Dermatological Reviews最新文献

{"title":"Nutritional Support and Wound Healing in Dermatology and Dermatologic Surgery","authors":"Andrew Pugliese,&nbsp;Valerie Foy","doi":"10.1002/der2.70061","DOIUrl":"https://doi.org/10.1002/der2.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To synthesize evidence on nutritional influences and interventions in wound healing, particularly in dermatology and at-risk populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Systematic search of PubMed, Google Scholar, and other databases (2015–2025) using terms like “nutritional deficiencies,” “wound healing,” “dermatologic surgery,” “key nutrients,” and “supplementation.” Included English-language peer-reviewed articles, trials, reviews, and meta-analyses on nutrient roles in healing phases and interventions (oral/topical supplementation, immunonutrition, emerging therapies). Narrative synthesis applied due to heterogeneity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From PubMed records, 63 studies included after screening. Key nutrients (protein; vitamins A, C, D, E; zinc, copper, iron) support immunity, collagen synthesis, angiogenesis, and re-epithelialization. Deficiencies, common in elderly, diabetic, oncology, and surgical patients, delay healing and raise complications. Targeted interventions show benefits in Mohs surgery, burns, and keloid-prone individuals. Screening tools and dietitian involvement recommended.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Nutrition is a modifiable factor optimizing wound outcomes. Personalized interventions reduce burden; further high-quality trials needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camouflage and Cosmetic Innovation: Long-Wear Micropigmentation, Optical Correctors, and Sunscreen Science","authors":"Kanika Sahni,&nbsp;Shreya K. Gowda","doi":"10.1002/der2.70058","DOIUrl":"https://doi.org/10.1002/der2.70058","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vitiligo affects approximately 0.5%–2% of the global population, with prevalence reaching up to 8.8% in India. The condition's visibility, particularly in darker phototypes, causes considerable psychosocial distress, including anxiety, depression, and low self-esteem. Addressing the cosmetic and emotional impact of vitiligo is central to holistic management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>A comprehensive literature synthesis was conducted examining cosmetic camouflage, optical correctors, micropigmentation, and advanced techniques such as simulated second skin and melanin-based formulations. The review highlights product types, formulation principles, ingredients, application techniques, and innovations improving durability and patient satisfaction. Camouflage therapy employs high-coverage, waterproof, and skin-safe formulations to mask depigmented lesions, thereby enhancing self-esteem and quality of life. Modern products integrate non-allergenic ingredients and broad-spectrum sunscreens, providing both concealment and photoprotection. Optical correctors are specialized cosmetic formulations based on color theory that neutralize skin tone irregularities and enhance complexion uniformity, by using complementary color. Sunscreens with tinted or hybrid formulations offer dual cosmetic and protective benefits. Micropigmentation provides semi-permanent coverage through intradermal pigment implantation and is especially effective in stable vitiligo. Innovations such as AI-assisted pigment matching, melanin-extracted creams, and simulated second skin technology (e.g., Microskin™) have advanced personalization, adherence, and cosmetic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Camouflage therapy and micropigmentation serve as vital adjuncts in vitiligo management, addressing both cosmetic and psychosocial dimensions. Emerging technologies promise improved precision, durability, and patient satisfaction. Incorporating camouflage into patient-centered care enhances confidence, social functioning, and overall quality of life, underscoring its role in comprehensive vitiligo therapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI at the Bedside: Automated Diagnosis, Progression Tracking, and Treatment Forecasting in Vitiligo","authors":"Shreya K. Gowda,&nbsp;Keepa Manandhar,&nbsp;Somesh Gupta","doi":"10.1002/der2.70055","DOIUrl":"https://doi.org/10.1002/der2.