reports, and four case series/retrospective cohort studies. Despite the precise pathway of action of various antigens is undetermined, immunotherapies offer a secure and economically feasible method of treating warts. Other frequently employed therapies include cryotherapy and salicylic acid and are generally effective for the management of warts at the area of interest. The majority of the studies analyzed had low RoB when assessed using the ROBINS-E approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review summarised the available literature on the application of immunotherapies for managing resistant warts. It revealed that immunotherapy is a viable treatment for ID people who have not responded to previous medications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Periocular Aging: A Narrative Review of its Causes and Aesthetic Interventions","authors":"Evalicia Murúa,&nbsp;Luis Alberto Parra,&nbsp;Andreina Martinez Amado,&nbsp;Alejandra Bugallo,&nbsp;Victoria De la Fuente,&nbsp;Eliana Garcés,&nbsp;Andrea Marcela Parra","doi":"10.1002/der2.70041","DOIUrl":"https://doi.org/10.1002/der2.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Importance</h3>\u0000 \u0000 <p>The periocular area is crucial for facial aesthetics and communication, significantly impacting perceptions of youth and vitality. Understanding its aging mechanisms and refining intervention strategies are essential for optimal outcomes. This review integrates clinical insights from multidisciplinary practice to address gaps in personalized decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Observations</h3>\u0000 \u0000 <p>Contemporary literature and clinical experience identify key periocular aging factors, including sequenced fat compartment deflation, bony resorption, and skin quality decline. Novel findings include a structured algorithm for injectable sequencing, emphasizing deep medial cheek volumization before tear trough correction to mitigate complications. Clinical pearls highlight hybrid techniques (e.g., microdroplet botulinum toxin with HA fillers) for dynamic wrinkles. While hyaluronic acid fillers remain central, case examples demonstrate synergistic outcomes when combined with surgical referrals (e.g., ptosis repair). Emerging ultrasound-guided approaches enhance precision in high-risk zones.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions and Relevance</h3>\u0000 \u0000 <p>Periocular rejuvenation demands a holistic, individualized strategy. The proposed algorithm, supported by complication management protocols and a surgery-injectables decision framework, optimizes outcomes. Clinicians must balance volume restoration with anatomical stability, leveraging multidisciplinary insights to address both aesthetic and functional decline.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Gender and Sex Disparities in Melanoma: Advances in Diagnosis, Treatment, and the Role of Artificial Intelligence”","authors":"","doi":"10.1002/der2.70034","DOIUrl":"https://doi.org/10.1002/der2.70034","url":null,"abstract":"<p>D. R. K. Kakish, J. F. Alsamhori, L. N. Qaqish, et al. “Gender Disparities in Melanoma: Advances in Diagnosis, Treatment, and the Role of Artificial Intelligence,” <i>Dermatologic Therapy</i> 2025; e70022, https://doi.org/10.1002/der2.70022.</p><p>In the title of the published article, the phrase “Gender Disparities in Melanoma” should read “Gender and Sex Disparities in Melanoma” to more accurately reflect the scope of the manuscript, which discusses disparities related to both gender identity and biological sex in melanoma diagnosis, treatment, and research.</p><p>We apologize for this error.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Persistent Facial Rash in a 15-Year-Old: Uncovering Rosacea in the Context of Duchenne Muscular Dystrophy","authors":"Kathleen Ward,&nbsp;Valerie Foy,&nbsp;Haowei Han,&nbsp;Sourab Choudhury","doi":"10.1002/der2.70040","DOIUrl":"https://doi.org/10.1002/der2.70040","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We were presented with a 15-year-old male with Duchenne Muscular Dystrophy and a 5-year history of worsening and treatment-resistant facial erythema.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To investigate, an H&amp;E punch biopsy was sampled from the left temporal lobe, showing minute vellus-type hairs surrounded by small granulomas and mononuclear cells, including plasma cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The findings were most consistent with rosacea, likely the telangiectatic type. Although current research connecting Duchenne Muscular Dystrophy and rosacea is limited, both conditions involve chronic inflammatory states and dysregulation of the immune system, with a notable convergence in NLRP3 inflammasome activation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Highlighting this connection between DMD and rosacea may pave the way for targeted treatment regimen for both conditions. The similarities in these two disease processes showcase the importance of interdisciplinary communication and research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest Editor's Introduction: New Concepts in Laser Hair Removal","authors":"Rahul Pillai","doi":"10.1002/der2.70035","DOIUrl":"https://doi.org/10.1002/der2.70035","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moisturizing Treatment Outcomes: A Comparative Study of Diabetic and Nondiabetic Skin, Associated With the Presence or Absence of Dermatoporosis","authors":"Juliana Rodrigues Pinto,&nbsp;Silas Arandas Monteiro e Silva,&nbsp;Gislaine Ricci Leonardi","doi":"10.1002/der2.70037","DOIUrl":"https://doi.org/10.1002/der2.