Dentistry Review最新文献

{"title":"Relative immunogenicity and cytotoxicity of native collagen, crosslinked collagen, polytetrafluoroethylene, and electrospun nanofiber poly(ester urea) membranes in vitro","authors":"Andrew Egger DDS","doi":"10.1016/j.dentre.2026.100368","DOIUrl":"10.1016/j.dentre.2026.100368","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Absorbable and non-absorbable barrier membranes are commonly used in contemporary periodontics for a variety of clinical purposes including alveolar ridge preservation/augmentation, guided tissue regeneration, and sinus elevation surgery. The purpose of this investigation is to evaluate the immunogenicity and cytotoxicity of four barrier membrane materials on human gingival epithelial cells in an <em>in vitro</em> model.</div></div><div><h3>METHODS</h3><div>Four barrier membrane materials, native collagen (NC), crosslinked collagen (CC), dense polytetrafluoroethylene (dPTFE), and an electrospun nanofiber poly(ester urea) membrane (NP) based membrane, were introduced into culture wells containing confluent Human gingival epithelial cells (HGECs) (ATCC primary oral keratinocytes PCS 200-014). Culture media was sampled at one day, three day, and five day membrane incubation timepoints. Media concentrations of interleukin (IL)-4, IL-6, IL-7, IL-8, IL-10, tumor necrosis factor-α (TNF-α), granulocyte colony-stimulating factor (G-CSF), macrophage inflammatory protein-1β (MIP-1β), and interferon-γ (IFN- γ) were subsequently determined via cytokine analysis (Bio-Plex Pro, Bio-Rad, Hercules, CA, USA) and multiplex assay system (MagPix, Luminex, Austin, TX, USA). A two-way factorial ANOVA was used to identify statistically significant differences in cytokine concentrations between treatment groups. Where statistically significant differences were found in the overall model, post-hoc Bonferroni tests were applied.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> NC membranes exhibited marked visual degradation over time, whereas CC, dPTFE, and NP membranes showed little to no change in visual appearance through five days. Incubation with the NC membrane was found to consistently stimulate the production of IL-4, IL-6, IL-8, G-CSF, and MIP-1β. All other membrane materials did not demonstrate a consistent increase in cytokine level above the negative control and the NP membrane tended to have the lowest overall cytokine concentration of all tested materials. We also observed that the NC membrane increased the production of inflammatory cytokines: IL-4, IL-6, G-CSF, and MIP-1b compared to other three membranes tested in this study (p<0.05).</div></div><div><h3>CONCLUSIONS</h3><div>Under the described conditions, NC membranes exhibited higher immunogenicity compared with CC, dPTFE, or NP. These observations may relate to the rate of membrane degradation and the immunogenic potential of the breakdown products. Of the four evaluated membranes, NP exhibited the most favorable cytokine profile.</div></div><div><h3>IMPLICATIONS</h3><div>The most common complication of barrier membrane placement is wound dehiscence and membrane exposure, which can lead to treatment failure. Understanding the relative biocompatibility of commonly used membrane materials may aid in clinical decision-making and reduce morbidity for pat","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficiency of Hydrophilic Compared to Hydrophobic Dental Sealants in Complex Patients","authors":"Aubree Comtois,&nbsp;Jenna Kinzle","doi":"10.1016/j.dentre.2026.100361","DOIUrl":"10.1016/j.dentre.2026.100361","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Sealants on complicated patients tend to have lower retention rates. This study was used to compare the retention rates in hydrophobic vs hydrophilic sealants during unideal conditions.</div></div><div><h3>METHODS</h3><div>PubMed was the database used for this study. Keywords used were water-repellent, water-responsive, children, pit, and fissure.</div><div>P: Complex patients</div><div>I: Efficiency of sealants</div><div>C: Hydrophobic vs hydrophilic</div><div>O: Higher retention rates.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Hydrophobic did better overall in the retention rate field. However, it was close on all three studies. All studies showed that the retention rates of the two sealants were very close and both are ethical choices.</div></div><div><h3>CONCLUSIONS</h3><div>Retention is not as high in hydrophilic compared to hydrophobic. Although hydrophobic proved to be the better option in less complicated cases, the stress-free application of hydrophilic may make it worth reapplying. Both sealants prove to be vital in the prevention of high-risk patients.