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vitiligo is an acquired depigmenting disorder characterized by selective melanocyte destruction, leading to visible psychosocial burden and diagnostic challenges. Conventional assessment tools such as VASI and VIDA are semi-quantitative and subjective, with limited reproducibility. Early detection, accurate monitoring, and treatment response prediction remain unmet needs. Artificial intelligence (AI) has emerged as a promising adjunct to enhance diagnostic precision, track disease progression, and forecast therapeutic outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A narrative synthesis of recent studies was undertaken, focusing on AI-assisted imaging modalities (clinical photography, dermoscopy, multisource fusion), deep learning algorithms (CNNs, transformers, attention-based models), and explainable AI tools. Primary outcomes included accuracy in diagnosis, reproducibility of progression tracking, and feasibility of treatment response prediction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AI-based tools demonstrated high diagnostic accuracy (&gt; 90% in several studies) in distinguishing vitiligo from mimickers and in lesion segmentation. Automated progression tracking using serial imaging and OCT improved objectivity over conventional indices. Mobile AI applications enabled remote monitoring with reliable lesion detection. Predictive models integrating clinical, imaging, and laboratory data showed potential for individualized treatment forecasting, particularly for NB-UVB and JAK inhibitors. However, limitations include small, heterogeneous datasets, underrepresentation of skin-of-color, lack of prospective trials, and concerns over model transparency.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AI shows substantial promise in vitiligo by enhancing diagnosis, monitoring progression, and forecasting treatment response. To realize clinical utility, future efforts must address dataset diversity, standardization, explainability, and regulatory validation. AI has the potential to become an effective bedside adjunct for personalized vitiligo management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145572387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Evaluation of a Mesotherapy Formulation for Weakened and Sparse Eyebrows With Assessment of Some Psychological and Social Aspects","authors":"Krenar Dobroshi,&nbsp;Marija Glavash Dodov,&nbsp;Maja Simonovska Crcarevska,&nbsp;Renata Slaveska Raichki,&nbsp;Selvete Shuleta-Qehaja,&nbsp;Blerim Krasniqi,&nbsp;Qendresa Hoti,&nbsp;Merita Vuniqi Krasniqi,&nbsp;Gabriela Stelian","doi":"10.1002/der2.70056","DOIUrl":"https://doi.org/10.1002/der2.70056","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Eyebrows (EBs) are essential to facial symmetry, expression, and self-image. EB thinning can negatively impact psychological and social well-being. Mesotherapy (MT) has gained traction as a minimally invasive treatment for hair restoration, yet its impact on eyebrow regeneration and psychosocial outcomes remains under-investigated.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aims&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study assesses the psychological and clinical effects of eyebrow mesotherapy (EB MT) using a growth factor-based serum in individuals with sparse or weakened eyebrows.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Patients/Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Thirty-two participants (ages 18–65) underwent three sessions of EB MT at two—to 4-week intervals. Treatment utilized “point by point” and “nappage” injection techniques with growth factor-based serum (GF Advanced Hair Complex+, AQ Skin Solutions Inc., Irvine, CA, USA). This cosmetic-grade formulation contains human fibroblast–conditioned media rich in growth factors and is manufactured under Good Manufacturing Practice (GMP) standards and FDA cosmetic compliance. The product was commercially purchased for clinical use, with no manufacturer involvement in study design or data interpretation.” Participants outcomes were evaluated using structured questionnaires measuring social engagement, quality of life, confidence, and mood. In addition, eyebrow width, length, and density were objectively measured across sessions. Statistical analysis was performed using Python (vX.X), applying non-parametric tests.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;EB MT was associated with significant improvements participants' psychosocial scores, with mean values of 7.81 for social engagement, 6.71 for quality of life, 6.09 for confidence, and 6.13 for mood. Due to the ordinal nature of our outcome data (0–10 scales), we employed non-parametric tests. A Spearman's rank correlation revealed a strong association between social engagement and quality of life (&lt;i&gt;ρ&lt;/i&gt; = 0.667, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), a moderate association between confidence and mood (&lt;i&gt;ρ&lt;/i&gt; = 0.471, &lt;i&gt;p&lt;/i&gt; &lt; 0.01), and a weak, nonsignificant association between social engagement and confidence (&lt;i&gt;ρ&lt;/i&gt; = 0.152, &lt;i&gt;p&lt;/i&gt; &gt; 0.05). Furthermore, the Mann–Whitney &lt;i&gt;U&lt;/i&gt; test confirmed that social engagement scores were significantly higher than confidence scores (&lt;i&gt;U&lt;/i&gt; = 916.0, &lt;i&gt;p&lt;/i&gt; &lt; 0.001). Objective measurements showed increased eyebrow width (+11 µm), length (+3.1 mm), and density (+8 hairs/cm²), all statistically significant (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). The treatment was well tolerated and showed consistent clinical improvement.