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Skin disorders are highly common in type 1 and 2 diabetes mellitus patients. This study assessed the effects of a moisturizing formulation on photoprotected (volar forearm) and photoexposed (dorsal hand) skin in diabetic and nondiabetic participants, with or without stage I dermatoporosis, comparing it to a reference product.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty participants, aged 61–81 years, were included and equally divided into diabetic and nondiabetic groups. Biophysical assessments, including capacitance (hydration), transepidermal water loss (TEWL) measurements, and skin micro-imaging for roughness evaluation, were performed at baseline, 45, and 60 days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The test formulation significantly increased skin hydration, up to 34% on the forearm (FO) and 35% on the dorsal hand (DH) in diabetic participants, and up to 21% on the FO and 27% on the DH in nondiabetic participants. TEWL reduction, indicating improved barrier function, was more pronounced in diabetics (8% on FO and DH), while non-diabetics showed a 1% reduction on the FO. Skin roughness decreased more in diabetics (16% on FO and 18% on DH) than in non-diabetics (11% on DH). Diabetic participants showed greater improvements overall. The test formulation and the reference product demonstrated similar effects in improving skin condition. Participants with stage I dermatoporosis showed significant improvements in skin condition, with the test formulation providing greater benefits for diabetics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The test formulation effectively enhanced skin hydration and barrier function while reducing skin roughness in diabetic and nondiabetic subjects, regardless of dermatoporosis diagnosis. These findings offer valuable guidance for developing targeted skincare treatments.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Oculocutaneous Disease: Review, Update, and Practical Approach","authors":"Daniel L. Fischer,&nbsp;Valerie Foy,&nbsp;Nicole E. Fischer,&nbsp;Graham Litchman,&nbsp;Suzanne Sirota Rozenberg,&nbsp;Adam J. Friedman","doi":"10.1002/der2.70036","DOIUrl":"https://doi.org/10.1002/der2.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Periocular skin is notably thinner than other areas of the body, making it more susceptible to environmental factors and topical medications. Conditions affecting this region often require specialized care due to their impact on quality of life and potential to impair vision.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This review aims to address the unique characteristics, diagnostic challenges, and therapeutic strategies for oculocutaneous inflammatory conditions, offering guidance for dermatologists in managing this specialized area of skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search was conducted on PubMed reviewing the most relevant periocular inflammatory conditions, including glandular and eyelid inflammation, conjunctival and corneal disorders, allergic and irritant contact dermatitis, autoimmune diseases, and infections. Key diagnostic and therapeutic approaches are highlighted to assist in effective patient management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Inflammatory oculocutaneous diseases stem from various causes, including eczematous dermatoses, infections, autoimmune conditions, meibomian gland dysfunction. Treatments range from traditional options like warm compresses, antibiotics, and corticosteroids to newer approaches such as biologic therapies and intense pulsed light. These conditions are often associated with allergies, side effects of biologic drugs, and systemic diseases like atopic dermatitis, highlighting the need for accurate diagnosis, personalized treatment, and proper eyelid hygiene for effective management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Effective management of periocular inflammatory conditions can be challenging due to the unique anatomy of the area and often requires a targeted and specialized approach to treatment. Dermatologists are essential in diagnosing and managing oculocutaneous diseases. Collaboration with optometrists and ophthalmologists is often needed to ensure the best outcomes, as