</div></div><div><h3>IMPLICATIONS</h3><div>Our findings during this study showed us that both hydrophobic and hydrophilic sealants can be used to treat high-risk patients effectively. Using hydrophilic sealants instead of hydrophobic in complex patients could offer some relief to dental professionals. In the future, we hope to see more successful studies of hydrophilic being placed in complex case studies.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic computer-assisted implant surgery: a systematic review and meta-analysis of positional accuracy and clinical implications","authors":"Soo-Yeon Yoo ,&nbsp;Ji-Man Park ,&nbsp;Zhiyan Piao ,&nbsp;Seong-Kyun Kim ,&nbsp;Jai-Young Koak ,&nbsp;Kwang-Suk Seo ,&nbsp;Adriana da Fonte Porto Carreiro ,&nbsp;Feng Liu","doi":"10.1016/j.dentre.2026.100424","DOIUrl":"10.1016/j.dentre.2026.100424","url":null,"abstract":"<div><h3>Background</h3><div>Transferring a digital implant plan accurately to the surgical field remains a persistent limitation in implant dentistry. Static computer-assisted implant surgery (static CAIS) improves plan transfer but provides limited intraoperative correction, and the clinical accuracy of robotic computer-assisted implant surgery (robotic CAIS) has not been comprehensively synthesized.</div></div><div><h3>Objectives</h3><div>To evaluate the positional accuracy of robotic CAIS and compare it with freehand implant placement and static CAIS.</div></div><div><h3>Methods</h3><div>A PRISMA 2020-compliant systematic review and meta-analysis was conducted using PubMed, Embase, Scopus, and Web of Science from inception to December 2025. Eligible in vitro and in vivo studies reporting positional deviations (angular, coronal, and/or apical) between planned and placed implant positions were included. Separate single-arm and comparative meta-analyses were performed using random-effects models. Heterogeneity was assessed using the I² statistic. Reporting bias and potential small-study effects were evaluated through visual inspection of funnel plots. Risk of bias was assessed using ROB 2, ROBINS-I, and QUIN tools.</div></div><div><h3>Results</h3><div>In vitro studies showed low angular and linear deviations under controlled conditions. In clinical studies, pooled angular deviation was approximately 1–2°, with submillimeter coronal and apical deviations. Compared with freehand placement, robotic CAIS reduced angular and linear deviations, with an approximate 5° reduction in angular error and about 1 mm reduction in apical deviation. Comparisons with static CAIS showed smaller but consistent reductions in positional deviations across in vitro and clinical analyses, although the magnitude of difference was more limited.</div></div><div><h3>Conclusions</h3><div>Robotic CAIS improves implant positioning accuracy compared with freehand placement and provides modest advantages over static CAIS. However, evidence regarding long-term clinical outcomes remains limited.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100424"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Caries Detection Through Artificial Intelligence in Radiographs and intraoral Images","authors":"Gabriel Brunkow-Schnell,&nbsp;Laquita Addison,&nbsp;Ashley Christman RDH, BS","doi":"10.1016/j.dentre.2026.100349","DOIUrl":"10.1016/j.dentre.2026.100349","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>The aim was to find a method that is more efficient and consistent in caries detection utilizing Al technology. A literature review was conducted using randomized clinical studies found on PubMed that focused on Al use in radiographs and intraoral images.</div></div><div><h3>METHODS</h3><div>The population of concern was dental patients and the intervention was the use of artificial intelligence. This study compared visual examination of caries with caries detection by artificial intelligence. The outcome explored was the effectiveness of artificial intelligence in detecting caries. The Pubmed database was used to search for keywords including Al, Machine Learning, Decay, Cavities, x-rays, and Diagnostic Imaging.</div></div><div><h3>RESULTS</h3><div>PubMed and keywords produced 34 studies. Of those studies, 5 were chosen for review, and 3 were used. Study 1 used a ResNet-18 deep learning model which was trained to provide radiographs. Study 2 used a convolutional neural network (CNN) model. Study 3 used deep learning based on CNN and consumer products, such as cell phones and cameras, to detect caries in low income areas where dental equipment and dental specialists are not readily available.