&lt;/p&gt;\u0000 ","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145529917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional Variability in Botulinum Toxin Type A Practices: A Latin American Survey on Dosing, Preferences, and Clinical Outcomes","authors":"Luis Alberto Parra,&nbsp;Andreina Martinez Amado,&nbsp;Eugenia Cure,&nbsp;Ingrid Salas,&nbsp;Carolina Schneider,&nbsp;Andrea Marcela Parra","doi":"10.1002/der2.70054","DOIUrl":"https://doi.org/10.1002/der2.70054","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Regional practices for botulinum toxin type A (BoNT-A) in Latin America remain underexplored. This study characterizes dosing, brand preferences, and clinical outcomes across 12 countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To characterize regional variations in BoNT-A dosing, brand preferences, and clinical outcomes for upper facial treatments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A cross-sectional survey of 107 practitioners across 12 Latin American countries (March 2025) analyzed dosing (Speywood/International Units), duration, adverse events, and brand preferences using descriptive statistics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participants primarily practiced in Colombia (65.4%), Mexico (7.5%), and Central America (4.7%). AbobotulinumtoxinA required higher doses (total upper face: 114.98 ± 24.32 Speywood units) versus IncobotulinumtoxinA (66.36 ± 10.12 IU) and OnabotulinumtoxinA (62.94 ± 7.36 IU). Duration was comparable across brands (12.1–14.3 weeks). Regional preferences included AbobotulinumtoxinA in Brazil (55%) and IncobotulinumtoxinA in Mexico (48%), driven by cost or precision. Adverse events were transient (headache: 58.2%, ptosis: 12.2%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Latin American practitioners balance cost-effectiveness and precision, with standardized dosing reflecting regional expertise. Long-term safety studies are warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145223828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial Radiation Therapy in Keloid Management","authors":"Karina Butani,&nbsp;Michael H. Gold,&nbsp;Angela N. Brown","doi":"10.1002/der2.70053","DOIUrl":"https://doi.org/10.1002/der2.70053","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Keloids are pathological scars that result due to prolonged inflammation and dysregulation in normal wound healing processes. Treatment options include both surgical and nonsurgical options. Superficial radiation therapy (SRT), a low-energy form of radiation used to treat keloids and nonmelanoma skin cancers, has recently been reconsidered as an adjuvant treatment following keloid excision. This review aims to explore current literature on the role of SRT in keloid treatment efficacy and clinical outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A literature search was conducted via PubMed to review pathophysiology and current treatment methods for keloids and efficacy of SRT. Peer-reviewed research articles were investigated to highlight its uses in the field.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Numerous studies and clinical outcomes highlight the efficacy of SRT in reducing recurrence rates after surgical intervention. While consensus guidelines were established to determine dosing protocols in 2019, there is still conflicting evidence about duration of treatment, recommended dose, radiation, and units of gray (Gy) for different anatomical sites. Additionally, there is some concern regarding side effects, such as hyperpigmentation, radiation-induced dermatitis, and wound healing difficulties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SRT has proven to be an extremely promising treatment method for keloids as a form of adjuvant therapy to surgery. This review highlights the need for further clinical studies to further develop therapeutic outcomes and universal guidelines.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145101409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Culprits of Hyperhidrosis: An Updated Review of Incidence, Mechanisms, and Management","authors":"Colin Burnette,&nbsp;Joseph Gofman,&nbsp;Emily Didia,&nbsp;Daniel Fischer,&nbsp;Charles Gropper","doi":"10.1002/der2.70052","DOIUrl":"https://doi.org/10.1002/der2.