Dermatological Reviews最新文献

{"title":"Botulinum Toxin-Induced Nodules: A Review and Report of Five New Cases","authors":"Joe Khodeir,&nbsp;Paul Ohanian,&nbsp;Maya Habre,&nbsp;Jennifer Akl,&nbsp;Hala Abi Rached Megarbane,&nbsp;Alfred Ammoury","doi":"10.1002/der2.70023","DOIUrl":"https://doi.org/10.1002/der2.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Botulinum toxin, commonly used for cosmetic and therapeutic purposes, is generally safe. However, rare complications, such as nodular granuloma formation at injection sites, can arise, leading to significant distress for affected patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To analyze the clinical presentation, etiopathogenesis, diagnosis, and management of botulinum toxin-induced nodules, consolidating existing knowledge and introducing five new cases from our practice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review of the literature was conducted, identifying reported cases of nodules following botulinum toxin injections. Data from 23 cases, including 5 new cases, were analyzed to identify common patterns. A stepwise algorithmic approach for diagnosis and management was proposed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nodules developed weeks to months postinjection. Histopathology revealed granulomatous inflammation, confirming the diagnosis. Etiologies included infectious causes (e.g., nontuberculous mycobacteria) and noninfectious causes (e.g., foreign body reactions and sarcoidal granulomas). Management strategies varied based on etiology, ranging from conservative approaches to systemic immunosuppressants or antimicrobial therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Botulinum toxin-induced nodules, though rare, represent a significant complication. Preventive measures, such as aseptic techniques and thorough patient screening, are crucial. Our findings underscore the importance of cause-directed treatments and propose an algorithmic approach to enhance diagnosis and management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor in Chief's Introduction: New Technologies in Dermatology: Bridging Gaps and Exploring New Frontiers","authors":"Michael H. Gold","doi":"10.1002/der2.70026","DOIUrl":"https://doi.org/10.1002/der2.70026","url":null,"abstract":"","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143689619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Disparities in Melanoma: Advances in Diagnosis, Treatment, and the Role of Artificial Intelligence","authors":"Diala Ra'Ed Kamal Kakish,&nbsp;Jehad Feras Alsamhori,&nbsp;Lana N. Qaqish,&nbsp;Layan Aburumman,&nbsp;Razan Sarsur,&nbsp;Asham Al Salkhadi,&nbsp;Zbeida Bassam Nassif,&nbsp;Mustafa Ahmed Akmal,&nbsp;Abdulqadir J. Nashwan","doi":"10.1002/der2.70022","DOIUrl":"https://doi.org/10.1002/der2.70022","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Melanoma, a highly aggressive skin cancer, demonstrates significant gender disparities, with men facing later-stage diagnoses, more aggressive tumor characteristics, and worse survival rates. This review examines the biological, behavioral, and environmental factors driving these disparities, alongside recent advancements in diagnosis and treatment. Additionally, it explores how artificial intelligence (AI) can address gender-specific differences in melanoma incidence and outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Gender disparities in melanoma stem from biological factors, such as hormonal and genetic differences, and behavioral patterns like delayed health-seeking among men. AI-driven diagnostic tools, including convolutional neural networks (CNNs), show promise but often reflect biases in training data sets, underrepresenting darker skin tones and gender-specific patterns. Ensuring diverse data sets, integrating “super-prompts” or region-specific demographic prompts, and utilizing bias-aware algorithms can help mitigate these biases, thereby improving diagnostic accuracy and equity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Reducing gender disparities in melanoma requires integrating innovative technologies with equitable healthcare policies and education. Early detection using inclusive AI models tailored to diverse skin tones and genders, alongside targeted therapeutic strategies, is critical to improving outcomes for high-risk groups, particularly men and underserved populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Complications After Exosome Treatment for Aesthetic Skin Rejuvenation”","authors":"","doi":"10.1002/der2.70017","DOIUrl":"https://doi.org/10.1002/der2.70017","url":null,"abstract":"&lt;p&gt;(2024), “Complications After Exosome Treatment for Aesthetic Skin Rejuvenation,” &lt;i&gt;Dermatological Reviews&lt;/i&gt; 5: e242, https://doi.org/10.1002/der2.242.&lt;/p&gt;&lt;p&gt;In the article, the errors detailed below were identified. These corrections are due to an earlier version of the manuscript being published without patient consent. These have been corrected in the online version of the article, and they do not affect the overall conclusions.&lt;/p&gt;&lt;p&gt;The second sentence of the Background paragraph originally stated ‘aesthetics purposes in South Korea’. This has been corrected to ‘aesthetics purposes primarily in South Korea, including one patient residing in Australia.’