Dermatological Reviews最新文献

{"title":"Dermatological Reviews Introduction—Potpourri Issue April 2025","authors":"Michael H. Gold","doi":"10.1002/der2.70032","DOIUrl":"https://doi.org/10.1002/der2.70032","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Focused Ultrasound Devices for Skin Tightening: A Comparative Literature Review of Device Specifications","authors":"Valentina Dicker,&nbsp;Luis Alberto Parra,&nbsp;Andreina Martinez Amado,&nbsp;Andrea Acevedo,&nbsp;Desiree Castelanich,&nbsp;Lina Velasquez,&nbsp;Andrea Marcela Parra","doi":"10.1002/der2.70030","DOIUrl":"https://doi.org/10.1002/der2.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nonsurgical skin tightening using high-intensity focused ultrasound (HIFU) and micro focused ultrasound (MFU) is a rapidly growing aesthetic procedure. However, a lack of comparative data on the technical specifications of leading devices (Ultherapy, Ultraformer, Liftera) hinders optimal treatment selection. This review addresses this gap.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>For each device, a literature search (PubMed, Google Scholar, grey literature) focused on skin-tightening applications. Inclusion criteria included articles published in English or Spanish after 2017 detailing technical specifications. Data extraction included regulatory approvals, ultrasound frequency, energy levels, treatment depths, thermal coagulation points per shot, and other treatment parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The review analyzed data from available publications and manufacturer documentation. Significant heterogeneity was identified across devices regarding ultrasound frequency, energy levels, treatment depths, and real-time visualization capabilities. Ultherapy uniquely offers real-time imaging. Due to limited published research, Ultraformer and Liftera data relied heavily on manufacturer information.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This literature review reveals substantial heterogeneity in the technical specifications of Ultherapy, Ultraformer, and Liftera for nonsurgical skin tightening. The lack of published literature for Ultraformer and Liftera highlights the need for further research to confirm manufacturer-provided specifications and to establish clear evidence-based guidelines for optimal treatment selection. The value of real-time imaging in treatment optimization is also discussed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction Dermatological Reviews Cosmeceuticals II","authors":"Michael H. Gold","doi":"10.1002/der2.70029","DOIUrl":"https://doi.org/10.1002/der2.70029","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor in Chief's Introduction: New Concepts in Laser Hair Removal","authors":"Michael H. Gold","doi":"10.1002/der2.70025","DOIUrl":"https://doi.org/10.1002/der2.70025","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Keratinocytes in Skin Health and Disease","authors":"Mohammed Saleh Al-Dhubaibi,&nbsp;Ghada Farouk Mohammed,&nbsp;Saleh Salem Bahaj,&nbsp;Ahmed Ibrahim AbdElneam,&nbsp;Ahmed Mohammed Al-Dhubaibi,&nbsp;Lina Mohammed Atef","doi":"10.1002/der2.70028","DOIUrl":"https://doi.org/10.1002/der2.70028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aims to provide a comprehensive analysis of keratinocytes, the predominant cell type in the epidermis, by examining their structural, functional, and regulatory roles in skin biology. The study explores the intricate processes of keratinocyte differentiation, proliferation, and immune interactions, emphasizing their essential contributions to skin homeostasis, wound healing, and barrier integrity. Additionally, it investigates the involvement of keratinocytes in dermatological disorders such as psoriasis, atopic dermatitis, and skin cancer, highlighting their pathological alterations and molecular mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review covers a broad range of studies, including in vitro and in vivo research on keratinocyte biology, their interactions with growth factors, and their contributions to inflammatory responses in the skin. It also discusses therapeutic advancements such as biologics and gene therapy that focus on restoring keratinocyte function in skin diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The review highlights that keratinocytes play a pivotal role in skin inflammation and the regulation of growth factors that promote wound healing and skin regeneration. Dysregulation of keratinocyte function is linked to several skin diseases, emphasizing the need for targeted therapeutic approaches. Recent advancements in treatments, such as gene therapy and biologics, offer promising outcomes for managing conditions driven by keratinocyte dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The primary aim of this review is to provide an in-depth overview of the functions of keratinocytes, particularly their roles in skin health, inflammation, and disease development. The review also aims to highlight the latest therapeutic strategies targeting keratinocytes for the treatment of skin diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in Atopic Dermatitis Using a Novel Topical 2% Cannabidiol (CBD) Application","authors":"Sarah Hakim,&nbsp;Sanjeev Goel,&nbsp;John Papastergiou,&nbsp;David J. Goldberg","doi":"10.1002/der2.70024","DOIUrl":"https://doi.org/10.1002/der2.70024","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition characterized by Th2-type inflammation, significantly impacting patients' quality of life. Patients often experience dryness, severe itching, and skin lesions, necessitating interventions to manage discomfort and flare-ups. Common treatments, such as topical corticosteroids and calcineurin inhibitors, are effective but have adverse effects, making them unsuitable for long-term use. Consequently, there is an ongoing effort to find sustainable and safe alternative treatments. Recently, cannabidiol (CBD), a non-psychoactive compound derived from the <i>Cannabis sativa</i> plant, has gained attention in dermatology for its anti-inflammatory properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This pilot study utilized a 4-week open-label observational prospective cohort design to evaluate the effects of a 2% CBD cream-based topical application in patients (<i>n</i> = 19) with moderate-to-severe atopic dermatitis. Participants were given the topical CBD product to apply daily to affected areas and were examined at baseline, week 1, week 2, week 4, and week 8. Primary outcomes measured included the appearance of eczema lesions and patient satisfaction with the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants reported improvements in skin hydration, comfort, inflammation relief, and overall skin appearance. Various objective evaluations and clinical photography were