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Drug-induced hyperhidrosis (DIH) is an underrecognized adverse effect that can impair quality of life and reduce treatment adherence. While prior reviews have addressed known causes, the emergence of new agents and evolving use of established drugs require ongoing identification of additional culprits and updated synthesis of previously implicated classes. This study aims to identify the growing body of evidence on DIH, focusing on implicated drug classes, underlying mechanisms, and management strategies to support early recognition and optimal care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature review was conducted across three databases (PubMed, Scopus, and Google Scholar) from January 2007 to April 2025. Search terms included “drug-induced hyperhidrosis,” “secondary hyperhidrosis,” and related variations. Studies were eligible if published in English and reported on the incidence, pathophysiology, or treatment of DIH. References were manually screened by two reviewers, with disagreements resolved by a third reviewer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Antipsychotics, opioids, acetylcholinesterase inhibitors, antidepressants, and stimulants were the most frequently implicated drug classes. Proposed mechanisms include cholinergic overstimulation, serotonergic or dopaminergic dysregulation, and sympathetic overactivity. Newly implicated classes include cholinergic agonists, triptans, and antimicrobials. Management approaches include dose reduction or drug discontinuation, microneedling procedures, and pharmacologic adjuncts such as anticholinergics, adrenergic blockers, or botulinum toxin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>DIH is relatively common and associated with an expanding range of medications. Maintaining a low threshold for clinical suspicion, along with ongoing vigilance and prompt identification, is essential to optimize management, improve adherence, and reduce unnecessary diagnostic workups.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superficial Radiation Therapy: The Gentle Giant of Nonmelanoma Skin Cancer Treatment","authors":"Barbara Kania,&nbsp;David J. Goldberg","doi":"10.1002/der2.70051","DOIUrl":"https://doi.org/10.1002/der2.70051","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Nonmelanoma skin cancer (NMSC), primarily basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), represents a significant and growing health concern. These cancers, largely attributed to cumulative sun exposure, present unique challenges in treatment due to their prevalence, particularly in cosmetically sensitive areas, and the varied health statuses of affected patients. Traditional treatment modalities, such as surgical excision and Mohs micrographic surgery, while effective, may not be suitable for all individuals, especially the elderly population or those with comorbidities. Superficial radiation therapy (SRT) has emerged as a valuable alternative, offering a noninvasive approach that targets superficial tumors with low-energy X-rays. This literature review aims to consolidate current knowledge regarding SRT, focusing on its indication, treatment parameters, efficacy, safety, and patient selection, to provide a comprehensive overview of its role in NMSC management.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This literature review compiles data from a wide range of clinical studies, meta-analyses, and systematic reviews published in peer-reviewed journals. The search strategy involved utilizing medical databases such as PubMed, MEDLINE, and Wiley, with keywords including “superficial radiation therapy,” “nonmelanoma skin cancer,” “basal cell carcinoma,” “squamous cell carcinoma,” “SRT efficacy,” “SRT side effects,” and “SRT treatment protocols.” Studies were included if they provided relevant data on SRT's efficacy, safety, treatment protocols, and patient selection for NMSC. Emphasis was placed on studies with robust methodologies, including randomized controlled trials, large cohort studies, and meta-analyses. Data extracted from these studies included tumor control rates, recurrence rates, side effect profiles, treatment protocols, and patient-reported outcomes. The findings were then summarized to provide a comprehensive overview of SRT's role in NMSC management.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;SRT stands as a highly effective and safe treatment modality for NMSC, particularly for BCC and SCC. This review demonstrates that SRT achieves high tumor control rates with low recurrence, offering a favorable safety profile compared to surgical alternatives. Its noninvasive nature and minimal recovery time make it especially suitable for elderly patients, those with comorbidities, and individuals seeking cosmetic preservation. Standardized treatment protocols, including fractionated dosing, optimize therapeutic outcomes while minimizing side effects. Patient selection, based on tumor characteristics, health status, and personal preferences, is ","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternative Therapies for Hair Loss: Stem Cells, Oils, and Laser Treatment","authors":"William Abou Shahla,&nbsp;Rose-Mary Daou,&nbsp;Dana Saade","doi":"10.1002/der2.70050","DOIUrl":"https://doi.org/10.1002/der2.