&lt;/p&gt;&lt;p&gt;The second sentence of the Methods paragraph originally read, ‘The case series included eight female patients, ranging in age from 26 to 52 years old’. This has been corrected to “The case series included seven female patients ranging in age from 26 to 37 years old.’&lt;/p&gt;&lt;p&gt;The third paragraph, last sentence originally read ‘aesthetic dermatologists from South Korea’, who observed the complications. This has been corrected to ‘aesthetic dermatologists, who observed the complications. .’&lt;/p&gt;&lt;p&gt;In 2.8 Case 8, the case study was originally stated that, ‘This is a 52-year-old female who developed multiple erythematous papules (pea-sized) on the right cheek in a grid-like pattern (Figure 9), after a month of self-treatment with MTS microneedling and exosomes. These lesions were not painful or pruritic. Six weeks after the exosome self-treatment, she saw another dermatologist and received topical and oral steroids. On presentation to her current dermatologist (2 months after exosome treatment), she had a biopsy of a lesion demonstrating a necrotizing granuloma on H and E staining (Figure 10 A), and an AFB stain of the lesion was also negative (Figure 10B). Blood work involving a complete blood count, smooth muscle antibody, erythrocyte sedimentation rate, and C-reactive protein were within normal limits. Tissue cultures for mycobacteria and atypical mycobacteria were negative. Fungus culture was also negative. Moreover, PCR analysis of the tissue also demonstrated negativity for mycobacteria and atypical mycobacteria. For the first 5 weeks, the patient was given a course of methylprednisolone 8 mg once a day, clarithromycin 500 mg twice a day, and doxycycline 100 mg twice a day.’&lt;/p&gt;&lt;p&gt;This has been replaced by:‘A 29-year-old Chinese female residing in Australia came to South Korea seeking cosmetic treatment, where she received a single exosome treatment administered by a nurse practitioner in August 2023, using a 9-pin multineedle and injection gun. The patient reported that erythematous papules initially appeared at the needle insertion sites approximately 1 month after the treatment and were associated with pruritus. While some lesions resolved spontaneously within the first month after appearance, others persisted and progressively worsened over the next 6 months.’&lt;/p&gt;&lt;p&gt;Two months aft","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid Injection Treatment for Nodulocystic Acne: A Literature Review","authors":"Kar Wai Alvin Lee,&nbsp;Lisa Kwin Wah Chan,&nbsp;Cheuk Hung Lee,&nbsp;Jovian Wan,&nbsp;Kyu-Ho Yi","doi":"10.1002/der2.70021","DOIUrl":"https://doi.org/10.1002/der2.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nodulocystic acne is a severe form of acne characterized by inflamed nodules and cysts, often causing significant emotional distress and scarring. While oral corticosteroids are commonly used to treat nodulocystic acne, they can have systemic side effects. Intralesional corticosteroid injections offer a targeted and localized approach, reducing the risk of systemic side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This literature review aims to evaluate the efficacy, safety, and tolerability of steroid injections for the treatment of nodulocystic acne.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>A comprehensive search of electronic databases was conducted to identify relevant studies on the use of intralesional corticosteroids for nodulocystic acne. Studies were included if they reported on the use of intralesional corticosteroids as a primary treatment modality for nodulocystic acne.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The review included studies that reported on the use of intralesional corticosteroids for nodulocystic acne. The results suggest that steroid injections can be an effective treatment option, with significant reductions in lesion size and severity reported in several studies. The addition of lincomycin to intralesional corticosteroids was found to enhance therapeutic efficacy, while cold anesthesia was effective in reducing pain during injections. Proper technique and dosage are essential to minimize discomfort and reduce the risk of complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This review suggests that steroid injections can be a valuable treatment option for nodulocystic acne, offering targeted and localized delivery of corticosteroids with reduced risk of systemic side effects. Further research is needed to confirm these findings and establish optimal treatment regimens.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Percutaneous Suture Suspension Biomaterials in Brow Lift: A Systematic Review","authors":"Rashesh Shah,&nbsp;Vaibhav Kumar,&nbsp;Debraj Shome,&nbsp;Rinky Kapoor,&nbsp;Harshal Tandel","doi":"10.1002/der2.70019","DOIUrl":"https://doi.org/10.1002/der2.