</div></div><div><h3>CONCLUSIONS</h3><div>Artificial intelligence tools have detected caries with over 80-90% accuracy consistently in more than 3,000 radiographic images. Al used in conjunction with professional dental knowledge improves accuracy and efficiency of detecting caries in radiographs and clinical images. All three studies that we investigated showed Al technology to be an effective tool for detecting caries in radiographs. Further research proved that Al usage makes detecting caries more cost efficient and is able to be incorporated in low income populations where expensive technology is absent.</div></div><div><h3>IMPLICATIONS</h3><div>The findings from this research will improve the accuracy and speed of early caries detection, reduce diagnostic errors, and increase accessibility to dental care in underserved areas. This could reduce untreated caries in low-income communities.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Bonding Techniques on Bond Strength of Core Buildups in Simulated Endodontic Accesses in Zirconia Crowns","authors":"Ahren Blake DDS","doi":"10.1016/j.dentre.2026.100413","DOIUrl":"10.1016/j.dentre.2026.100413","url":null,"abstract":"<div><h3>Objective(s)</h3><div>Providers frequently opt to perform root canal therapy through pre-existing full-coverage restorations, subsequently repairing the access cavity with a composite restoration. The capacity to effectively bond zirconia remains a subject of ongoing debate. Particularly in the anterior region, zirconia crown restorations underscore the importance of evaluating the bond strength between composite restorations and zirconia crowns. The objective of this study is to assess whether the choice of bonding technique enhances the shear bond strength of repaired endodontic accesses in zirconia crowns.</div></div><div><h3>METHODS</h3><div>Researchers milled forty zirconia discs to include a simulated endodontic access. The discs were divided into four groups consisting of dual cure and light cure resins bonded with two bonding systems. Researchers performed pushout testing using an Instron machine and evaluated the results using Fisher’s Exact test.</div></div><div><h3>RESULTS</h3><div>The study found a statistically significant difference in shear bond strengths between dual-cure and light-cure adhesives with MDP, with a P-value of 0.023. No other groups showed statistical significance, although the dual-cure adhesive groups exhibited 2 to 4 times more bonded specimens than the light-cure adhesive samples.</div></div><div><h3>Conclusion</h3><div>The findings of this study underscore the ongoing challenges in achieving a durable bond between composite resins and zirconia materials. Despite the use of different resin-based materials and bonding systems, the bond strengths remain insufficient for achieving optimal clinical performance, especially in the anterior region where esthetics and longevity are paramount.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100413"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Breast-Feeding Guidance and Prevention of Dental Caries: A Survey","authors":"Savanah Price DMD","doi":"10.1016/j.dentre.2026.100390","DOIUrl":"10.1016/j.dentre.2026.100390","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>The purpose of this study is to gain understanding of provider guidance on breast feeding and the impact on caries prevention in children. Specific aims are to determine the effectiveness of breast-feeding education on oral health outcomes, evaluate the level of knowledge and practice regarding breast-feeding guidance, and develop recommendations for integrating this knowledge into pediatric practices.</div></div><div><h3>METHODS</h3><div>This study design involves collecting data via qualitative survey using standardized questionnaire inquiring about provider guidance on breast-feeding. Procedure involves collecting data via survey responses from participants on the active AAPD mailing list. Questions will be a combination of multiple choice and check box questions aiming to collect data from pediatric dentists on their knowledge of breast-feeding guidance and patient intervention.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Results of this study are currently in progress.