15岁持续性面部皮疹1例：发现酒渣鼻在杜氏肌营养不良的背景下

Dermatological Reviews Pub Date : 2025-05-28 DOI:10.1002/der2.70040

Kathleen Ward, Valerie Foy, Haowei Han, Sourab Choudhury

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引用次数: 0

摘要

我们报告了一名15岁的男性杜氏肌营养不良症患者，有5年的面部红斑恶化和治疗难治性病史。方法从左侧颞叶取H&；E穿刺活检，显示微小的绒毛型毛发被小肉芽肿和单个核细胞（包括浆细胞）包围。结果与酒糟鼻最一致，可能是毛细血管扩张型。虽然目前关于杜氏肌营养不良症和酒渣鼻的研究有限，但这两种疾病都涉及慢性炎症状态和免疫系统失调，且NLRP3炎症小体激活具有显著的趋同性。结论强调DMD与酒渣鼻之间的联系可能为这两种疾病的靶向治疗方案铺平道路。这两种疾病过程的相似之处显示了跨学科交流和研究的重要性。

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A Case of Persistent Facial Rash in a 15-Year-Old: Uncovering Rosacea in the Context of Duchenne Muscular Dystrophy

Background

We were presented with a 15-year-old male with Duchenne Muscular Dystrophy and a 5-year history of worsening and treatment-resistant facial erythema.

Methods

To investigate, an H&E punch biopsy was sampled from the left temporal lobe, showing minute vellus-type hairs surrounded by small granulomas and mononuclear cells, including plasma cells.

Results

The findings were most consistent with rosacea, likely the telangiectatic type. Although current research connecting Duchenne Muscular Dystrophy and rosacea is limited, both conditions involve chronic inflammatory states and dysregulation of the immune system, with a notable convergence in NLRP3 inflammasome activation.

Conclusion

Highlighting this connection between DMD and rosacea may pave the way for targeted treatment regimen for both conditions. The similarities in these two disease processes showcase the importance of interdisciplinary communication and research.

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Dermatological Reviews

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