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Aging is a global biological process characterized by degenerative changes in physiological systems, most notably a decrease in face muscle tone and soft tissue volume, which have a substantial impact on facial esthetics in the periorbital area. This systematic study assesses the clinical outcomes of different thread lifting procedures for brow rejuvenation, with an emphasis on safety, efficacy, and side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To promote scientific rigor and transparency, this systematic review used the latest PRISMA-E guidelines (2020). A thorough literature search was carried out using numerous databases, including Google Scholar, PubMed/MEDLINE, Embase, PsycINFO, TRIP, and the Cochrane Library. The <i>I</i>² value of 0.92 indicates significant variety in study designs, patient characteristics, and therapies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 6 studies were included, with 419 patients in sample sizes ranging from 12 to 193 (mean = 69). Participants had an average age of 55 years (range: 21–89) and were monitored for 10–11 months. All investigations used standardized photographic assessments (100%). Ecchymosis and post-procedural edema were the most common side effects observed, accounting for 83.4% of all cases. Notably, two-thirds of the studies (66.7%) demonstrated a low risk of bias, indicating moderate methodological robustness and internal validity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Thread lifting procedures for brow rejuvenation have a positive safety and efficacy profile, providing a viable nonsurgical alternative to established approaches. Future research, particularly large-scale, long-term randomized controlled trials, is critical for refining these strategies and developing evidence-based clinical recommendations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Cyperus rotundus L. As a Natural Hair Removal Agent: A Review of Traditional and Modern Applications","authors":"Ghada Farouk Mohammed,&nbsp;Mohammed Saleh Al-Dhubaibi,&nbsp;Saleh Salem Bahaj,&nbsp;Ahmed Ibrahim AbdElneam,&nbsp;Ahmed Mohammed Al-Dhubaibi,&nbsp;Lina Mohammed Atef","doi":"10.1002/der2.70020","DOIUrl":"https://doi.org/10.1002/der2.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Hair removal is a fundamental aspect of daily life, with various hair removal methods evolving throughout hair removal history to meet cultural, aesthetic, and spiritual needs. Traditional hair removal practices have long sought effective hair removal products that not only remove hair but also promote skin health. <i>Cyperus</i> rotundus L. (<i>C</i>r L.), known as nut grass or purple nut sedge, has long been used in traditional medicinal systems like Ayurveda and Traditional Chinese Medicine (TCM) for treating various ailments, including skin conditions and depilation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To understand the role of <i>C</i>r L. in decreasing hair growth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>C</i>r L. contains essential oils (EOs) and phytochemicals such as flavonoids, alkaloids, and saponins, which contribute to its hair-removal properties. These compounds target hair follicles, dissolve keratin, and inhibit hair regrowth by modulating biological pathways. γ-curcumene, a key component, has been shown to suppress hair growth. Recent clinical trials have demonstrated the efficacy of <i>Cyperus</i> rotundus EO (CREO) in reducing hair growth, with minimal side effects. CREO has been found as effective as Alexandrite laser treatments in some cases, particularly in reducing white hair. This positions <i>C</i>r L. as a promising natural alternative to chemical depilatories, which often cause skin irritation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p><i>C</i>r L. shows significant potential as a natural hair removal agent. With its strong safety profile and growing consumer demand for natural, sustainable beauty products, <i>C</i>r L. could serve as a viable alternative to synthetic depilatories, pending further clinical validation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Aquasomes-Based Topical Drug Delivery for Enhanced Dermatological Treatments","authors":"Soumick Das,&nbsp;Amlan Bishal,&nbsp;Biplab Debnath,&nbsp;Swarupananda Mukherjee","doi":"10.1002/der2.70014","DOIUrl":"https://doi.org/10.1002/der2.70014","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Aquasomes are novel nanoparticulate carriers that are applied topically to deliver medications, particularly in dermatology. These carriers are composed of a polyhydroxy oligomer layer covering a solid core, usually composed of ceramic or calcium phosphate. The bioactivity of delicate molecules, such as proteins, peptides, and genetic material, is preserved by this special structure. Aquasomes are especially useful for improving the stability, bioavailability, and controlled release of therapeutic substance, while reducing systemic absorption and unfavorable side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>The efficacy of aquasomes in treating dermatological conditions has been the subject of recent research. Their capacity to administer anti-inflammatory medications for ailments like acne, psoriasis as well as wound healing has been investigated. Additionally, research has looked into how well aquasomes can help bigger molecules pass through the epidermal barrier. The effectiveness, safety, as well as skin irritation of aquasomes have been evaluated through comparisons with traditional topical formulations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Aquasomes were less irritating and more effective than conventional topical applications for localized skin conditions. Furthermore, a 2024 study showed that aquasomes improved the ability of big molecules to pass through the epidermal barrier, which made them appropriate for noninvasive medication administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In the fields of dermatology and cosmetics, aquasomes hold great promise as a topical treatment delivery system. With fewer adverse effects, they provide improved stability, bioavailability, along with controlled drug release. The therapeutic value for dealing with skin conditions and enhancing cosmetic formulations will be maximized with continued research to optimize their properties.