</div></div><div><h3>CONCLUSIONS</h3><div>Dental caries is one of the most prevalent chronic conditions affecting children worldwide. Early childhood caries (ECC) can have significant impacts on a child’s health, nutrition, growth, and overall quality of life. The World Health Organization (WHO) recognizes the numerous health benefits of breast-feeding and recommends exclusively breast-feeding for the first six months of life, followed by continued breast-feeding accompanied with food for up to two years of beyond. While breast-feeding promotes health growth and development, prolonged and frequent night time feedings may increase the risk of dental caries.</div></div><div><h3>IMPLICATIONS</h3><div>Gaining understanding of breast-feeding guidance and how it impacts children’s oral health and caries rate.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100390"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoration of Non-Carious Cervical Lesions: A Clinical Review","authors":"Caroline G. Dudish BS, RDH,&nbsp;Martha G. Brackett DDS, MSD,&nbsp;Rafael R. Pacheco DDS, MSc, PhD,&nbsp;William W. Brackett DDS, MSD","doi":"10.1016/j.dentre.2026.100397","DOIUrl":"10.1016/j.dentre.2026.100397","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>To review the clinical relevance, indications, and material choices for restoring non-carious cervical lesions (NCCLs) to minimize lesion progression and maintain tooth integrity.</div></div><div><h3>METHODS</h3><div>A literature review was conducted analyzing the etiology, morphology, and restorative approaches for NCCLs. The effectiveness of resin composite and glass ionomer materials using various adhesive strategies was assessed.</div></div><div><h3>RESULTS</h3><div>NCCLs, being multifactorial in etiology, often progress erratically. Wedge-shaped NCCLs generate stress concentrations that can be alleviated by adhesive restoration. Restorations using total-etch or self-etching primer adhesive systems with selective enamel etching have shown to be effective. Glass ionomer restorations offer an alternative to resin composite when maintaining isolation through multiple bonding steps is challenging. elvis</div></div><div><h3>CONCLUSIONS</h3><div>Restoration of NCCLs is indicated for lesions reaching a depth of 1.5 mm to prevent structural compromise. Resin composite restorations require careful adhesive selection, air abrasion and enamel beveling. Glass ionomer restorations require no tooth preparation and provide an efficient alternative when faster application employing fewer bonding steps is indicated.</div></div><div><h3>IMPLICATIONS</h3><div>Appropriate restoration of NCCLs preserves tooth structure and function. Selecting the correct material and adhesive technique can improve clinical outcomes and long-term restoration success.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100397"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Ion Channels in Dentine Hypersensitivity","authors":"Anna Sanders","doi":"10.1016/j.dentre.2026.100378","DOIUrl":"10.1016/j.dentre.2026.100378","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>Dentin hypersensitivity (DH) is a common condition caused by exposure of dentinal tubules to the oral environment. This results in sharp pain in response to mechanical, thermal, chemical, and osmotic stimuli.</div><div>This review examined the roles of various ion channels in DH, focusing on how they contribute to pain perception and intercellular communication between odontoblasts and afferent sensory neurons.</div></div><div><h3>METHODS</h3><div>A comprehensive review of literature on ion channels involved in DH was conducted, with emphasis on transient receptor potential (TRP) channels, Piezo channels, acid-sensing ion channels (ASICs), and voltage-gated ion channels. Special focus was placed on the physiological function of these channels, their response to stimuli, and their role in DH-related pain pathways.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Ion channels such as TRPV1, TRPA1, and ASICs are activated by pressure, heat, acidic environments, and chemical irritants, all of which contribute to DH pain. Activation of ion channels located on odontoblasts triggers the release of adenosine triphosphate and glutamate from odontoblasts. These neurotransmitters bind to purinergic and glutamate receptors, respectively, on sensory neurons. This interaction causes depolarization and generates action potentials that relay pain signals to the brain. In addition, voltage-gated sodium channels such as NaV1.7 amplify neuronal excitability, promoting rapid pain signal transmission in response to DH stimuli.