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hair loss is a common condition that significantly impacts quality of life. While conventional medical and surgical treatments are available, many patients seek noninvasive and alternative approaches. This review aimed to examine the efficacy and mechanisms of action of biologics (e.g., stem cells and exosomes, regulated under CBER by the US FDA), medical devices (e.g., lasers), Nonmedical and oils for alopecia, focusing on stem cell-based therapies, natural oils, and low-level laser therapy (LLLT).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive review of clinical trials, systematic reviews, and animal studies was conducted to assess the safety, mechanisms, and clinical outcomes of the selected treatment modalities in various forms of alopecia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stem cell-based interventions, especially those using adipose-derived stem cells, hair follicle stem cells, and induced pluripotent stem cells, showed improvements in hair density and thickness through paracrine signaling and angiogenesis. Natural oils such as rosemary and pumpkin seed oil demonstrated hair regrowth potential via anti-inflammatory and hormonal modulation effects. LLLT has shown hair growth-promoting potential in several studies by stimulating the Wnt/β-catenin pathway and improving scalp blood flow; however, results remain mixed across trials depending on patient and device factors. Most treatments reported minimal adverse effects and moderate patient satisfaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Stem cells, natural oils, and LLLT represent promising alternatives for managing alopecia, offering diverse mechanisms of action with generally favorable safety profiles. However, further standardized, long-term clinical trials are necessary to confirm their efficacy and establish consistent treatment protocols.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144897416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teledermatology as a Solution for Rural and Rare Dermatologic Care: A Review of Strategies and Opportunities","authors":"Victoria Griffith,&nbsp;Valerie Foy","doi":"10.1002/der2.70049","DOIUrl":"https://doi.org/10.1002/der2.70049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Teledermatology offers a transformative approach to delivering dermatologic care in rural areas where access to specialists is limited. This modality shows particular promise for managing rare skin conditions in underserved populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate effective teledermatology strategies for rural healthcare delivery, with a focus on diagnostic accuracy, patient access, and the management of rare dermatologic diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search of PubMed was conducted from January 1995 through December 2024, identifying 49 studies that addressed teledermatology in rural populations, including outcomes related to care delivery models, diagnostic efficacy, and case reports involving rare conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Store-and-forward, synchronous, and hybrid teledermatology models all demonstrated high efficacy in improving diagnostic accuracy and reducing in-person referrals. Store-and-forward platforms, in particular, facilitated successful diagnoses of rare conditions such as morphea when supported by primary care provider (PCP) training in clinical photography and history-taking. Barriers included limited broadband connectivity, interstate licensure restrictions, and increased provider workload. Enhancements such as smartphone-compatible platforms, instructional videos for patients, and targeted PCP training improved usability and access in low-resource settings. Emerging tools, including AI-based mobile applications like <i>MoleMapper</i>, show promise in triage and self-monitoring applications. However, data on the effectiveness of teledermatology for rare skin conditions remain sparse.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Teledermatology is a scalable and cost-effective solution for addressing dermatologic disparities in rural communities. To fully realize its potential-especially for rare disease management-further research, policy reforms around licensure and reimbursement, and expanded provider and patient education are essential.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144888384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}