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Update on Teledermatology","authors":"Mahsa Babaei,&nbsp;Nasim Gholizadeh,&nbsp;Ghasem Rahmatpour Rokni","doi":"10.1002/der2.256","DOIUrl":"https://doi.org/10.1002/der2.256","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Teledermatology, a branch of telemedicine, utilizes telecommunication technologies for remote dermatological care, covering diagnosis, treatment planning, and patient monitoring. This study presents a review of the latest advances in teledermatology.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Database searches were performed within PubMed, EMBase, and Google Scholar using the keywords “Artificial Intelligence,” “Teledermatology,” “Telemedicine,” and “Dermatology.” All relevant documents were screened and included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Teledermatology employs synchronous and asynchronous interactions alongside remote monitoring, breaking geographical barriers to access dermatologic expertise. Supported by digital imaging, secure communication platforms, and artificial intelligence, teledermatology aids in diagnosis, treatment, and follow-up. In education, teledermatology facilitates remote learning, case review, and interdisciplinary collaboration, providing access to diverse patient populations and mentorship opportunities. It also contributes to continuing medical education and telemedicine skill development. In research, teledermatology supports epidemiological studies, diagnostic accuracy assessments, clinical trials, and quality improvement initiatives. Despite its benefits, challenges like image quality, regulatory issues, and the digital divide persist.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The evolution of teledermatology depends on technological advancements, regulatory frameworks, and reimbursement models. By addressing challenges and embracing innovation, teledermatology promises to enhance dermatologic care, patient outcomes, and healthcare efficiency in the digital era.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.256","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Janus Kinase Inhibition Modulation as Standalone or Synergistic Therapy With Narrowband UVB Photo Stimulation in Vitiligo Management: A Systematic Review and Meta-Analysis","authors":"Vaibhav Kumar,&nbsp;Rinky Kapoor,&nbsp;Avani Gulhane,&nbsp;Debraj Shome,&nbsp;Atrey J. Pai Khot,&nbsp;Pranjal Mhatre,&nbsp;Depti Bellani","doi":"10.1002/der2.70016","DOIUrl":"https://doi.org/10.1002/der2.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Vitiligo is a chronic autoimmune dermatosis characterized by progressive hypopigmentation, which affects ~0.2%–2% of the global population. This condition can have significant psychosocial impacts, particularly in individuals with darker skin phenotypes. Recent studies have suggested that Janus kinase (JAK) inhibitors, especially topical ruxolitinib, could offer therapeutic potential in managing vitiligo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To systematically review the therapeutic efficacy, safety profile, and potential synergistic effects of topical JAK inhibitors, particularly ruxolitinib, in the treatment of vitiligo.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic review was conducted in accordance with the PRISMA guidelines. Data from 6 studies, encompassing 385 subjects, were synthesized. The primary outcome measure was the improvement in Vitiligo Area Scoring Index (VASI), and the methodological quality was assessed using the MINORS scale.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Topical ruxolitinib demonstrated a statistically significant improvement in VASI scores (pooled estimate = 0.58; 95% CI: 0.44–0.73; <i>p</i> ≤ 0.001). The synergistic effect of ruxolitinib combined with narrowband ultraviolet B (NB-UVB) phototherapy yielded a mean VASI score improvement of 37.6%. Furthermore, 30.4% of patients receiving 1.5% ruxolitinib cream achieved a 75% improvement in facial VASI (F-VASI) scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Topical JAK inhibitors, including ruxolitinib, show considerable efficacy in improving VASI scores and facilitating repigmentation in vitiligo patients. The combination of JAK inhibitors with NB-UVB therapy demonstrates enhanced therapeutic effects. These findings underscore the potential of JAK inhibitors as effective treatment modalities, although further research is needed to standardize treatment protocols and evaluate long-term impacts on patient quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100366,"journal":{"name":"Dermatological Reviews","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/der2.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}