</div></div><div><h3>CONCLUSIONS</h3><div>The presence of diverse ion channels in odontoblasts and trigeminal ganglion-associated sensory neurons provides an intricate system for detecting and relaying DH-associated pain signals. Activation of these ion channels converts external stimuli into electrical signals that the central nervous system interprets as pain.</div></div><div><h3>IMPLICATIONS</h3><div>Although ion channels are crucial for pain perception, it is challenging to target them directly for DH management. Most of these channels are expressed in tissues other than the dental pulp, raising the risk of off-target systemic effects and adverse outcomes. Because of the essential roles of these channels in general physiological processes, approaches that desensitize dentinal tubules to prevent fluid movement appears to be safer and more effective for managing DH pain.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100378"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Scanning In Dentistry","authors":"Dominic F. Stecklein DDS","doi":"10.1016/j.dentre.2026.100405","DOIUrl":"10.1016/j.dentre.2026.100405","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>To provide a picture of the purpose and applications of digital scanning in patient treatment leading to successful patient outcomes.</div></div><div><h3>METHODS</h3><div>Analyzing and comparing the top intraoral scanning technologies available in dentistry. Weaving through the various applications from diagnostic, fixed, removable, surgical, orthodontic.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Each scanner has its own advantages and limitations, not all scanners are alike. Different characteristics of the scanners/technology influence the final result of the restoration/prostheses.</div></div><div><h3>CONCLUSIONS</h3><div>Intraoral scanners improve the efficiency of the process from initial dental exam to dental treatment, with requirement of fewer materials, less cleanup and waste, less storage space needed, improved patient satisfaction, minimized chair time, quicker turnaround times for restorations/prostheses.</div></div><div><h3>IMPLICATIONS</h3><div>Digital scanning will allow for greater production in a shorter span of time in the dental office.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100405"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Photodynamic Therapy for Treating Oral Lesions","authors":"April Parrish,&nbsp;Ariana George,&nbsp;Petrina Hutto EdD, RDH","doi":"10.1016/j.dentre.2026.100356","DOIUrl":"10.1016/j.dentre.2026.100356","url":null,"abstract":"<div><h3>OBJECTIVES</h3><div>A literature review was conducted to determine whether photodynamic therapy is a more practical alternative strategy for fighting oral infections when compared to traditional treatments.</div></div><div><h3>METHODS</h3><div>Our PICO question was: How Effective is Photodynamic Therapy for Treating Oral Lesions? We used PubMed as our database. Our search string involved using Scars “and” lesions “and “Apraxia “and” lichen planus Aphthous “or” canker sores. Keywords that were used are as follows: Dental, Lasers, Healing, Treatment, Lesions.</div></div><div><h3>RESULTS</h3><div><strong>(If applicable)</strong> Publications meeting the inclusion criteria consisted of five articles. The type of articles used from highest evidence level to lowest were randomized control trials, case-control studies, case reports and case series. We found five relevant articles but used three within our study. Treatment of Reticular Oral Lichen Planus with Photodynamic Therapy: A Case Series, Photodynamic Therapy- A promising treatment of oral mucosal infections-Clinical research study, Photodynamic Therapy of oral lichen planus-Randomized clinical control study.</div></div><div><h3>CONCLUSIONS</h3><div>Evidence supports photodynamic therapies such as Methylene blue, In the treatment of oral lesions. Studies show when applied to the site of infection a highly significant reduction of the size of OLP lesions will appear with little to no pain or patient discomfort. It is absorbed by the microbes, and visible light of a certain wavelength is used to irradiate the PS-microbial mixture.</div></div><div><h3>IMPLICATIONS</h3><div>Based on the observed evidence, a clinician can offer photodynamic therapy as a noninvasive method for treating oral lesions, promote faster recovery times, and improve the efficiency of patient care.</div></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"6 2","pages":"Article 100356"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}