consistent with patient reported improvement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results support the potential of CBD as a sustainable and effective treatment option for mild to moderate atopic dermatitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest Editor's Introduction: New Technologies in Dermatology: Bridging Gaps and Exploring New Frontiers","authors":"Mohamad Goldust","doi":"10.1002/der2.70027","DOIUrl":"https://doi.org/10.1002/der2.70027","url":null,"abstract":"<p>In recent years, the field of dermatology has undergone transformative changes driven by rapid technological advancements. This special issue, titled “New Technologies in Dermatology: Bridging Gaps and Exploring New Frontiers,” reflects the innovative spirit that is redefining clinical practice, research, and education in our specialty. As the guest editor, I am pleased to present a collection of articles that highlight cutting-edge tools and techniques while also exploring their significant implications for patient care and disease management.</p><p>The integration of digital imaging, artificial intelligence, teledermatology, and personalized medicine into everyday practice has created huge opportunities for diagnosing, monitoring, and treating skin conditions with greater accuracy and efficiency. Within these pages, you will find contributions from leading experts who examine the technological advances that are bridging longstanding gaps between traditional methodologies and emerging digital solutions. Their insights shed light on how these innovations are addressing challenges such as access to specialized care, early detection of skin cancers, and the management of chronic dermatological disorders.</p><p>Furthermore, this issue emphasizes the collaborative nature of modern dermatology. By bringing together perspectives from clinicians, researchers, and technology developers, we highlight a future in which interdisciplinary cooperation drives further breakthroughs. The discussions contained in this issue not only outline the current landscape of technological applications in dermatology but also open the doors for future explorations into uncharted territories.</p><p>I invite you to explore the diverse array of articles, and reviews that comprise this issue. Together, they illustrate the dynamic interplay between technology and dermatology, one that holds the promise of improved patient outcomes and a more connected, innovative approach to skin health.</p>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin-Induced Nodules: A Review and Report of Five New Cases","authors":"Joe Khodeir,&nbsp;Paul Ohanian,&nbsp;Maya Habre,&nbsp;Jennifer Akl,&nbsp;Hala Abi Rached Megarbane,&nbsp;Alfred Ammoury","doi":"10.1002/der2.70023","DOIUrl":"https://doi.org/10.1002/der2.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Botulinum toxin, commonly used for cosmetic and therapeutic purposes, is generally safe. However, rare complications, such as nodular granuloma formation at injection sites, can arise, leading to significant distress for affected patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To analyze the clinical presentation, etiopathogenesis, diagnosis, and management of botulinum toxin-induced nodules, consolidating existing knowledge and introducing five new cases from our practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review of the literature was conducted, identifying reported cases of nodules following botulinum toxin injections. Data from 23 cases, including 5 new cases, were analyzed to identify common patterns. A stepwise algorithmic approach for diagnosis and management was proposed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nodules developed weeks to months postinjection. Histopathology revealed granulomatous inflammation, confirming the diagnosis. Etiologies included infectious causes (e.g., nontuberculous mycobacteria) and noninfectious causes (e.g., foreign body reactions and sarcoidal granulomas). Management strategies varied based on etiology, ranging from conservative approaches to systemic immunosuppressants or antimicrobial therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Botulinum toxin-induced nodules, though rare, represent a significant complication. Preventive measures, such as aseptic techniques and thorough patient screening, are crucial. Our findings underscore the importance of cause-directed treatments and propose an algorithmic approach to enhance diagnosis and management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor in Chief's Introduction: New Technologies in Dermatology: Bridging Gaps and Exploring New Frontiers","authors":"Michael H. Gold","doi":"10.1002/der2.70026","DOIUrl":"https://doi.org/10.1002/der2.70026","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Disparities in Melanoma: Advances in Diagnosis, Treatment, and the Role of Artificial Intelligence","authors":"Diala Ra'Ed Kamal Kakish,&nbsp;Jehad Feras Alsamhori,&nbsp;Lana N. Qaqish,&nbsp;Layan Aburumman,&nbsp;Razan Sarsur,&nbsp;Asham Al Salkhadi,&nbsp;Zbeida Bassam Nassif,&nbsp;Mustafa Ahmed Akmal,&nbsp;Abdulqadir J. Nashwan","doi":"10.1002/der2.70022","DOIUrl":"https://doi.org/10.1002/der2.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melanoma, a highly aggressive skin cancer, demonstrates significant gender disparities, with men facing later-stage diagnoses, more aggressive tumor characteristics, and worse survival rates. This review examines the biological, behavioral, and environmental factors driving these disparities, alongside recent advancements in diagnosis and treatment. Additionally, it explores how artificial intelligence (AI) can address gender-specific differences in melanoma incidence and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gender disparities in melanoma stem from biological factors, such as hormonal and genetic differences, and behavioral patterns like delayed health-seeking among men. AI-driven diagnostic tools, including convolutional neural networks (CNNs), show promise but often reflect biases in training data sets, underrepresenting darker skin tones and gender-specific patterns. Ensuring diverse data sets, integrating “super-prompts” or region-specific demographic prompts, and utilizing bias-aware algorithms can help mitigate these biases, thereby improving diagnostic accuracy and equity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Reducing gender disparities in melanoma requires integrating innovative technologies with equitable healthcare policies and education. Early detection using inclusive AI models tailored to diverse skin tones and genders, alongside targeted therapeutic strategies, is critical to improving outcomes for high-risk groups, particularly men and underserved populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}