these conditions greatly affect patients’ quality of life and cosmetic appearance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Paradoxical Hypertrichosis as a Result of Energy-Based Hair Removal Devices","authors":"Karen Montecinos,&nbsp;Sure Aygun,&nbsp;Margarita S. Lolis,&nbsp;David J. Goldberg","doi":"10.1002/der2.70038","DOIUrl":"https://doi.org/10.1002/der2.70038","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Laser hair removal has been regarded as a relatively safe and effective treatment for the removal of unwanted body hair. While there are a variety of reported side effects like post-inflammatory hyperpigmentation or erythema, a rare and underreported complication is paradoxical hypertrichosis (PH). PH involves the unexpected increase of hair in or near the treatment area following laser hair removal. The mechanism behind this phenomenon is not fully understood but is important to address to improve treatment outcomes and minimize the occurrence of PH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This paper aims to consolidate and analyze literature pertaining to PH as a side effect resulting from laser hair removal (LHR), focusing on identifying commonalities and trends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted utilizing the PubMed database, employing keywords such as “laser paradoxical effect” and “paradoxical hypertrichosis.” The gathered findings were synthesized and are presented in this review.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The Alexandrite and Intense Pulsed Light (IPL) lasers are frequently associated with inducing PH. PH predominantly manifests in facial and neck regions, with sporadic occurrences on other body areas, notably the upper arms and periareolar region. Patients with darker skin tones, particularly Fitzpatrick Skin Types III−VI, and those with hormonal imbalances such as polycystic ovarian syndrome (PCOS), are more predisposed to experiencing PH after LHR. Proposed preventive measures include sun protection and avoiding shaving before LHR sessions. Continuation of LHR treatments on affected areas is the standard approach for treating PH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PH, although rare, poses a tangible side effect of LHR, occurring in about 3% of patients. The literature highlights specific regions of the body and laser types associated with PH, alongside potential patient predispositions. Further research is warranted to elucidate preventive strategies and enhance patient satisfaction and trust in LHR procedures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication-Induced Lichen Sclerosus: A Systematic Review","authors":"Samar Alyousef,&nbsp;Lama Alqahtani,&nbsp;Asem Shadid,&nbsp;Mohammed Almashali","doi":"10.1002/der2.70031","DOIUrl":"https://doi.org/10.1002/der2.70031","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lichen sclerosus (LS) is an inflammatory skin disease that predominantly affects the anogenital region, although it can occasionally present in extragenital areas. The precise etiology of LS remains uncertain; however, recent studies suggest that certain medications may contribute to its onset or exacerbate its progression. This systematic review and meta-analysis aims to evaluate the association between specific medications and the development of LS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search of multiple databases identified 16 publications that met the inclusion criteria. These studies, primarily comprising case reports and case series, revealed a significant correlation between LS and immune checkpoint inhibitors (ICIs), such as nivolumab and pembrolizumab, as well as hormonal therapies, including anti-androgenic oral contraceptives and aromatase inhibitors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The findings suggest that these medications may disrupt immune tolerance or hormonal homeostasis, thereby contributing to the pathogenesis of LS. The analysis highlights the challenges in managing medication-induced LS, particularly in patients who cannot discontinue the implicated drug due to underlying conditions such as cancer or chronic illnesses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite offering valuable insights into the potential risks of specific medications, the study's limitations—including reliance on small case studies and data heterogeneity—underscore the need for further research. Larger observational studies and randomized controlled trials are essential to validate these associations and inform targeted prevention and treatment strategies. Clinicians should remain vigilant for signs of LS in patients undergoing treatment with these medications to facilitate early diagnosis and intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction—Dermatological Reviews—April 2025","authors":"Faraz Yousefian","doi":"10.1002/der2.70033","DOIUrl":"https://doi.org/10.1002/der2.70033","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}